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Abstrak :
The reaction of cis-[Pt(15NH3)2(H2O)2]2+ (3) with glutathione (GSH) was investigated in aqueous solution. In this reaction, the ammine in the platinum complex formed was liberated. Surprisingly two chelate rings were observed, six-membered-S,O-chelate ring complex cis-[Pt(15NH3)2(SG-S,O) (7) and five-membered-S,N-chelate ring complex cis-[Pt(15NH3)2(SG-S,N)] (8). The bis (thiolate) platinum(II) complex, cis-[Pt(15NH3)2(SG)2] (9) was always present in this reaction in any mole ratio used. The dinuclear sulphur-bridged complex (10), giving a broad peak in 15N NMR, was only present in very tiny amounts.

Abstrak :
Isatin (indoline-2,3-dione atau indole -1H-2,3-dione merupakan produk alami yang banyak ditemukan pada tanaman yang bergenus Isatis dan pada Couropita guiananci aub. Isatin dan senyawa turunannya memiliki berbagai aktivitas biologis seperti senyawa anti kanker, anti jamur, anti oksidan, anti diabetes, anti HIV, pelindung saraf, anti inflamasi, analgesik. Pada penelitian ini, dilakukan proses sintesis dari senyawa turunan isatin dengan berbagai variasi prekusor dan penggunaan MgCl2 sebagai katalis. Prekusor utama yang digunakan dalam penelitian ini adalah Isatin dan Lawson (1,4 naphtoquinon) serta variasi prekusornya berupa malononitril, hidrazin, fenil hidrazin, dan etil asetoasetat. Hasil sintesis dari masing-masing variasi diisolasi untuk mendapatkan produk murni dan dilakukan karakterisasi FT-IR. Untuk karakterisasi NMR dilakukan hanya untuk produk variasi 1 dan variasi 3. Massa produk yang didapatkan setelah diisolasi yakni variasi 1 sebesar 0.0378 gram; variasi 2 sebesar 0.0232 gram; variasi 3 sebesar 0.0494 gram; variasi 4 sebesar 0.0266 gram. Berdasarkan hasil NMR yang dilakukan, produk variasi 1 dan variasi 3 bukan merupakan produk yang diharapkan. Prediksi struktur dari produk variasi 1 memiliki rumus molekul C11H7N3O dengan m/z 197 ......Isatin (indoline-2,3-dione or indole -1H-2,3-dione) is a natural product which is found in many plants with the genus name of Isatis and in Couropita guiananci aub. Isatin and its derivatives have various biological activities such as anti-cancer, anti-fungi, anti-oxidants, anti-diabetes, anti-HIV, neuroprotective, antiinflammatory, and analgesic. In this study, the synthesis process of isatin derivatives with various precursors was carried out and the use of MgCl2 as a catalyst. The main precursors used in this study were Isatin and Lawson (1,4 naphtoquinone) and its precursor variations in the form of malononitrile, hydrazine, phenyl hydrazine, and ethyl acetoacetate. The synthesis results of each variation were isolated to obtain a pure product and performed FT-IR characterization. and variation 3. The mass of the product obtained after being isolated for variation 1 is 0.0378 grams; variation 2 is 0.0232 grams; variation 3 is 0.0494 grams; and variation 4 is 0.0266 grams. Based on the results of the NMR, the product of variation 1 and variation 3 was not the expected product. The predicted structure of the product variation 1 has the molecular formula C11H7N3O with m / z 197

Abstrak :
Periode neonatal bayi usia 0-28 hari dalam kelangsungan hidup anak merupakan periode yang sangat rentan. Penelitian ini bertujuan untuk mengetahui hubungan antara cakupan pelayanan kesehatan yang terdiri atas kunjungan antenatal care lengkap K4, persalinan di fasilitas kesehatan PF, kunjungan neonatal pertama KN1, kunjungan antenatal care pertama K1, kunjungan neonatal lengkap KN Lengkap, kelas ibu hamil, Program Perencanaan Persalinan dan Pencegahan Komplikasi P4K, dan jumlah puskesmas mampu melaksanakan Pelayanan Obstetri dan Neonatal Emergensi Dasar PONED dengan angka kematian neonatal AKN. Penelitian ini menggunakan desain studi ekologi dengan unit analisis agregat kabupaten/kota se Jawa-Bali tahun 2016. Data yang digunakan adalah data sekunder yang bersumber dari data Laporan Feedback Kesga Kemenkes RI. Hasil univariat menunjukkan AKN Jawa-Bali sebesar 5,98 per 1000 kelahiran hidup. Rata-rata persentase cakupan K1, K4, Pf, KN1, KN lengkap, Kelas Ibu Hamil, dan P4K sudah lebih dari 90, rata-rata persentase Puskesmas mampu PONED 32,72. Hasil bivariat menunjukkan korelasi antara penurunan AKN dengan P4K r=-0,177, p = 0,064. Kesimpulannya, faktor P4K berkorelasi dengan penurunan AKN. ......Neonatal period infant age 0 28 days in child survival is a very vulnerable period. This study aims to determine the relationship between coverage of health services consisting of complete antenatal care visit K4, delivery at health facility Pf, first neonatal visit KN1, first antenatal care visit K1, complete neonatal visits, maternity education program, birth planning and complication prevention program P4K, and Puskesmas which able to do Basic Essential Neonatus Obstetrics Service PONED with neonatal mortality rate NMR. This study uses ecological study design with aggregate analysis unit of districts cities in Java Bali in 2016. The data used are secondary data sourced from the report of the Directorate of Family Health, Health Ministry, Republic of Indonesia. The univariate result shows Java Bali NMR is 5.98 per 1000 live births. The average percentage of K1, K4, Pf, KN1, complete neonatal visits, maternity education program, and P4K have been more than 90, the average percentage of Puskesmas able to do PONED is 32,72. Bivariate results show the correlation between decreasing of AKN with Program of Birth Planning and Prevention of Complication P4K r 0,177, p 0,064. In conclusion, the P4K factor is correlated with the decrease in AKN.