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"Latar Belakang : Gangguan Pemusatan Perhatian dan Hiperaktivitas (GPPH) merupakangangguan psikiatrik paling sering dijumpai pada anak, dengan prevalensi 26,2 % di Jakarta.Berbagai penelitian menyatakan patofisiologi GPPH terkait dengan aktivitas dopaminergik,yang diduga dipengaruhi oleh serum feritin.Tujuan: Mengetahui hubungan kadar feritin dengan gejala klinis GPPH serta mengetahuiadakah perbedaan kadar feritin pada anak GPPH dan bukan GPPHMetode: Desain penelitian ini adalah potong lintang, membandingkan 47 anak GPPH dan 47anak sehat sebagai kontrol yang berusia 7-12 tahun (rerata usia 9,09± 1,29). Uji korelasiSpearman digunakan untuk mengetahui hubungan kadar feritin dengan gejala klinis GPPH.Pemeriksaan serum feritin menggunakan metode Electrochemiluminescent ImmunoAssay(ECLIA). Diagnosis GPPH ditegakkan dengan MINI KID sedangkan gejala klinis GPPHdinilai berdasarkan SPPAHI.Hasil : Tidak didapatkan hubungan bermakna antara kadar feritin dengan gejala klinis GPPH,koefisien korelasi 0,108 (p>0,05). Rerata kadar feritin anak GPPH adalah 38,7 ng/mL(median), yang tidak berbeda bermakna dengan kontrol (median 28 ng/mL).Kesimpulan: Pada penelitian ini, tidak terbukti adanya hubungan antara feritin dengan gejalaklinis GPPH. Masih diperlukan studi lebih lanjut untuk melihat peran feritin melalui dopaminpada GPPH.......Background : Attention Deficit Hyperactivity Disorder (ADHD) is the most commonpsychiatric disorder in children with prevalence of 26,2% in Jakarta. Various studies haveacknowledged the pathophysiology of ADHD in relation to dopaminergic activity possiblyinfluenced by serum ferritinObjectives: To find relationship between ferritin level with clinical symptomsof ADHD, andto identify any difference in ferritin level in children with and without ADHD.Methods: This study is cross sectional by design, comparing 47 ADHD children and 47healthy controls aged 7-12 years old (mean age 9.09 ± 1,29). Spearman test was performed tofind correlation between ferritin level and clinical symptoms of ADHD. Serum ferritin wasexamined using Electrochemiluminescent ImmunoAssay (ECLIA) method. ADHD wasdiagnosed by MINI KID while clinical symptoms of ADHD were assessed with SPPAHI.Results : No signification correlation was found between ferritin level and clinical symptomsof ADHD, coefficient correlation 0,108 (p> 0,05). Mean ferritin level of ADHD children was38,7 ng/mL (median) and was not significant in comparison to control group (median 28ng/mL)Conclusions: In this study, ferritin has been found to have no correlation with clinicalsymptoms of ADHD. Further study needs to be performed to identity ferritin role throughdopamine in ADHD"

"Zat besi merupakan mikronutrien esensial yang diperlukan tubuh seperti pertumbuhan sel darah merah dan sel otak Kebutuhan besi meningkat pada masa kehamilan Komposisi mikrobiota dapat berubah selama tahap kehidupan yang dipengaruhi oleh berbagai faktor misalnya besi Penelitian ini merupakan penelitian dengan desain potong lintang yang bertujuan untuk mengetahui korelasi antara asupan besi dan kadar feritin serum dengan jumlah Bifidobacterium pada ibu hamil trimester ketiga Penelitian ini dilakukan di seluruh puskesmas kecamatan di Jakarta Timur dari bulan Maret sampai April 2015 Pengambilan subjek dilakukan dengan cara konsekutif dan didapatkan 52 ibu hamil yang memenuhi kriteria penelitian Data dikumpulkan dengan wawancara meliputi kuesioner data asupan besi heme dan non heme protein serta vitamin C dengan FFQ semikuantitatif Pengukuran antropometri untuk menilai status asupan gizi pemeriksaan laboratorium untuk mengetahui kadar feritin serum dan kadar CRP serta jumlah Bifdobacterium dalam tinja Didapatkan rerata usia 29 1 5 9 tahun nilai median asupan besi 66 7 3 3 144 1 mg hari kadar feritin serum 31 1 3 6 96 1 g L dan jumlah Bifidobacterium usus 7 45 5 1 9 5 log g tinja Tidak didapatkan korelasi yang bermakna asupan besi dengan jumlah Bifidobacterium usus r 0 202 p 0 152 juga tidak didapatkan korelasi bermakna antara kadar feritin serum dengan jumlah Bifidobacterium usus (r=0,116 p=0,411).

