Hasil Pencarian  ::  Simpan CSV :: Kembali

Abstrak :
Kebenaran data identitas para pihak dalam suatu transaksi jual beli tanah merupakan hal yang sangat penting yang harus diperhatikan oleh Pejabat Pembuat Akta Tanah (PPAT) dalam menjamin kepastian hukum dan melindungi kepentingan para pihak. Jika hal tersebut diabaikan, maka akan menimbulkan kerugian bagi salah satu pihak yang dapat mengakibatkan pembatalan transaksi yang telah dilakukan. Pemilik hak atas tanah telah mengajukan gugatan ke Pengadilan Negeri Depok yang mempunyai wilayah hukum terhadap pengalihan hak atas tanah yang dilakukan oleh pihak yang mempunyai itikad tidak baik dengan melakukan pemalsuan data identitas pemilik. Pokok permasalahan dalam penulisan tesis ini yaitu bagaimana pengaturan pemindahan hak atas tanah yang berdasarkan peraturan perundang-undangan yang berlaku, bagaimana bentuk, substantif cacat yuridis pemindahan hak atas tanah dan bagaimana Implikasi hukum cacat yuridis pemindahan hak atas tanah terhadap aktanya, para pihak, pihak ketiga yang beritikad baik. Penelitian ini adalah penelitian yuridis normatif dengan tipologi eksplanatoris dan preskriptif. Hasil penelitian menyarankan agar Pejabat Pembuat Akta Tanah (PPAT) harus melakukan tugasnya lebih professional, independen dan melakukan penelitian terlebih dahulu tentang identitas atau kebenaran dari para pihak sebelum melakukan penandatangan akta pengalihan hak atas tanah. Kepada Kantor Pertanahan disarankan sebaiknya tidak dengan mudah menerima pendaftaran pengalihan hak atas tanah, jika secara normatif akta tersebut terdapat ketidaksesuaian atau tidak lengkapnya data para pihak. Demikian juga kepada masyarakat agar tidak dengan mudah melakukan transaksi jual beli tanah tanpa melibatkan Pejabat Pembuat Akta Tanah (PPAT) yang memang memiliki kewenangan untuk membuat akta pengalihan hak tersebut berdasarkan peraturan perundang-undangan. ......The accuracy of the identity of each party in a transaction of sale and purchase of land is a significant matter that has to be analyzed and paid attention by the Land Deed Official (PPAT) in order to secure the legal consistency and accuracy and protect the interest of the related parties. The failure of which, then it shall make loss of one of the parties and may cause the cancelation of the transaction which has been executed. The owner of the right on land has filed a lawsuit at District Court of Depok that has legal authority on the transfer of land executed by a party who have no goodwill by forgery of the owner identity of right on land. The problem of this thesis is how the regulation of the transfer of right on land according to the prevailing laws and regulation, the form and Juridical defect of the transfer of land to the deed, each party and the third party who has goodwill. This research uses Normative Juridical its research methodology systems with Explanatory and Prescriptive typology. The results suggest that the Land Deed Official (PPAT) must perform its duties more professionally, independent and check of the accuracy of the identity of each party prior to the execution the transaction. To the Land Office, it is suggested not to easily register the transfer of right of land unless the fulfillment of all requirement including the accurately of identity has been completed. To Public, it is suggested not to do the execution of transfer of right of land without the participation of the Land Deed Official (PPAT) who has the authority to make deed of transfer of land according to prevailing laws and regulations.

Abstrak :
Six Sigma is a quality target of -3,4 Defect Per Million Opportunities- that allows quality characteristic being measured by perspective of total? defects compare to the total' opportunities of defect to occur. Six Sigma quality improvement methodology is coiled Six Sigma Improvement Framework which consist of 5 phases DMAIC (Define, Measure, Analyze, Improve, and Control. Sir Sigma focused on customer and oriented to the process which affect the final quality characteristic required on a product. This research analyzed the implementation of Six Sigma in a garment company PT X to reduced the number of appearance defect, and the high number of rework for the clothes product. Quantitative and qualitative data were processed by means of some Six Sigma tools for each phase ofDMA1C_ This research focused on the product with style number 148 824 which has I I critical quality characteristic (CTQ). Metric value acquired : defect per unit (DPDQ = Q603974, and the sigma value = 3, 095. Throughput yield = 39, 1026%.

