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Abstrak :
ABSTRAK
Berbagai studi terkini menunjukkan hubungan antara vitamin D dan sepsis. Vitamin D berperan sebagai stimulator produksi peptida antimikroba dan mencegah inflamasi yang berlebihan. Insufisiensi dan defisiensi vitamin D berhubungan dengan risiko terjadinya sepsis. Saat ini belum terdapat data mengenai hubungan status vitamin D dengan pasien infeksi tanpa sepsis, sepsis, dan sepsis berat. Tujuan penelitian ini dilakukan untuk mendapatkan hubungan antara proporsi status vitamin D dengan pasien infeksi tanpa sepsis, sepsis, dan sepsis berat. Desain penelitian potong lintang, terdiri dari 60 pasien infeksi terbagi menjadi kelompok infeksi tanpa sepsis, sepsis, dan sepsis berat masing-masing 20 pasien. Diagnosis sepsis berdasarkan modifikasi SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference 2001. Status vitamin D ditetapkan menurut rekomendasi Holick. Pada ketiga kelompok tersebut dicatat data karakteristik subjek dan dilakukan pemeriksaan 25(OH)D. Status vitamin D pada subjek penelitian ini didapatkan sebanyak 5 (8,33%) orang insufisiensi dan 55 (91,67%) orang defisiensi vitamin D Proporsi insufisiensi pada kelompok infeksi tanpa sepsis adalah 5%, sepsis 10%, dan sepsis berat 10%. Proporsi defisiensi pada kelompok infeksi tanpa sepsis adalah 95%, sepsis 90%, dan sepsis berat 90%. Didapatkan perbedaan tidak bermakna proporsi insufisiensi dan defisiensi vitamin D pada kelompok infeksi tanpa sepsis, sepsis, dan sepsis berat. Kami menyimpulkan status vitamin D tidak berhubungan dengan beratnya sepsis. Proporsi insufisiensi dan defisiensi pada pasien infeksi tanpa sepsis, sepsis, dan sepsis berat masing-masing didapatkan 5% dan 95%; 10% dan 90%; 10% dan 90%.

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ABSTRACT
Recent studies have shown that there is a relationship between vitamin D and sepsis. Vitamin D has a a role as a potent stimulator of antimicrobial peptides and prevent an over reaction of the inflammatory response. Insufficiency and deficiency of vitamin D have been associated with sepsis event. Nevertheless, there is no data about the relationship between vitamin D status with infection without sepsis, sepsis, and severe sepsis patient. The aim of this study was to obtain the relationship between proportions of vitamin D with infection without sepsis, sepsis, and severe sepsis patient. This was a cross-sectional study, 60 patients with infection were divided into groups of infection without sepsis, sepsis, and severe sepsis, each consisted of 20 patients. Diagnosis of sepsis was based on modified SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference 2001. Vitamin D status was defined according to Holick recommendations. Baseline characteristics of subjects were recorded and 25(OH)D concentrations were measured in subjects of each groups. According to status of Vitamin D, 5 (8,33%) subjects were insufficiency and 55 (91,67%) were deficiency. The proportions of vitamin D insufficiency at infection without sepsis group were 5%, sepsis 10%, and severe sepsis 10%. The proportions of vitamin D deficiency at infection without sepsis group were 95%, sepsis 90%, and severe sepsis 90%. The proportions of insufficiency and deficiency at infection without sepsis, sepsis, and severe sepsis patient were not significantly different (p > 0.05). It is concluded that vitamin D status were not related to infection severity. The proportions of vitamin D insufficiency and deficiency at infection without sepsis, sepsis, and severe sepsis, i.e. 5% and 95%; 10% and 90%; 10% and 90%, respectively.