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Iron is an essensial micronutrient which body needed such as for blood growth cell and brain cell Iron rsquo s requirement increases in pregnancy Microbiota composition can change in cycle of life which be affected by many factors likely iron The aim of this cross sectional study was to find the correlation between iron intake and serum ferritin with Bifidobacterium third trimester of pregnancy Data collection was conducted from March 2015 until April 2015 in all of sub district of public health centre in east Jakarta Subjects were obtained using consecutive sampling method A total of 52 pregnancy subjects had met the study criteria Data were collected through interviews including questionnare iron intake heme and non heme protein and vitamin C used semiquantitative FFQ Anthropometry measurementsto assess the nutritional status and laboratory examination i e blood levels of serum ferritin and CRP and Bifidobacterium in feces Mean age 29 1 5 9 years Median of intake of iron was 66 7 3 3 144 1 mg day serum ferritin was 31 1 3 6 96 1 g L and gut Bifidobacterium 7 45 5 1 9 5 log g feces No significant correlation was found between iron intake and Bifidobacterium in feces r 0 202 p 0 152 and negative correlations and no significant between serum ferritin and Bifidobacterium in feces (r=0, 116, p=0,411)"

"ABSTRAKLatar Belakang: Mangiferin diketahui memiliki aktivitas sebagai agen pengikat besi, namun pemberian mangiferin melalui oral memiliki bioavailabilitas yang rendah. Sistem hantaran dengan nanopartikel diharapkan dapat meningkatkan bioavailabilitas dan efektivitas mangiferin. Penelitian bertujuan menguji efektivitas mangiferin nanopartikel kitosan-alginat dalam menurunkan kadar besi di plasma dan organ, kadar ferritin, transferrin, SGOT dan SGPT. Metode: Penelitian menggunakan desain eksperimental in vivo dengan hewan coba tikus Sprague-Dawley dibagi dalam 5 kelompok, yaitu kelompok normal, kelebihan besi, terapi mangiferin 50 mg/KgBB, terapi mangiferin dalam nanopartikel kitosanalginat 25 mg/KgBB, dan terapi mangiferin dalam nanopartikel kitosan-alginat 50 mg/KgBB. Pengukuran kadar Fe plasma, hati dan jantung, kadar Ferritin, kadar Transferrin, dan nilai aktivitas SGPT dan SGOT. Hasil: Kadar besi plasma, besi hati dan jantung, ferritin, dan transferrin pada kelompok kelebihan besi adalah 45,52 mg/L; 3661,98 μg/gram; 1734,4 μg/gram; 3578,16 ng/mL; 388,96 μg/dL, sedangkan pemberian terapi mangiferin 50 mg/KgBB (p < 0,05) menghasilkan 5,17 mg/L; 1572,96 μg/gram; 776,68 μg/gram; 1136,51 ng/mL; 272,18 μg/dL, pemberian terapi mangiferin dalam nanopartikel kitosan-alginat 25 mg/KgBB (p < 0,05) menghasilkan 5,74 mg/L; 1090,01 μg/gram; 753,90 μg/gram; 520,89 ng/mL; 231,97 μg/dL, pemberian terapi mangiferin dalam nanopartikel kitosan-alginat 50 mg/KgBB (p < 0,05) menghasilkan 3,34 mg/L; 1703,92 μg/gram; 759,2 μg/gram; 559,48 ng/mL; 235,70 μg/dL. Tidak terdapat perbedaan bermakna antar kelompok terhadap nilai aktivitas SGOT dan SGPT Kesimpulan: Mangiferin dalam nanopartikel kitosan-alginat efektif menurunkan kadar besi, ferritin, transferrin plasma, dan kadar besi di organ hati dan jantung, namun tidak menurunkan nilai aktivitas SGOT dan SGPT. Efektivitas mangiferin dalam nanopartikel kitosan-alginat tidak berbanding lurus dengan dosis.

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ABSTRACTBackground: Mangiferin was known to have activity as an iron-chelating agent, but oral administration of mangiferin has poor bioavailability. Nanoparticles delivery system is expected to increase bioavailability and effectiveness of mangiferin. This study aims to examine the effectiveness of mangiferin in chitosanalginate nanoparticles in reducing iron levels in plasma and organs, ferritin, transferrin, SGOT and SGPT activities. Methods: This is an in vivo experimental study using Sprague-Dawley rats, divided into 5 groups, normal, iron overload, mangiferin 50mg/KgBW, mangiferin in chitosan-alginate nanoparticles 25mg/KgBW, and mangiferin in chitosanalginate nanoparticles 50mg/KgBW. Fe levels were measured in plasma, liver and heart. In addition ferritin levels, transferrin levels, and SGPT and SGOT activities also measure at day 29th. Results: Plasma iron levels, liver and heart iron levels, ferritin, and transferrin in the iron overload group were 45.52 mg/L; 3661.98 μg/gram; 1734.4 μg/gram; 3578.16 ng/mL; 388.96 μg/dL, treatment with mangiferin 50 mg/KgBW (p < 0.05) reduced those parameters to 5.17 mg/L; 1572.96 μg/gram; 776.68 μg/gram; 1136.51 ng/mL; 272.18 μg/dL, treatment with mangiferin in chitosan-alginate nanoparticles 25 mg/KgBW (p < 0.05) reduced those parameters 5.74 mg/L; 1090.01 μg/gram; 753.90 μg/gram; 520.89 ng/mL; 231.97 μg/dL, treatment with mangiferin in chitosan-alginate nanoparticles 50 mg/KgBW (p < 0.05) reduced those parameters 3.34 mg/L; 1703.92 μg/gram; 759.2 μg/gram; 559.48 ng/mL; 235.70 μg/dL. There is no significant difference in SGOT and SGPT activities. Conclusions: Mangiferin in chitosan-alginate nanoparticles was effective in preventing the increase of iron, ferritin, transferrin plasma levels, and iron levels in the liver and heart, but not prevent the increasing of SGOT and SGPT. The effectiveness of mangiferin in chitosan-alginate nanoparticles is not directly proportional to the dose."

