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"[ABSTRAKLatar belakang. Rekomendasi Global Alliance dalam penanganan AVS meliput antibiotik, asam retinoat, dengan atau tanpa BPO. Resistensi obat menjadi perhatian utama pada penggunaan antibiotik jangka panjang dalam terapi akne vulgaris sedang. Kombinasi antibiotik dan BPO direkomendasikan untuk mengatasi masalah tersebut. Pada tipe kulit IV-V hiperpigmentasi pasca akne merupakan masalah yang sering dikeluhkan. Tujuan. Membandingkan efektivitas, efek samping dan kejadian hiperpigmentasi pasca inflamasi penggunaan BPO sebagai paduan terapi lini pertama AVS pada tipe kulit IV-V Fitzpatrick. Metode. Penelitian analitik dengan desaain uji klinis acak tersamar ganda membandingkan dua sisi wajah. Subyek diberikan paduan terapi lini pertama. Sisi wajah perlakuan diberikan gel BPO 2,5% sedangkan kelompok kontrol gel plasebo. Hasil. Pada minggu ke-2,4,6,8 didapatkan penurunan persentase total lesi sebesar 51,47%, 71%, 75%, 82,84% pada kelompok BPO dan 30%, 53,75%, 62,28, 71% pada kelompok plasebo (p<0,001 .) Efek samping dan kejadian HPI pada minggu ke 2,4,6 dan 8 tidak berbeda bermakna. Kesimpulan. Penggunaan BPO sebagai bagian dari paduan terapi lini pertama AVS lebih efektif, tidak meningkatkan efek samping ataupun kejadian HPI.Kata kunci. akne vulgaris, gel BPO 2,5%,

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ABSTRACTBackground. Global alliance recommendation for moderate acne treatment are antibiotic, retinoic acid with or without benzoyl peroxide. Drug resistance become the most common problem due to longterm use of antibiotic in acne treatment. Combination of antibiotic and BPO is recommeded to overcome this problem. In patient with skin type IV-V post acne hyperpigmentation is one of the most significant complaint. Aim. To compare efectivity, side effect and post inflammatory hyperpigmentation of BPO 2,5% gel as a part of first line therapy regiment in patient with skin type IV-V. Method. This is an analytic study with randomized control trial design comparing both half-face (split-face). Subjects were given first line therapy regiment. Half-face was given BPO 2,5% gel twice daily while other half face with placebo. Result. Total lesions reduction in BPO group on week 2,4,6,8 were 51,47%, 71%, 75%, 82,84% respectively and 30%, 53,75%, 62,28, 71% in placebo group respectively. Conclusion. BPO as a part of first line therapy regiment for moderate acne is more effective, with no increase of side effect nor post inflammatory hyperpigmentation compared to placebo., Background. Global alliance recommendation for moderate acne treatment are antibiotic, retinoic acid with or without benzoyl peroxide. Drug resistance become the most common problem due to longterm use of antibiotic in acne treatment. Combination of antibiotic and BPO is recommeded to overcome this problem. In patient with skin type IV-V post acne hyperpigmentation is one of the most significant complaint. Aim. To compare efectivity, side effect and post inflammatory hyperpigmentation of BPO 2,5% gel as a part of first line therapy regiment in patient with skin type IV-V. Method. This is an analytic study with randomized control trial design comparing both half-face (split-face). Subjects were given first line therapy regiment. Half-face was given BPO 2,5% gel twice daily while other half face with placebo. Result. Total lesions reduction in BPO group on week 2,4,6,8 were 51,47%, 71%, 75%, 82,84% respectively and 30%, 53,75%, 62,28, 71% in placebo group respectively. Conclusion. BPO as a part of first line therapy regiment for moderate acne is more effective, with no increase of side effect nor post inflammatory hyperpigmentation compared to placebo.]"

