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Hasil Pencarian

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Sondakh, Agustine H.S.
"ABSTRAK
Hasil pemeriksaan berkala pada pekerja di industri pengolahan minyak dan gas alam Kalimantan timur, menunjukkan adanya peningkatan enzim-enzim hati yaitu ALT, AST, SGGT. Hal ini menunjukkan adanya gangguan fungsi hati yang masih reversibel bila tidak segera ditangani akan dapat mengakibatkan penyakit hati yang lebih berat atau dapat menyebabkan sirosis hepatis.
Timbul pertanyaan: Adakah hubungan antara peningkatan enzim hati pekerja di industri pengolahan minyak dan gas alam Kalimantan Timur dengan tempat kerja, beban kerja, kepangkatan, kegemukan, umur, dan lama kerja ?
Penelitian ini menggunakan data sekunder dengan desain penelitian Cross Sectional.
Analisis statistik data dilakukan dengan program SPSS versi 4.0, untuk mendapatkan gambaran karakteristik masing-masing variabel (univariat), bivariat dengan uji beda proporsi, perhitungan nilai 'Odds Ratio', dan confiders interval (CI) 95%.
Hasil penelitian :
- Tidak ada hubungan antara peningkatan enzim hati pekerja dengan tempat kerja yang diduga terpajan pada zat hepatotoksik.
- Ada hubungan antara peningkatan enzim hati pekerja dengan beban kerja fisik ringan, kepangkatan senior staf, umur, kegemukan.
- Tidak ada hubungan peningkatan enzim hati pekerja dengan lama kerja.
Kesimpulan hasil penelitian peningkatan enzim hati pada pekerja di industri pengolahan minyak dan gas di Kalimantan Timur dihubungkan dengan kepangkatan senioritas pekerja, umur, kegemukan, beban kerja mental yang berat sedangkan tempat kerja yang diduga terpajan pada zat hepatotoksik dan lama kerja, dengan analisis bivariat tidak ada hubungan secara statistik tetapi analisis multivariat mempunyai kontribusi walaupun hanya sedikit dengan adanya interaksi dan konfounding dengan variabel lainnya.
Saran pada pekerja yang berumur di atas 45 tahun, untuk mengadakan pemeriksaan berkala setiap sekurang- kurangnya 6 bulan sekali, dan dipindahkan ketempat yang tidak terpajan pada bahan toksik. Pekerja yang mempunyai HMI >25kg/m2 disarankan diet rendah kalori dan lemak, dan mengadakan olah raga teratur. Pekerja senior staf dan beban kerja mental yang tinggi disarankan waktu pemeriksaan berkala lebih pendek (sekurang-kurangnya 6 bulan sekali), istirahat waktu lebih panjang dan olah raga teratur yang sesuai.