"Menurut data WHO 2018, angka kejadian stunted mencapai 21,9% yang berarti sekitar 140 juta anak di dunia mengalami kejadian stunted. Prevalensi stunted di Indonesia pada tahun 2018 mencapai 30,8%. Artinya, kejadian stunted diderita oleh sekitar 7,3 juta anak Indonesia. Pandemi Covid 19 yang terjadi sejak 2020 menyebabkan banyak perubahan pola kondisi sosial ekonomi pada masyarakat, yang tentu saja mempengaruhi kemampuan orang tua menyediakan makanan yang bergizi untuk memenuhi kebutuhan asupan nutrisi anak. Jika kecukupan zat gizi inadekuat, proses metabolisme tubuh dapat terganggu dan akan menyebabkan terhambatnya proses pembentukan sel atau jaringan dalam tubuh yang selanjutnya menjadi stunted. Salah satu nutrisi yang harus tercukupi adalah zat besi. Tujuan penelitian ini adalah untuk mengetahui perbedaan asupan dan status besi pada anak stunted dan non stunted pada anak usia 24 – 35 bulan pada masa pandemi Covid-19 di Jakarta. Metode penelitian yang digunakan adalah potong lintang komparatif menggunakan data sekunder dari 77 anak usia 24 – 35 bulan di Puskesmas Kampung Melayu, Jakarta Timur pada bulan September sampai dengan Oktober 2020. Data karakteristik subjek diambil dengan kuesioner. Data asupan zat besi, kalori dan protein didapat dengan metode semikuantitatif Food Frequency Questionnaire. Dilakukan pemeriksaan antropometri dan laboratorium untuk kadar hemoglobin, ferritin dan hs–CRP. Analisis bivariat t tidak berpasangan digunakan untuk mengetahui perbedaan kadar Hb antara anak stunted dan non-stunted, dan uji Mann-Whitney untuk mengetahui perbedaan asupan besi dan kadar ferritin antara anak stunted dan non-stunted, dengan batas kemaknaan p<0,05. Didapatkan perbedaan rerata yang bermakna kadar Hb (9,91±1,93 g/dL kelompok stunted dan 12,18±1,20 g/dL kelompok non-stunted, p<0,001) dan kadar ferritin (4,9 (1,5 - 67,4) μg/L kelompok stunted dan (26,8 (1,6 - 91,1) μg/Lkelompok non-stunted, p<0,001). Asupan besi tidak terdapat perbedaan bermakna di antara kedua kelompok (8,85 (1,5 -74) mg kelompok stunted dan 11,1 (1,9 - 118,6) mg kelompok non-stunted, p = 0,676). Hasil analisis menemukan Kadar Hb dan ferritin anak stunted lebih rendah dibandingkan pada anak non-stunted.......According to WHO 2018 data, the stunted incidence rate reached 21.9%, which means that around 140 million children in the world experienced stunted events. The prevalence of stunted in Indonesia in 2018 reached 30.8%. This means that around 7.3 million Indonesian children are stunted. Since 2020, the Covid 19 pandemi has caused many changes in the pattern of socioeconomic conditions in society, which, of course, affects parents' ability to provide nutritious food to meet the nutritional needs of their children. If nutrients are insufficient, the body's metabolic processes will be disrupted, and the process of forming cells or tissues in the body will be inhibited, causing growth to be stunted. Iron is one of the nutrients that must be met. The goal of this study was to see if there were any differences in iron intake and status between stunted and non-stunted children aged 24-35 months during the Covid-19 pandemi in Jakarta. From September to October 2020, 77 children aged 24-35 months were studied in a cross-sectional comparative study using secondary data at the Kampung Melayu Health Center in East Jakarta. A questionnaire was used to collect data on the subjects' characteristics. Data on iron, calorie and protein intake were taken using the semi-quantitative Food Frequency Questionnaire method. Anthropometric and laboratory examinations were performed for hemoglobin, ferritin and hs-CRP levels. Independent sample t-test was used to determine differences in Hb levels between stunted and non-stunted children, and the Mann-Whitney test to determine differences in iron intake and ferritin levels between stunted and non-stunted children, using a significance limit of p < 0.05. There was a significant difference in Hb levels (9.91±1.93 g/dL in the stunted group and 12.18±1.20 g/dL in the non-stunted group, p<0.001) and ferritin levels (4.9 (1.5 - 67.4) μg/L in the stunted group and (26.8 (1.6 -91.1) μg/L in the non-stunted group, p<0.001) There was no significant difference in iron intake between the two groups (8.85 (1.5-74) mg in the stunted group and 11.1 (1.9 - 118.6) mg in the non-stunted group, p = 0.676. The results of the analysis found Hb and ferritin levels in stunted children were lower than in non-stunted children"