Abstrak :
Latar belakang: Status gizi dan kadar vitamin D adalah dua masalah yang menjadi sorotan di dunia karena masih banyak negara dengan kejadian status gizi yang buruk dan defisiensi kadar vitamin D pada anak termasuk negara Indonesia. Anak dengan usia dibawah lima tahun dengan berat badan normal dan pendek dapat mengalami berat badan berlebih di kemudian hari. Kadar vitamin D yang menurun pada BMI lebih tinggi menjadi kemungkinan adanya pengaruh antara kadar vitamin D dengan status gizi. Tujuan: Mengetahui korelasi antara kadar vitamin D dengan status gizi anak Metode: Penelitian ini merupakan penelitian potong lintang. Menggunakan data dari SEANUTS II bulan September 2019 – Maret 2020. Digunakan 132 sampel pada anak usia 6-59 bulan di Indonesia yang memenuhi kriteria penelitian dengan random sampling. Hasil kadar vitamin D dari hasil pemeriksaan lab, asupan vitamin D menggunakan food recall 24 jam, dan status gizi diukur dengan Z-skor BB/TB. Kemudian dilakukan uji normalitas Kolmogorov- Smirnov dan uji korelasi Spearman. Hasil: Status gizi anak usia 6-59 bulan di Indonesia 89,4% memiliki status gizi normal.Sebanyak 88,6% anak kurang mendapatkan asupan vitamin D sesuai dengan rekomendasi AKG. Didapatkan 90,2% anak mengalami defisiensi vitamin D. Ditemukan korelasi bermakna antara asupan vitamin D dan kadar. Vitamin D (r= 0,234, nilai p=0,007). Tidak ada korelasi bermakna antara kadar vitamin D dengan Z skor BB/ TB ( r= -0,016, p=0,854). Simpulan: Tidak terdapat korelasi antara kadar vitamin D dengan Z-skor BB/TB pada anak usia 6-59 bulan di Indonesia. ......Background: Nutritional status and vitamin D levels are two highlighted global problem because there are still many countries with incidence of poor nutritional status and deficiency of vitamin D in children, including Indonesia. Children under five years of age with normal weight and short can develop to overweight later in life if not treated. A decreased vitamin D level at a higher BMI is a possible influence between vitamin D levels and nutritional status. Objective: To determine the correlation between vitamin D levels and children's nutritional status Methods: This research is a cross sectional study. Using data from SEANUTS II collected from September 2019 until March 2020. A total of 132 samples children aged 6-59 months in Indonesia who met the research criteria chosen by random sampling. Vitamin D levels data from lab tests, vitamin D intake record with 24- hour food recall, and nutritional status was measured based on Z-score BW / TB. Then, performed normality test with Kolmogorov- Smirnov and correlation test with Spearman. Results: The nutritional status of children aged 6-59 months in Indonesia 89,4% had normal nutritional status. Most of the children ( 88.6% ) did not get enough vitamin D intake according to the RDA recommendation. It was found that 90.2% of children had vitamin D deficiency. There was a significant correlation between vitamin D intake and levels. Vitamin D (r = 0.234, p value = 0.007). There was no significant correlation between vitamin D levels and Z score BW / TB (r = -0.016, p = 0.854). Conclusion: There was no correlation between vitamin D levels and Z-score Weight/Height in children aged 6-59 months in Indonesia.

Abstrak :

Vitamin D dapat mempengaruhi pertumbuhan tulang. Penelitian ini bertujuan untuk mengetahui korelasi kadar vitamin D dengan panjang badan bayi di Jakarta Pusat. Studi cross-sectional dilakukan terhadap 75 subjek yang memenuhi kriteria penelitian. Kadar vitamin D dalam serum diukur dengan metode CLIA (Chemiluminescence Immunoassay), dan panjang badan bayi diukur dengan teknik terstandarisasi dengan ketelitian 1mm oleh tenaga terlatih. Data dianalisis dengan uji Kolmogorov-Smirnov dan uji korelasi Pearson (korelasi bermakna jika p<0,05). Hasil penelitian menunjukkan bahwa mayoritas subjek penelitian (80%) tidak memiliki asupan vitamin D yang cukup. Nilai tengah kadar vitamin D bayi berusia 8-10 bulan di Jakarta Pusat sebesar 26,4 ng/dL, sedangkan nilai tengah panjang badan bayi 70,63 cm. Hasil penelitian menunjukkan tidak terdapat korelasi bermakna antara kadar vitamin D dengan panjang badan bayi 8-10 bulan di Jakarta Pusat (p=0,563).

 

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Vitamin D can influence bone growth. This study aims to determine the correlation between vitamin D levels and body length on 8 to 10 months old infants in Central Jakarta. Cross-sectional study was conducted on 75 infants which met the criteria. Serum vitamin D levels were measured with CLIA (Chemiluminescence Immunoassasy), while body length was measures by antropometric standardized technique by trained personnel. The data was analyzed with Kolmogorov-Smirnov test and Pearson test (significant correlation if p<0,05). The result shows that the majority of subjects (80%) do not have adequate vitamin D intake. The median value of vitamin D levels on 8 to 10 months old infants in Central Jakarta is 26.4 ng/dL, while the median value of body length is 70.63 cm. The result shows that there are no significant correlation between vitamin D levels and body length on 8 to 10 months old infants in Central Jakarta (p=0,563).