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Hasil Pencarian

Ditemukan 3 dokumen yang sesuai dengan query
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Eva Risalia
Pengaruh Peningkat Penetrasi dari Alam Pada Transdermal Obat Anti-inflamasi Nonsteroid Nonselektif = Effects of Penetration Enhancers from Nature in Nonselective Nonsteroid Anti-Inflammatory Drugs Transdermal
"ABSTRAK
Obat anti-inflamasi nonsteroid (OAINS) nonselektif banyak digunakan oleh lansia. OAINS nonselektif oral memiliki efek samping terhadap gastrointestinal baik lokal maupun sistemik. Oleh karena itu, diperlukan rute untuk menghantarkan OAINS nonselektif yang nyaman dan efek samping yang minimal. Salah satunya rute alternatif yaitu penghantaran melalui kulit yang disebut rute transdermal. Stratum korneum menjadi tantangan utama dalam rute transdermal. Hal ini dapat dibantu dengan adanya peningkat penetrasi agar jumlah obat dapat mencapai efek terapeutiknya. Peningkat penetrasi sintesis menyebabkan berbagai masalah. Terpen, minyak atsiri, dan asam lemak dapat diperoleh dari alam. Minyak atsiri daun zodia (Evodia suaveolens) memiliki kandungan terpen yaitu linalool, alfa-pinen, dan limonen. Tinjauan ini membahas mengenai hubungan antara OAINS nonselektif dengan sistem penghantaran transdermal, pengaruh peningkat penetrasi dari alam terhadap OAINS nonselektif, serta potensi minyak atsiri daun zodia sebagai peningkat penetrasi pada OAINS nonselektif. Sistem penghantaran transdermal dapat mengurangi efek samping lokal yang terdapat pada gastrointestinal, selain itu sistem transdermal nyaman dan mudah digunakan. Peningkat penetrasi dapat menjadi alternatif untuk peningkat penetrasi sintesis OAINS nonselektif. Dari beberapa penelitian menunjukkan bahwa peningkat penetrasi dari alam mampu meningkatkan penetrasi obat melalui kulit. Kandungan minyak atsiri daun zodia mengandung linalool, alfa-pinen, dan limonen yang dapat berpotensi untuk menjadi peningkat penetrasi OAINS nonselektif. Untuk memperbaiki dari penelitian-penelitian sebelumnya, maka disarankan penelitian dilengkapi dengan membandingkan pengaruh dari kontrol, peningkat penetrasi sintesis (sebagai standar), serta peningkat penetrasi uji; uji kompatibilitas; penggunaan membran hewan (tikus/kelinci) pada uji in vitro; serta uji mekanisme kerja dari peningkat penetrasi
ABSTRACT
Non-selective anti-inflammatory drugs (NSAIDs) are widely used by the elderly. Oral non-selective NSAIDs have side effects on both local and systemic gastrointestinal. Therefore, a route is needed to deliver convenient non-selective NSAIDs and minimal side effects. One alternative route is delivery through the skin called the transdermal route. The stratum corneum is the main challenge on the transdermal route. This can be helped by increasing penetration so that the amount of drug can reach its therapeutic effect. Synthesis penetration enhancers causes various problems. The terpenes, essensial oil, and fatty acid can be obtained from nature. Zodia (Evodia suaveolens) contain terpenes namely linalool, alpha-pinene, and limonene. This review discusses the relationship between non-selective NSAIDs and transdermal delivery systems, the effect of penetration enhancers from nature on non-selective NSAIDs, and the potential of Zodia as penetration enhancers in non-selective NSAIDs. The transdermal delivery system can reduce the local side effects in the gastrointestinal, besides that the transdermal system is comfortable and easy to use. Penetration enhancers can be an alternative to synthesis penetration enhancers nonselective NSAIDs. Several studies shown that natural penetration enhancers can increase drug penetration through the skin. The zodia leaf oil contains linalool, alpha-pinene, and limonene which can be potential to increase penetration of non-selective NSAIDs. To improve from previous studies, it is recommended that research should be completed by comparing the effects of controls, synthetic penetration enhancers (as a standard), and penetration enhancer test; compatibility test; use of animal membranes (mice/rabbits) for in vitro tests; and the mechanism action of penetration enhancers testing.