"Latar Belakang: Penyakit COVID-19 yang disebabkan oleh virus SARS-CoV-2 bisa menyebabkan kelainan pada paru-paru berupa pulmonary intravascular coagulation, suatu koagulopati akibat infeksi. Banyak menduga keadaan ini disebabkan oleh cytokine strorm yang salah satu komponen utamanya adalah IL-6. Sampai saat ini belum diketahui hubungan antara IL-6 dengan koagulopati pada penyakit ini. Tujuan: Kami ingin megetahui apakah IL-6 memiliki korelasi dengan pertanda koagulopati d-Dimer, fibrinogen, dan prothrombin time, serta apakah IL-6 memiliki korelasi dengan ferritin sebagai acute phase reactant. Kami juga ingin mengetahui apakah IL-6, ferritin, fibrinogen, d-Dimer, dan PT berkorelasi dengan perburukan subjek COVID-19 derajat sedang dan berat. Metode: Kami melakukan penelitian kohort prospektif pada pasien COVID-19 derajat sedang dan berat di suatu rumah sakit khusus yang menangani perawatan pasien COVID-19 mulai dari Juni 2020 sampai Januari 2021. Kami melakukan pemeriksaan serial IL-6, d-Dimer, fibrinogen, ferritin dan prothrombin time (PT), serta observasi keadaan pasien tersebut saat masuk rawat dan pada hari ke 14 hari atau sebelum hari ke 14 jika terjadi perbaikan, perburukan, atau pulang; mana yang lebih dahulu terjadi. Penelitian ini sudah mendapat persetujuan dari Panitia Tetap Etik Penelitian Kedokteran FKUI-RSUPN Cipto Mangunkusumo. Hasil: Selama Juni 2020 sampai dengan Januari 2021 kami temukan sebanyak 374 pasien COVID-19 derajat sedang dan berat. Tujuh puluh tiga subjek masuk kriteria inklusi 61 orang termasuk kategori berat, dan 12 orang sedang. Jumlah pasien perburukan adalah 35 dari 61 pasien derajat berat, dan 1 dari 12 pasien derajat sedang. Uji korelasi Spearman antara IL-6 dengan ferritin, d-Dimer, fibrinogen, dan PT berturut-turut koefisien korelasinya 0,08 (p=0,5), -0,13 (p=0,27), 0,01 (p=0,91), 0,03 (p=0,77). Uji korelasi Spearman antara ferritin dengan d-Dimer, fibrinogen, dan PT berturut-turut 0,17 (p=0,14), 0,05 (p=0,63), dan 0,07 (p=0,51). ROC yang memiliki luas lebih dari 60% adalah selisih d-Dimer dan selisih IL-6 (74,77% dan 71,32%). Kesimpulan: Tidak ditemukan korelasi antara IL-6 dengan d-Dimer, fibrinogen, PT. Ferritin tidak berkorelasi dengan d-Dimer, fibrinogen dan PT. IL-6 tidak berkorelasi dengan ferritin. Perubahan IL-6 dan d-Dimer dapat memprediksi perburukan pada pasien COVID-19 derajat sedang dan berat.......Background: COVID-19 disease caused by the SARS-CoV-2 virus can cause abnormalities in the lungs in the form of pulmonary intravascular coagulation, a coagulopathy due to infection. Many suspect this situation is caused by cytokine storm, one of the main components of which is IL-6. Until now, there is no known relationship between IL-6 and coagulopathy in this disease. Objectives: We wanted to know whether IL-6 correlated with markers of d-Dimer coagulopathy, fibrinogen, and prothrombin time, and whether IL-6 correlated with ferritin as an acute phase reactant. We also wanted to find out whether IL-6, ferritin, fibrinogen, d-Dimer, and PT correlated with moderate and severe worsening of COVID-19 subjects. Methods: We conducted a prospective cohort study of moderate and severe COVID-19 patients in a specialized hospital that treats COVID-19 patients from June 2020 to January 2021. We performed serial tests of IL-6, d-Dimer, fibrinogen, ferritin and prothrombin time (PT), as well as observing the patient's condition at the time of admission and on day 14 or before day 14 if there is improvement, worsening, or discharge; whichever happens first. This research has been approved by the Permanent Committee of Medical Research Ethics FKUI-RSUPN Cipto Mangunkusumo. Results: During June 2020 to January 2021, we found 374 moderate and severe COVID-19 patients. Seventy-three subjects entered the inclusion criteria, 61 people were included in the heavy category, and 12 people were moderate. The number of deteriorating patients was 35 of 61 severe grade patients, and 1 of 12 moderate grade patients. Spearman correlation test between IL-6 and ferritin, d-Dimer, fibrinogen, and PT, respectively, the correlation coefficients were 0.08 (p=0.5), - 0.13 (p=0.27), 0.01 ( p=0.91), 0.03 (p=0.77). Spearman correlation test between ferritin and d-Dimer, fibrinogen, and PT was 0.17 (p=0.14), 0.05 (p=0.63), and 0.07 (p=0.51) . ROCs that have areas of more than 60% are the d-Dimer-difference and IL-6-difference (74.77% and 71.32%).Conclusions: No correlation was found between IL-6 and d-Dimer, fibrinogen, PT. Ferritin did not correlate with d-Dimer, fibrinogen and PT. IL-6 was not correlated with ferritin. Changes in IL-6 and d-Dimer can predict worsening in moderate and severe COVID-19 patients."

