Hasil Pencarian  ::  Simpan CSV :: Kembali

Abstrak :

Indonesia merupakan negara kepulauan yang memiliki banyak kekayaan dari bahan alam laut. Flora dan fauna laut terbukti menghasilkan senyawa kimia yang dapat menghasilkan senyawa bioaktif. Akan tetapi, hingga saat ini penelitian senyawa kimia bahan laut untuk menjadi kandidat obat masih minim sekali. Hal ini disebabkan belum tersedianya pangkalan data senyawa kimia bahan laut yang lengkap dan gratis untuk dilakukan penelitian in silico. Penelitian ini bertujuan membuat pangkalan data senyawa kimia bahan laut yang lengkap dan gratis agar pangkalan data dapat membantu penelitian in silico untuk pengembangan obat baru dari bahan laut. Penelitian ini diawali dengan mengumpulkan data-data senyawa kimia bahan laut yang pernah dilakukan Fakultas Farmasi Universitas Indonesia. Kemudian dilakukan optimasi dan validasi struktur menggunakan metode MMFF94 dan AM1-BCC, pengumpulan parameter fisikokimia dan informasi ADME/T serta sumber referensinya. Setelah data-data ini berhasil dikumpulkan, dibuatkanlah basis data menggunakan bahasa pemrograman PHP/MySQL yang dapat diakses menggunakan website. Pangkalan data senyawa kimia bahan laut ini dapat diakses secara gratis melalui laman sementara  https://marine-db.vercel.app/ dan akan dipindah ke marinedb.herbaldb.info diharapkan dapat memperbanyak penelitian obat dari senyawa kimia bahan laut dilakukan. ......Indonesia is a country that consists of many island which has a lot of wealth from natural marine materials. Marine flora and fauna have been proven to produce chemical compounds that can produce bioactive compounds. However, until now research on chemical compounds from marine materials to become drug candidates is still minimal. This is due to the unavailability of a complete and free database of marine chemical compounds for in silico research. This research aims to create a complete and free database of marine chemical compounds so that the database can assist in silico research for the development of new drugs from marine ingredients. This research began by collecting data on chemical compounds from marine materials which had been carried out by the Faculty of Pharmacy, University of Indonesia. Then optimization and validation of the structure were carried out using the MMFF94 and AM1-BCC methods, collecting physicochemical parameters and ADME/T information as well as reference sources. After this data has been collected, a database is created using the PHP/MySQL programming language which can be accessed using the website. The marine compound database temporarily accessible at https://marine-db.vercel.app/and will be migrated to marinedb.herbaldb.info is expected to improve drug discovery and development from marine bioactive compounds.

 

Abstrak :
ABSTRAK
Telah dilakukan penelitian mengenai analisis sebaran kelimpahan kista Dinoflagellata penyebab HAB di lokasi budidaya kerang hijau (Perna viridis) Kamal Muara, Jakarta Utara, pada bulan Oktober 2014 di 9 titik stasiun. Tujuan dari penelitian ini adalah untuk mengetahui keberadaan serta kelimpahan kista Dinoflagellata penyebab HAB, memetakan sebaran spasial kista Dinoflagellata penyebab HAB, dan untuk mengetahui faktor lingkungan yang memengaruhi sebaran kista Dinoflagellata penyebab HAB. Pengambilan sampel sedimen dilakukan menggunakan Eijkman Grab, dan pemisahan kista dari sampel sedimen dilakukan menggunakan metode sieving technique. Hasil penelitian menunjukkan bahwa terdapat 8 genus kista Dinoflagellata di lokasi penelitian, yaitu Alexandrium, Cochlodinium, Diplopsalis, Gonyaulax, Gymnodinium, Polykrikos, Protoperidinium, dan Scrippsiella, dimana 5 diantaranya merupakan genus penyebab HAB, yaitu Alexandrium, Cochlodinium, Gonyaulax, Gymnodinium, dan Scrippsiella. Kelimpahan kista di sedimen lokasi penelitian memiliki kisaran antara 4--324 kista/ml. Kista dengan kelimpahan tertinggi adalah genus Alexandrium (324 kista/ml) dan terendah adalah genus Diplopsalis (4 kista/ml). Pola sebaran kista di lokasi penelitian menunjukkan bahwa kista terkonsentrasi pada stasiun-stasiun di wilayah timur. Faktor lingkungan yang paling memengaruhi sebaran kista di lokasi penelitian adalah arus, sedangkan faktor lingkungan yang memengaruhi germinasi kista adalah DO, cahaya, dan suhu.

