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"Exfoliative cheilits is a rare chronic superficial inflammation disorder which affect vermilion border of the lips, especially lower lip. This disorder mostly happens in woman. The characteristics of this disease are a large amount production and desquamation of the keratin layers. The etiology and pathogenesis of exfoliative cheilitis is unknown. Diagnosis of exfoliative cheilitis can only be established if the conditions of the disease couldn't be connected to others factors , exfoliative cheilitis is very resistant to many treatment modalities which gave a difficulty to determine a therapy with an optimum result. Topical steroid was the most effective therapy for the disease. Antifungal therapy can be used only if there is a secondarily infection caused by Candida. This case report is about an exfoliative cheilitis on 42 years- old women with unknown etiology background. On intra-oral examination we found out that there were several focus of infections that can delay the healing proccess. The patient's conditions wereresolved after a few month of topical steroid therapy, a month of antifungal therapy and a management of the focus of infections. An exact diagnosis, an appropriate management, good corporation between sections which are related to patient condition and patient corporation are very important on the healing of exfoliative cheilitis."

"Tingginya konsumsi ayam meningkatkan pembuangan limbah bulu ayam, yang mengandung sekitar 90% keratin, menyebabkan pencemaran lingkungan. Keratin, protein struktural utama dalam jaringan hewan, berfungsi untuk berbagai aplikasi biomedis dan memerlukan ekstraksi ramah lingkungan. Penelitian ini mengoptimasi ekstraksi keratin dari bulu ayam menggunakan cairan ionik 1-Butyl-3-Methylimidazolium Asetat ([Bmim]-Asetat) dengan bantuan ultrasonic bath. Hasil penelitian menunjukkan bahwa metode panas dengan waktu 120 menit menghasilkan yield keratin tertinggi sebesar 78.20% dibandingkan metode optimasi ultrasonik dan metode ultrasonik tanpa optimasi. Karakterisasi FTIR menunjukkan spektra konsisten dengan struktur keratin, dan uji Bradford menunjukkan konsentrasi protein tertinggi pada metode panas dengan 112.42 mg/mL dibandingkan metode ultrasonik 120 menit dan optimasi ultrasonik 120 menit yang menghasilkan 12.13 mg/mL dan 8.834 mg/mL masing-masing. Analisis SDS-PAGE memastikan keberadaan protein keratin pada sampel hasil ekstraksi dengan berat molekul yang terlihat sebesar 10 kDa. Kombinasi gelombang ultrasonik dan suhu 90 oC dapat meningkatkan efisiensi ekstraksi dan pemulihan keratin dari limbah bulu ayam, menjadikannya metode yang lebih efisien dan ramah lingkungan.......The high consumption of chicken increases the disposal of chicken feather waste, which contains about 90% keratin, leading to environmental pollution. Keratin, the main structural protein in animal tissues, serves various biomedical applications and requires environmentally friendly extraction methods. This study optimizes the extraction of keratin from chicken feathers using the ionic liquid 1-Butyl-3-Methylimidazolium Acetate ([Bmim]-Acetate) with the assistance of an ultrasonic bath. The results show that the heat method with a duration of 120 minutes produced the highest keratin yield of 78.20%, compared to the optimized ultrasonic method and the non-optimized ultrasonic method. FTIR characterization indicated spectra consistent with the structure of keratin, and the Bradford assay revealed the highest protein concentration in the heat method at 112.42 mg/mL, compared to 12.13 mg/mL and 8.834 mg/mL in the 120-minute ultrasonic and optimized ultrasonic methods, respectively. SDS-PAGE analysis confirmed the presence of keratin protein in the extracted samples with a visible molecular weight of 10 kDa. The combination of ultrasonic waves and a temperature of 90°C can enhance the efficiency of keratin extraction and recovery from chicken feather waste, making it a more efficient and environmentally friendly method."