"Latar belakang dan tujuan: Akne vulgaris AV merupakan inflamasi kronik pada unit pilosebasea. Beberapa penelitian telah meneliti kadar 25-hydroxyvitamin D [25 OH D] serum pada pasien AV dengan hasil bervariasi, namun umumnya rendah. Kadar vitamin D diduga terpengaruh oleh pajanan sinar matahari, letak geografis, ras/tipe kulit, dan asupan makanan, sehingga mungkin temuan di Indonesia akan berbeda daripada penelitian terdahulu di luar negeri. Penelitian ini bertujuan untuk mengetahui kadar 25 OH D serum dan hubungan dengan derajat keparahan, lesi inflamasi, noninflamasi, dan total lesi AV. Metode: Penelitian potong lintang ini melibatkan 30 subjek penelitian SP, direkrut secara consecutive sampling, terbagi rata ke dalam kelompok AV ringan AVR, AV sedang AVS, dan AV berat AVB berdasarkan klasifikasi Lehmann. Faktor risiko AV yang berkaitan dengan vitamin D pajanan sinar matahari, penggunaan tabir surya, suplementasi, jumlah lesi, dan kadar 25 OH D serum dinilai pada seluruh SP. Hasil : Median kadar 25 OH D serum pada kelompok AVR, AVS, dan AVB yaitu 16,3 9,1- 17,8 ng/mL, 12,7 9,6-15,6 ng/mL, dan 9,35 4,9-10,9 ng/mL Median pada kelompok AVR dan AVS lebih tinggi dibandingkan AVB. ......Background and objective: Acne vulgaris AV is chronic inflammation of pilosebaceous units. Several studies have investigated the levels of serum 25 hydroxyvitamin D 25 OH D in AV patients with varying outcomes, but mostly decreased. Vitamin D levels are thought to be affected by sun exposure, geographical location, race skin type, and food intake, that research in Indonesia may yield different results. This study aimed to determine the level of serum 25 OH D and its association with the severity and the number of inflammatory, noninflammatory, and total AV lesions. Methods: This cross sectional study included 30 patients. Subjects were recruited by consecutive sampling, grouped equally into mild, moderate, and severe AV based on Lehmann's classification. The risk factors for inadequate vitamin D such as sun exposures, sunscreen, and suplements, the number of lesions, and serum 25 OH D levels were assessed on all subjects. Results: The median concentrations of serum 25 OH D in the three groups were respectively 16.3 9.1 17.8 ng mL, 12.7 9.6 15.6 ng mL, and 9.35 4.9 10.9 ng mL p."

"Latar belakang: Studi epidemiologi menunjukkan bahwa jumlah akne vulgaris AV perempuan dewasa mengalami peningkatan. Hormon, produksi sebum, p. ance, proses inflamasi menjadi berbagai faktor yang terlibat dalam patogenesis terbentuknya AV dewasa. Tujuan: Mengetahui korelasi antara kadar Dehydroepiandrosterone sulfate DHEAS dan kadar sebum pada pasien AV perempuan dewasa. Metode: Studi potong lintang dilakukan pada Bulan Juni-Oktober 2017. Sebanyak 50 sampel perempuan dewasa usia 25-49 tahun didapatkan dengan consecutive sampling. Dilakukan anamnesis, pemeriksaan fisik, pengukuran kadar sebum wajah dan pengukuran kadar hormon DHEAS. Hasil: Terdapat hubungan bermakna antara kadar DHEAS dengan kadar sebum wajah pada pasien AV p:0.008; r:0.371 . Setiap kenaikan kadar DHEAS diikuti dengan peningkatan kadar sebum wajah. Diskusi: Androgen berikatan dengan reseptor androgen pada sebosit kulit sehingga androgen dapat mengontrol perkembangan kelenjar sebasea dan produksi sebum. Selain diproduksi secara sistemik, hormon androgen juga diproduksi secara lokal di kulit. Hal inilah yang dapat menjelaskan terjadinya AV dewasa tanpa disertai adanya hiperandrogenisme. ......Background: Epidemiologic studies have shown that number of adult female acne vulgaris AV increases. Hormone, sebum production, Propionibacterium acne and inflammatory process are factors involved in adult AV development. Objective: The aims of this study is knowing the correlation between Dehydroepiandrosterone sulfate DHEAS and sebum level in adult female acne. Method: This research used cross sectional study, and held from June to October 2017. Fifty samples aged 25 49 years were collected by consecutive sampling. Anamnesis, physical examination, sebum and DHEAS measurement were conducted. Result: There was significantly difference between DHEAS and skin sebum level in AV patients p 0.008 r 0.371. Every increased DHEAS level was followed by increasing of sebum production in AV patient. Discussion: Androgen binds to androgen reseptor in skin sebocyte, so that androgen could control sebaceous gland development and sebum production. Besides being produced by systemic, androgen is also produced locally in the skin. This could explain how adult AV develops without any hyperandrogenism."