Abstrak :
Latar belakang: Pembedahan merupakan baku emas penutupan defek septum ventrikel, namun penutupan dengan prosedur transkateter sudah banyak dilakukan karena bersifat kurang invasif, mortalitas minimal dan tidak memerlukan pintasan jantung paru saat tindakan, walaupun perlu perhatian terhadap komplikasi blok atrioventrikular total. Penelitian yang membandingkan mortalitas, penutupan komplit dan komplikasi blok AV total pasien pasca-penutupan DSV dengan prosedur transkateter dan pembedahan belum ada sebelumnya di Indonesia. Tujuan: Mengetahui perbandingan mortalitas, penutupan komplit dan komplikasi blok AV total pasien pasca-penutupan DSV dengan transkateter tahun 2012-2016 di RSCM. Metode: Metode retrospektif analitik dengan pengambilan data rekam medis pasien DSV anak yang dilakukan prosedur pembedahan atau transkateter di PJT RSCM selama tahun 2012-2016. Hasil: Tidak didapatkan mortalitas dan komplikasi blok AV pada kedua kelompok. Penutupan komplit kelompok pembedahan 100 dan transkateter 96,4 karena 1 subyek 3,6 mengalami kegagalan penutupan. Pencapaian penutupan komplit hari pertama pasca-penutupan DSV kelompok pembedahan 83,3 dan transkateter 92,8 . Tidak didapatkan perbedaan bermakna pada kedua kelompok dalam hal waktu pencapaian dan penutupan komplit. Simpulan: Tidak terdapat perbedaan mortalitas, penutupan komplit dan komplikasi blok AV total pasien pasca-penutupan DSV transkateter dan pembedahan. ...... Background: Surgery is still the gold standard for the closure of ventricular septal defect, but closure by transcatheter procedure has been largely undertaken because of less invasive, minimal mortality and do not require cardio pulmonary bypass during intervention, although we should beware of the total atrioventricular block complication. A study comparing mortality, completed closure and total AV block complication of post closure VSD with transcatheter and surgical procedures was not present yet in Indonesia. Objective: To examine the comparison of mortality, completed closure and complication of total AV block post closure with transcatheter and surgical procedures in VSD patients at RSCM in 2012 2016. Method: Analytical retrospective method with data retrieval from medical record of children with VSD which performed transcatheter or surgical procedure at PJT RSCM during 2012 2016. Results: No mortality and AV block complications were found in both groups. Completed closure of 100 surgical group and 96.4 transcatheter because 1 subject 3.6 had a failure in closure. Completed closure from the first day VSD closure in surgical group was 83.3 and transcatheter was 92.8. No significant differences were found in both groups in terms of completed achievement and closure time. Conclusions: There were no differences in mortality, completed closure and complications of total AV block post closure of VSD patients with transcatheter and surgical.

