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"Pendahuluan: Kekakuan arteri merupakan prediktor mortalitas pasien hemodialisis. Hemodialisis merupakan proses yang menginduksi inflamasi, ditandai dengan peningkatan penanda inflamasi, Pentraxin 3 (PTX3), intradialisis. Rerata kekakuan arteri pada pasien HD dua kali seminggu di Indonesia menunjukkan hasil yang lebih rendah daripada literatur. Tujuan: Mengetahui faktor risiko kekakuan arteri pada pasien hemodialisis kronik dengan berfokus pada frekuensi hemodialisis dan PTX3.Metode: Penelitian ini merupakan penelitian potong lintang di RS Cipto Mangunkusumo, RS Fatmawati, dan RS Medistra pada pasien yang menjalani hemodialisis minimal 1 tahun dengan frekuensi dua dan tiga kali seminggu. Kekakuan arteri diukur dengan carotid-femoral pulse wave velocity. Pemeriksaan PTX3 dilakukan sebelum hemodialisis dimulai.Hasil: Penelitian dilakukan pada 122 subjek, 82 subjek diantaranya menjalani hemodialisis dua kali seminggu. Tidak ada perbedaan kekakuan arteri antara pasien HD 2x dan 3x seminggu. PTX3 > 2,3 ng/ml berhubungan dengan kekakuan arteri (p=0,021). Pada analisis multivariat, PTX3 berhubungan dengan kekakuan arteri (adjusted OR 5,18; IK 95% 1,07-24,91), demikian juga penyakit kardiovaskular (adjusted OR 3.67; IK 95% 1.40-10.55), kolesterol LDL (adjusted OR 3.10; IK 95% 1.04-9.24), dan dialysis vintage (adjusted OR 2.72; IK 95% 1.001-7.38).Simpulan: PTX >2,3 ng/ml berhubungan dengan kekakuan arteri. Tidak terdapat perbedaan kekakuan arteri antara pasien HD dua kali dan tiga kali seminggu.

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Introduction: Arterial stiffness is a mortality predictor in hemodialysis patients. Hemodialysis induces inflammation, marked by intradialysis increment of inflammatory marker, Pentraxin 3 (PTX3). The mean arterial stiffness in twice-weekly hemodialysis patients in Indonesia is lower than studies done in thrice-weekly patients.

Objective: To determine factors associated with arterial stiffness in hemodialysis patients, focusing on the role of hemodialysis frequency and PTX3.

Methods: This study is a cross-sectional study conducted in Cipto Mangunkusumo Hospital, Fatmawati Hospital, and Medistra Hospital Jakarta in twice- and thrice-weekly hemodialysis patients. Arterial stiffness is measured by carotid-femoral pulse wave velocity.

Results: The study is conducted in 122 subjects, 82 of them undergo twice-weekly hemodialysis. There is no difference in arterial stiffness between twice- and thrice-weekly subjects. PTX3>2.3 ng/ml is associated with arterial stiffness (p= 0.021). In multivariate analysis, PTX3 is associated with arterial stiffness (adjusted OR 5.18; 95% CI 1.07-24.91), as well as cardiovascular disease (adjusted OR 3.67; 95% CI 1.40-10.55), LDL cholesterol (adjusted OR 3.10; 95% CI 1.04-9.24), and dialysis vintage (adjusted OR 2.72; 95%CI 1.001-7.38).

Conclusions: Predialysis PTX3 level above 2.3 ng/ml is associated with arterial stiffness. There is no difference in arterial stiffness between twice- and thrice-weekly hemodialysis patients."

"Background: arterial stiffness is a mortality predictor in hemodialysis patients, hemodialysis induces inflammation, marked by an intradialysis increase in the inflammatory marker pentraxin 3 (PTX3). Arterial stiffness in twice-weekly hemodialysis patients in Indonesia is lower than has been found in studies of thrice-weekly patients. This study therefore aims to determine the factors associated with arterial stiffness, focusing on the role of hemodialysis frequency and PTX3. Methods: a cross-sectional study was conducted at Cipto Mangunkusumo Hospital, Fatmawati Hospital, and Medistra Hospital involving patients with twice- and thrice-weekly hemodialysis. Arterial stiffness was measured by carotid-femoral pulse wave velocity after hemodialysis, and blood samples for PTX3 testing were taken before hemodialysis. Bivariate and multivariate analyses were performed using chi-squared tests and logistic regression. Results: out of 122 subjects, 82 underwent twice-weekly hemodialysis. There was no difference in arterial stiffness between patients with twice- and thrice-weekly hemodialysis. In bivariate analysis, PTX3, cardiovascular disease, dialysis vintage had p values of <0.05, while the subsequent multivariate analysis showed that PTX3>2.3 ng/ml was associated with arterial stiffness (adjusted OR 5.18; 95% CI 1.07–24.91), as well as cardiovascular disease (adjusted OR 3.67; 95% CI 1.40–10.55), LDL (adjusted OR 3.10; 95% CI 1.04–9.24), and dialysis vintage (adjusted OR 2.72; 95% CI 1.001–7.38). Conclusion: predialysis PTX3 levels above 2.3 ng/ml were associated with arterial stiffness. There was no difference in arterial stiffness between patients with twice- and thrice-weekly hemodialysis."