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"Latar Belakang: Polymer Induced Liquid Precursor (PILP) merupakan remineralisasi biomimetik dengan menggunakan bahan polimer anionik sintetik yang dapat menggantikan peran protein non kolagen dalam remineralisasi intrafibrillar. Asam poliaspartik merupakan salah satu material analog protein non kolagen yang penting dalam proses PILP. Nanodroplet yang terbentuk dalam proses PILP mampu berdifusi ke dalam intrafibrillar kolagen ataupun gap zone yang memiliki ukuran 40 nanometer dan mengalami kristalisasi. Tujuan: Menganalisis remineralisasi intrafibrillar dan ukuran kristal hidroksiapatit yang terbentuk. Metode: Evaluasi efek asam poliaspartik dalam proses PILP pada remineralisasi intrafibrillar selama 3, 7 dan 14 hari melalui TEM dan ukuran kristal hidroksiapatit yang terbentuk melalui XRD. Hasil: Ada perbedaan signifikan secara evaluasi deskriptif antar kelompok remineralisasi 3, 7 dan 14 hari terhadap kelompok demineralized dentin pada remineraliasi intrafibrillar. Tidak terdapat perbedaan bermakna antar kelompok remineralisasi maupun kelompok demineralized dentin terhadap ukuran kristal hidroksiapatit. Kesimpulan: Asam poliaspartik dalam proses PILP memiliki potensi dalam remineralisasi intrafibrillar.

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Background: Polymer Induced Liquid Precursor (PILP) is a biomimetic remineralization using synthetic anionic polymer material that can replace the role of non-collagen proteins in intrafibrillar remineralization. Polyaspartic acid is one of the non collagen protein analog materials that is important in the PILP process. Nanodroplet formed in the PILP process is able to diffuse into intrafibrillar collagen or gap zones that have a size of 40 nanometers and crystallize. Purpose: To analyze the intrafibrillar remineralization and the size of hydroxyapatite crystal formed.

Methods: Evaluation of the effect of polyaspartic acid in PILP process on intrafibrillar remineralization for 3, 7 and 14 days through TEM and the size of hydroxyapatite crystal formed through XRD.

Result: There was a significant difference in descriptive evaluation between remineralization groups of 3, 7 and 14 days against the demineralized dentin group in intrafibrillar remineralization. There were no significant differences between the remineralization group and the demineralized dentin group to the size of hydroxyapatite crystals.

Conclusion: Polyaspartic acid within PILP process has potential ability in intrafibrillar remineralization."

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Latar Belakang: Perawatan karies dengan minimal intervensi, yaitu dengan membuang infected dentin, dan meninggalkan affected dentin, kemudian dilakukan remineralisasi pada affected dentin. Pada affected dentin masih terdapat ikatan silang kolagen. Remineralisasi dentin lebih kompleks karena pada karies dentin sudah tidak ada sisa kristal mineral. Untuk terjadinya remineralisasi ekstrafibrilar dan intrafibrilar pada dentin, maka dibutuhkan dentin matrix protein 1 (DMP 1)  yang merupakan protein non-kolagen. Proses polymer-induced liquid precursor (PILP) merupakan metode Guided Tissue Remineralization yang bertujuan untuk remineralisasi dentin secara intrafibrilar dan ekstrafibrilar dengan penambahan polimer sebagai analog DMP1. Salah satu material analog protein non kolagen adalah asam poliaspartik.

Tujuan: Mengevaluasi remineralisasi dentin pada permukaan demineralized dentin setelah perendaman dengan larutan remineralisasi yang mengandung asam poliaspartik sebagai analog protein non kolagen.

Metode: Empat kelompok dilakukan demineralisasi buatan. Setelah itu, tiga kelompok dilakukan perendaman dengan larutan remineralisasi yang mengandung asam poliaspartik, sedaangkan satu kelompok tidak dilakukan perendaman larutan remineralisasi asam poliaspartik. Evaluasi remineralisasi dengan Micro-CT.