Abstrak :
Pendahuluan Salah satu tantangan dalam tatalaksana fraktur saat ini adalah rekonstruksi fraktur dengan defek tulang yang luas, di mana dibutuhkannya restorasi alignment dan fiksasi yang stabil untuk keberhasilan rekonstruksi. Pada kasus fraktur dengan defek tulang tidak ada lagi komponen osteoinduksi dan osteokonduktif sehingga diperlukan penggunaan graft tulang ataupun tindakan transport tulang. Walaupun perkembangan teknologi dan kemajuan dalam pembedahan orthopaedi telah berkembang saat ini, hasil akhir dari penyembuhan tulang paska pembedahan pada beberapa kasus fraktur akan mengalami penyembuhan tulang yang kurang baik yang akhirnya akan menyebabkan defek ataupun non-union dari fraktur tersebut. Metode Desain penelitian adalah studi post test control group design. Sampel yang digunakan adalah dua puluh delapan tikus putih Sprague Dawley yang telah mengalami maturasi skeletal (8-12 minggu), dibagi menjadi empat kelompok, tiap tikus akan dilakukan tindakan fraktur dengan defek tulang pada tulang femur selebar 4mm, kemudian tikus dibagi berdasarkan implantasi yang diberikan, yaitu kelompok kontrol, kelompok implantasi amnion liofilisasi steril, kelompok implantasi xenograft morcalized bovine, dan kelompok implantasi kombinasi amnion dengan xenograft. Hewan coba akan dikorbankan setelah 8 minggu, kemudian dilakukan pemeriksaan radiologis dan histopatologis dari fraktur. Evaluasi radiologis menggunakan skor menurut Lane dan Sandhu, evaluasi histopatologis menggunakan skor menurut Salkeld. Hasil Berdasarkan uji statistik non parametrik Kruskal-Wallis terhadap skor radiologis tulang pada minggu ke-8 paska pembedahan didapat nilai p 0,25. Secara statistik dapat diambil kesimpulan bahwa tidak terdapat perbedaan bermakna perbandingan skor radiologis antara empat kelompok tersebut. uji statistik non parametrik Kruskal-Wallis pada skor histopatologis menurut Salkeld minggu ke-8 paska pembedahan didapat nilai p 0,001 secara statistik, dapat diambil kesimpulan bahwa terdapat perbedaan bermakna perbandingan skor histopatologis antara empat kelompok tersebut. Kesimpulan Skor radiologis pada implantasi amnion liofilisasi steril dibanding dengan kelompok kontrol pada fraktur dengan defek tulang tidak memberikan perbedaan bermakna, sementara skor histologis memberikan perbedaan percepatan penyembuhan bermakna pada implantasi amnion liofilisasi steril dibanding dengan kelompok kontrol. Skor radiologis dan histologis pada implantasi xenograft morcalized bovine dibanding kelompok kontrol tidak memberikan perbedaan percepatan penyembuhan bermakna. Skor radiologis pada implantasi kombinasi amnion liofilisasi steril dan xenograft morcalized bovine dibanding dengan kelompok kontrol tidak memberikan perbedaan bermakna, sementara skor histologis memberikan perbedaan percepatan penyembuhan bermakna dibanding dengan kelompok kontrol. ......Introduction One of the current chalenge on fracture treatment is reconstruction of fracture with critical size bone defect, where the restoration of the alignment dan stable fixation for succesfull result is necessary. bone graft or bone transport is usually needed for bone defect reconstruction because there isnt any osteoinductive and osteoconductive component on fracture with bone defect. Although new technologies and advances in orthopaedic surgery have enhanced fracture healing and surgical outcomes, there are fracture that continue to be deficient in bone repair or become non-union. Methode The research design is post test control group using twenty eight skeletally matured Sprague Dawley rats, divided into four groups, 4mm sized femoral defects were surgically created in the right femur of 28 rats. 7 rats were ran­domly assigned to each treatment group, in which the femoral defect was filled with sterile lyophilized amnion, morcalized bovine xenograft and combination. In the empty defect group (control group) defects were left empty. Animals were sacrificed at 8 weeks postoperatively. Then the radiologic and histopathologic examination were completed. Radiologic evaluation using Lane and Sandhu score, histologic evaluation using Salkeld score. Result Non parametric Kruskal-Wallis statistic analysis for the radiologic score 8 weeks postoperatively reveal p value 0,25 which mean there is no significance difference between four groups. However for the histopathologic score statistic analysis examination reveal the p value 0,001 which mean there are significance differences between four groups. The statistic analysis for histopathologic is then continued with Man Whitney analysis. Conclusion Regarding the radiologic score, amniotic membrane has similar radiological score to control, however the histopathologic score is better. Xenograft have similar radiological and histopathological score to the control. Combination of amniotic membrane with xenograft has better histopathological score to control. Although the radiologic score is similar.

