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"S03tu studi cross - sectional terhadap gangguan skizofrenia dengan simptom negatif telah dilakukan di Rumah Sakit Jiwa Jakarta, Indonesia. Telah dilakukan pemeriksaan terhadap 50 pasien yang menderita gangguan skizofrenia dengan simptom negatif, terdiri atas 34 pasien laki - laki dan 16 pasien perempuan, yang meliputi wawancara psikiatri, pengisian kuesioner-kuesioner yang berhubungan dengan fungsi kognitif ( Mini Mental State Examination ), indeks komposit PANSS ( Positive and NegatzJ Symptom Scale) dan derajat disabilitas so sial (Disability Assesment Scale I DAS). Basil pcnclitian mcnWljukkan bahwa tcrdapat korclasi yang bermakna secara statistik antara variabel pcndidikan dan fungsi kognitif dengan derajat disabilitas so sial yang berhubWlgan dengan overall behaviour, social role performance, ward behaviour and nurse's opinion. Dengan uji regresl temyata hanya fungsi kognitif yang merupakan prediktor yang kuat. Hubungan antara fungsi kognitif dengan DAS dalam hal overall behaviour ( p = 0,00081 ), social role performance ( p = 0,01012), ward behaviour ( p = 0,00004 ), dan nurse's opinion (p = 0,02895)."

"Menelan merupakan mekanisme neurologis dan perilaku kompleks dikontrol oleh otak. Kemampuan menelan memerlukan fungsi kognitif yaitu atensi, memori dan fungsi eksekusi. Disfagia pada stroke disebabkan oleh hilangnya jaringan konektivitas menelan karena berkurangnya aktivasi regio yang terkena dan hemisfer kontralateral. Pada stroke iskemik, lesi otak yang terkena dapat mempengaruhi menelan dan fungsi kognitif. Penurunan fungsi kognitif dapat mempengaruhi fungsi menelan dengan berkurangnya fungsi lipseal, pergerakan otot-otot lidah yang mengakibatkan adnya residu sehingga menjadi disfagia oral. Penelitian ini merupakan studi cross-sectional pada 72 subjek stroke subakut-kronik stroke iskemik. Subjek dengan nilai MoCA <26 akan dilakukan pemeriksaan disfagia dengan FEES (Flexible Endoscopic Evaluation of Swallowing). Hasil penelitian didapatkan 38 subjek dengan disfagia dan 34 orang dengan non-disfagia, dengan rata-rata nilai MoCA INA 23. Domain yang paling terganggu adalah visuospasial/fungsi eksekutif, memori dan atensi. Kesimpulan penelitian ini adalah tidak didapatkan hasil yang signifikan hubungan fungsi kognitif terhadap kejadian disfagia.

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Swallowing is a complex neurological and behavioral mechanism controlled by the brain. Swallowing ability requires cognitive function consists attention, memory and execution function. Dysphagia in stroke is caused by loss of swallowing tissue connectivity due to decreased activation of the affected and contralateral hemispheres. In ischemic stroke, the affected brain lesion can simultaneously affect swallowing and cognitive function. Decreased cognitive function can affect swallowing function which decreased lipseal function, impaired movement of the tongue muscles affected residues in the mouth and result in oral phase dysphagia. The research method used was a cross-sectional on 72 subacute-chronic ischemic stroke subjects. Subjects with MoCA INA results <26 will be assessed for their dysphagia using FEES (Flexible Endoscopic Evaluation of Swallowing). Of the 72 subjects with MoCA INA score <26, 38 subjects had dysphagia and 34 Non-dysphagia. The mean value of the MoCA INA was 23. The most impaired of cognitive domains was visuospatial/executive function, memory and attention. There is no significant relationship between cognitive function and the incidence of dysphagia.

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"ABSTRAKPenurunan fungsi kognitif merupakan keadaan normal yang dialami oleh lansia. Keadaan ini dapat dikurangi atau dihambat dengan cara meningkatkan aktivitas fisik. Tujuan penelitian ini adalah untuk mengetahui hubungan antara tingkat aktivitas fisik dengan fungsi kognitif lansia. Desain penelitian ini adalah cross sectional dengan metode cluster sampling dengan jumlah sampel sebanyak 104 responden lansia. Sampel penelitian ini rata-rata didominasi lansia perempuan yang berusia 60-74 tahun, tidak lulus SD/tidak sekolah, masih berstatus menikah, dan memiliki penyakit kronis. Hasil penelitian menunjukkan ada hubungan antara tingkat aktivitas fisik dengan fungsi kognitif lansia (p=0,000; ɑ=0,05). Perawat diharapkan dapat mencegah penurunan fungsi kognitif dengan cara meningkatkan aktivitas fisik lansia berupa latihan fisik. Selain itu, penelitian selanjutnya diharapkan dapat melakukan studi mengenai intensitas, durasi, frekuensi, dan jenis latihan fisik yang paling baik untuk meningkatkan fungsi kognitif pada lansia."

