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"ABSTRAKHingga 2018 32.469 kasus kanker serviks diambil pada wanita Indonesia, perbedaan 17,2% dari total kasus kanker di Indonesia. Berbagai upaya dilakukan untuk mengurangi kematian akibat penyakit ini, menentang pengembangan sistem pemberian obat nanoteknologi. Dalam penelitian ini, konjugasi doxorubicin pada partikel nano magnetik Fe3O4 (MNPs) dengan agen capping berbasis karboksilat digunakan untuk menstabilkan partikel nano Fe3O4 untuk melihat pengaruhnya terhadap pemuatan obat dan pelepasan obat dari MNPs. Nanopartikel yang disintesis dikarakterisasi dengan spektroskopi Fourier Transform Infrared (FTIR), Difraksi Sinar-X (XRD), Transmission Electron Microscope (TEM), Particle Size Analyzer (PSA), dan Vibrating Sample Magnetometer (VSM). Pengukuran efisiensi pemuatan dan pelepasan obat dari tiga nanokomposit menghasilkan hasil yang baik, dengan persentase efisiensi pemuatan terbesar, yaitu 90.230% dicapai oleh AA-MNPs. Sementara itu, persentase terbesar dari obat yang dilepaskan adalah 98,590% yang disetujui oleh SA-MNPs. Hasil tes MTT pada sel HeLa menunjukkan bahwa nanokomposit CA-MNP memiliki efisiensi pelepasan obat terbaik, dengan nilai persen sel hidup hanya 23,460%.hr>ABSTRACTntil 2018 32,469 cases of cervical cancer were taken in Indonesian women, a difference of 17.2% of the total cancer cases in Indonesia. Various attempts were made to reduce mortality due to this disease, opposing the development of nanotechnology drug delivery systems. In this study, doxorubicin conjugate on Fe3O4 magnetic nanoparticles (MNPs) with carboxylic-based capping agents used to stabilize Fe3O4 nanoparticles to see their effect on drug loading and drug release from MNPs. The synthesized nanoparticles were characterized by Fourier Transform Infrared (FTIR) spectroscopy, X-Ray Diffraction (XRD), Transmission Electron Microscope (TEM), Particle Size Analyzer (PSA), and Vibrating Sample Magnetometer (VSM). Measurement of drug loading & release efficiency from three nanocomposites produced good results, with the largest percentage loading efficiency, ie 90,230% achieved by AA-MNPs. Meanwhile, the largest percent of drug released was 98.590% approved by the SA-MNPs. MTT test results on HeLa cells showed that the CA-MNP nanocomposite had the best drug release efficiency, with a live cell percent value of only 23.460%."

""By understanding the mechanisms by which compounds cross the skin, it becomes possible to devise means for improving drug delivery. Providing an overview of the current science in drug and cosmetic application to and through the skin, Topical and Transdermal Drug Delivery includes treatment of skin conditions, skin permeation, and enhancement and measurement of skin permeation. The book provides pharmaceutical scientists, skin product development experts, and those in the cosmetic and personal care industry with practical knowledge and insight into future product development"--Provided by publisher."

"Banyak senyawa protein, peptida dan peptidomimetik yang ditemukan akhir-akhir ini memiliki potensi terapeutik yang besar, namun terhambat aplikasinya sebagai obat karena mengalami masalah penghantaran ke situs sasarannya (drug delivery).Dalam beberapa tahun belakangan ini telah dikembangkan satu metode baru dalam modulasi junction antar sel menggunakan senyawa-senyawa peptida kadherin, yaitu peptida yang sekuensnya diturunkan dari sekuens fragmen peptida yang terdapat pada situs pengikatan kadherin. Dalam penelitian ini telah dievaluasi aktivitas beberapa peptida kadherin dalam memodulasi junction antar sel. Hasilnya menunjukan bahwa peptida-peptida Ac-LFSHAVSSNG-NH2 (HAV-10), Ac-SHAVSS-NH2 (HAV-6), Ac-QGADTPPVGV-NH2 (ADT-10), dan Ac-ADTPPV-NH2 (ADT-6) memiliki aktivitas yang cukup tinggi dalam memodulasi junction antar sel-sel MDCK (Madin Darby Canine Kidney). Hasil penelitian ini telah memberikan sumbangan yang berarti dalam pemantapan suatu metoda baru dalam penghantaran obat melalui modulasi junction antar sel menggunakan senyawa-senyawa peptida kadherin.

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Modulation of Intercellular Junction by Utilization of Cadherin Peptides as an Effort to Improve Drug Delivery. Rapid advances in combinatorial chemistry and molecular biology has influenced the discovery of many proteins, peptides and peptidomimetics as potential therapeutic agents. Unfortunately, the practical application of these potential drugs is often restricted by the difficulties of delivering them to target site(s) due to the presence of biological barriers.