Abstrak :
Defect masih menjadi ketidaksesuian pekerjaan yang mengharuskan adanya pekerjaan Rework dalam sebuah pekerjaan konstruksi agar kualitas mutu yang direncanakan dapat tercapai dengan baik. Identifikasi penyebab sering terjadinya rework dapat meminimalisir defect yang mungin terjadi . Proposal tesis ini membahas rencana penelitian yang berkaitan dengan Metode Pelaksanaan Konstruksi Pondasi Dalam Tiang Bore Pile Gedung Bertingkat Tinggi pada PT. X berbasis Risk Untuk Meningkatkan Kualitas Mutu Pondasi Dalam akan dianalisis dan dievaluasi terhadap kualitas mutu berdasarkan metode pelaksanaan yang telah dilakukan dilapangan. . Penelitian ini dilaksanakan dengan mengumpulkan data melalui survei kuesioner, selanjutnya diolah menggunakan metode statistik yaitu uji homogenitas, uji kecukupan data, uji validitas, uji reliabilitas, dan dilanjutkan dengan penilaian risiko menggunakan matriks risiko. kemudian disetiap tahapan akan dievaluasi pula manajemen risiko yang ditimbulkan dari setiap kegiatan untuk dikembangkan dalam metode analisisnya. ......Defect is still a work incompatibility that requires rework work in a construction work so that the planned quality can be achieved properly. Identification of the causes of frequent rework can minimize defects that may occur. This thesis proposal discusses a research plan related to the Implementation Method of Foundation Construction in Bore Pile High-rise Buildings at PT. X based on Risk To Improve the Quality of Deep Foundation Quality will be analyzed and evaluated against the quality based on the implementation method that has been carried out in the field. . This research was conducted by collecting data through a questionnaire survey, then processed using statistical methods, namely homogeneity test, data adequacy test, validity test, reliability test, and continued with risk assessment using a risk matrix. Then at each stage, the risk management arising from each activity will also be evaluated to be developed in the analysis method

Abstrak :
Akta Jaminan Perorangan dan Akta Jaminan Perusahaan merupakan bentuk dari Perjanjian Penanggungan (1820-1850 KUH Perdata). Sesuai dengan sifat accessoir dari perjanjian jaminan Penanggungan, maka perjanjian tersebut lahir dengan maksud untuk menegaskan dan memperkuat segala yang dimaksud dalam Perjanjian Pokoknya. Bentuknya yang bersifat bebas, tidak terikat dalam bentuk tertentu, dan dapat dibuat lisan maupun tulisan dalam akta, memungkinkan adanya perkembangan-perkembangan pemahaman di dunia praktek dalam pembuatan, dan peruntukan sebuah akta Jaminan Penanggungan. Kasus Putusan Nomor: 161/ Pdt/G/2018/PN.Jkt-Selatan merupakan salah satu contoh kasus yang melibatkan notaris dalam sengketa utang piutang antara Koperasi X (Penggugat I/Debitur) dan Koperasi Y (tergugat 1/Penjamin). Dimana Notaris digugat karena diduga bekerjasama dengan Tergugat lainnya, menempatkan Penggugat yang seharusnya Penjamin dari suatu Hutang menjadi Debitur dalam Perjanjian tersebut. Oleh karenanya, Tesis ini akan membahas bagaimana Peran dan tanggung jawab Notaris dalam pembuatan akta Perjanjian Kredit dengan Jaminan Perusahaan, dan perlindungan Hukum Notaris dan Kreditur atas pembuatan akta Perjanjian Kredit dengan Jaminan Perusahaan yang diduga mengandung unsur cacat kehendak. Penelitian ini menggunakan bentuk penelitian yuridis normatif, tipologi penelitian Deskriptif, data sekunder yang terdiri atas bahan hukum primer, sekunder dan tersier, pengumpulan data dengan studi dokumen dan wawancara, metode analisis kualitatif serta bentuk hasil penelitian Deskriptif analitis. Sehingga mencapai simpulan bahwa kebenaran akan terjadinya sebuah cacat kehendak dalam Perjanjian Penjaminan tersebut sangat bergantung pada pemenuhan unsur formil dan materil akta tersebut, sehingga menghindarkan notaris dari resiko-resiko hukum akta yang dibuatnya

---

