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"Garcinia mangostana L. merupakan salah satu tanaman obat yang diketahuimempunyai berbagai manfaat, diantaranya sebagai antibakteri, antidiare,antiinflamasi, serta memiliki aktivitas antioksidan yang tinggi. Penelitian inibertujuan untuk menguji aktivitas antioksidan dari ekstrak etanol 50% kulit buah G.mangostanaterhadap hati dan plasma tikus dari kerusakan oksidatif akibat pemberiankarbon tetraklorida (CCl4). Dua puluh lima ekor tikus putih jantan Sprague-Dawleydibagi menjadi 5 kelompok yaitu kelompok kontrol; kelompok CCl4 dengan dosis0,55 mg/g BB peroral; serta kelompok ekstrak dosis 900, 1080, dan 1296 mg/kg BBperoral selama 8 hari sebelum pemberian CCl4. Karbon tetraklorida diberikan 48 jamsebelum tikus dikorbankan. Parameter biokimia yang diukur adalah aktivitassuperoksida dismutase (SOD), katalase (CAT) dan senyawa karbonil di jaringan hatidan plasma darah tikus. Hasil penelitian memperlihatkan aktivitas SOD hatikelompok ekstrak (900 dan 1080 mg/kg BB) dan aktivitas SOD plasma kelompokekstrak (900 dan 1296 mg/kg BB) lebih tinggi bermakna (p<0,05) terhadapkelompok CCl4. Aktivitas CAT hati kelompok ekstrak (900, 1080, dan 1296 mg/kgBB) lebih tinggi bermakna (p<0,05) dibandingkan kelompok CCl4. Pemberianekstrak dosis 900 mg/kg BB memperlihatkan kadar senyawa karbonil hati lebihrendah tidak bermakna (p>0,05) terhadap kelompok CCl4. Dari penelitian ini dapatdisimpulkan bahwa ekstrak etanol 50% kulit buah manggis dapat memberikanpengaruh terhadap aktivitas antioksidan endogen sehingga mampu mencegahterjadinya stres oksidatif di hati akibat pemberian CCl4.

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Garcinia mangostana L. is a medicinal plant known many benefits, including its

potency as antibacterial, antidiarrheal, antiinflammatory, and high antioxidant

activity. This study aimed to test the antioxidant activity of 50% ethanolic extract of

G. mangostana rind against oxidative damage in liver and plasma of rats caused by

administration of carbon tetrachloride (CCl4). Twenty-five male Sprague-Dawley

rats were divided into 5 groups consist of control group; CCl4 group aregiven a dose

of 0.55 mg/g b.w orally; group that are given doses of extract 900, 1080, and 1296

mg/kg b.w orally for 8 days prior to CCl4 administration. Carbon tetrachloride

(CCl4)are given 48 hours before the rats were sacrificed. Parameters measured were

superoxide dismutase (SOD), catalase (CAT) activity and carbonyl compounds in

liver tissue and blood plasma of rats. The results of this study showed that the

activity of liver SOD in extract groups (900 and 1080 mg/kg b.w) and activity of

plasma SOD in extract group (900 and 1296 mg/kg b.w) were significantly higher (p

<0.05) compared to CCl4 group. Activity of the liver CAT in extractgroups (900,

1080, and 1296 mg/kg b.w) were significantly higher (p <0.05) compared to CCl4

group. Extract administration on900 mg/kg b.w showed the levels of carbonyl

compounds in liver was lower not significant (p> 0.05) compared to the CCl4 group.

From this study it can be concluded that the 50% ethanolic extract of mangosteen

rind influence the activity of endogenous antioxidant and prevent oxidative stress in

the liver caused by CCl4 administration."

"Tujuan penelitian adalah untuk mengetahui korelasi antara kadar vitamin C serumdengan kadar SOD eritrosit pada penderita HIV/AIDS . Penelitian dilakukan di UPTHIV RSUPNCM Jakarta mulai bulan Februari sampai Maret 2013. Penelitian inimerupakan studi potong lintang terhadap 52 orang penderita HIV. Data yang diambilmeliputi data karakteristik subyek berdasarkan usia, jenis kelamin dan pendidikan,asupan energi, asupan vitamin C, status gizi, riwayat pengobatan ARV, jumlahlimfosit T CD4. Dilakukan pemeriksaan laboratorium untuk mengukur kadar vitaminC serum dan kadar SOD eritrosit. Analisis korelasi menggunakan uji Pearson dengankemaknaan p<0,05. Hasil: Subyek penelitian 25 perempuan dan 27 laki-laki, reratausia 33,60±4,84 tahun. 80,8% berada dalam rentang usia 30–40 tahun dan 82,7%berpendidikan sedang. Asupan energi 76,9% kurang dengan rerata untuk perempuan1700,41±316,25kkal/hari dan rerata laki-laki 1996,33±525,72kkal/hari. Asupanvitamin C 100% kurang dengan rerata untuk perempuan 46,62±15,66mg/hari danlaki-laki 46,97±13,39mg/hari. Status gizi 44,2% cukup dan 40,4% lebih dengan rerataIMT 21,98±3,48kg/m2. Sebanyak 94,2% sudah mendapat ARV dan jumlah limfosit TCD4 terbanyak berada pada kategori II CDC (200–499sel/?L) yaitu sebanyak 63,5%dengan median 245(50–861)sel/?L. Kadar vitamin C serum sebanyak 92,3% dalamkategori rendah dengan median 0,23(0,10–0,56)mg/dL. Kadar SOD eritrositterbanyak (53,8%) dalam kategori normal dengan rerata 1542,10±5,42U/gHb.Terdapat korelasi negatif lemah yang tidak bermakna antara kadar vitamin C serumdengan kadar SOD eritosit (r= −0,109 dan p=0,442)

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The objective of this study was to investigate the correlation between serum vitamin

C concentration and erythrocyte SOD concentration of HIV/AIDS patients. Study

was conducted at UPT HIV/AIDS RSUPNCM from February to March 2013. The

study was a cross sectional study of 52 HIV/AIDS patients. Data collected including

subject characteristic age, sex, education, energy intake by food record 2x24 hour,

vitamin C intake by FFQ semikuantitatif, nutritional status, history of ART, and CD4

lymphocyte count. Conducted laboratory tests to measure serum vitamin C

concentration and erythrocyte SOD concentration. Statistical analysis was done using

Pearson’s correlation test.

Result: Subject consisted of 27 men and 25 women, mean of age 33.60±4.84years

old. 80.8% age in range 30–40years old. 82.7% were medium education level. 76.9%

subject had low energy intake, mean 1700.41±316.25kcal/day for women and mean

1996.33±525.72kcal/day for men. 100% subject had low vitamin C intake with mean

46.62±15.66mg/day for women and 46.97±13.39mg/day for men. . Nutritional status

of 44.2% had normal and 40.4% over enough with a mean BMI 21.98±3.48 kg/m2.

94.2% had ART and 63.5% lymphocyte count at category II CDC with mean

245(50–861)cell/?L. 92.3% subyek had low serum vitamin C concentration with

median 0.23(0.10–0.56)mg/dL. 53.8% subject had normal erythrocyte SOD

concentration with mean 1542.10±5.42U/gHb. There was no correlation between

serum vitamin C and erythrocyte SOD. (r=−0.109 and p=0.442)"