ABSTRACT
;Regular medical examination has been conducted for employees of crude oil and gas industry in Kalimantan Timur. There was elevation liver enzyme test such as: ALT, AST, and GGT. This was an indication that there was some liver dysfunction, which was reversible.
The question is what is the stage of elevation, which was related with to the exposure of hepatotoxic material. Some of the variables such as: rank, work responsibility, obesity, age and duration of employment were measured.
This study used secondary data and the design of the study was Cross Sectional.
Statistical analysis was done by the use of SPSS program it had been described the characteristic of variables, using bivariat technique by Chi-Square test, to determined `Odds Ratio' and Confidence Interval (CI) 95%.
The study confirmed that there was no relation between liver enzyme elevation and department exposure to hepatotoxic material and duration of employment. There was correlation between liver enzyme elevation and work responsibility light physical load, rank, age and obesity.
It was concluded that liver enzyme elevation was correlated with age, obesity, rank, work responsibility. How ever department with high exposure to hepatotoxic and duration of employment had no significant different if we used the bivariat test. But if we used multivariate test, it showed a contribution to the interaction and it showed a confounding with another variable.
It was suggested that: workers over 45 year should have a medical examination at least every 6 month, and it was suggested also to be transferred to other department with less exposure of hepatotoxic materials. The workers who have BMI more than 25kg/m2 were suggested diet of low calorie and regular physical exercise. The workers senior staff and work responsibility who had mental work load were suggested to have a medical examination at least every 6 month, regular physical exercise and their rest pause should longer than the others.
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Depok: Universitas Indonesia, 1994
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UI - Tesis Membership  Universitas Indonesia Library
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Thomas Aquino Da Gomez
"ABSTRAK
Latar Belakang: Pada penelitian tahun 2005-2010 ditemukan pekerja PT. X yang terpajan VCM berisiko 2.15 kali menderita gangguan enzim hati. Sehingga perusahaan melakukan program pencegahan dan pengendalian faktor resiko. Pada penelitian ini ingin melihat pengaruh pajanan VCM serta faktor lainnya terhadap perubahan kadar enzim hati pekerja PT. X ini setelah dilakukan upaya perbaikan.
Metode: Desain penelitian adalah Kohort Retrospektif menggunakan data sekunder MCU tahun 2011-2015. Melibatkan 196 orang sampel, dimana pekerja terpajan VCM 98 orang dan sisanya tidak terpajan VCM. Saat awal, kondisi enzim hati seluruh sampel dalam batas normal. Penilaian peningkatan enzim hati berdasarkan enzim AST dan ALT. Analisis statistik menggunakan Chi Square dengan p< 0.05. Multivariat menggunakan Regresi Cox.
Hasil: Didapatkan 76 orang (38.8%) mengalami peningkatan enzim hati, 40 orang (40.8%) pekerja terpajan VCM dan 36 orang (36.7%) tidak terpajan VCM. Jumlah kasus baru tahun 2012 adalah 14.3% menurun menjadi 4.6% tahun 2015. Hasil analisis Chi Square menyatakan tidak ada hubungan bermakna antara faktor usia, jenis kelamin, masa kerja, posisi jabatan, indeks masa tubuh, obesitas sentral, riwayat DM dan kebiasaan olah raga dengan perubahan kadar enzim hati (p > 0.05). Untuk Regresi Cox menegaskan bahwa tidak ada hubungan bermakna antara pajanan VCM (RRsuaian=0.82; IK95% = 0.52-1.31; p=0.410) terhadap perubahan kadar enzim hati.
Kesimpulan: Pajanan VCM tidak berpengaruh terhadap perubahan kadar enzim hati. Perubahan kadar enzim hati yang terjadi berupa penurunan karena jumlah kasus baru terus menurun setiap tahun.

ABSTRACT
Background: In the 2005-2010 study found that PT. X workers exposed to VCM had a 2.15 times greater risk of liver enzyme disorders. So the company conducted prevention and control programs against the risk factors. In this study we want to see the effect of VCM exposure and other factors on alteration in liver enzyme levels of PT. X workers after the improvement effort.
Method: The study design is Retrospective Cohort using secondary data of MCU in 2011-2015. There are 196 persons involved as samples, where 98 workers are exposed to VCM and the rest are not exposed to VCM. At baseline, the liver enzyme conditions throughout the sample are within normal limits. Assessment of elevated liver enzymes based on AST and ALT enzymes. The Chi-squared test with p <0.05 is used for statistical analysis. Multivariate uses Cox Regression.
Results: 76 people (38.8%) had elevated liver enzymes, 40 (40.8%) exposed workers VCM and 36 people (36.7%) were not exposed to VCM. The number of new cases in 2012 is 14.3% decreased to 4.6% in 2015. Chi Square analysis results show no significant relationship between age, sex, work period, job title, body mass index, central obesity, history of DM and exercise habits with liver enzyme levels alteration (p> 0.05). The Cox Regression test confirms that there is no significant association between VCM exposure (RRadjusted=0.82; CI95%=0.52-1.31; p=0.410) to liver enzyme levels alteration.
Conclusions: VCM exposure has no effect on alteration in liver enzyme levels. Alteration of liver enzyme that occur is a decrease as number of new cases continues to decline every year."
2017
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UI - Tesis Membership  Universitas Indonesia Library