Personal guarantee deed and Corporate guarantee deed is a form of Guarantee/Coverage agreement based on 1820-1850 Indonesian Civil code. In accordance to its nature of the agreement, Guarantee deed is a accessoir agreement which means the existence of Guarantee agreement is by reason to reaffirm and corroborate all the purposes and objectives stated in the master agreement. Guarantee deed is not bound in a certain form, can be made orally or in writing allows the development of understanding related to its purpose and objective. Case Number: 161/ Pdt/G/2018/PN.Jkt-Selatan is one of an example that involving Notary in loan agreement dispute between X Cooperative (Plaintiff/Debtors) and Y Cooperative (defendant/Guarantor). The notary was sued because he was suspected of collaborating with other Defendants, placing the Plaintiff, who was supposed to be a Guarantor of a Debt to a Debtor in the Agreement. Therefore, this thesis will discuss how the role and responsibility of notary on drawing up of Loan Agreement and Corporate Guarantee Deed, and the legal protection of notary and creditor on drawing up of Loan Agreement and Corporate Guarantee Deed that alleged to defect of will. This research uses normative juridical research, descriptive typology of research, secondary data consisting of primary, secondary and tertiary legal materials, data collection by document study and interviews, qualitative analysis methods and descriptive analytical research results. So as to reach the conclusion that the truth of the occurrence of a defect of will in the Guarantee Agreement is very dependent on the fulfillment of the formal and material elements of the deed, thus preventing notaries from making legal risks of deeds

Abstrak :
Penyakit jantung bawaan dan abnormalitas jalan napas merupakan dua kondisi yang saling berkaitan dan dapat terjadi bersamaan. Terjadinya abnormalitas jalan napas pada pasien penyakit jantung bawaan dapat berpengaruh pada tata laksana serta prognosis pasien. Penelitian ini dilakukan secara retrospektif dengan melihata data dari rekam medis pasien penyakit jantung bawaan di RSCM tahun 2020–2022. Data yang diambil ialah usia, jenis kelamin, berat badan, diagnosis penyakit jantung bawaan, dan kondisi abnormalitas jalan napas. Data disajikan untuk melihat prevalensi abnormalitas jalan napas pada pasien penyakit jantung bawaan. Dari 69 subjek pasien penyakit jantung bawaan yang memenuhi kriteria inklusi, 15 atau 21,7% diantaranya memiliki abnormalitas jalan napas. Jenis penyakit jantung bawaan yang paling banyak ditemukan ialah Tetralogy of Fallot sebanyak 27 (39,1%) kasus. Jenis abnormalitas jalan napas yang paling banyak ditemukan ialah Laringomalasia sebanyak 9 (13%) kasus. Oleh karena itu, prevalensi abnormalitas jalan napas pada pasien penyakit jantung bawaan ialah sebesar 21,7%, dengan jenis abnormalitas jalan napas terbanyak ialah laringomalasia sebesar 13%. Terjadinya abnormalitas jalan napas pada pasien penyakit jantung bawaan memerlukan perhatian khusus dalam penanganan pasien.  ......Congenital heart disease and airway abnormalities are two related conditions that can occur together. The occurrence of airway abnormalities in patients with congenital heart disease can affect patient management and prognosis. The research was conducted retrospectively by looking at data from medical records of congenital heart disease patients at RSCM from 2020–2022. The data collected were age, gender, weight, diagnosis of congenital heart disease, and airway abnormality conditions. The data was presented to see the prevalence of airway abnormalities in patients with congenital heart disease. From 69 subjects of congenital heart disease patients who met the inclusion criteria, 15 or 21.7% of them had airway abnormalities. The most commonly found type of congenital heart disease was Tetralogy of Fallot, with 27 (39.1%) cases. The most commonly found type of airway abnormality was Laryngomalacia, with 9 (13%) cases. Therefore, the prevalence of airway abnormalities in patients with congenital heart disease is 21.7%, with the most common type of airway abnormality being Laryngomalacia at 13%. The occurrence of airway abnormalities in patients with congenital heart disease requires special attention in patient management.

