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Abstrak :
Penelitian ini adalah penelitian berbasis komuniias untuk memperoleh gambaran kadar alergen tungau debu rumah (TDR) dan sensitisasi alergen sebagai faktor risiko asma. Penelitian ini merupakan studi potong lintang dengan responden 3.840 pelajar sekolah menengah pertama dari 19 sekolah yang dipilih secara acak dari 131 sekolah di Jakarta Pusat. Seinua responden mengisi kuesioner International Study on Asthma and Allergy in Children (ISAAC). Dari 3.840 responden, 288 (7,5%) digolongkan dalatn kelompok asma karena mempunyai riwayat mengi selama 12 bulan terakhir. Pada kelompok asma, 207 responden melakukan uji kulit dan 135 diambil sampel debu rumah. Dari 2.601 responden yang tidak memiliki riwayat asma atau atopi lain, dipilih secara acak 274 orang untuk uji kulit dan 165 di antaranya diambil sampel debu rumah. Kadar alergen TDR tidak berbeda bermakna antara kelompok asma maupun non-asma baik untuk Der pi, Der fl, rnaupun Grup I. Risiko asma terutama disebabkan oleh sensitisasi alergen TDR D.pteronyssinuss (rasio odds (OR):12,68, interval kepercayaan (Cl): 7,50-21,44), D.farinae (OR: 10,50, CI: 6,35-17,34), serta kecoak (OR-.5.57, Cf:3,44-9.0l). Perbedaan risiko asma tidak berhubungan dengan tinggi rendahnya kadar alergen TDR tetapi oleh sensitisasinya. Kesimpulannya, sensitisasi alergen TDR dan kecoak perlu diperhatikan dalam upaya menurunkan risiko dan prevalensi asma. (MedJ Indones 2006; 15:55-9).

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This study is a community-based study to get an overview about House Dust Mite (HDM) allergen level, allergen sensitization as risk factors of asthma. This is a cross-sectional study on 3,840 students from 19 junior high schools, aged 13-14 years. AH of the respondents filled out the International Study on Asthma and Allergy in Children (ISAAC) questionnaire. Of 3840 respondents, 288 (7.5%) were assigned to asthma group (experience wheezing during the last 12 months). The skin prick test was performed on 207 respondents and the house dust mite was collected from 135 respondents. Of 2601 respondents in non-asthma group, the skin prick test was randomly performed on 274 respondents and the house dust mite was collected from 165 respondents. There is no significant difference on HDM allergen concentration for Der pi, Derfl or Group I between asthma and control group. The risk of asthma was caused especially by sen D.pteronyssinus (crude odds ration (OR): 12.68, 95% confidence interval (Cl): 7.50-21.44), D.farinae (OR: 10.50, Cl: 6.35-17.34) and cockroach allergen {OR: 5.57, Cl:3.44-9.01). The risk for asthma was not correlated with the level of house dust mile allergens but its sensitization. In conclusion, sensitization to HDM and cockroach allergen should be concerned in order to reduce risk and prevalence of asthma. (MedJ Indones 2006; 15:55-9).

Abstrak :
General aim: this study aims to determine the prevalence of sensitization reaction on exposed and unexposed groups of workers at a latex factory. Specific aim: to determine the latex allergen sensitization reaction and factors such as atopy, age, sex, smoking, length of working, exposure concentration. Sample and method: the sample population consists of workers at a sphygmomanometer and condom factory who were, exposed and un-exposed to latex material at the factory. The number of sample was determined based on the two proportion formula. This study was a cross-sectional study using the Chi square test, Fisher test, Mann Whitney test, and Kruskal Wallis test. The results of the study and conclusion: The prevalence oj latex allergen sensitization reaction in the exposed group was 2.38%, while in the un-exposed group 3.33%. The correlation between exposed and un-exposed group to the latex allergen sensitization reaction (overall) was not significant (p=0.l8I), but if the correlation of each factor was calculated, the most significant correlation was between the negative latex allergen sensitization reaction with a strength of +2 or above (p=O.OJ4). In this study, atopy (p=0.000), exposed concentration (p=0.014), and smoking (p=0.018) are factors that were associated with latex allergen sensitization reaction. Workers at the condom factory were at higher risk than those at the sphygmomanometer factory, with a prevalence oj'7.14% and 2.31% respectively.

Abstrak :
House dust mites (HDM) are an important inhalant allergen in allergic asthma. However, molecular diagnostic study of specific IgE to HDM allergens has not been done in Indonesia. in addition, the association of quantitative specific IgE measurement with asthma severity has not been investigated. This study aimed to investigate difference of serum quantitative specific IgE levels induced by Dermatophagoides (D).

