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Abstrak :
S03tu studi cross - sectional terhadap gangguan skizofrenia dengan simptom negatif telah dilakukan di Rumah Sakit Jiwa Jakarta, Indonesia. Telah dilakukan pemeriksaan terhadap 50 pasien yang menderita gangguan skizofrenia dengan simptom negatif, terdiri atas 34 pasien laki - laki dan 16 pasien perempuan, yang meliputi wawancara psikiatri, pengisian kuesioner-kuesioner yang berhubungan dengan fungsi kognitif ( Mini Mental State Examination ), indeks komposit PANSS ( Positive and NegatzJ Symptom Scale) dan derajat disabilitas so sial (Disability Assesment Scale I DAS). Basil pcnclitian mcnWljukkan bahwa tcrdapat korclasi yang bermakna secara statistik antara variabel pcndidikan dan fungsi kognitif dengan derajat disabilitas so sial yang berhubWlgan dengan overall behaviour, social role performance, ward behaviour and nurse's opinion. Dengan uji regresl temyata hanya fungsi kognitif yang merupakan prediktor yang kuat. Hubungan antara fungsi kognitif dengan DAS dalam hal overall behaviour ( p = 0,00081 ), social role performance ( p = 0,01012), ward behaviour ( p = 0,00004 ), dan nurse's opinion (p = 0,02895).

Abstrak :
Menelan merupakan mekanisme neurologis dan perilaku kompleks dikontrol oleh otak. Kemampuan menelan memerlukan fungsi kognitif yaitu atensi, memori dan fungsi eksekusi. Disfagia pada stroke disebabkan oleh hilangnya jaringan konektivitas menelan karena berkurangnya aktivasi regio yang terkena dan hemisfer kontralateral. Pada stroke iskemik, lesi otak yang terkena dapat mempengaruhi menelan dan fungsi kognitif. Penurunan fungsi kognitif dapat mempengaruhi fungsi menelan dengan berkurangnya fungsi lipseal, pergerakan otot-otot lidah yang mengakibatkan adnya residu sehingga menjadi disfagia oral. Penelitian ini merupakan studi cross-sectional pada 72 subjek stroke subakut-kronik stroke iskemik. Subjek dengan nilai MoCA <26 akan dilakukan pemeriksaan disfagia dengan FEES (Flexible Endoscopic Evaluation of Swallowing). Hasil penelitian didapatkan 38 subjek dengan disfagia dan 34 orang dengan non-disfagia, dengan rata-rata nilai MoCA INA 23. Domain yang paling terganggu adalah visuospasial/fungsi eksekutif, memori dan atensi. Kesimpulan penelitian ini adalah tidak didapatkan hasil yang signifikan hubungan fungsi kognitif terhadap kejadian disfagia. ......Swallowing is a complex neurological and behavioral mechanism controlled by the brain. Swallowing ability requires cognitive function consists attention, memory and execution function. Dysphagia in stroke is caused by loss of swallowing tissue connectivity due to decreased activation of the affected and contralateral hemispheres. In ischemic stroke, the affected brain lesion can simultaneously affect swallowing and cognitive function. Decreased cognitive function can affect swallowing function which decreased lipseal function, impaired movement of the tongue muscles affected residues in the mouth and result in oral phase dysphagia. The research method used was a cross-sectional on 72 subacute-chronic ischemic stroke subjects. Subjects with MoCA INA results <26 will be assessed for their dysphagia using FEES (Flexible Endoscopic Evaluation of Swallowing). Of the 72 subjects with MoCA INA score <26, 38 subjects had dysphagia and 34 Non-dysphagia. The mean value of the MoCA INA was 23. The most impaired of cognitive domains was visuospatial/executive function, memory and attention. There is no significant relationship between cognitive function and the incidence of dysphagia.