"Bahan dan Metode : Desain cross seksional pada 99 subyek laki-laki tahun yang dipilih secara simple random sampling dari sarnpel MONICA Jakarta III. Data yang dikumpulkan meliputi data umum subyek, asupan makanan, antropometri, tekanan darah, EKG dan pemeriksaan laboratorium darah. Uji statistik yang digunakan adalah uji X2, Fisher dan Kolmogorov-Smimov, Mann Whitney dan korelasi Pearson / Spearman rank.Hasil : Kadar feritin serum ?200 p.glL tedapat pads 8,1% subyek. Asupan besi total 4,81 mg (1,59-13,24 mglhari), besi hem 0,21 mg (0-1,22 mg/had), 93,9% asupan besi kurang 1 AKG. Terdapat 13,1% dengan IMT >27 kglm2, 20,2% dengan Lpe X94 cm aan rasio LpelLpa X0,95; 34,3% dengan tekanan darah >149190 mm Hg, Kadar kolesterol total abnormal 41,4% (?200 mgldL); kolesterol HDL abnormal 63,6%(z40 mgldL); kolesterol LDL abnormal 52,5% (?130 mgldL); trigiiserida abnormal 11,I%(200 mg/dL); gula puasa abnormal 5,1% (?126 mgldL). Kebiasaan merokok pada 54,5% subyek. Tidak trdapat korelasi bermakna antara asupan besi total (r--0,038) dan besi hem (r,027) dengan feritin serum. Rasio Odds kasar antara feritin serum dengan PJK (diagnostik EKG) 5,5 kali (CI. 0,87-34,33). Pada uji statistik didapat perbedaan bermakna median feritin serum pads subyek diabetes daengan non diabetes (p~,001) dan subyek dengan kelebihan lemak tubuh dengan subyek dengan lemak tubuh normal (Lpe dengan p:1,009; LpelLpa dengan p"0,047).Kesimpulan: Didapatkan hubungan tidak bermakna antara feritin serum dengan asupan zat gizi. Terdapat hubungan moderat antara feritin serum dengan risiko PJK. Subyek dengan feritin serum ? 200 .iglL mempunyai kecenderungan risiko 5,5 kali menderita PJK (diagnostik EKG) dibandingkan subyek dengan feritin serum <200 p.g(L,

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Serum ferritin in men 35 years old or over and its relating factors at Mampang PrapatanMethods : A cross sectional study had been carried out of on 99 subjects age 35 years selected using simple random sampling method from MONICA Jakarta's III sample. Data collected consist of socio-economic state, dietary intake, anthropometric, laboratory, blood pressure and electrocardiogram examination. Statistical analysis was performed by X-, Fisher, Kolmogorov-Sm imov, Mann-Whitney, and Pearson/ Spearman rank correlation.Result : Serum ferritin 1200 1.tglL was found in 8,1% subjects. Total iron intake 4,81 mg (1,59-13,24 mg/day), heme iron 0,21 mg (0-1,22 mg/day), 93,9%% of iron intake below the RDA. There were 13,1% subjects with BMI >27 kg/m2; 20,2% with AC >94 cm and WHR >0,95; 34,5% with blood pressure >140/90 mm Hg. Abnormal total cholesterol level 41,4% (1200 mg/dL); abnormal HDL cholesterol 63,6% (<40 mg/dL); abnormal LDL cholesterol 52,5% (1130 mg/dL); abnormal triglyceride 1,1% (~0d mg/dL); abnormal fasting glucose 5,1% (?126 mgldL); 54,5% had smoking habits. Lack association between total iron (r=-0,038) and heme iron (r 0,027) with serum ferritin. Men with ferritin serum 1200 l.tg1L had an crude odds ration 5,5 fold suffer from CHD (according to ECG diagnostic) compare to subjects with ferritn serum <200 .iglL (CI. 0,87-34,33). Statistical analysis showed significant difference of serum ferritin median in diabetic and non diabetic subjects (p:1,001), overfatness subjects and normo fatness subjects (AC with. pC,009 and WHR with p=0,047).Conclusion : There is no significant relationship between serum ferritin level and dietary intake. Bivariate analysis found moderate relationship between serum ferritin and CHD. Men with serum ferritin 1200 pglL had a crude odds ratio 5,5 fold suffer from CHD (according to ECG diagnostic) compare to the subjects with serum ferritin < 200 pg/L."