"Fungsi kognitif pada usia lanjut akan menurun sejalan dengan proses penuaan yang terjadi secara alami. Senam lansia merupakan salah satu cara untuk mencegah penurunan fungsi kognitif pada lansia. Penelitian ini bertujuan mengetahui hubungan antara keaktifan mengikuti senam lansia dengan tingkat fungsi kognitif. Desain penelitian ini adalah analitik korelatif dengan pendekatan cross sectional, menggunakan 85 responden lansia di kelurahan Depok Jaya, dipilih menggunakan teknik cluster sampling pada setiap posbindu. Keaktifan mengikuti senam lansia diukur menggunakan kuesioner untuk menilai keaktifan mengikuti senam selama tiga bulan dan tingkat fungsi kognitif diukur dengan Mini-Mental State Examination MMSE . Uji analisis bivariat menggunakan uji chi square, hasil uji statistik menyatakan terdapat hubungan yang signifikan antara keaktifan mengikuti senam lansia dengan tingkat fungsi kognitif.

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Cognitive function in the elderly will decrease along with the natural aging process. Physical exercise such as elderly gymnastic is one way to prevent cognitive decline in elderly. This study aimed to determine the relationships between elderly gymnastics liveliness and cognitive function level. The design of this research was correlative analytic with cross sectional approach, with 85 elderly as respondents in Depok Jaya village, selected using cluster sampling technique at each senior center. The liveness of elderly gymnastics was measured by using questionnaire that assessed the level of gymnastics liveness during three months and cognitive function measured by Mini Mental State Examination MMSE . The bivariate analysis test using chi square test, disclosed that there was significant correlation between the liveness of elderly gymnastics with cognitive function level."

"Berbagai penelitian telah menunjukkan berbagai jenis latihan memiliki dampak positif terhadap fungsi kognitif pada lansia. Studi literatur ini bertujuan untuk merangkum berbagai jenis latihan yang meningkatkan fungsi kognitif bagi lanjut usia dan mengusulkan program pelatihan yang efektif dalam desain eksperimental yang sesuai. Metode yang diterapkan yaitu pencarian literatur dari database Scopus, Science Direct, Proquest, dan CINAHL. Hasil pencarian dan penyeleksian diperoleh 10 artikel penelitian yang sesuai dengan kriteria. Berdasarkan analisis, latihan peningkatan fungsi kognitif pada lansia memberikan manfaat terhadap fungsi kognitif secara umum maupun spesifik pada aspek kognitif tertentu. Studi literatur ini menyarankan tenaga kesehatan khususnya perawat di tatanan komunitas ataupun panti werdha sebaiknya membuat program bagi lanjut usia yang mengalami gangguan fungsi kognitif dengan menerapkan jenis latihan fisik untuk memberikan manfaat yang lebih besar.

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Numerous studies have shown various types of exercise have a positive effect on cognitive function in older adults. This review aims to summarise various types of exercises that improve cognitive function for older adults and propose an effective exercise program within the appropriate experimental design. The method uses a literature search from Scopus, Science Direct, Proquest, and CINAHL databases. The results of the search and selection obtained ten research articles in accordance with the criteria. Based on the analysis, exercise in improving cognitive function in older adults provides benefits to cognitive function in general or specifically on certain cognitive aspects. This review suggests health providers, especially nurses in the community setting or nursing home care, should make a program for older adults who experience cognitive decline by applying physical exercise type to provide greater benefits."