Abstrak :
ABSTRAK
Pendahuluan. Kesulitan dalam tatalaksana defek tulang yang luas merupakan salah satu tantangan dewasa ini. Selain tatalaksananya yang kompleks juga dapat memberikan dampak jangka panjang negatif yang berat. Penggunaan BMP-2 dalam tatalaksana fraktur dengan defek tulang yang luas memegang peranan penting. BMP-2 berperan pada proses osteogenesis dan chondrogenesis dan menghambat osteoclastogenesis melalui RANKL signaling. Penelitian ini bertujuan untuk mengetahui efek dari perbedaan dosis BMP-2 terhadap penyembuhan fraktur dengan defek tulang yang luas. Metode. Penelitian dilakukan di Laboratorium Animal Gizi di FKUI dan Laboratorium Patologi Anatomi FKUI-RSCM, pada bulan Juli hingga September 2015. Desain penelitian adalah randomized post test control group. Sejumlah 25 ekor tikus putih Sprague Dawley dengan usia 3-4 bulan dan berat badan antara 250 ? 350 gram, dibagi secara acak menjadi kelompok kontrol hidroksiapatit (HA) saja dan kelompok kombinasi HA + BMP-2 1 μg/ml, HA + BMP-2 5 μg/ml, HA + BMP-2 10 μg/ml, HA + BMP-2 20 µg/ml. Tiap kelompok dilakukan tindakan berupa frakturisasi dengan defek tulang 10mm pada femur kanan dan dilakukan fiksasi interna dengan menggunakan intramedullary k-wire ukuran 1,4 mm secara retrograd. Setelah 6 minggu dilakukan penilaian secara histomorfometri, radiologis dan Scanning Electron Microscope (SEM). Hasil. Berdasarkan hasil penelitian secara histomorfometri ditemukan terdapat perbedaan rerata total area kalus yang bermakna diantara kelompok penelitian (p<0,001),terdapat perbedaan bermakna rerata area penulangan antara kelompok kontrol dengan kelompok 1 μg/ml, 5 μg/ml, 10 μg/ml, 20 μg/ml (masing-masing p=0,009, p=0,016, p=0,009 dan p=0,016), terdapat perbedaan bermakna rerata area kartilago antara kelompok kontrol dengan kelompok 1 μg/ml, 5 μg/ml, 10 μg/ml, 20 μg/ml (masing-masing p=0,009, p=0,009, p=0,009 dan p=0,028), terdapat perbedaan bermakna rerata area fibrosis antara kelompok kontrol dengan kelompok 1 μg/ml dengan kelompok kontrol dan 10 μg/ml(masing-masing p=0,047 dan p=0,009).Secara radiologis dengan RUST score didapatkan perbedaan bermakna antara kelompok kontrol dengan kelompok 1 μg/ml, 5 μg/ml, 10 μg/ml, 20 μg/ml (masing-masing p=0,005, p=0,006, p=0,005 dan p=0,006). Dengan SEM didapatkan gambaran kalus yang lebih homogen dan padat pada kelompok 10μg/ml dibandingkan dengan 5 μg/ml dan 20 μg/ml. Kesimpulan: Pemberian BMP-2 dapat menstimulasi proses penyembuhan fraktur pada defek tulang luas (critical bone defect) yang bermakna secara statistik, histomorfometri, radiologis maupun secara kualitatif dengan SEM. Terdapat dosis optimal dalam pemberian BMP-2.ABSTRACT
Introduction: Difficulties in the management of extensive bone defects is one of today's challenges. It is not only complex treatment but also can provide long-term negative severe effects. The use of BMP-2 in the treatment of fractures with extensive bone defect plays an important role. BMP-2 plays a role in the process of osteogenesis and chondrogenesis and inhibits osteoclastogenesis via the RANKL signaling. This study aims to determine the effect of differences in doses of BMP-2 on the healing of the fracture with extensive bone defects. Methods: The study was conducted at the Laboratory of Animal Nutrition at the Faculty of Medicine University of Indonesia (FMUI) in July until September 2015. The study design was randomized posttest control group. A number of 25 Sprague Dawley rats aged 3-4 months and bodyweight between 250-350 grams, were randomly divided into a control group of hydroxyapatite (HA) alone and HA+BMP-2 1 µg / ml, HA+BMP -2 5 ug / ml, HA + BMP-2 10 µg / ml, HA + BMP-2 20 ug / ml. Each group carried out fracturization with 10mm bone defect in right femur and internal fixation by using intramedullary K-wire size of 1.4 mm retrograde. After 6 weeks we did histomorfometri assessment, radiological and Scanning Electron Microscope (SEM). Results: Based on the research results histomorfometrcally found there are differences in the mean total