Abstrak :
Latar belakang: Tungau debu rumah TDR merupakan alergen hirup yang penting pada asma alergik. Namun, penelitian diagnostik molekuler menggunakan Imunoglobulin E IgE spesifik akibat sensitisasi alergen TDR dihubungkan dengan derajat keparahan asma alergik belum pernah dilakukan di Indonesia. Tujuan: Mengetahui perbedaan kadar IgE spesifik serum kuantitatif akibat sensitisasi alergen Dermatophagoides D. pteronyssinus, D. farinae dan Blomia B. tropicalis pada asma alergik intermiten dan persisten. Metode: Desain penelitian potong lintang pada pasien asma alergik dewasa yang diundang untuk pemeriksaan IgE spesifik serum dan merupakan bagian dari penelitian payung di Divisi Alergi dan Imunologi Klinik, RS Cipto Mangunkusumo. Derajat keparahan asma ditentukan berdasarkan kriteria Global Initiative on Asthma GINA 2015 dan dikelompokkan menjadi intermiten dan persisten. Pemeriksaan IgE spesifik serum kuantitatif menggunakan metode multiple allergosorbent test Polycheck Allergy, Biocheck GmbH, Munster, Germany . Alergen TDR yang diperiksa adalah D. pteronyssinus, D. farinae, dan B. tropicalis. Perbedaan antara dua kelompok dianalisis dengan uji Mann-Whitney. Hasil: Sebanyak 87 subyek dilibatkan dalam penelitian ini; 69 79,3 subyek adalah perempuan. Rerata usia pasien adalah 40,2 tahun. Enam puluh tiga 72,4 pasien menderita asma dan rinitis alergik. Sebanyak 58 66,7 pasien asma persisten. Gambaran sensitisasi alergen TDR adalah 62,1 D. farinae; 51,7 D. pteronyssinus dan 48,3 B.tropicalis. Median kadar IgE spesifik secara bermakna lebih tinggi pada asma persisten dibandingkan asma intermiten untuk alergen D. farinae 1,30 vs. 0,0 kU/L; p=0,024 dan B. tropicalis 0,57 vs. 0,0 kU/L; p=0,015 . Kadar IgE spesifik D. pteronyssinus lebih tinggi pada asma persisten dibandingkan intermiten 0,67 vs. 0,00 kU/L; p=0,066. Kesimpulan:Gambaran sensitisasi alergen secara berurutan didapatkan D. farinae 62,1, D. pteronyssinus 51,7 dan B. tropicalis 48,3 . Kadar IgE spesifik akibat sensitisasi D. farinae dan B. tropicalis lebih tinggi secara bermakna pada pasien asma persisten dibandingkan asma intermiten. Kadar IgE spesifik akibat sensitisasi D. pteronyssinus lebih tinggi pada pasien asma persisten dibandingkan asma intermiten, tetapi secara statistik tidak bermakna.

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Introduction House dust mites HDM are an important inhalant allergen in allergic asthma. However, molecular diagnostic study using specific IgE level induced by HDM allergens associated with asthma severity has not been done in Indonesia. Objective To investigate the difference of serum quantitative specific IgE levels induced by Dermatophagoides D. pteronyssinus, D. farinae and Blomia B. tropicalis sensitization in intermittent and persistent allergic asthma. Method This was a cross sectional study on adult allergic asthma patients who were invited for serum specific IgE testing. This study was a part of a larger research within the Division of Allergy and Immunology, Cipto Mangunkusumo Hospital. Asthma severity was defined based on Global Initiative on Asthma GINA 2015 criteria and were grouped as intermittent or persistent. Quantitative specific IgE testing was done on blood serum using a multiple allergosorbent test Polycheck Allergy, Biocheck GmbH, Munster, Germany . The HDM allergens tested were D. pteronyssinus, D. farinae, and Blomia tropicalis. Difference between two groups were analyze using Mann Whitney test. Results A total of 87 subjects were enrolled in this study 69 79.3 were women. Mean patients rsquo age was 40, 2 years. Sixty three 72.4 patients had asthma and allergic rhinitis. Fifty eight 66.7 patients were classified as persistent asthma. The prevalence of sensitization was 62.1 D. farinae, 51.7 D. pteronyssinus, and 48.3 Blomia tropicalis. The median of specific IgE levels is significantly higher in persistent asthma compares to intermittent asthma induced by D. farinae median 1.30 vs. 0.0 kU L p 0.024 and B. tropicalis median 0.57 vs. 0.0 kU L p 0.015 sensitization. Level of Specific IgE D. pteronyssinus is also to be higher in persistent asthma than the level measured in intermittent asthma 0.67 vs. 0.00 kU L p 0.066. Conclusion Sensitization of HDM allergens is shown to be highest for D. farinae 62.1 , followed by D. pteronyssinus 51, 7 and Blomia tropicalis 48, 3 . Specific IgE level induced by D. farinae and Blomia tropicalis sensitization are significantly higher in patients with persistent compares to intermittent asthma, whereas specific IgE level induced by D. pteronyssinus sensitization to be higher in persistent asthma although not statistically significant.