Abstrak :
Fungsi kognitif pada usia lanjut akan menurun sejalan dengan proses penuaan yang terjadi secara alami. Senam lansia merupakan salah satu cara untuk mencegah penurunan fungsi kognitif pada lansia. Penelitian ini bertujuan mengetahui hubungan antara keaktifan mengikuti senam lansia dengan tingkat fungsi kognitif. Desain penelitian ini adalah analitik korelatif dengan pendekatan cross sectional, menggunakan 85 responden lansia di kelurahan Depok Jaya, dipilih menggunakan teknik cluster sampling pada setiap posbindu. Keaktifan mengikuti senam lansia diukur menggunakan kuesioner untuk menilai keaktifan mengikuti senam selama tiga bulan dan tingkat fungsi kognitif diukur dengan Mini-Mental State Examination MMSE . Uji analisis bivariat menggunakan uji chi square, hasil uji statistik menyatakan terdapat hubungan yang signifikan antara keaktifan mengikuti senam lansia dengan tingkat fungsi kognitif. ...... Cognitive function in the elderly will decrease along with the natural aging process. Physical exercise such as elderly gymnastic is one way to prevent cognitive decline in elderly. This study aimed to determine the relationships between elderly gymnastics liveliness and cognitive function level. The design of this research was correlative analytic with cross sectional approach, with 85 elderly as respondents in Depok Jaya village, selected using cluster sampling technique at each senior center. The liveness of elderly gymnastics was measured by using questionnaire that assessed the level of gymnastics liveness during three months and cognitive function measured by Mini Mental State Examination MMSE . The bivariate analysis test using chi square test, disclosed that there was significant correlation between the liveness of elderly gymnastics with cognitive function level.

Abstrak :
Berbagai penelitian telah menunjukkan berbagai jenis latihan memiliki dampak positif terhadap fungsi kognitif pada lansia. Studi literatur ini bertujuan untuk merangkum berbagai jenis latihan yang meningkatkan fungsi kognitif bagi lanjut usia dan mengusulkan program pelatihan yang efektif dalam desain eksperimental yang sesuai. Metode yang diterapkan yaitu pencarian literatur dari database Scopus, Science Direct, Proquest, dan CINAHL. Hasil pencarian dan penyeleksian diperoleh 10 artikel penelitian yang sesuai dengan kriteria. Berdasarkan analisis, latihan peningkatan fungsi kognitif pada lansia memberikan manfaat terhadap fungsi kognitif secara umum maupun spesifik pada aspek kognitif tertentu. Studi literatur ini menyarankan tenaga kesehatan khususnya perawat di tatanan komunitas ataupun panti werdha sebaiknya membuat program bagi lanjut usia yang mengalami gangguan fungsi kognitif dengan menerapkan jenis latihan fisik untuk memberikan manfaat yang lebih besar.

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Numerous studies have shown various types of exercise have a positive effect on cognitive function in older adults. This review aims to summarise various types of exercises that improve cognitive function for older adults and propose an effective exercise program within the appropriate experimental design. The method uses a literature search from Scopus, Science Direct, Proquest, and CINAHL databases. The results of the search and selection obtained ten research articles in accordance with the criteria. Based on the analysis, exercise in improving cognitive function in older adults provides benefits to cognitive function in general or specifically on certain cognitive aspects. This review suggests health providers, especially nurses in the community setting or nursing home care, should make a program for older adults who experience cognitive decline by applying physical exercise type to provide greater benefits.

Abstrak :
ABSTRAK
Penurunan fungsi kognitif merupakan keadaan normal yang dialami oleh lansia. Keadaan ini dapat dikurangi atau dihambat dengan cara meningkatkan aktivitas fisik. Tujuan penelitian ini adalah untuk mengetahui hubungan antara tingkat aktivitas fisik dengan fungsi kognitif lansia. Desain penelitian ini adalah cross sectional dengan metode cluster sampling dengan jumlah sampel sebanyak 104 responden lansia. Sampel penelitian ini rata-rata didominasi lansia perempuan yang berusia 60-74 tahun, tidak lulus SD/tidak sekolah, masih berstatus menikah, dan memiliki penyakit kronis. Hasil penelitian menunjukkan ada hubungan antara tingkat aktivitas fisik dengan fungsi kognitif lansia (p=0,000; ɑ=0,05). Perawat diharapkan dapat mencegah penurunan fungsi kognitif dengan cara meningkatkan aktivitas fisik lansia berupa latihan fisik. Selain itu, penelitian selanjutnya diharapkan dapat melakukan studi mengenai intensitas, durasi, frekuensi, dan jenis latihan fisik yang paling baik untuk meningkatkan fungsi kognitif pada lansia.

