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"Chronic adult periodontitis (CAP) is the most common type of periodontal disease. Treatment of moderate CAP has primarily been directed at the physical removal of bacterial plaque, calculus and contaminated cementum by scaling and root planing (SRP) with or without surgical access. Irrigation solutions reach the apical portion of the pocket has flushing action properties and easy to apply. Tetracyline HCI (TTC HCI) solutions demonstrated its antimicrobial activity against subgingival microflora, shown to be substantive to dentin surface and subsequently released in active form, also has anti-collagenase properties. This study evaluates the clinical outcomes of treatment with locally TTC HCI 10% irrigation as an adjunct to SRP in subset of moderate CAP patients. The data examined were obtained from 24 patients. All patient were scaled and root planed prior to baseline measurement. The patients were monitored by parameters : bleeding on probing (BOP), probing pocket depth (PPD), and attachment loss (LA). 56 contralateral surface exhibiting residual pocket depths 4-6 mm were randomly assigned as test or control sites. After baseline measurement, each subgingival root surface was irrigated with approximately 10ml for 1 minute either with TTC HCI 10% solution (test), or Aquabides solution (control). The clinical parameters were assessed at baseline and weeks 3. The two sites resulted in significant statistical and clinical improvement in all parameters. BOP was not significantly reduced in test site compared to control site. PPD and I.A was significantly reduced at test site compared to control site. The result indicate that subgingival irrigation with TTC HCI 10% solution 10 ml for 1 minute may have a role in the management of moderate CAP. This treatment reduces surgical needs."

"Pada penelitian ini dilakukan sintesis dan karakterisasi nanopartikel ZnO, nanopartikel DyVO4 dan nanokomposit ZnO/DyVO4 serta uji aktivitas fotokatalitik nya terhadap degradasi tetrasiklin. Metode sintesis yang digunakan adalah green synthesis dengan menggunakan ekstrak daun malaka (Emblica officinalis) dengan sistem dua fasa. Ekstrak n-heksana daun malaka memiliki kandungan metabolit sekunder seperti alkaloid, flavonoid, saponin, dan steroid yang berperan sebagai basa lemah dan capping agent untuk sintesis nanopartikel. Uji Karakterisasi pada penelitian ini adalah FTIR, UV-Vis DRS, XRD, dan SEM. Nilai band gap dari nanopartikel ZnO, nanopartikel DyVO4, nanokomposit ZnO/DyVO4 masing-masing sebesar 3,23 eV; 2,33 eV , dan 2,81 eV . Berdasarkan hasil uji aktivitas fotokatalitik menunjukkan nanokomposit ZnO/DyVO4 memiliki aktivitas fotokatalitik paling baik diantara nanopartikel ZnO dan DyVO4 dalam mendegradasi tetrasiklin dibawah sinar tampak selama 120 menit. Hasil degradasi tetrasiklin ZnO/DyVO4, DyVO4, dan ZnO berturut-turut adalah 94,34%, 81,56%, 31,63%. Untuk reaksi fotodegradasi tetrasiklin menggunakan ZnO/DyVO4 pada massa optimum 6 mg mengikuti model kinetika laju orde satu sebesar 2,23 x 10-2 min-1.......In this research, synthesis and characterization of ZnO nanoparticles, DyVO4 nanoparticles and ZnO/DyVO4 nanocomposites were carried out as well as testing their photocatalytic activity against tetracycline degradation. The synthesis method used is green synthesis using Malaka leaf extract (Emblica officinalis) with a two-phase system. The n-hexane extract of Malacca leaf contains secondary metabolites such as alkaloids, flavonoids, saponins, and steroids which act as weak bases and capping agents for the synthesis of nanoparticles. Characterization tests in this study were FTIR, UV-Vis DRS, and XRD, FESEM-EDX. The band gap values of ZnO nanoparticles, DyVO4 nanoparticles, ZnO/DyVO4 nanocomposites were 3.23 eV; 2.33 eV, and 2.81 eV. Based on the results of the photocatalytic activity test, it was shown that the ZnO/DyVO4 nanocomposite had the best photocatalytic activity among the ZnO and DyVO4 nanoparticles in degrading tetracycline under visible light for 120 minutes. The results of the degradation of tetracycline ZnO/DyVO4, DyVO4, and ZnO were 94.34%, 81.56%, and 31.63%, respectively. For the photodegradation reaction of tetracycline using optimum mass 6 mg of ZnO/DyVO4 it follows a first-order rate kinetics model were 2,23 x 10-2 min-1."