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Depok: Fakultas Farmasi Universitas Indonesia, 2020
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UI - Skripsi Membership  Universitas Indonesia Library
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Fatima Rahmanita
Terpen dan Minyak Esensial Sebagai Peningkat Penetrasi Mikroemulsi = Terpene and Essential Oil as Microemulsions Penetration Enhancer
"ABSTRAK
Penghantaran obat melalu jalur transdermal memiliki beberapa keuntungan dibandingan dengan penghantaran obat jalur lainnya. Salah satu sediaan penghantaran transdermal adalah mikroemulsi. Pada sistem penghantaran transdermal, kulit manusia berkerja sebagai barrieryang menghalangi masuknya obat sehingga diperlukannya peningkat penetrasi. Terpen dan minyak esensial merupakan peningkat penetrasi yang efektif. Beberapa terpen yang berguna sebagai peningkat penetrasi mikroemulsi adalah mentol, cineole, eugenol. Minyak esensial memiliki aktivitas peningkat penetrasi lebih baik dibandingkan dengan komponen terpen secara individu Mekanisme kerja terpen dan minyak esensial sebagai peningkat penetrasi dipelajari dengan FTIR dan diketahui berfungsi sebagai peningkat penetrasi dengan menggangu integritas lapisan lipid stratum korneum. Hasil studi menunjukan bahwa penggunaan terpen dan minyak esensial sebagai peningkat penetrasi dipengaruhi oleh komponen mikroemulsi seperti kosurfaktan dan sifat fisikokimia zat aktif obat yang digunakan.
ABSTRACT
Drug delivery via the transdermal route has several advantages compared to other drug delivery pathways. One of the transdermal delivery fomulation is microemulsion. In transdermal delivery system, human skin works as a barrier that prevents the penetration of drug, therefore penetration enhancer are needed to increase the penetration of drug. Terpene and essential oil are known as an effective penetration enhancer. Some of the terpenes that are useful as enhancers of microemulsion penetration are menthol, cineole, eugenol. Essential oils have better penetration enhancing activity compared to individual terpenes. The mechanism of terpenes as enhancing penetration was studied with FTIR and the result suggested that terpene and essential oil work by interfering with the integrity of the stratum corneum lipid layer. Studies suggest that the use of terpenes and essential oils as a penetration enhancer is influenced by microemulsion components such as cosurfactants and the physicochemical propertiesof the drug."
Depok: Fakultas Farmasi Universitas Indonesia, 2020
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UI - Skripsi Membership  Universitas Indonesia Library
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Skin biophysics: from experimental characterisation to advanced modelling
"This book presents state-of-the-art experimental and modelling techniques for skin biophysics that are currently used in academic and industrial research. It also identifies current and future challenges, as well as a growing number of opportunities in this exciting research field. The book covers the basics of skin physiology, biology, microstructural and material properties, and progressively introduces the reader to established experimental characterisation protocols and modelling approaches. Advanced topics in modelling theories and numerical implementation are also presented.
The book focusses especially on:
1. Basic physiology, molecular biology, microstructural and material properties of the skin.
2. Experimental characterisation techniques for the skin (including imaging): in vivo and in vitro techniques and combination of those with in silico approaches.
3. State-of-the-art constitutive models of the skin: elastic, anelastic and mechanobiological formulations (e.g. growth, ageing, healing).
4. Applications: mechanics, damage, biological growth, healing, ageing and skin tribology."
Switzerland: Springer Fachmedien Wiesbaden, 2019
e20509782
eBooks  Universitas Indonesia Library