Abstrak :
[ABSTRAK
Latar Belakang. Gangguan fungsi kognitif dapat terjadi pada pekerja yang terpajan toluen. Gangguan fungsi kognitif tersebut terutama adalah penurunan memori, atensi dan konsentrasi, yang dapat menurunkan produktifitas kerja. Penelitian ini bertujuan mengetahui prevalensi gangguan fungsi kognitif dan faktor-faktor yang mempengaruhi Metode Penelitian. Desain potong lintang dilakukan pada 102 orang pekerja perempuan usia 19-40 tahun dan pendidikan minimal SMA. Data dikumpulkan dengan kuesioner, pemeriksaan fisik dan laboratorium serta MMSE. Kriteria inklusi adalah masa kerja ≥ 1 tahun dan bersedia menjadi responden dengan menandatangani informed consent. Kriteria eksklusi adalah hamil, menstruasi,merokok, minum alkohol, riwayat cedera kepala, hipertensi, gula darah dan dislipidemia. Faktor risiko yang diteliti antara lain umur, status perkawinan, masa kerja, lama kerja, kepatuhan pakai masker , stres kerja dan status gizi. Umur, status perkawinan,masa kerja dan lama kerja diambil dari data HRD. Status gizi didapatkan dari perhitungan Indeks Massa Tubuh. Kepatuhan pakai masker berdasarkan pengawasan kepatuhan APD. Stres kerja dinilai menggunakan kuesioner Survey Diagnostik Stress . Hasil. Walaupun kadar toluen didapat lebih kecil dari nilai ambang batas toluen , didapatkan prevalensi gangguan fungsi kognitif sebesar 52 %. Area kognitif yang menurun adalah atensi kalkulasi dan visuospasial. Faktor risiko yang secara bermakna mempengaruhi gangguan fungsi kognitif adalah masa kerja, lama kerja, kepatuhan pemakaian masker, stres kerja yang meliputi konflik peran, ketaksaan peran, beban kerja kualitatif, beban kerja kuantitatif, pengembangan karir dan tanggung jawab rekan kerja. Hasil analisis multivariat menunjukkan konflik peran merupakan faktor risiko yang paling mempengaruhi gangguan fungsi kognitif ( OR 7,546 Interval kepercayaan 95% 1,5 ? 41,88 ) Kesimpulan. Prevalensi penurunan fungsi kognitif studi ini lebih besar dari penelitian sebelumnya dan teori. Aspek kognitif yang menurun didominasi oleh atensi kalkulasi dan visuospasial. Konflik peran merupakan faktor risiko yang paling mempengaruhi gangguan fungsi kognitif.

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ABSTRACT
Background. Cognitive Function Impairment can happen among workers expose by Toluene. This impairment mainly effect in attention, concentration and memory function, and can decrease working productivity. This study aims to calculate the prevalence of Cognitive Function impairment and related risk factors Method. Cross sectional design study was conducted on 102 female workers, age 19-40 years old and graduated from senior high school. Age and education were obtained from secondary data, and followed by interviews, physical and laboratory examination and Mini Mental States Examination. The inclusion criteria were age ≥ 1 year of work and willing to be the subject of research. Exclusion criteria were pregnancy, menstruation, smoker, Alcohol consumption, history of head injury, hypertension, diabetes mellitus and Dyslipidemia. Risk factor included in this study were age, marital status, duration of work,time of work, PPE obedience ,work stress and nutritional status. Age, Marital status, Duration and Time of work were from secondary data of HRD department. Nutritional status was obtained from body mass index calculation. face mask obedience was obtained from data of wearing mask compliance. Work stress was assessed using Survey Diagnostic Stress Questionnaire. Results. The prevalence of Cognitive Function Impairment was 52 % , mainly at Attention ? Calculation and Visuospasial Aspect respectively. Significant risk factors ( p value < 0,05 ) in this study were duration of work and time of work, PPE obedience and all of work stress domain. The Result of multivariate analysis show that conflict of role was the most influence factor ( OR 7,546 C.I 95% 1,5 ? 41,88 ) Conclusion. This study found that the prevalence of cognitive function impairment was higher than theory and other similar studies . Cognitive aspects mainly affected were attention ? calculation and visuospatial. Conflict of role was the most inluence risk factor relating with cognitive function impairment;Background. Cognitive Function Impairment can happen among workers expose by Toluene. This impairment mainly effect in attention, concentration and memory function, and can decrease working productivity. This study aims to calculate the prevalence of Cognitive Function impairment and related risk factors Method. Cross sectional design study was conducted on 102 female workers, age 19-40 years old and graduated from senior high school. Age and education were obtained from secondary data, and followed by interviews, physical and laboratory examination and Mini Mental States Examination. The inclusion criteria were age ≥ 1 year of work and