"[ABSTRAKAkne vulgaris (AV) merupakan kelainan kulit menahun folikel pilosebasea yang banyak dijumpai remaja dan dewasa muda. Beberapa penelitian melaporkan adanya hubungan antara seng dan AV. Penelitian dengan desain kasus kontrol ini bertujuan mencari hubungan kadar seng serum dengan derajat keparahan AV berdasarkan klasifikasi Lehmann dan dengan jumlah lesi inflamasi. Tujuh puluh subyek dengan AV, terdiri atas 35 AV ringan (AVR) [kelompok A] dan 35 AV sedang (AVS) dan AV berat (AVB) [kelompok B] berdasarkan klasifikasi Lehmann diperiksakan kadar seng serum yang diukur menggunakan Atomic absorption spectrophotometry. Hasil kadar seng serum kelompok A median (min-maks) 11,15 (10,23-14,21) μmol/L dan kelompok B median (min-maks) 9,93 (6,72-10,69) μmol/L. Kadar seng serum kelompok A lebih tinggi dibandingkan kelompok B (p<0,001). Terdapat korelasi negatif yang bermakna antara kadar seng serum dengan jumlah lesi inflamasi pada AV(r -0,488). Sebagai tambahan didapatkan korelasi negatif kadar seng serum dengan jumlah lesi non inflamasi (r-0,582) ataupun total lesi AV (r-0,662). Hasil penelitian ini membuktikan bahwa kadar seng serum berhubungan dengan derajat keparahan AV menurut klasifikasi Lehmann, yakni kadar seng serum lebih rendah pada AV derajat berat dan sedang dibandingkan derajat ringan, dan sejalan dengan hubungannya terhadap jumlah lesi, baik inflamasi, non inflamasi, dan total lesi.

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ABSTRACTAcne vulgaris (AV) is a chronic cutaneous disorder in pilosebaceous follicles affecting many of the adolescents and young adults. Several studies have reported an association between serum zinc level and acne vulgaris. This case-control study aimed to find the relationship between serum zinc level with severity of AV according on Lehmann?s classification and the number of inflamatory lesions. Seventy AV subjects, consisting of 35 subjects with mild AV (Group A) and 35 subjects with moderate and severe AV (Group B) based on Lehmann?s classification are measured their serum zinc levels with Atomic absorption spectrophotometry. In group A serum zinc level median (min-max) was 11,15 (10,23-14,21) μmol/L and in group B, median (min-max) was 9,93 (6,72-10,69) μmol/L. Serum zinc levels in group A were statistically significant higher than group B (𝑃𝑃<0,001). There was a negative correlation between serum zinc levels with the number of inflammatory lesions (r-0,488). Additional result obtained were negative correlation between serum zinc levels with number of non-inflammatory lesions (r-0,582) and total lesion of AV (r-0,662). The results of this study proved that serum zinc levels was associated with the severity of AV according to Lehmann?s classification,i.e. serum zinc levels were lower in severe and moderate acne compared with mild acne, and in line with its correlation to number of lesions, either inflammatory, non-inflammatory, and total lesions.;Acne vulgaris (AV) is a chronic cutaneous disorder in pilosebaceous follicles affecting many of the adolescents and young adults. Several studies have reported an association between serum zinc level and acne vulgaris. This case-control study aimed to find the relationship between serum zinc level with severity of AV according on Lehmann?s classification and the number of inflamatory lesions. Seventy AV subjects, consisting of 35 subjects with mild AV (Group A) and 35 subjects with moderate and severe AV (Group B) based on Lehmann?s classification are measured their serum zinc levels with Atomic absorption spectrophotometry. In group A serum zinc level median (min-max) was 11,15 (10,23-14,21) μmol/L and in group B, median (min-max) was 9,93 (6,72-10,69) μmol/L. Serum zinc levels in group A were statistically significant higher than group B (𝑃𝑃<0,001). There was a negative correlation between serum zinc levels with the number of inflammatory lesions (r-0,488). Additional result obtained were negative correlation between serum