"ABSTRAKRuang lingkup dan cara penelitianTingginya prevalensi anemia defisiensi besi pada wanita usia reproduksi di Indonesia. Asupan zat besi melalui makanan dan aktifitas fisik/olahraga yang berat dapat merupakan salah satu faktor penyebab anemia defisiensi besi. Telah dilakukan penelitian quasi eksperimental pada 60 siswa wanita untuk melihat pengaruh latihan fisik yang teratur dan konsumsi makanan yang didapat setiap hari terhadap kadar hemoglobin dan feritin serum di suatu pendidikan khusus selama 12 minggu. Pada awal dan akhir penelitian, kepada subjek dilakukan pemeriksaan; kesehatan, antropometri, kadar hemoglobin dan feritin serum. Sedangkan asupan makanan dan kegiatan 24 jam dinilai selama masa penelitian berlangsung. Dengan metode 3 days record dan metode faktorial.Hasi1 dan KesimpulanPada awal dan akhir penelitian didapatkan kejadian defisiensi besi dengan atau tanpa anemia dan anemia bukan defisiensi besi yang cukup tinggi. Kualitas makanan yang diterima mempunyai imbangan sumber energi yang sesuai dengan anjuran, dan kuantitas asupan zat gizi yang diteliti (lemak, protein, zat besi dan vitamin C) berada di atas nilai kebutuhan yang disesuaikan dengan kecukupan yang dianjurkan, kecuali asupan energi dan karbohidrat sedikit di bawah nilai kecukupan. Jenis aktifitas/kegiatan yang dilakukan to nnasuk kategori jenis aktifitas berat dengan keluaran energi dalam sehari sebesar 3496,88+134,21 Kal. Latihan fisik dan asupan makanan yang diterima selama penelitian ini berlangsung, dapat menurunkan berat badan dan indeks masa tubuh (p<0,05), tetapi meningkatkan kadar hemoglobin (p;0,05) dan feritin serum (p<0,05). Perubahan ini dipikirkan karena selain adanya efek konsumsi zat besi dari makanan yang diterima, jenis intensitas dan lama latihan fisik yang dilakukan, distribusi populasi subjek berdasarkan kadar hemoglobin dan feritin serum turut pula mempengaruhinya.

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ABSTRACT

Scope and Method of Study:

The prevalence of iron deficiency anaemia in reproductive age women in Indonesia is high. Two factors involved on causing iron deficiency anaemia are food intake and hard physical training.

A quacy experimental study was done on 60 women to investigate the changes of hemoglobin and serum ferritin on women student who had regular meals and taking basic physical training during 12 weeks in special education. Physical, anthropometric examination, hemoglobin and serum ferritin concentration determination were done on each subject at the beginning and at the end of the basic special education. The evaluation of food intake and 24 hours activities were done using three days record and factorial method during this study.

Result and Conclusions:

The incidence of iron deficiency at the beginning and at the end of study were quite high, both among the anaemic and the non anaemic group. The quality of food intake was well balanced and the quantity of each nutritional element under study (fat, protein, iron and vitamin C) were above the optimal requirement, except calorie and carbohydrate were slightly below the optimal requirement. The exercises done by the subjects were categorized as heavy exercise with energy expenditure of 3496.88±134.21 calories per day. Heavy exercise and food intake during the study managed, to lower the body weight and body mass index (p<0.05) and increased the hemoglobin and serum ferritin concentrations (p<0.05). The changes were thought due to iron consumption, intensity and duration of physical training, subject population distribution according to hemoglobin and serum ferritin concentrations."

"TUJUAN: (1) Mengetahui perubahan fungsi sistolik dan diastolik serta massa ventrikel kin pada remaja dan dewasa muda penderita Talasemia mayor dibandingkan dengan remaja dan dewasa muda normal. (2) Mengetahui hubungan antara kadar feritin serum dan fungsi sistolik dan diastolik ventrikel kiri yang diperoleh dengan pemeriksaan ekokardiografi pada remaja dan dewasa muda penderita Talasemia mayor.TEMPAT PENELITIAN: Divisi Kardiologi dan Divisi Hematologi Anak FK UI/RSCM JakartaSUBYEK PENELITIAN: Remaja dan dewasa muda penderita Talasemia mayor yang menjalani pemeriksaan dan transfusi rutin di Pusat Talasemia RSCM sejak bulan Agustus - Desember 2005.METODOLOGI: Dilakukan penelitian observasional dengan rancang bangun cross sectional. Data meliputi parameter hematologis pasien Talasemma mayor dan parameter fungsi sistolik ventrikel kiri (EF dan FS), fungsi diastolik ventrikel (E, A, rasio E/A, IVRT), serta massa ventrikel kiri (LVDDi, LVDSi, LVMi) dengan menggunakan mesin ultrasonografi Sonas 4500, transduser 8 MHz. Data diolah dengan SPSS versi 10. Dilakukan uji t, analisa regresi liner dan analisa multivariat dengan regresib multiple. Nilai a yang dipakai adalah 0,05. Jumlah subyek minimal yang diperlukan adalah 28.HASIL : Dan 32 subyek Talasemia mayor yang diperiksa, 30 subyek diikutsertakan dalam penelitian. Fungsi sistolik dan diastolik Talasemia mayor lebih rendah dibanding kontrol dan perbedaan ini secara statistik bermakna. Rerata EF Talasemia mayor dan kontrol masing-masing adalah 66,1% (SB 4,9) dan 71,6% (SB 5,6) ; p < 0,0001. Rerata FS 36,0% (SB 3,7) dan 39,8% (SB 5,5) ; p = 0,003. Rerata rasio E!A Talasemia mayor dan kontrol masing-masing 2,14 (SB 0,4) dan 1,83 (SB 0,3); p = 0,002. Massa ventrikel kin Talasemia mayor secara bermakna lebih berat dibanding kontrol. Rerata LVMi (g/m2) Talasemia mayor dan kontrol masing-masing 111,1 (SB 30,8) dan 75,4 (SB 14,5); p < 0,0001. Dengan regresi linier sederhana dan regresi multipel dijumpai hubungan yang cukup kuat dan bermakna antara fungsi diastolik ventrikel kiri (rasio FA) dengan kadar feritin serum (r = 0,71;p < 0,0001).KESIMPULAN: Fungsi sistolik dan fungsi diastolik remaja dan dewasa muda penderita Talasemia mayor telah mulai mengalami perubahan dan abnormalitas. Massa ventrikel kin remaja dan dewasa muda penderita Talasemia mayor lebih berat dari pada orang normal. Semakin tinggi kadar feritin serum semakin besar kemungkinan penderita Talasemia mayor untuk menderita gangguan fungsi diastolik.