willing to be the subject of research. Exclusion criteria were pregnancy, menstruation, smoker, Alcohol consumption, history of head injury, hypertension, diabetes mellitus and Dyslipidemia. Risk factor included in this study were age, marital status, duration of work,time of work, PPE obedience ,work stress and nutritional status. Age, Marital status, Duration and Time of work were from secondary data of HRD department. Nutritional status was obtained from body mass index calculation. face mask obedience was obtained from data of wearing mask compliance. Work stress was assessed using Survey Diagnostic Stress Questionnaire. Results. The prevalence of Cognitive Function Impairment was 52 % , mainly at Attention – Calculation and Visuospasial Aspect respectively. Significant risk factors ( p value < 0,05 ) in this study were duration of work and time of work, PPE obedience and all of work stress domain. The Result of multivariate analysis show that conflict of role was the most influence factor ( OR 7,546 C.I 95% 1,5 – 41,88 ) Conclusion. This study found that the prevalence of cognitive function impairment was higher than theory and other similar studies . Cognitive aspects mainly affected were attention – calculation and visuospatial. Conflict of role was the most inluence risk factor relating with cognitive function impairment, Background. Cognitive Function Impairment can happen among workers expose by Toluene. This impairment mainly effect in attention, concentration and memory function, and can decrease working productivity. This study aims to calculate the prevalence of Cognitive Function impairment and related risk factors Method. Cross sectional design study was conducted on 102 female workers, age 19-40 years old and graduated from senior high school. Age and education were obtained from secondary data, and followed by interviews, physical and laboratory examination and Mini Mental States Examination. The inclusion criteria were age ≥ 1 year of work and willing to be the subject of research. Exclusion criteria were pregnancy, menstruation, smoker, Alcohol consumption, history of head injury, hypertension, diabetes mellitus and Dyslipidemia. Risk factor included in this study were age, marital status, duration of work,time of work, PPE obedience ,work stress and nutritional status. Age, Marital status, Duration and Time of work were from secondary data of HRD department. Nutritional status was obtained from body mass index calculation. face mask obedience was obtained from data of wearing mask compliance. Work stress was assessed using Survey Diagnostic Stress Questionnaire. Results. The prevalence of Cognitive Function Impairment was 52 % , mainly at Attention – Calculation and Visuospasial Aspect respectively. Significant risk factors ( p value < 0,05 ) in this study were duration of work and time of work, PPE obedience and all of work stress domain. The Result of multivariate analysis show that conflict of role was the most influence factor ( OR 7,546 C.I 95% 1,5 – 41,88 ) Conclusion. This study found that the prevalence of cognitive function impairment was higher than theory and other similar studies . Cognitive aspects mainly affected were attention – calculation and visuospatial. Conflict of role was the most inluence risk factor relating with cognitive function impairment]

Abstrak :
[ABSTRAK
Peningkatan stres oksidatif selama penuaan, dianggap sebagai kontributor utama pada proses neuro-degenerasi dan kehilangan neuron, dan merupakan faktor utama dalam patologi penyakit Alzheimer dan penurunan kognitif terkait usia. Vitamin E merupakan antioksidan potensial yang menjadi fokus utama penelitian gangguan fungsi kognitif dan penyakit Alzheimer. Penelitian potong lintang pada populasi lansia sehat di Kelurahan Cikoko ini dilakukan pada bulan Desember 2014 untuk menilai hubungan antara kadar vitamin E serum dengan fungsi kognitif. Selain itu juga menilai asupan vitamin C dan E dengan metode FFQ. Penilaian fungsi kognitif dengan instrumen MoCA-Ina. Pemeriksaan laboratorium untuk mengetahui kadar vitamin E menggunakan metode HPLC. Data dianalisis dengan uji Mann-Whitney dan Chi-square. Sebagian besar subyek (75,9%) adalah perempuan dengan usia rata-rata 65 tahun. Sementara, kadar rata-rata vitamin E adekuat, yaitu 21,6 μmol/L. Hasil penelitian ini menunjukkan bahwa tidak ada hubungan signifikan antara kadar vitamin E serum dengan fungsi kognitif yang dinilai dengan skor MoCA-Ina. Meskipun berat badan normal hingga obes I menunjukkan hubungan signifikan dengan skor kognitif (r = 0,17 p = 0,026), tetapi tidak ada hubungan signifikan antara asupan vitamin C dengan fungsi kognitif (r = 0,19 p = 0,15) atau antara asupan vitamin E dengan fungsi kognitif (r = 0,04, p = 0.72) pada penelitian ini. Kesimpulan, tidak terdapat hubungan antara kadar vitamin E serum dengan fungsi kognitif.

