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Abstrak :
ABSTRAK
Pendahuluan. Metode KB banyak jenisnya, salah satunya adalah susuk yang memiliki efektivitas tinggi, durasi pemakaian jangka panjang, dan kenyamanan penggunaan. Indoplant® sudah dipasarkan di Indonesia pada tahun 2005 dan mendapatkan respon baik di Indonesia. Diharapkan Monoplant® ini dapat menjadi salah satu alat kontrasepsi yang diminati para akseptor KB karena hanya menggunakan satu batang. Metode. Pengambilan data dilakukan sejak November 2015 hingga Mei 2016 di Klinik Raden Saleh. Sebanyak 153 pasien memenuhi kriteria inklusi dan eksklusi penelitian dan dibagi menjadi 77 pasien yang menerima susuk Monoplant® dan 76 pasien menerima susuk Indoplant®. Penelitian dilakukan secara kohort prospektif hingga observasi selama 6 bulan. Hasil. Data yang didapat menunjukkan tidak terdapat perbedaan bermakna pada efektivitas yaitu kejadian hamil pada penggunaan Monoplant® dan Indoplant®. Selain itu, efek samping seperti gangguan haid dan kenaikan berat badan tidak berbeda bermakna pada kedua kelompok penelitian. Namun, waktu penyisipan antara Monoplant® dan penyisipan Indoplant® (162,91+49,81 detik vs 197,04+44,96 detik, p<0,001) berbeda secara berkmakna. Untuk komplikasi seperti iritasi kulit, peradangan, tidak terdapat perbedaan komplikasi pada saat penyisipan Monoplant® (0,0%) dan Indoplant® (0,0%). Kesimpulan. Tidak terdapat perbedaan bermakna pada efektivitas serta efek samping pada penggunaan Monoplant® dan Indoplant®. Namun, waktu penyisipan lebih singkat untuk penggunaan Monoplant® dibandingkan Indoplant®

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ABSTRACT
Background. There are various methods of contraception, one of which is implant that has high efficacy, long-term usage, and convenient usage. Indoplant® has already marketed in Indonesia in 2005 and got good response. Monoplant® is expected to become one of the desirable contraceptive because using only one rod. Method. Data were collected from November 2015 until May 2016 in Raden Saleh Clinic. A total of 153 patients met the inclusion and exclusion criteria for the study and were divided into 77 patients who received Monoplant® and 76 patients received Indoplant®. The prospective cohort study was conducted until 6 months-observation. Results. The data obtained showed no significant difference in effectiveness which are incidence of pregnancy between Indoplant® and Monoplant®. In addition, side effects such as menstrual disorders and weight gain do not differ significantly in those study groups. However, the time of insertion between Monoplant® and Indoplant® is siginificantly different (162.91 + 197.04 + 49.81 seconds versus 44.96 seconds, p<0.001). For complications such as skin irritation, inflammation, there are no differences between Monoplant®(0.0%) and Indoplant®(0.0%). Conclusion. There are no significant differences in efficacy and side effects using Monoplant® and Indoplant®. However, the insertion time of Monoplant® is shorter compared to Indoplant®

Abstrak :
ABSTRAK Latar belakang: Implan merupakan metoda kontrasepsi dengan efektivitas yang tinggi. Namun salah satu efek samping yang sering dikeluhkan sehingga menjadi alasan tidak melanjutkan atau tidak memilih kontrasepsi implan adalah peningkatan berat badan. Penelitian ini bertujuan untuk mengetahui perubahan berat badan (BB) dan indeks massa tubuh (IMT) akseptor implan satu batang (Monoplant®). Metode: Penelitian ini merupakan bagian dari suatu penelitian uji klinis fase 2 yang lebih besar. Data perubahan BB dan IMT diperoleh dari pengukuran serial yang tercatat dalam rekam medis pasien selama tiga tahun pemasangan Monoplant® di Klinik Raden Saleh, Jakarta. Hasil: Dari 21 subjek penelitian ini, didapatkan rerata BB dan IMT sebelum dan setelah 3 tahun pemasangan Monoplant® yakni 53,1 (SB 11,0) kg dan 22,4 (SB 4,5) kg/m2, serta 54,8 (SB 9,4) kg dan 23,1 (SB 3,9) kg/m2 . Meskipun ada kecenderungan naik, tetapi secara statistik kenaikan BB dan IMT tersebut tidak bermakna (p=0,09) dan (p=0,08). Terdapat perbedaan berat badan dalam pengukuran serial, terutama setelah bulan ke-12 (Uji repeated ANOVA p=0,024). Walaupun tidak terdapat perbedaan rerata IMT, terdapat perbedaan proporsi subjek berdasarkan kategori IMT sebelum dan setelah pemasangan Monoplant® (Uji Marginal homogeinity p=0,046). Peningkatan kadar levonorgestrel terjadi pada bulan ke-6 yang kemudian diikuti oleh kenaikan IMT pada bulan ke-12. Kesimpulan: Terdapat kecenderungan peningkatan BB dan IMT pengguna Monoplant®, khususnya setelah satu tahun meskipun secara statistik tidak bermakna.

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ABSTRACT Background: Implant is contraception method which has high effectiveness. However, one of the side effects which is mostly experienced that becomes the reason of not continuing or not choosing implant contraception is the increasing of weight. This research is aimed at finding out the change of weight and body mass index (BMI) of single rod implant acceptor (Monoplant®). Method: This method is the part of a research of a bigger phase two in clinical test. Data changes of weight and BMI is obtained from series of measurement which is recorded in patients? medical record in three years of Monoplant® placement in Raden Saleh Clinic, Jakarta. Result: From 21 subjects of this research, the average weight and BMI before and after 3 years of Monoplant® placement is gained, i.e. 53.1 (SD 11,0) kg and 22.4 (SD 4.5) kg/m2, and 54.8 (SD 9.4) kg and 23.1 (SD 3.9) kg/m2. Despite the tendency of increasing, statistically the increasing of weight and BMI, however, is meaningless (p=0.09) and (p=0.08). There is a difference of weight in series of measurement, particularly after the 12th month (Repeated test ANOVA p=0.024). Even thought there is no difference of BMI average, there is a difference of subject?s proportion based on BMI categories before and after Monoplant® placement (Marginal homogeneity test p=0.046). The increasing of levonorgestrel level occurs in the 6th month and subsequently followed by the increasing of BMI in the 12th month. Conclusion: There is a tendency of increasing weight and BMI in Monoplant® users, specifically after one year despite the fact that it is statistically meaningless.

Abstrak :
Abstrak
The use of levonorgestrel implants as a contraceptive method have undergone changes in the number of implants used, beginning from six rods in the early methods to two rods in the present method and have been proven effective. This study aims to evaluate the efficacy of single rod implant (Monoplant®) by measuring serum levonorgestrel concentration and cervical mucus quality. Methods: Thirty healthy women, aged 20-40 year old, and have been proven fertile, underwent single rod implant insertion. Levonorgestrel serum levels was measured every month and cervical mucus viscosity was examined every three month, until six months. Results: Levonorgestrel serum concentration was consistently above minimum effective level (200 pg/mL), from month 3 to 6 respectively 338.9 pg/mL, 424.8 pg/mL, 320.3 pg/mL, and 337.5 pg/mL. Almost all of the acceptors (96.7%) had good cervical mucus viscosity since three months following implant insertion. Conclusion: Levonorgestrel serum concentration in Monoplant® users was still above minimum contraceptive level until the sixth month. Viscosity of cervical mucus increased immediately following implant insertion. This indicates that single rod levonorgestrel implant is effective as a contraceptive method.