zinc levels with number of non-inflammatory lesions (r-0,582) and total lesion of AV (r-0,662). The results of this study proved that serum zinc levels was associated with the severity of AV according to Lehmann?s classification,i.e. serum zinc levels were lower in severe and moderate acne compared with mild acne, and in line with its correlation to number of lesions, either inflammatory, non-inflammatory, and total lesions., Acne vulgaris (AV) is a chronic cutaneous disorder in pilosebaceous follicles affecting many of the adolescents and young adults. Several studies have reported an association between serum zinc level and acne vulgaris. This case-control study aimed to find the relationship between serum zinc level with severity of AV according on Lehmann’s classification and the number of inflamatory lesions. Seventy AV subjects, consisting of 35 subjects with mild AV (Group A) and 35 subjects with moderate and severe AV (Group B) based on Lehmann’s classification are measured their serum zinc levels with Atomic absorption spectrophotometry. In group A serum zinc level median (min-max) was 11,15 (10,23-14,21) μmol/L and in group B, median (min-max) was 9,93 (6,72-10,69) μmol/L. Serum zinc levels in group A were statistically significant higher than group B (𝑃𝑃<0,001). There was a negative correlation between serum zinc levels with the number of inflammatory lesions (r-0,488). Additional result obtained were negative correlation between serum zinc levels with number of non-inflammatory lesions (r-0,582) and total lesion of AV (r-0,662). The results of this study proved that serum zinc levels was associated with the severity of AV according to Lehmann’s classification,i.e. serum zinc levels were lower in severe and moderate acne compared with mild acne, and in line with its correlation to number of lesions, either inflammatory, non-inflammatory, and total lesions.]"

"Latar Belakang: Prevalensi akne vulgaris (AV) pada perempuan dewasa tinggi dengan morbiditas psikososial bermakna. Akne vulgaris yang timbul saat remaja dan berlanjut hingga umur lebih dari 25 tahun disebut sebagai AV menetap (AVM). Hormon androgen memiliki peranan terpenting dalam patogenesis AVM. Indeks Androgen Bebas (IAB) adalah metode yang bagus untuk mengevaluasi kadar hormon androgen. Perbedaan ras berpengaruh pada variasi kadar hormon androgen antara individu. Tujuan: Untuk mengetahui perbandingan nilai IAB dalam darah pada perempuan dewasa dengan AVM dan tanpa AV. Metode: Penelitian kasus kontrol. Hasil: Nilai IAB dalam darah pada perempuan dewasa dengan AVM memiliki median 1,93 (minimum 0,46 - maksimum 9,88). Nilai IAB dalam darah pada perempuan dewasa tanpa AV memiliki median 1,05 (minimum 0,24 - maksimum 2,42). Nilai IAB dalam darah pada perempuan dewasa dengan AVM lebih tinggi dibandingkan tanpa AV, dengan perbedaan yang bermakna secara statistik (p=0,014). Kesimpulan: Nilai IAB dalam darah pada perempuan dewasa dengan AVM lebih tinggi dibandingkan tanpa AV. ......Background: The prevalence of acne vulgaris (AV) in adult women is high with significant psychosocial morbidity. Acne vulgaris which occur in adolescence and continue until age more than 25 years is mentioned as persistent acne vulgaris (PAV). Androgen hormone has the most important role in PAV pathogenesis. Free Androgen Index (FAI) is a good methode to evaluate androgen hormone level. Race difference influent the variation of androgen hormone level between individual. Objective: To investigate the comparison of blood FAI in adult women with PAV and without AV. Methods: Case control study. Result: The blood FAI in adult women with PAV has median 1,93 (minimum 0,46 - maksimum 9,88). The blood FAI in adult women without AV has median 1,05 (minimum 0,24 - maksimum 2,42). The blood FAI in adult women with PAV is higher than without AV, with difference which is statisticaly significant. (p=0,014). Conclusion: The blood FAI in adult women with PAV is higher than without AV."