Hasil: Terlihat remineralisasi pada permukaan demineralized dentin yang ditandai dengan penurunan kedalaman lesi demineralized dentin yang ditandai dengan peningkatan grey scale index setelah dilakukan perendaman dengan larutan remineralisasi asam poliaspartik. Perbandingan rerata empat kelompok menunjukkan perbedaan bermakna.

Kesimpulan: Asam poliaspartik memiliki potensi untuk meremineralisasi demineralized dentin.

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Background: Caries treatment with minimal intervention, namely by removing infected dentine, and leaving affected dentine, then remineralization of affected dentine. In the affected dentine there are still have collagen cross bonds. Dentin remineralization is more complex because there is no residual mineral crystals in dentinal caries. For extrafibrillary and intrafibrillary remineralization in dentine, dentin matrix protein 1 (DMP 1) is a non-collagen protein. The polymer-induced liquid precursor (PILP) process is a Guided Tissue Remineralization method which aims to remineralize intrafibrilar and extafibrilar dentine by adding polymers as analogous to DMP1. One of the non collagen protein analog material is polyacpartic acid.

Objective: To evaluate remineralization of dentine on the demineralized dentin surface after immersion with remineralization solutions containing polyacpartic acid as a non-collagen protein analog.

Method: Four groups carried out artificial demineralization. After that, three groups were immersed with remineralization solution containing polypartic acid, while one group was not immersed in polyacpartic acid remineralization solution. Remineralization evaluation with Micro-CT.

Results: It appears remineralization on the demineralized dentin surface which is characterized by a decrease in the depth of demineralized dentin lesions which is characterized by an increase in gray scale index after immersion with polyacpartic acid remineralization solution. The comparison of the mean of the four groups showed significant differences.

Conclusion: Polyacpartic acid has the potential to remineralize for demineralized dentine.

 

 

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"Latar Belakang: Remineralisasi pada dentin affected dapat terjadi secara guided tissue remineralization (GTR). Remineralisasi ini terjadi pada matriks intrafibrilar kolagen dentin karena peran protein non kolagen yaitu Dentin Matriks Protein 1 (DMP1) yang dapat rusak saat proses demineralisasi. Dibutuhkan material analog pengganti DMP1 untuk proses remineralisasi, salah satunya adalah asam poliaspartik dalam proses Polymer-Induced Liquid Precursor (PILP). Tujuan: Menganalisis remineralisasi yang terjadi pada demineralized dentin setelah diinduksi oleh asam poliaspartik dalam proses PILP. Metode: Sampel berupa dentin blok direndam pada larutan demineralisasi lalu dibagi menjadi empat kelompok, yaitu kelompok demineralized dentin tanpa perendaman larutan asam poliaspartik dan kelompok dengan perendaman larutan asam poliaspastik selama 3, 7, dan 14 hari. Sampel di evaluasi dengan uji SEM dan EDX. Hasil: Terdapat perbedaan signifikan antara kelompok demineralized dentin dengan kelompok remineralisasi asam poliaspartik pada hari ke 3, 7, dan 14. Remineralisasi yang terjadi berupa deposit ion kalsium dan fosfat. Kesimpulan: Asam poliaspartik dalam proses PILP memiliki potensi untuk meremineralisasi demineralized dentin.

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Background: Remineralization on affected dentin can be occurred by guided tissue remineralization (GTR) method. The remineralization process took place in intrafibilar matrix dentin collagen which regulated by a non collagenous protein, Dentin Matrix Protein (DMP 1) which can be destroyed during demineralization process. Remineralization process requires non collagenous protein analog material, one in particular is poliaspartic acid in Polymer-Induced Liquid Precursor (PILP) process. Objective: To analyze remineralization process that occured on demineralized dentin after application polyaspartic acid in PILP process. Method: Dentin block sample was soaked in demineralized solution. The sample then divided into four groups which are demineralized dentin without application of poliasparticacid solution, and demineralized dentin soaked in polyaspartic acid solution in the period of 3 ,7 and 14 days. The samples were evaluated by using SEM and EDX. Result: A statistically significant result between demineralized dentin group and remineralization with poliaspartic acid group within 3, 7, 14 days. Remineralization occurred by calcium and phosphate ions deposition. Conclusion: Polyaspartic acid in PILP process has the capability of remineralizing demineralized dentin."