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OBJECTIVES: To detect the left ventricular systolic and diastolic functions and mass alteration among adolescents and young adults with Thalassemia major compared to those of normal adolescents and young adults, and to find out the relationship between serum ferritin level and left ventricular functions which are obtained from echocardiography examination.SETTING: Division of Pediatric Cardiology and Hematology Department of Child Health, Medical Faculty, Cipto Mangunkusumo Hospital JakartaSUBJECTS: Adolescents and young adults with Thalassemia major whose got blood transfusion in Thalassemia Center Cipto Mangunkusumo Hospital Jakarta between August to December 2005.METHODS: A cross-sectional study was conducted. The data includes the Thalassemia major patients' hematology data, left ventricular systolic function (EF and FS), and diastolic function (A, E, F/A ratio, IVRT), mass (LVDD1, LVDSi, LVMi) by using an ultrasonography Sonos 4500, transducer 8 MHz. That data were processed with SPSS version 10. The t test, liner regression and multiple regression analysis were performed. Statistical significant was assumed with a 0.05. The minimal number of subjects needed was 28.RESULTS: Out of 32 Thalassemia major patients, 30 were enrolled to study. Left ventricular systolic and diastolic function of Thalassemia major patients were lower than the control and it was statistically significant.[ EF 66.1% (SD 4.9) and 71.6% (SD 5.6); p < 0.0001, FS 36.0% (SD 3.7) and 39.8% (SD 5.5); p = 0.003, E/A 2.14 (SD 0.4) and 1.83 (SD 0.3); p = 0.002], respectively. Left ventricular mass of Thalassemia major patients was greater than control, and it was statistically significant [LVMi (g/m2) 111.1 (SD 30.8) and 75.4 (SD 14.5); p < 0.0001], respectively. Linier and multiple regression analysis showed that there was significant and powerful relation between left ventricular diastolic function (E/A ratio) and serum ferritin ( r = 0.71; p < 0.0001).CONCLUSION: The systolic and diastolic functions of adolescents and young adults with Thlassemia major have started to alter and abnormalities. The left ventricular mass of adolescents and young adults with Thalassemia major more than heavier that of a normal person. The higher the level of serum ferritin is, the more likely it is for Thalassemia major patient to suffer from diastolic abnormalities."

"Latar Belakang. Kondisi hipoksia kronik pada pasien dengan penyakit jantung bawaan sianotik akan menurunkan oksigenasi jaringan sehingga terjadilah mekanisme adaptasi yaitu eritrositosis sekunder. Besi merupakan substrat yang penting dalam produksi hemoglobin dan cadangan besi untuk menjaga kadar hemoglobin yang adekuat. Namun 50% pasien dengan kelainan penyakit jantung bawaan sianotik mengalami defisiensi besi dan kondisi ini dikaitkan dengan gangguan kapasitas fungsional akibat berkurangnya pengiriman oksigen dan efeknya terhadap metabolisme pada otot rangka. Kadar feritin serum merupakan pemeriksaan yang paling awal dan akurat untuk menilai defisiensi besi. Studi ini bertujuan untuk mengetahui hubungan antara kadar feritin serum dengan kapasitas fungsional pada pasien Tetralogi Fallot (TF). Metode. Studi potong lintang dilakukan di Departemen Kardiologi dan Kedokteran Vaskular Fakultas Kedokteran Universitas Indonesia/Rumah Sakit Jantung dan Pembuluh Darah Harapan Kita, Jakarta pada pasien TF usia 4-8 tahun yang belum menjalani operasi paliatif dan atau operasi definitif. Dilakukan pengumpulan karakteristik dasar, kadar feritin serum, ekokardiografi, serta uji jalan 6 menit. Dilakukan uji korelasi dan analisis multivariat menggunakan uji regresi. Hasil. Diteliti sebanyak 20 pasien TF dengan rentang usia 51 hingga 98 bulan. Nilai tengah kadar feritin serum adalah 39.75 g/L (kadar terendah 5g/L, kadar tertinggi 246g/L). Nilai tengah kadar hemoglobin adalah 16.4 g/dL, kadar terendah 12 g/dL dan kadar tertinggi 20 g/dL. Limapuluh persen pasien memiliki kadar feritin serum di bawah normal (< 40 g/L). Pada uji korelasi antara kadar feritin serum dengan jarak uji jalan 6 menit didapatkan nilai r = 0.23 dengan nilai p = 0.34. Pada uji regresi linear pada 2 kelompok, ditemukan perbedaan rerata jarak uji jalan 6 menit pada kelompok dengan kadar feritin lebih tinggi (> 40 g/L, n = 10) sebesar 46,83 m dibandingkan dengan kelompok feritin rendah (< 40 g/L, n = 10) dengan koefisien β = 46,83; IK 95 -47,81- 141,47 p = 0,307. Kesimpulan. Secara klinis terdapat kecenderungan pasien TF dengan kadar feritin serum yang lebih tinggi mampu menempuh jarak uji jalan 6 menit yang lebih jauh walaupun secara satistik tidak bermakna. ......Background. Chronic hypoxia in cyanotic congenital heart disease (CCHD) result in reduced of tissue oxygenation, therefore stimulates adaptive mechanism of secondary erythrocytosis. Iron is a vital substrate for hemoglobin production and sufficient iron stores are necessary to achieve and maintain adequate levels of hemoglobin. Unfortunately, 50% of patients with cyanotic CHD are iron-deficient and this condition is associated with exercise intolerance through reduced oxygen delivery and its effect on skeletal muscle cell metabolism Ferritin serum level is the most accurate test to determine iron deficiency. Aim of this study is to evaluate the association between ferritin serum level and functional capacity in patient with Tetralogy of Fallot (TOF). Methods. A cross-sectional study was done in Department Cardiology and Vascular Medicine, Faculty Medicine Universitas Indonesia / National Cardiovascular Center Harapan Kita, Jakarta in patients with TOF aged 4-8 years old before the palliatif and or definite operation. The data collected from patients including basic characteristic, ferritin serum level and erythocyte index and six minute walk test result. Statistical analysis was done using correlation test and multivariat analysis using regression test. Result. Twenty subjects of TF aged 51 to 98 months was collected. Median level of ferritin serum level was 39.75 g/L (the lowest level 5g/L, the highest level 246g/L). Median level of hemoglobin level was (the lowest level 12 g/dL, the highest level 20 g/dL). Fifty percent of patients had abnormal feritin serum level (< 40 g/dL). There was a correlation coefficient (r) of 0,23 with p value of 0,34 found on the correlation between ferritin serum level and six minute walk test distance. However, on linear regression test between 2 groups of ferritin serum, 46,83 m mean difference of six minute walk test distance found between higher level of ferritin serum group (> 40 g/d, n = 10), and lower level of ferritin serum group (< 40 g/d, n = 10) with β = 46,83; IK 95 -47,81- 141,47 p = 0,307. Conclusion. Clinically in patients with higher level of feritin serum there is a tendency able to walk farther on six minute walk test, although statitically not significant."