"Kulit merupakan bagian terluar dari tubuh manusia yang mempengaruhi penampilan seseorang. Penggunaan skincare secara rutin dan tepat merupakan salah satu cara untuk menjaga kesehatan kulit. Sekarang ini, produk kecantikan berbahan alami mulai diminati konsumen karena aman digunakan. Salah satu bahan alami yang berpotensi adalah jamur pangan (edible mushroom). Telah banyak penelitian yang menunjukkan kemampuan antimikroba terhadap bakteri pemicu jerawat, Cutibacterium acnes, dan antioksidan dalam mengatasi radikal    bebas penyebab penuaan dini. Aktivitas antimikroba jamur pangan terhadap C. acnes diuji menggunakan metode disc diffusion dan broth macrodilution. Selain itu, jamur pangan dilakukan uji aktivitas antioksidan dengan metode DPPH (1,1-diphenyl2picrylhydrazil). Sebanyak 4 dari 23 jamur yang diuji pada penelitian ini menunjukkan kemampuan menghambat pertumbuhan C, acnes. Jamur Hypsizygus marmoreus (kode: Buna - KS) menunjukkan aktivitas antimikroba terbaik terhadap C. acnes dengan LC50 sebesar 292,5 mg/mL. Jamur pangan pada penelitian ini seluruhnya menunjukkan aktivitas antioksidan yang beragam dimana 11 dari 23 jamur pangan (200 mg/mL) memberikan inhibisi sebesar > 50%. Dengan metode DPPH untuk uji aktivitas antioksidan, nilai IC50 terbaik dihasilkan oleh jamur Calocybe indica (kode: JS(KJ) - KS) sebesar 1,6 × 103 ppm. Selanjutnya, analisis metabolomik dengan metode GC-MS (Gas Chromatography – Mass Spectrophotometry) dilakukan untuk jamur tertentu dengan aktivitas antimikroba terhadap C. acnes dan aktivitas antioksidan terbaik. Senyawa asam tartarat dan asam laktat ditemukan dari hasil analisis GC-MS. Kedua senyawa kelompok asam organik tersebut diketahui mempengaruhi kemampuan antimikroba jamur terhadap C. acnes. Senyawa metabolit silanol dan asam butirat yang diketahui mempengaruhi aktivitas antioksidan agen biologis tertentu juga ditemukan dari esktrak jamur tertentu yang dianalisis. Oleh karena itu, senyawa metabolit potensial tertentu berhubungan dengan kemampuan jamur sebagai agen antimikroba terhadap C. acnes dan agen antioksidan.......Skin is the outermost part of human body that affects a person’s look. Regular and proper use of skincare is an among way to maintain skin’s health. Nowadays, natural-based material skincare began to interest the society due to its safety. An among potensial natural material for skincare is edible mushroom. There had been numerous research prove edible mushroom’s antimicrobial ability against acne-causing bacteria, Cutibacterium acnes, and antioxidant ability in overcoming free radicals that cause premature aging. Antimicrobial against C. acnes activity was tested using the disc diffusion and the broth macrodilution method. Moreover, edible mushrooms were tested for antioxidant activity by the DPPH (1,1-diphenyl-2-picrylhydrazil) method. There were 4 of 23 edible mushrooms terted in this study showed growth inhibition of C. acnes. Hypsizygus marmoreus (code: Buna - KS) gave the best antimicrobial activity against C. acnes with LC50 was 292,5 mg/mL. All of edible mushroomns used in this study showed various antioxidant activity that 11 of 23 mushrooms (200 mg/mL) gave more than 50% inhibition. Using DPPH method for antioxidant activity test, the best IC50 was given by Calocybe indica (kode: JS(KJ)-KS) reached 1,6 × 103 ppm. Moreover, metabolomic analysis using GC-MS (Gas Chromatography - Mass Spectrophotometry) method was tested to certain mushrooms with great antimicrobial and antioxidant activites. Tartaric acid and lactic acid were identified from the results of GC-MS analysis. These organic acid compounds have been reported to affect the mushroom’s antimicrobial ability against C. acnes. Metabolite compounds of silanol and butyric acid that are known to affect the antioxidant activity of certain biological agents was also found from the extracts of certain mushroom analyzed. Therefore, certain potential metabolite compounds related to the ability of mushroom as antimicrobial agent against C. acnes and antioxidant agent."