"Peningkatan harapan hidup manusia akan menambah populasi lanjut usia diikuti dengan peningkatan problem, antara lain penurunan fungsi kognitif. Salah satu faktor risiko penurunan fungsi kognitif ialah social engagement yang dipengaruhi oleh lingkungan tempat tinggal. Penelitian dilakukan menggunakan metode cross sectional di kelurahan Jelambar dan Jelambar Baru, Jakarta atas 286 lanjut usia yang tinggal di keluarga dan di panti werdha menunjukkan adanya pengaruh social engagement terhadap fungsi kognitif lanjut usia, terutama di kalangan panti werdha. Social engagement buruk berhubungan dengan gangguan fungsi kognitif setelah dikendalikan oleh aktivitas kognitif, khususnya pada kelompok social engagement buruk dan tinggal di panti; di kelompok lanjut usia perempuan, social engagement buruk berhubungan dengan fungsi kognitif lebih rendah. Komponen social engagement yang paling berperan terhadap fungsi kognitif para lanjut usia adalah aktivitas di masyarakat dan keanggotaan di kelompok masyarakat lain. Kegiatan ke luar rumah dan berbelanja, dan kerja sukarela/amal merupakan komponen aktivitas di masyarakat yang paling berpengaruh. Di kalangan perempuan, komponen social engagement yang paling berpengaruh adalah keanggotaan di kelompok lain. Aktivitas kognitif yang terbesar pengaruhnya adalah masak sendiri dan menonton siaran televisi berita.

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The increase of life expectancy brings a problem of elderly, among others is problem of cogntive decline. One of the risk factors for cognitive decline is social engagement which can be influenced by living environment. This research was done with cross sectional method in kelurahan Jelambar and Jelambar Baru with 286 respondents living in family and institution. Social disengagement was associated with lower cognitive function, especially in institution, influenced by cognitive activity. Among women, social disengagement was associated with lower cognitive function. The most important component of social engagement are to become a member of social club and active in the community, especially outdoor activities and doing shopping for daily needs. Among women, the most important component of social engagement is to become a member of social club. Cognitive activity with biggest influence on cognitve function are self-cooking and watching news in television."

"[ABSTRAKLatar Belakang. Gangguan fungsi kognitif dapat terjadi pada pekerja yang terpajan toluen. Gangguan fungsi kognitif tersebut terutama adalah penurunan memori, atensi dan konsentrasi, yang dapat menurunkan produktifitas kerja. Penelitian ini bertujuan mengetahui prevalensi gangguan fungsi kognitif dan faktor-faktor yang mempengaruhi Metode Penelitian. Desain potong lintang dilakukan pada 102 orang pekerja perempuan usia 19-40 tahun dan pendidikan minimal SMA. Data dikumpulkan dengan kuesioner, pemeriksaan fisik dan laboratorium serta MMSE. Kriteria inklusi adalah masa kerja ≥ 1 tahun dan bersedia menjadi responden dengan menandatangani informed consent. Kriteria eksklusi adalah hamil, menstruasi,merokok, minum alkohol, riwayat cedera kepala, hipertensi, gula darah dan dislipidemia. Faktor risiko yang diteliti antara lain umur, status perkawinan, masa kerja, lama kerja, kepatuhan pakai masker , stres kerja dan status gizi. Umur, status perkawinan,masa kerja dan lama kerja diambil dari data HRD. Status gizi didapatkan dari perhitungan Indeks Massa Tubuh. Kepatuhan pakai masker berdasarkan pengawasan kepatuhan APD. Stres kerja dinilai menggunakan kuesioner Survey Diagnostik Stress . Hasil. Walaupun kadar toluen didapat lebih kecil dari nilai ambang batas toluen , didapatkan prevalensi gangguan fungsi kognitif sebesar 52 %. Area kognitif yang menurun adalah atensi kalkulasi dan visuospasial. Faktor risiko yang secara bermakna mempengaruhi gangguan fungsi kognitif adalah masa kerja, lama kerja, kepatuhan pemakaian masker, stres kerja yang meliputi konflik peran, ketaksaan peran, beban kerja kualitatif, beban kerja kuantitatif, pengembangan karir dan tanggung jawab rekan kerja. Hasil analisis multivariat menunjukkan konflik peran merupakan faktor risiko yang paling mempengaruhi gangguan fungsi kognitif ( OR 7,546 Interval kepercayaan 95% 1,5 ? 41,88 ) Kesimpulan. Prevalensi penurunan fungsi kognitif studi ini lebih besar dari penelitian sebelumnya dan teori. Aspek kognitif yang menurun didominasi oleh atensi kalkulasi dan visuospasial. Konflik peran merupakan faktor risiko yang paling mempengaruhi gangguan fungsi kognitif.