area of ​​callus significantly between the study group (p <0.001), there were significant differences in the mean area of ​​woven bone between the control group with group 1 ug / ml, 5 µg / ml, 10 µg / ml, 20 ug / ml (respectively p = 0.009, p = 0.016, p = 0.009 and p = 0.016), there were significant differences in the average area of ​​the cartilage between the control group with group 1 ug / ml, 5 µg / ml, 10 µg / ml, 20 ug / ml (respectively p = 0.009, p = 0.009, p = 0.009 and p = 0.028), there were significant differences in the average area of ​​fibrosis between the control group with group 1 ug / ml in the control group and 10 mg / ml (respectively -masing p = 0.047 and p = 0.009) .In radiologist assessment with RUST scores obtained significant differences between the control group and group 1 ug / ml, 5 µg / ml, 10 µg / ml, 20 µg / ml (respectively p = 0.005 , p = 0.006, p = 0.005 and p = 0.006). SEM features with callus more homogeneous and dense in the group of 10μg / mL compared with 5 ug / ml and 20 µg / ml. Conclusion: Administration of BMP-2 could stimulate the process of fracture healing in large bone defects (critical bone defect) which was statistically significant with histomorfometri assestment, radiological and qualitatively with the SEM. There is an optimal dose in the administration of BMP-2.;Introduction: Difficulties in the management of extensive bone defects is one of today's challenges. It is not only complex treatment but also can provide long-term negative severe effects. The use of BMP-2 in the treatment of fractures with extensive bone defect plays an important role. BMP-2 plays a role in the process of osteogenesis and chondrogenesis and inhibits osteoclastogenesis via the RANKL signaling. This study aims to determine the effect of differences in doses of BMP-2 on the healing of the fracture with extensive bone defects. Methods: The study was conducted at the Laboratory of Animal Nutrition at the Faculty of Medicine University of Indonesia (FMUI) in July until September 2015. The study design was randomized posttest control group. A number of 25 Sprague Dawley rats aged 3-4 months and bodyweight between 250-350 grams, were randomly divided into a control group of hydroxyapatite (HA) alone and HA+BMP-2 1 µg / ml, HA+BMP -2 5 ug / ml, HA + BMP-2 10 µg / ml, HA + BMP-2 20 ug / ml. Each group carried out fracturization with 10mm bone defect in right femur and internal fixation by using intramedullary K-wire size of 1.4 mm retrograde. After 6 weeks we did histomorfometri assessment, radiological and Scanning Electron Microscope (SEM). Results: Based on the research results histomorfometrcally found there are differences in the mean total area of ​​callus significantly between the study group (p <0.001), there were significant differences in the mean area of ​​woven bone between the control group with group 1 ug / ml, 5 µg / ml, 10 µg / ml, 20 ug / ml (respectively p = 0.009, p = 0.016, p = 0.009 and p = 0.016), there were significant differences in the average area of ​​the cartilage between the control group with group 1 ug / ml, 5 µg / ml, 10 µg / ml, 20 ug / ml (respectively p = 0.009, p = 0.009, p = 0.009 and p = 0.028), there were significant differences in the average area of ​​fibrosis between the control group with group 1 ug / ml in the control group and 10 mg / ml (respectively -masing p = 0.047 and p = 0.009) .In radiologist assessment with RUST scores obtained significant differences between the control group and group 1 ug / ml, 5 µg / ml, 10 µg / ml, 20 µg / ml (respectively p = 0.005 , p = 0.006, p = 0.005 and p = 0.006). SEM features with callus more homogeneous and dense in the group of 10μg / mL compared with 5 ug / ml and 20 µg / ml. Conclusion: Administration of BMP-2 could stimulate the process of fracture healing in large bone defects (critical bone defect) which was statistically significant with histomorfometri assestment, radiological and qualitatively with the SEM. There is an optimal dose in the administration of BMP-2.