"Latar belakang: Akne vulgaris AV adalah penyakit kulit yang ditandai dengan terjadinya sumbatan dan peradangan kronik pada unit pilosebasea. Penelitian sebelumnya tentang kadar lipid darah pada pasien AV menunjukkan hasil yang bervariasi. Lipid darah diduga memengaruhi aktivitas kelenjar sebasea. Tujuan: Mengetahui korelasi antara kadar lipid darah dan kadar sebum dengan derajat keparahan AV, serta mengetahui korelasi kadar lipid darah dengan kadar sebum kulit wajah. Metode: Studi potong lintang ini dilakukan terhadap 30 pasien AV non-obesitas, yang terbagi berdasarkan tiga derajat keparahan AV. Dilakukan pemeriksaan kolesterol total, trigliserida, LDL, HDL darah dan kadar sebum kulit wajah pada SP. Hasil: Terdapat korelasi yang bermakna antara kadar sebum dengan derajat keparahan AV r = 0,6689, p = 0,0001 . Tidak terdapat korelasi antara kadar kolesterol total, trigliserida, LDL, HDL darah dengan derajat keparahan AV. Tidak terdapat korelasi antara sebum kulit wajah dengan kadar kolesterol total, trigliserida, LDL, HDL darah. Kesimpulan: Hasil penelitian ini menunjukkan bahwa kadar lipid darah tidak memengaruhi keparahan AV dan kadar sebum, sedangkan peningkatan kadar sebum kulit wajah dapat meningkatkan keparahan AV. ......Background: Acne vulgaris is a common chronic skin disease involving blockage and inflammation of pilosebaceous units. Previous studies about blood lipids in acne patients revealed variable results. Blood lipids were considered affecting sebum production. Objective: To identify the correlation between blood lipids, sebum excretion rate and acne severity. This study also determines the correlation between blood lipids and sebum excretion rate. Methods: This study was conducted at Dr. Cipto Mangunkusumo Hospital in Jakarta. This was a cross sectional study with total of 30 non obese AV patients. The patients were divided into 3 groups based on the severity of AV. Total cholesterol, triglycerides, LDL, HDL serum and sebum excretion rate were measured. Results: The results revealed significant correlation between sebum excretion rate and severity of acne vulgaris r 0,6689, p 0,0001 . There were no correlation between total cholesterol, LDL, triglycerides, HDL and acne severity. Blood lipids had no correlation with sebum excretion rate. Conclusion: The results of this study has proven that blood lipids does not affect the severity of acne and sebum excretion rate. While increased sebum secretion would increase acne severity."