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ABSTRACTBackground. Cognitive Function Impairment can happen among workers expose by Toluene. This impairment mainly effect in attention, concentration and memory function, and can decrease working productivity. This study aims to calculate the prevalence of Cognitive Function impairment and related risk factors Method. Cross sectional design study was conducted on 102 female workers, age 19-40 years old and graduated from senior high school. Age and education were obtained from secondary data, and followed by interviews, physical and laboratory examination and Mini Mental States Examination. The inclusion criteria were age ≥ 1 year of work and willing to be the subject of research. Exclusion criteria were pregnancy, menstruation, smoker, Alcohol consumption, history of head injury, hypertension, diabetes mellitus and Dyslipidemia. Risk factor included in this study were age, marital status, duration of work,time of work, PPE obedience ,work stress and nutritional status. Age, Marital status, Duration and Time of work were from secondary data of HRD department. Nutritional status was obtained from body mass index calculation. face mask obedience was obtained from data of wearing mask compliance. Work stress was assessed using Survey Diagnostic Stress Questionnaire. Results. The prevalence of Cognitive Function Impairment was 52 % , mainly at Attention ? Calculation and Visuospasial Aspect respectively. Significant risk factors ( p value < 0,05 ) in this study were duration of work and time of work, PPE obedience and all of work stress domain. The Result of multivariate analysis show that conflict of role was the most influence factor ( OR 7,546 C.I 95% 1,5 ? 41,88 ) Conclusion. This study found that the prevalence of cognitive function impairment was higher than theory and other similar studies . Cognitive aspects mainly affected were attention ? calculation and visuospatial. Conflict of role was the most inluence risk factor relating with cognitive function impairment;Background. Cognitive Function Impairment can happen among workers expose by Toluene. This impairment mainly effect in attention, concentration and memory function, and can decrease working productivity. This study aims to calculate the prevalence of Cognitive Function impairment and related risk factors Method. Cross sectional design study was conducted on 102 female workers, age 19-40 years old and graduated from senior high school. Age and education were obtained from secondary data, and followed by interviews, physical and laboratory examination and Mini Mental States Examination. The inclusion criteria were age ≥ 1 year of work and willing to be the subject of research. Exclusion criteria were pregnancy, menstruation, smoker, Alcohol consumption, history of head injury, hypertension, diabetes mellitus and Dyslipidemia. Risk factor included in this study were age, marital status, duration of work,time of work, PPE obedience ,work stress and nutritional status. Age, Marital status, Duration and Time of work were from secondary data of HRD department. Nutritional status was obtained from body mass index calculation. face mask obedience was obtained from data of wearing mask compliance. Work stress was assessed using Survey Diagnostic Stress Questionnaire. Results. The prevalence of Cognitive Function Impairment was 52 % , mainly at Attention – Calculation and Visuospasial Aspect respectively. Significant risk factors ( p value < 0,05 ) in this study were duration of work and time of work, PPE obedience and all of work stress domain. The Result of multivariate analysis show that conflict of role was the most influence factor ( OR 7,546 C.I 95% 1,5 – 41,88 ) Conclusion. This study found that the prevalence of cognitive function impairment was higher than theory and other similar studies . Cognitive aspects mainly affected were attention – calculation and visuospatial. Conflict of role was the most inluence risk factor relating with cognitive function impairment, Background. Cognitive Function Impairment can happen among workers expose by Toluene. This impairment mainly effect in attention, concentration and memory function, and can decrease working productivity. This study aims to calculate the prevalence of Cognitive Function impairment and related risk factors Method. Cross sectional design study was conducted on 102 female workers, age 19-40 years old and graduated from senior high school. Age and education were obtained from secondary data, and followed by interviews, physical and laboratory examination and Mini Mental States Examination. The inclusion criteria were age ≥ 1 year of work and willing to be the subject of research. Exclusion criteria were pregnancy, menstruation, smoker, Alcohol consumption, history of head injury, hypertension, diabetes mellitus and Dyslipidemia. Risk factor included in this study were age, marital status, duration of work,time of work, PPE obedience ,work stress and nutritional status. Age, Marital status, Duration and Time of work were from secondary data of HRD department. Nutritional status was obtained from body mass index calculation. face mask obedience was obtained from data of wearing mask compliance. Work stress was assessed using Survey Diagnostic Stress Questionnaire. Results. The prevalence of Cognitive Function Impairment was 52 % , mainly at Attention – Calculation and Visuospasial Aspect respectively. Significant risk factors ( p value < 0,05 ) in this study were duration of work and time of work, PPE obedience and all of work stress domain. The Result of multivariate analysis show that conflict of role was the most influence factor ( OR 7,546 C.I 95% 1,5 – 41,88 ) Conclusion. This study found that the prevalence of cognitive function impairment was higher than theory and other similar studies . Cognitive aspects mainly affected were attention – calculation and visuospatial. Conflict of role was the most inluence risk factor relating with cognitive function impairment]"