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ABSTRACT
Oxidative stress increases during ageing, is considered as a major contributor to neuro-degeneration and neuronal loss, and is a primary factor in the pathology of both Alzheimer’s disease and age-related cognitive decline. Vitamin E has been the main focus of investigation in studies of cognitive impairment and alzheimer’s disease during aging as a potent antioxidant. A cross-sectional study of an elderly population in Cikoko Regency in December 2014 was conducted to evaluate the association between serum vitamin E levels and cognitive function in elderly. Correlation between intakes of vitamin C and E as well as Body Mass Index to the MoCA-Ina scores were also investigated. Fifty four elderly were included in the study and interviewed for their vitamins intake using a Food Frequency Questionnaires (FFQ). Cognitive function was examined by Montreal Cognitive Assessment Indonesian version (MoCA-Ina). Levels of vitamin E serum were assessed by high performance liquid chromatography. Data were analyzed by using the Mann-Whitney and Chi-square test. The majority of the subjects were female (75.9%) with median age 65 years old. While, the median levels of vitamin E was 21.55 μmol/L. The result of this study showed that there was no association between vitamin E level and MoCA-Ina scores. Although normal weight to obese I was significantly associated with cognitive scores (r = 0,17 p = 0.026), no significant correlation between vitamin C intake and cognitive function scores (r = 0.19 p = 0.15) or between vitamin E intake and MoCA-Ina scores were found in this study (r = 0.04, p = 0.72). In conclusion, there is no association between vitamin E serum and cognitive function.;Oxidative stress increases during ageing, is considered as a major contributor to neuro-degeneration and neuronal loss, and is a primary factor in the pathology of both Alzheimer’s disease and age-related cognitive decline. Vitamin E has been the main focus of investigation in studies of cognitive impairment and alzheimer’s disease during aging as a potent antioxidant. A cross-sectional study of an elderly population in Cikoko Regency in December 2014 was conducted to evaluate the association between serum vitamin E levels and cognitive function in elderly. Correlation between intakes of vitamin C and E as well as Body Mass Index to the MoCA-Ina scores were also investigated. Fifty four elderly were included in the study and interviewed for their vitamins intake using a Food Frequency Questionnaires (FFQ). Cognitive function was examined by Montreal Cognitive Assessment Indonesian version (MoCA-Ina). Levels of vitamin E serum were assessed by high performance liquid chromatography. Data were analyzed by using the Mann-Whitney and Chi-square test. The majority of the subjects were female (75.9%) with median age 65 years old. While, the median levels of vitamin E was 21.55 μmol/L. The result of this study showed that there was no association between vitamin E level and MoCA-Ina scores. Although normal weight to obese I was significantly associated with cognitive scores (r = 0,17 p = 0.026), no significant correlation between vitamin C intake and cognitive function scores (r = 0.19 p = 0.15) or between vitamin E intake and MoCA-Ina scores were found in this study (r = 0.04, p = 0.72). In conclusion, there is no association between vitamin E serum and cognitive function., Oxidative stress increases during ageing, is considered as a major contributor to neuro-degeneration and neuronal loss, and is a primary factor in the pathology of both Alzheimer’s disease and age-related cognitive decline. Vitamin E has been the main focus of investigation in studies of cognitive impairment and alzheimer’s disease during aging as a potent antioxidant. A cross-sectional study of an elderly population in Cikoko Regency in December 2014 was conducted to evaluate the association between serum vitamin E levels and cognitive function in elderly. Correlation between intakes of vitamin C and E as well as Body Mass Index to the MoCA-Ina scores were also investigated. Fifty four elderly were included in the study and interviewed for their vitamins intake using a Food Frequency Questionnaires (FFQ). Cognitive function was examined by Montreal Cognitive Assessment Indonesian version (MoCA-Ina). Levels of vitamin E serum were assessed by high performance liquid chromatography. Data were analyzed by using the Mann-Whitney and Chi-square test. The majority of the subjects were female (75.9%) with median age 65 years old. While, the median levels of vitamin E was 21.55 μmol/L. The result of this study showed that there was no association between vitamin E level and MoCA-Ina scores. Although normal weight to obese I was significantly associated with cognitive scores (r = 0,17 p = 0.026), no significant correlation between vitamin C intake and cognitive function scores (r = 0.19 p = 0.15) or between vitamin E intake and MoCA-Ina scores were found in this study (r = 0.04, p = 0.72). In conclusion, there is no association between vitamin E serum and cognitive function.]

