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Abstrak :
Summary: Arthritis in Black and White, by Anne C. Brower, MD and Donald J. Flemming, MD, provides you with a concise, practical introduction to the radiographic diagnosis of arthritic disorders. Completely revised, this popular, easy-to-read resource contains high-quality digital radiographs with correlating MRIs throughout and a practical organization that aids in your recognition, diagnosis, and treatment of common arthritides. In print and online at www.expertconsult.com, it is perfect for residents in training and experienced radiologists wishing to refresh their knowledge. Easily reference diagnostic guidance by presenting symptom, see what to look for, and understand how to effectively diagnose the patient. Reference key information quickly and easily thanks to a consistent, user-friendly format and a unique two-part organization (radiologic approaches to specific joints and full description of the individual common arthritides) that facilitates finding the exact information you need for any joint in the body.

Abstrak :
Artritis reumatoid ialah penyakit poliartritis kronik progresif yang menimbulkan deformasi, meliputi multisistem dan disertai morbiditas yang nyata. Obat-obatan imunosupresif telah digunakan untuk mengurangi/menghambat progresi penyakit. Penelitian ini diadakan untuk membandingkan keberhasilan azatioprin dan siklosporin pada penderita artritis reumatoid. Penelitian meliputi 100 penderita artritis reumatoid (sesuai kriteria American Rheumatism Association, 1987) yang dibagi atas dua kelompok: kelompok I mendapat azatioprin 1 mg/kg/h dan kelompok II mendapat siklosporin 2,5-3,0 mg/kg/h selama 16 minggu. Penilaian keberhasilan berdasarkan parameter klinis, biokimiawi dan radiologis. Semua penderita menunjukkan perbaikan nyata (nilai p < 0.001) pada semua parameter klinis, yaitu hilangnya nyeri, berkurangnya kekakuan pagi hari, sendi yang nyeri/membengkak dan waktu yang diperlukan untuk berjalan sejauh 50 kaki serta menguatnya kekuatan genggaman. Semua penderita menunjukkan penurunan LED (p < .001) tanpa perubahan apapun pada titer faktor reumatoid. Kedua obat menunjukkan keberhasilan yang sama (nilai p tidak bermakna) dalam hal perbaikan parameter klinis dan biokimiawi. Tetapi dengan siklosporin erosi tulang dan osteoporosis yukstaartikular lebih banyak berkurang. Sepuluh penderita menunjukkan nefrotoksisitas dengan siklosporin. Siklosporin lebih baik dari azatioprin dalam hal mengurangi derajat progresi kelainan sendi pada artritis reumatoid, tetapi insidens efek samping lebih tinggi, yang pada umumnya dapat diatasi. (Med J Indones 2002; 11: 153-7)

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Rheumatoid Arthritis (RA) is a chronic progressive deforming polyarthritic disease involving multisystems and associated with considerable morbidity. Immunosuppressive drugs have been used to reduce/arrest the progression of the disease. The present study was undertaken to compare the efficacy of Azathioprine and cyclosporin in Rheumatoid Arthritis patients. Study consisted of 100 patients of Rheumatoid Arthritis (as per criteria of American Rheumatism Association, 1987) divided into two groups : group I received Azathioprine 1 mg/kg/d and group II received cyclosporin 2.5-3.0 mg/kg/d for 16 weeks. Assessment of efficacy was based on clinical, biochemical and radiological parameters. All patients showed marked improvemen (p value < 0.001) in all clinical parameters i.e. relief in pain, reduction in morning stiffness, painful/swollen joint along with walking time for 50 feet and increase in grip strength. All patients showed reduction (p < 0.001) in ESR without any change in rheumatoid factor titres. Both drugs showed equal efficacy (p value = NS) in improvement of clinical and biochemical parameters. But cyclosporin showed more reduction in bony erosions and juxtaarticular osteoporosis. Ten patients showed nephrotoxicity with cyclosporin. Cyclosporin has an edge over azathioprine in reducing the rate of progression of joint change in Rheumatoid Arthritis but is associated with increased incidence of side effects that are generally manageable. (Med J Indones 2002; 11: 153-7)