"Pendahuluan : Muatan besi berlebih merupakan masalah utama pada pasien thalassemia beta bergantung transfusi karena menyebabkan toksisitas pada jaringan atau organ. Laporan mengenai korelasi antara muatan besi berlebih dengan fungsi endokrin pada pasien dewasa TDT beta yang mengalami retardasi pertumbuhan di Indonesia belum pernah dilaporkan.Tujuan: Mendapatkan profil muatan besi dengan fungsi endokrin pada pasien dewasa TDT beta yang mengalami retardasi pertumbuhan.Metode: Dilakukan studi potong lintang pada pasien thalassemia beta mayor homozigot dan beta HbE usia dewasa yang mendapat transfusi darah di Poliklinik Thalassemia RSCM Jakarta pada Desember 2017. Muatan besi berlebih diwakili oleh feritin serum FS dan saturasi transferin ST, fungsi endokrin yang diperiksa adalah TSHs, fT4, dan IGF-1. FS, fT4 dan TSHs diperiksa dengan metode ELISA. IGF-1 diperiksa berdasarkan metode Solid-Phase ECLIA.Hasil: Proporsi hipotiroid subklinis sebesar 32,7 , kadar IGF-1 rendah pada 79,3 subjek penelitian. Terdapat korelasi negatif lemah FS dengan fT4 r = -0,361; p=0,003 , dan IGF-1 r=-0,313; p=0,008 , tidak terdapat korelasi FS dengan kadar TSHs r=0,074; p=0,29 . Tidak terdapat korelasi ST dengan TSHs r =0,003; p=0,492 , fT4 r=0,018; p=0,448 , dan IGF-1 r=-0,142; p=0,143.Simpulan: Terdapat korelasi negatif antara muatan besi berlebih yang dinilai dari feritin serum dengan fungsi endokrin yang dinilai dengan fT4 dan IGF-1.

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Introduction. Iron overload is a major problem in patients with transfusion dependent beta thalassemia, because it causes toxicity to tissues or organs. The correlation between iron overload and endocrine function in adult TDT beta patients in Indonesia have not been reported.This study aims to obtain a profile of iron load and endocrine function of adult TDT beta patients with growth retardation.Methods Cross sectional study was performed on beta homozygous beta and adult HbE beta patients receiving blood transfusions at the Thalassemia Kiara RSCM Jakarta Clinic, December 2017. Iron overload was represented by serum ferritin FS and transferrin saturation ST, and the endocrine functions are TSHs, fT4 by ELISA method and IGF 1 by the Solid Phase ECLIA method.Results Subclinical hypothyroid proportion was 32,7 and low IGF 1 level was found in 79.3 of subjects. There is a weak negative correlation between FS and fT4 r 0.361 p 0.003, and IGF 1 r 0.313 p 0.008 . No correlation was found between ST with TSHs r 0,003 p 0,492, fT4 r 0,018 p 0,448, and IGF 1 r 0,142 p 0,143.Conclusion There was negative correlation between iron overload based on serum ferritin with endocrine function based on fT4 and IGF 1."