Recently, a new method to improve the drug delivery, that is by modulating the intercellular junction, has been evaluated. Modulation of intercellular junction could be achieved by modulating the proteins which play important role in establishing the intercellular junction, one of which is cadherin. In the present work we have demonstrated the ability of several cadherin peptides, i.e. Ac-LFSHAVSSNG-NH2 (HAV-10), Ac-SHAVSS-NH2 (HAV-6), Ac-QGADTPPVGV-NH2 (ADT-10), and Ac-ADTPPV-NH2 (ADT-6) to modulate the intercellular junction of MDCK (Madin Darby Canine Kidney) cells, this finding is a contribution to the establishment of a new method to improve the drug delivery by utilization of cadherin peptides by modulating the intercellular junction."

"Penggunaan vitamin C pada kulit dapat memberikan efek antioksidan dengan cara memutuskan radikal bebas, yang merupakan zat yang berbahaya yang dibentuk dari pemaparan sinar uv, dimana bila tidak dicegah atau dikontrol, akan menyebabkan penuaan, pembentukan kanker, bahkan kerusakan sel. Dalam penelitian ini, natrium askorbil fosfat (NAF) yang merupakan salah satu derivat vitamin C yang stabil, dienkapsulasi ke dalam liposom untuk meningkatkan penetrasinya melalui stratum korneum ke bagian lapisan kulit yang lebih dalam. Pembuatan liposom ini menggunakan metode lapis tipis, dimana masing-masing formulanya dibuat dengan komposisi fosfatidilkolin:kolesterol yang berbeda (200:40 mg; 200:60 mg; 200:80 mg). Karakterisasi liposom yang diamati meliputi bentuk vesikel, distribusi ukuran partikel dan persen penjerapan obat. Hasil penelitian menunjukkan bahwa penjerapan obat dalam liposom dipengaruhi oleh jumlah kolesterol, dan persen penjerapan obat terbesar ialah pada liposom formula II dengan komposisi fosfatidilkolin:kolesterol 200:60 mg, yaitu menghasilkan penjerapan obat sebanyak 31,09%."

"Sistem pelepasan obat terkendali adalah proses untuk menjaga konsentrasi senyawa aktif dari obat di dalam tubuh. Dosis dari obat dapat dilepaskan di antara batas toksik dan batas terapi, dan mengurangi efek samping dan kerusakan pada jaringan normal. Eksperimen mengenai pelepasan obat terkendali ini secara in vivo memakan waktu dan biaya. Karena itu, pemodelan diperlukan sebelum eksperimen dilakukan. Pemodelan yang dilakukan adalah pelepasan theophylline dengan meninjau pengaruh difusifitas dan ukuran dari obat tersebut. Theophylline memiliki jarak batas terapi dan toksik yang sempit, sehingga pelepasannya di dalam tubuh perlu di kontrol. Simulasi dilakukan dengan bantuan software COMSOL Multiphysics. Dari simulasi, didapatkan pada variasi D = 2 x 10-10 m2/s dan r = 0,007 m adalah variabel yang paling mendekati profil pelepasan yang diinginkan.Controlled drug release is a process to keep active substance concentration of drugs inside the body. Dosage from the drugs can be released between the toxic and therapeutic limit, and decrease the side effects and the damage on normal tissue. The experiment about drug release in vivo is time and money consuming. So, modeling is needed before the experiment is conducted. The modeling that is conducted is theophylline release with diffusivity and size of the drug as consideration. Theophylline has a narrow therapeutic and toxic limit, so the release in body should be controlled. Simulation is conducted using COMSOL Multiphysics software. From simulation, at the variation D = 2 x 10-10 m2/s and r = 0,007 m is the nearest desired release profile."

"In this first authoritative overview on modern cancer chemotherapy 121 international specialists have contributed their experience and recent data for what is likely to become the gold standard in the field. The authors summarize knowledge gained over the past decade, from basic concepts to successful applications in the clinic, covering active and passive targeting strategies as well as tissue-specific approaches. All current and future targeted delivery systems are discussed, from ligand-based to antibody-based polymer-based systems, right up to micro- and nanoparticulate systems. A special section covers the delivery of nucleic acid therapeutics, such as siRNA, miRNA and antisense nucleotides. In each case, a description of the basic technique is followed by a discussion of the latest preclinical and clinical developments in the field. "

"This topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in today's drug design. It summarizes current experiences and strategies for the rational design of prodrugs, beginning at the early stages of the development process, as well as discussing organ- and site-selective prodrugs. Every company employing medicinal chemists will be interested in this practice-oriented overview of a key strategy in modern drug discovery and development."

"Pitched at a level comprehensible to those new to the field, this authoritative text covers the scientific and technological fundamentals of drug delivery as well as clinical applications and the developmental potential in controlled release drug delivery."

"Topics covered in Long acting Injections and Implants include the historical development of the field, drugs, diseases and clinical applications for long acting injections and implants, anatomy and physiology for these systems, specific injectable technologies (including lipophilic solutions, aqueous suspensions, microspheres, liposomes, in situ forming depots and self-assembling lipid formulations), specific implantable technologies (including osmotic implants, drug eluting stents and microfabricated systems), peptide, protein and vaccine delivery, sterilization, drug release testing and regulatory aspects of long acting injections and implants."