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"Background: Although combipack has high effectivity in tuberculosis treatment but it has lower compliance, The unst.iccessfull problems might be caused by number of pills taken by patients. Therefore, World Health Organization (WHO) decided to make new preparation which consist of more than two antituberculosis agent in one pill which is called fixed dose combination (FDC).Methods: The efficacy of 2 antituberculosis agent (FDC and combipack) were compared after 6 months therapy of positive acid fast bacilli (AFB) pulmonary tuberculosis (PTB) patients in directly observed treatment, short course (DOTS) in Lung Clinics Persahabatan Hospital -Dep􀀛rtment Pulmonology and Respiratory Medicine, Faculty of Medicine University of Indonesia, with design randomized clinical trial.Results: FDC group consist of 52 patients, 32 male (mean of age 28.56 ± 10.74) is compared to 58 patients, 33 male in combipack group (mean of age 29.53 ± 10.1 ). Sputum conversion is 98% in FDC g,roup and combipack 94. 7% in the early evaluation, the results almost similar to the end of.evaluation 97 .3% in FDC group and combipack 97.7%, and both of them are not statistically significant (p>0.005). Cure rate in FDC group is 69.2% and combipack 72.4%, and success rate in FDC group is 97.3% and combipack 97.7%, both of them are not statisticallly significant (p>0.005). FDC causing less itchy skin (1.9% in FDC and 6.9% in combipack) and musculoskeletal pain (0% in FDC and 5.2% in combipack) than combipack although it has no statiscal significant (p>0.005).Conclusion: FDC has the same efficacy as combipack which can be used to treat PTB in DOTS strategy. Conversion rate, cure rate and success rate are almost the same in both groups."

"Laporan Praktik Kerja Profesi Apoteker ini membahas terkait pembuatan leaflet atasi TB RO dan kenali obat FDC pada TB dewasa dan anak sebagai sarana pendukung pelayanan farmasi klinis di Rumah Sakit Universitas Indonesia. Pembuatan leaflet menggunakan aplikasi Canva dengan isi leaflet yang mengacu pada pedoman nasional tatalaksana tuberculosis tahun 2020, petunjuk teknis penatalaksanaan tuberkulosis resisten obat di Indonesia tahun 2020, dan buku saku pasien TB resisten obat tahun 2020. Dari hasil penelitian ini disarankan agar sebaiknya media leaflet bisa dijadikan tambahan informasi dan secara langsung diberikan kepada pasien saat melakukan edukasi maupun konseling sehingga diharapkan pasien lebih mudah mengerti dan memahami konsep pengobatannya dan peneliti selanjutnya sebaiknya dilakukan evaluasi sebelum dan setelah diberikan leaflet apakah ada kemajuan dari segi pengetahuan dan kepatuhan selama pengobatan TB.

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This Pharmacist Professional Work Practices Report discusses the creation of leaflets for dealing with RO TB and recognizing FDC drugs for adult and pediatric TB as a means of supporting clinical pharmacy services at the University of Indonesia Hospital. Making leaflets using the Canva application with leaflet contents referring to the 2020 national guidelines for managing tuberculosis, technical instructions for managing drug-resistant tuberculosis in Indonesia in 2020, and the pocketbook for drug-resistant TB patients in 2020. From the results of this research, it is recommended that leaflets should be used as media. additional information and directly given to patients during education and counseling so that it is hoped that patients will more easily understand and comprehend the concept of treatment and future researchers should evaluate before and after being given the leaflet whether there is progress in terms of knowledge and compliance during TB treatment."