---

ABSTRACT
Research on the distribution analysis on the cyst abundance of HAB causing Dinoflagellates at green mussel (Perna viridis) culture area in Kamal Muara, North Jakarta, has been conducted in October 2014 at 9 sampling stations. The objectives of the research were to determine the presence and abundance, mapping the spatial distribution, and to determine the environmental factors that influence the distribution of cysts from HAB causing Dinoflagellates. Sediment sampling was carried out using Eijkman Grab. Cyst sample preparation was carried out using the sieving technique. The results showed 8 genus of Dinoflagellate cysts, which were Alexandrium, Cochlodinium, Diplopsalis, Gonyaulax, Gymnodinium, Polykrikos, Protoperidinium, and Scrippsiella, in which 5 of them were HAB causing, namely Alexandrium, Cochlodinium, Gonyaulax, Gymnodinium, dan Scrippsiella. The abundance of cyst at sediments were ranged between 4--324 cysts/ml. Cyst with highest abundance was genus Alexandrium (324 cysts/ml) and the lowest was genus Diplopsalis (4 cysts/ml). Cyst distribution pattern at the study site showed that cysts were concentrated at stations located in the eastern region. Environmental factors that mostly influence the distribution of cysts in the study site was water current, whereas environmental factors that affect the germination of cysts was DO, light, and temperature.

Abstrak :
Anthropogenic changes to the marine environment are causing some considerable concern and yet there is very little information on the overall effects of either single or multiple human influences on species, populations, or, indeed, communities. The indication is that anthropogenic stressors have significantly altered the composition and diversity of marine communities at almost every trophic level, which can have profound effects on surviving species and ecosystems, especially when major processes are supported by a limited number of species. Studies investigating the effects of multiple stressors, however, are challenging as ecological changes are underpinned by physiological adjustments and differences in tolerance levels which are highly variable among and within species and populations. To provide a more comprehensive understanding of the effects of multiple stressors, this volume summarizes current understanding of the physiological and ecological responses of marine species to a wide range of potential stressors (salinity, hypoxia, ocean acidification, temperature, chemical pollution, nitrogen deposition, ultraviolet radiation, and noise), before it considers what is currently known about effects of multiple co-occurring stressors in the marine environment. Expertise, ranging from emerging early career researchers to leaders in the field, have been brought together to outline the responses shown by different marine species and habitats at different levels of biological and ecological organization, as well as to provide perspectives on potential future outcomes for some of the most pressing environmental issues facing society today.

Abstrak :
Tumpahan minyak di perairan telah menimbulkan pencemaran di lingkungan laut maupun di daerah pesisir pantai, sehingga perlu dilakukan penelusuran kejadian tumpahan minyak dapat digunakan untuk mitigasi bencana. Penelitian ini bertujuan untuk mengetahui sebaran dan pergerakan tumpahan minyak di perairan Cilacap, Jawa Tengah tahun 2008, serta hubungannya dengan angin, arus, dan pasang surut. Identifikasi tumpahan minyak dilakukan dengan interpretasi citra Modis surface reflectance dengan melihat penurunan nilai spektral dan diikuti oleh peningkatan nilai fluorescence index. Tumpahan minyak menyebar di sekitar pesisir pantai Teluk Penyu Kecamatan Cilacap Selatan, Kecamatan Cilacap Utara, Kecamatan Kesugihan dan Kecamatan Adipala, dengan luas total area yang tercemar sebesar 1.378 ha. Angin merupakan faktor dominan yang berpengaruh terhadap pergerakan minyak dibandingkan dengan arus dan pasang surut. Pergerakan tumpahan minyak menyebar menjauhi lokasi sumber tumpahan dan bergerak searah dengan arah angin menuju ke arah timur. Dari kondisi oseanografis menunjukan bahwa jenis penyebarannya termasuk kedalam jenis difusi gabungan ekspansi dan relokasi. ...... The oil spill in the waters has occurred pollution in the marine environment as well as in coastal areas, so needs to do investigation of occurrence oil spill which can use for disaster mitigation. This research is going to describe the distribution and movement of oil spill in Cilacap coastal, Central Java in 2008, and its relation with the wind, currents, and tides. Identification of oil spill conducted by Modis image surface reflectance interpretation by looking at the impairment of spectral and was followed increase in fluorescence index value. Distribution of oil spill spreading around at Teluk Penyu coast of south Cilacap, North Cilacap, Kesugihan, and Adipala, with a total area of 1.378 ha contaminated. Wind is the dominant factor influencing the movement of oil compared with currents and tides. The movement away from the spreading oil spill and the spill source location moves in the direction of the wind toward the east. Of oceanographic conditions indicate that the type of distribution, including the type of diffusion into the combined expansion and relocation.