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"This book offers an overview of state-of-the-art in non amplified DNA detection methods and provides chemists, biochemists, biotechnologists and material scientists with an introduction to these methods. In fact all these fields have dedicated resources to the problem of nucleic acid detection, each contributing with their own specific methods and concepts. This book will explain the basic principles of the different non amplified DNA detection methods available, highlighting their respective advantages and limitations. Non-amplified DNA detection can be achieved by adopting different techniques. Such techniques have allowed the commercialization of innovative platforms for DNA detection that are expected to break into the DNA diagnostics market. The enhanced sensitivity required for the detection of non amplified genomic DNA has prompted new strategies that can achieve ultrasensitivity by combining specific materials with specific detection tools. Advanced materials play multiple roles in ultrasensitive detection. Optical and electrochemical detection tools are among the most widely investigated to analyze non amplified nucleic acids. Biosensors based on piezoelectric crystal have been also used to detect unamplified genomic DNA. The main scientific topics related to DNA diagnostics are discussed by an outstanding set of authors with proven experience in this field."

"Chapters authored by known leading figures in the fluorescence field, new volume publishes annually, comprehensive coverage of the year's hottest and emerging topics, each Reviews in fluorescence volume is citable (ISI) and indexed. Reviews in Fluorescence 2010 topics include, novel metal-based luminophores for biological imaging. Hydration dynamics of probes and peptides in captivity, how does tobacco etch viral mRNA get translated? A fluorescence study of competition, stability and kinetics, synchronous fluorescence spectroscopy and Its applications in clinical analysis and food safety evaluation, quantitative molecular imaging in living cells via FLIM, a multiparametric imaging of cellular coenzymes for monitoring metabolic and mitochondrial activities, optimal conditions for live cell microscopy and Raster Image Correlation Spectroscopy (RICS)."