"Olahraga aerobik terbukti mampu meningkatkan struktur dan fungsi kognitif. Data tentang jenis olahraga aerobik yang terbaik untuk menjaga keseimbangan oksidatif, serta memicu angiogenesis dan neuroplastisitas di berbagai regio otak masih terbatas. Penelitian ini menganalisis pengaruh olahraga aerobik halang rintang terhadap kadar neuroglobin otak, protein pemicu angiogenesis, neuroplastisitas di hipokampus dan korteks prefrontal, serta fungsi memori relasional. Mencit Mus musculus CBS-Swiss strain jantan berusia 10 bulan dilatih berlari di roda berjalan yang diberi halang rintang, berlari dengan kecepatan 10 m/menit, 30 menit/hari, 5 hari/minggu sambil melewati halang rintang untuk setiap 78 cm. Tiga jenis halang rintang diganti setiap 3 hari. Kelompok pembanding adalah mencit yang berlari dengan kecepatan dan waktu yang sama, namun tanpa halang rintang, serta kelompok kontrol yang tidak berolahraga. Kadar neuroglobin otak tidak berbeda bermakna pada tiga kelompok mencit. Latihan lari halang rintang memberikan efek lebih baik dibanding lari tanpa halang rintang pada kadar developmentally regulated brain protein-A (drebrin-A) di hipokampus. Kedua kelompok olahraga memiliki efek yang lebih baik dibanding kontrol pada ekspresi vascular endothelial growth factors (VEGF), kadar drebrin-A, dan paired associative cognitive test. Olahraga aerobik kompleks memicu neuroplastisitas yang lebih baik dibanding aerobik sederhana di hipokampus. Kedua tipe olahraga aerobik mampu meningkatkan angiogenesis dan neuroplastisitas di otak, dan meningkatkan kemampuan memori relasional. Olahraga aerobik tidak meningkatkan kadar neuroglobin secara bermakna. Hal ini menunjukkan bahwa intensitas olahraga aerobik memberikan efek hipoksia yang dapat ditoleransi oleh jaringan otak.

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Aerobic exercise has been proven to improve of cognitive structure and function. Study about the type of aerobic exercise affects on angiogenesis, neuroplasticity and oxidative homeostasis in brain?s specific regions is still limited. The present study was conducted to investigate the effects of hurdle aerobic exercise on brain neuroglobin level, angiogenesis and neuroplasticity proteins in hippocampus and prefrontal cortex, and relational memory among middle aged CBS-Swiss strain mice. Mice, age 10 months were subjected to hurdle running wheel for 8 weeks. They ran at speed of 10 m/min, 30 min/day, and 5 days/week with hurdles for every 78 cm. Three types of hurdles were changed for every 3 days. Another group of same age mice ran at same speed, time, and period, without hurdle as comparison, while other control group never exercises. The hurdle group exercise has significant higher level of developmentally regulated brain protein-A (drebrin- A) in hippocampus compared to non-hurdle group. Both of exercise groups have significant higher ability on paired associative cognitive test, and they have significant higher expression of vascular endothelial growth factor (VEGF) and higher level of drebrin-A compared to control. Neuroglobin level was not significant different among of all groups. More complex aerobic exercise has better effect on hippocampus neuroplasticity. Both of aerobic exercise has better effect on angiogenesis and neuroplasticity in the brain, and also on cognitive function. Aerobic exercise does not resulting high hypoxic stress and could be tolerated by brain."