"Latar Belakang: Akne vulgaris (AV) adalah peradangan kronik pilosebasea yang umum terjadi pada semua usia, terutama remaja dan dewasa muda serta dapat memengaruhi psikologis pasien. Tata laksana AV merupakan sebuah tantangan karena keberagaman dalam menentukan diagnosis dan pilihan terapi antar negara. Indonesia mempunyai beberapa pedoman tatalaksana AV yang mempunyai similaritas antara lain konsensus IAEM 2015, PPK Perdoski dan PPK RSCM di tahun 2017.Tujuan: Penelitian ini bertujuan untuk menganalisis efektivitas terapi standar AV berdasarkan panduan praktik klinis di Indonesia.Metode: Penelitian merupakan studi observasional analitik secara retrospektif di Rumah Sakit Umum Pusat Nasional dr. Cipto Mangunkusumo menggunakan rekam medis tahun 2017-2019. Sampel penelitian merupakan rekam medis pasien AV baru yang diikuti selama 3 bulan dan dengan metode total sampling. Data subjek yang diambil termasuk karakteristik sosiodemografi, karakteristik klinis, diagnosis, terapi berdasarkan PPK RSCM 2017, dan hasil terapi. Studi dan analisis dilakukan pada bulan April 2023 hingga Juli 2023.Hasil: Terdapat 131 SP yang memenuhi kriteria, 63,4% AV sedang, 20,6% AV ringan, dan 16% AV berat. Sebagian besar SP (92,4%) mempunyai AV dengan awitan sebelum usia 25 tahun. Median lama sakit AV yaitu 48 bulan. Riwayat terapi AV sebelumnya ditemukan pada 58% SP dan riwayat konsumsi obat akne pada 16% SP. Faktor risiko terbanyak berupa riwayat AV pada orang tua. Terapi utama paling banyak digunakan yaitu kombinasi retinoic acid, benzoyl peroxide, antibiotik topikal dan antibiotik oral pada 22,2% SP. Terapi standar AV secara bermakna menurunkan median jumlah lesi noninflamasi (25 vs. 8; p<0,001), median jumlah lesi inflamasi (10 vs. 2; p<001), median jumlah lesi total (41 vs. 10; p<0,001) setelah 3 bulan terapi, dengan median penurunan ketiga jumlah lesi lebih dari 50%. Proporsi derajat keparahan AV berbeda secara bermakna pada 3 bulan (p<0,001), dimana AV ringan meningkat (20,6% vs 93,1%) dan AV sedang atau berat menurun (sedang = 63,6% vs. 6,1%; berat = 16% vs. 0,8%).Kesimpulan: Terapi standar AV berdasarkan PPK di Indonesia efektif dalam mengurangi jumlah lesi noninflamasi, lesi inflamasi, dan lesi total, dan menurunkan derajat keparahan AV.......Background: Acne vulgaris is a prevalent chronic inflammation of the pilosebaceous unit affecting all ages, especially teenagers and young adults, and often leads to psychological impairment. Management of acne vulgaris has been challenging due to various diagnostic parameters and treatment options across nations. Several treatment guidelines are available in Indonesia, of which have similarities among one another, such as consensus by Indonesian Acne Expert Meeting in 2015 and clinical practice guidelines by the Indonesian Society of Dermatology and Venereology and by Dr. Cipto Mangunkusumo National Central General Hospital in 2017.Objective: This study aims to investigate the effectiveness of standard therapy for acne based on the clinical practice guidelines in IndonesiaMethods: This is an analytical retrospective observational study using medical records from Dr. Cipto Mangunkusumo National Central General Hospital between 2017 – 2019. Research samples were medical records of new acne patients followed for 3 months by a total sampling technique. Extracted data included sociodemographic and clinical characteristics, diagnosis, and therapy based on the clinical practice guideline by Dr.Cipto Mangunkusumo National Central General Hospital in 2017 and the results. This study was conducted from April 2023 to July 2023.Results: There were 131 subjects included, of which 63,4% were with moderate acne, 20,6% with mild acne, and 16% with severe acne. Most participants (92,4%) experienced acne for the first time before 25 years old. The median duration from the first occurrence of acne to the visit was 48 months. History of topical and oral acne therapy was found in 58% and 16% of participants, respectively. History of acne in parents was the most reported risk factor. Most subjects (22,2%) received a combination of retinoic acid, benzoyl peroxide, topical antibiotic, and oral antibiotic. Standard therapies significantly reduced the median of non-inflammatory lesions (25 vs. 8; p<0,001), inflammatory lesions (10 vs. 2; p<001), and total lesions (41 vs. 10; p<0,001) after a 3 month-therapy, with the median of reduction for all type of lesions over 50%. The proportion of acne severity differed significantly after three months (p<0,001), with an increasing proportion of mild acne (20,6% vs 93,1%) and decreasing percentage of moderate and severe acne (moderate = 63,6% vs. 6,1%; severe = 16% vs. 0,8%).Conclusion: Standard therapy for acne vulgaris in clinical practice guidelines in Indonesia is effective for noninflammatory lesions, inflammatory lesions, and total lesions, as well as acne severity after 12 weeks."