Abstrak :
KORELASI ANTARA KADAR VITAMIN D DENGAN FUNGSI KOGNITIF PADA SISWA SMA DI DEPOK, JAWA BARATThia Juniaty Manik1, Novi Silvia Hardiany2, Erfi Prafiantini1 1. Departemen Ilmu Gizi, Rumah Sakit Umum Pusat Nasional dr. Cipto Mangunkusumo, Fakultas Kedokteran Universitas Indonesia2. Departemen Biokimia dan Biologi Molekuler, Fakuktas Kedokteran Universitas IndonesiaE-mail :tjmanik@gmail.com AbstrakKeberhasilan dalam pendidikan tidak hanya ditentukan oleh sistem pendidikan, tetapi juga kemampuan kognitif para siswa. Siswa dengan kemampuan kognitif tinggi akan dapat menyerap pelajaran dengan baik. Nutrisi yang dikonsumsi merupakan faktor penting yang berkontribusi pada pengembangan daya kognitif. Penelitian-penelitian sebelumnya telah menghubungkan mikronutrien vitamin D dengan berbagai hasil yang berkaitan dengan kesehatan. Namun, hanya sedikit yang meneliti hubungan vitamin D dengan fungsi kognitif dan hasilnya masih belum konklusif terutama pada remaja. Penelitian ini mengeksplorasi hubungan vitamin D dengan fungsi kognitif pada siswa sekolah menengah atas di Kota Depok. Sebanyak 64 siswa dari 4 SMA di Kota Depok, menjalani tes fungsi kognitif. Hasil utama yang dinilai adalah tes kognisi untuk fleksibilitas kognitif BCST test , planning tower test , dan working memory digit span backward test . Hasil sekunder adalah status sosial ekonomi, asupan vitamin D, skor paparan sinar matahari, kadar haemoglobin, skor family assessment device, skor strenght and difficulties dan aktivitas fisik siswa. Tiga jenis tes yang digunakan adalah : BCST test, Tower Hanoi test, dan Digit backward test. Dari 64 subyek yang ikut penelitian ini 62,5 mengalami kekurangan vitamin D

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Success in education is not only determined by the education system, but also the cognitive power of the students. The students with high cognitive abilities will be able to absorb the lessons well. Nutrition consumed is one of the important factors that contributes to cognitive power development. Previous studies have linked micronutrient vitamin D to various health related outcomes. However, only few examined the correlation of vitamin D to cognitive function, and the result is still inconclusive especially in adolescent. This study explores the correlation of vitamin D to cognitive function in high school students. A samples of 64 adolescents from 4 high schools in Depok City, underwent cognitive function tests. The main outcomes assessed were cognitive flexibility, planning, and working memory test. The secondary outcomes were social economic status, dietary intake of vitamin D, sun light exposure score, haemoglobin level, family assessment device, strenght and difficulties score and physical activity. Sixty four participants 62,5 were vitamin D deficiencies

Abstrak :
Latar Belakang: Organofosfat (OP) merupakan pestisida yang paling banyak digunakan di dunia. Sebagai substansi kimia, zat ini memiliki efek toksik bagi manusia yang terpapar. Salah satu dampak OP adalah penurunan fungsi kognitif. Berdasarkan penelitian Bosma, et al, prevalensi gangguan kognitif ringan pada pekerja yang terpapar pestisida adalah 35%. Di Indonesia, penelitian dari Dewi RM menunjukkan bahwa 39,1% petani jeruk yang terpapar pestisida mengalami gangguan kognitif ringan. Sampai saat ini belum ada penelitian di Indonesia yang mengukur efek samping pestisida pada petani bunga. Padahal, penggunaan pestisida pada tanaman bunga diperkirakan lebih besar dibandingkan komoditas lain, sehingga risiko dan dampak paparan pada petani pun menjadi lebih besar. Tujuan penelitian ini adalah untuk mengetahui hubungan asetilkolinesterase (AChE) dalam sel darah merah terhadap fungsi kognitif