Abstrak :
ABSTRAK
Background Rheumatoid arhtirtis is a chronic autoimmune disease that mainly attacks joints. It may causes joint deformities which leads to lower quality of life of RA patients. RA is treated with metothrexate which inhibiting disease progression. MTX is known for its hepatotoxicity side effect, which is described by an elevation of aspartate aminotransferase and/or alanine aminotransferase beyond the upper normal limit. Factors that may enhance hepatotoxicity are gender, age, cummulative dose of MTX, and duration therapy of MTX. Prevalence of hepatotoxicity caused by MTX therapy in RA patients in Indonesia is still unknown. The objective of this research is to know the proportion of hepatotoxicity and its associations with the factors that may enhance hepatotoxicity caused by MTX therapy in RA patients in RSCM.Method Data about gender, age, cummulative dose and duration therapy of MTX are obtained from 115 RA patients medical records.Result Proportion of hepatotoxicity in RA patients treated with MTX in RSCM is 42.60 percent. Gender, age, cummulative dose and duration therapy of MTX do not significantly enhance hepatotoxicity p>0.05. Conclusion In conclusion gender, age, cummulative dose and duration therapy of MTX do not have association with hepatotoxicity in RA patients treated with MTX.

Abstrak :
Angka kejadian athritis gout di kota Masohi Kabupaten Maluku Tengah sebanyak 54 orang bedasarkan data rumah sakit umum kota Masohi. Tujuan penelitian untuk mengetahui faktor risiko kejadian arthritis gout di kota Masohi Kabupaten Maluku Tengah. Merupakan penelitian observasional analitik dengan rancangan case control study terhadap 196 responden yang terdiri dari 98 kasus dan 98 kontrol. Analisis bivariat dengan uji odds ratio (OR) dan multivariat dengan uji regresi logistik berganda. Variabel yang merupakan faktor risiko arthritis gout adalah hipertensi (OR = 2.20 CI 95%; 1.24-3.90), obesitas sentral (OR = 3.04 CI 95%; 1.66-5.55), konsumsi alkohol (OR = 2.28 CI 95%; 1.29-4.05), konsumsi makanan yang mengandung zat purin (OR = 5.14 CI 95%; 2.80-9.44), riwayat gout dalam keluarga (OR = 3.10 CI 95%; 1.73-5.55), minum softdrink (OR = 1.33), namun memberikan pengaruh yang lemah (CI 95%; 0.72-2.45). Analisis multivariat, variabel konsumsi makanan yang mengandung zat purin memiliki pengaruh paling besar (p = 0,000). Konsumsi makanan yang mengandung zat purin adalah faktor yang paling berpengaruh terhadap kejadian arthritis gout di Kota Masohi Kabupaten Maluku Tengah. Perlu pengaturan pola makan bagi penderita.

Risk Factors in the Incidence of Gouty Arthritis in Masohi Town, Central Maluku Regency in 2010. The gouty arthritis incidence rate in Masohi Town of Central Maluku Regency is 54 people based on the data from the general hospital in Masohi. The aim of study was to find out the risk factor in the incidence of gouty arthritis in Masohi Town of Central Maluku Regency. The study was analytic observation using a control case study. The number of respondents was 196 people consisting of 98 cases and 98 controls. The data were analyzed by using odds ratio (OR) and multiple logistic regression. The results of the study indicate that the risk factors in the incidence of gouty arthritis are hypertension (OR = 2.20 CI 95%; 1.24-3.90), central obesity (OR = 3.04 CI 95%; 1.66-5.55), alcoholic comsumption (OR = 2.28 CI 95%; 1.29-4.05), purine food consumption (OR = 5.14 CI 95% 2.80-9.44), gout history in family (OR = 3.10 CI 95%; 1.73-5.55), and soft drink consumption (OR = 1.33 CI 95%; 0.72-2.45). The multivariate analysis indicates that the most dominant factor affecting the incidence of gouty arthritis is purine food consumption (p = 0.000). Since the consumption of purine food is the most dominant factor affecting the incidence of gouty arthritis, diet pattern is necessary for the patients.