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ABSTRAK Tujuan: Menentukan prevalensi excessive daytime sleepiness (EDS) pada pasien
dengan epilepsi dan faktor-faktor yang berhubungan di Rumah Sakit Cipto
Mangunkusumo (RSCM).
Metode: Studi potong lintang deskriptif ini menggunakan kuesioner Epworth
Sleepiness Scale (ESS) pada pasien epilepsi yang diambil secara konsekutif di
poliklinik neurologi RSCM, pada bulan Oktober-November 2015. Faktor-faktor
yang dianalisis meliputi usia, jenis kelamin, jenis bangkitan, sindrom epilepsi,
etiologi epilepsi, frekuensi bangkitan, bangkitan nokturnal, risiko Obstructive
Sleep Apnea (OSA), depresi mayor, gangguan cemas menyeluruh, obat anti
epilepsi, dan potensial resistensi obat. EDS ditentukan jika skor ESS > 10. Risiko
OSA ditetapkan dengan kuesioner STOP-Bang; depresi mayor ditentukan dengan
kuesioner Neurological Disorders Depression Inventory for Epilepsy (NDDI-E)
versi Indonesia; gangguan cemas menyeluruh ditentukan dengan kuesioner Mini
International Neuropsychiatric Interview for International Classification of
Diseases-10 (MINI ICD-10).
Hasil: Diantara 93 pasien epilepsi, prevalensi EDS adalah sebanyak 32.3%;
wanita lebih banyak dari pria. Faktor-faktor yang berhubungan secara signifikan
dengan EDS adalah usia kurang dari 35 tahun, frekuensi bangkitan dalam 1 tahun
lebih dari sama dengan 8 kali, depresi mayor, dan potensial resisten obat. Dari
analisis multivariat, terdapat 2 faktor independen yang berhubungan dengan EDS
yaitu depresi mayor dan potensial resisten obat.
Kesimpulan: EDS umum dijumpai pada pasien epilepsi dengan prevalensi
32.3%. Depresi mayor dan potensial resistensi obat merupakan faktor yang
berhubungan dengan EDS pada pasien epilepsi
ABSTRACT Purpose: To determine the prevalence of excessive daytime sleepiness (EDS) in
epilepsy patients and its related factors at Cipto Mangunkusumo Hospital
Jakarta, Indonesia.
Materials and Method: This cross-sectional descriptive study using Epworth
Sleepiness Scale (ESS) questionnaire to identify EDS in epilepsy patients visited
our neurology clinic during October-November 2015 consecutively. Related
factors that had been analyzed were age, sex, seizure type, epilepsy syndrome,
etiology, seizure frequency, nocturnal seizures, risk of Obstructive Sleep Apnea
(OSA), major depression, general anxiety disorder, anti epileptic drug, and
potentially drug resistant epilepsy (DRE). EDS was determined if ESS score > 10.
Risk of OSA was assessed by STOP-Bang questionnaire; major depression was
assessed by Neurological Disorders Depression Inventory for Epilepsy (NDDI-E)
Indonesian version; general anxiety disorder was assessed by Mini International
Neuropsychiatric Interview for International Classification of Diseases-10 (MINI
ICD-10). Data analysis was done using SPSS 17.0.
Results: Among 93 subjects, prevalence of EDS was 32.3%; female was more
common than male. Related factors that significantly influenced to EDS were age
< 35 years old, seizure frequency within 1 year >8 times, major depression and
potentially DRE. From multivariate analysis, there were 2 independent factors
that related to EDS that were major depression and potentially DRE.
Conclusions: EDS is common in epilepsy patients (32.3%). Major depression and
potentially DRE were related factors of EDS in epilepsy patients.
;Purpose: To determine the prevalence of excessive daytime sleepiness (EDS) in
epilepsy patients and its related factors at Cipto Mangunkusumo Hospital
Jakarta, Indonesia.
Materials and Method: This cross-sectional descriptive study using Epworth
Sleepiness Scale (ESS) questionnaire to identify EDS in epilepsy patients visited
our neurology clinic during October-November 2015 consecutively. Related
factors that had been analyzed were age, sex, seizure type, epilepsy syndrome,
etiology, seizure frequency, nocturnal seizures, risk of Obstructive Sleep Apnea
(OSA), major depression, general anxiety disorder, anti epileptic drug, and
potentially drug resistant epilepsy (DRE). EDS was determined if ESS score > 10.
Risk of OSA was assessed by STOP-Bang questionnaire; major depression was
assessed by Neurological Disorders Depression Inventory for Epilepsy (NDDI-E)
Indonesian version; general anxiety disorder was assessed by Mini International
Neuropsychiatric Interview for International Classification of Diseases-10 (MINI
ICD-10). Data analysis was done using SPSS 17.0.
Results: Among 93 subjects, prevalence of EDS was 32.3%; female was more
common than male. Related factors that significantly influenced to EDS were age
< 35 years old, seizure frequency within 1 year >8 times, major depression and
potentially DRE. From multivariate analysis, there were 2 independent factors
that related to EDS that were major depression and potentially DRE.
Conclusions: EDS is common in epilepsy patients (32.3%). Major depression and
potentially DRE were related factors of EDS in epilepsy patients.
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