pada petani bunga laki-laki penyemprot pestisida. Metode: Desain potong lintang dengan besar sampel 40 orang. Penelitian dilakukan di Kecamatan Parongpong, Kabupaten Bandung Barat. Pengambilan sampel menggunakan consecutive sampling dengan instrumen wawancara, MMSE, dan pemeriksaan AChE eritrosit. Hasil: Aktivitas AChE dalam sel darah merah memiliki median 4599.06 (1760-6828). Prevalensi penurunan fungsi kognitif pada petani bunga laki-laki penyemprot pestisida mencapai 75%. Tidak terdapat hubungan antara AChE sel darah merah terhadap fungsi kognitif (p=0,87). Namun, terdapat hubungan yang bermakna antara variabel masa kerja (p=0,007), tingkat pendidikan (p=0,001), komposisi pestisida (p=0,014), dan exposure rate (p<0,001) terhadap fungsi kognitif. Tidak ada perbedaan bermakna antara perbandingan rerata AChE pada kelompok yang mengalami penurunan fungsi kognitif dan kelompok yang normal (OR=1 dengan 95% CI 0,2-4,1). Kesimpulan Saran: Prevalensi penurunan fungsi kognitif pada petani bunga laki-laki yang terpajan pestisida OP cukup tinggi (75%). Penelitian ini menunjukkan ada hubungan yang bermakna antara fungsi kognitif responden dengan faktor risiko okupasi, terutama dalam hal masa kerja. Untuk mencegah terjadinya dampak penggunaan pestisida yang lebih berat, perlu adanya program pengendalian bagi petani pengguna pestisida serta pengawasan pada produsen pestisida. ......Background: Organophosphate (OP) is the most widely used pesticide in the world. As a chemical substance, this substance has toxic effects for humans who are exposed. One of the effects of OP is a decline in cognitive function. Based on the research of Bosma, et al, the prevalence of mild cognitive impairment in workers exposed to pesticides is 35%. In Indonesia, research from Dewi RM shows that 39.1% of citrus farmers exposed to pesticides experience mild cognitive impairment. Until now there has been no research in Indonesia that measures the side effects of pesticides on cut-flower farmers. In fact, the use of pesticides in flower plants is estimated to be greater than other commodities, so that the risk and impact of exposure on farmers becomes even greater. The purpose of this study was to determine the relationship of acetylcholinesterase (AChE) in red blood cells to cognitive function in male cut-flower farmers spraying pesticides. Method: Cross-sectional design with a sample size of 40 people. The study was conducted in Parongpong District, West Bandung Regency. Sampling using consecutive sampling with interview instruments, MMSE, and erythrocyte AChE examination. Results. AChE activity in red blood cells has a median of 4599.06 (1760-6828). The prevalence of cognitive decline in male cut-flower farmers spraying pesticides reaches 75%. There was no relationship between red blood cell AChE and cognitive function (p = 0.87). However, there was a significant relationship between variables of years of work (p = 0.007), level of education (p = 0.001), pesticide composition (p = 0.014), and exposure rate (p <0.001) on cognitive function. There was no significant difference between the average comparison of AChE in the group that experienced a decline in cognitive function and the normal group (OR = 1 with 95% CI 0.2-4.1). Conclusion and Suggestions: The prevalence of cognitive impairment in male cut-flower farmers exposed to OP pesticides is quite high (75%). This study shows that there is a significant relationship between the cognitive function of the respondents with occupational risk factors, especially in terms of years of work. To prevent the impact of the use of pesticides, it is necessary to have a control program for farmers using pesticides and supervision of pesticide producers.