"[ABSTRAKPeningkatan stres oksidatif selama penuaan, dianggap sebagai kontributor utama pada proses neuro-degenerasi dan kehilangan neuron, dan merupakan faktor utama dalam patologi penyakit Alzheimer dan penurunan kognitif terkait usia. Vitamin E merupakan antioksidan potensial yang menjadi fokus utama penelitian gangguan fungsi kognitif dan penyakit Alzheimer. Penelitian potong lintang pada populasi lansia sehat di Kelurahan Cikoko ini dilakukan pada bulan Desember 2014 untuk menilai hubungan antara kadar vitamin E serum dengan fungsi kognitif. Selain itu juga menilai asupan vitamin C dan E dengan metode FFQ. Penilaian fungsi kognitif dengan instrumen MoCA-Ina. Pemeriksaan laboratorium untuk mengetahui kadar vitamin E menggunakan metode HPLC. Data dianalisis dengan uji Mann-Whitney dan Chi-square. Sebagian besar subyek (75,9%) adalah perempuan dengan usia rata-rata 65 tahun. Sementara, kadar rata-rata vitamin E adekuat, yaitu 21,6 μmol/L. Hasil penelitian ini menunjukkan bahwa tidak ada hubungan signifikan antara kadar vitamin E serum dengan fungsi kognitif yang dinilai dengan skor MoCA-Ina. Meskipun berat badan normal hingga obes I menunjukkan hubungan signifikan dengan skor kognitif (r = 0,17 p = 0,026), tetapi tidak ada hubungan signifikan antara asupan vitamin C dengan fungsi kognitif (r = 0,19 p = 0,15) atau antara asupan vitamin E dengan fungsi kognitif (r = 0,04, p = 0.72) pada penelitian ini. Kesimpulan, tidak terdapat hubungan antara kadar vitamin E serum dengan fungsi kognitif.

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ABSTRACTOxidative stress increases during ageing, is considered as a major contributor to neuro-degeneration and neuronal loss, and is a primary factor in the pathology of both Alzheimer’s disease and age-related cognitive decline. Vitamin E has been the main focus of investigation in studies of cognitive impairment and alzheimer’s disease during aging as a potent antioxidant. A cross-sectional study of an elderly population in Cikoko Regency in December 2014 was conducted to evaluate the association between serum vitamin E levels and cognitive function in elderly. Correlation between intakes of vitamin C and E as well as Body Mass Index to the MoCA-Ina scores were also investigated. Fifty four elderly were included in the study and interviewed for their vitamins intake using a Food Frequency Questionnaires (FFQ). Cognitive function was examined by Montreal Cognitive Assessment Indonesian version (MoCA-Ina). Levels of vitamin E serum were assessed by high performance liquid chromatography. Data were analyzed by using the Mann-Whitney and Chi-square test. The majority of the subjects were female (75.9%) with median age 65 years old. While, the median levels of vitamin E was 21.55 μmol/L. The result of this study showed that there was no association between vitamin E level and MoCA-Ina scores. Although normal weight to obese I was significantly associated with cognitive scores (r = 0,17 p = 0.026), no significant correlation between vitamin C intake and cognitive function scores (r = 0.19 p = 0.15) or between vitamin E intake and MoCA-Ina scores were found in this study (r = 0.04, p = 0.72). In conclusion, there is no association between vitamin E serum and cognitive function.;Oxidative stress increases during ageing, is considered as a major contributor to neuro-degeneration and neuronal loss, and is a primary factor in the pathology of both Alzheimer’s disease and age-related cognitive decline. Vitamin E has been the main focus of investigation in studies of cognitive impairment and alzheimer’s disease during aging as a potent antioxidant. A cross-sectional study of an elderly population in Cikoko Regency in December 2014 was conducted to evaluate the association between serum vitamin E levels and cognitive function in elderly. Correlation between intakes of vitamin C and E as well as Body Mass Index to the MoCA-Ina scores were also investigated. Fifty four elderly were included in the study and interviewed for their vitamins intake using a Food Frequency Questionnaires (FFQ). Cognitive function was examined by Montreal Cognitive Assessment Indonesian version (MoCA-Ina). Levels of vitamin E serum were assessed by high performance liquid chromatography. Data were analyzed by using the Mann-Whitney and Chi-square test. The majority of the subjects were female (75.9%) with median age 65 years old. While, the median levels of vitamin E was 21.55 μmol/L. The result of this study showed that there was no association between vitamin E level and MoCA-Ina scores. Although normal weight to obese I was significantly associated with cognitive scores (r = 0,17 p = 0.026), no significant correlation between vitamin C intake and cognitive function scores (r = 0.19 p = 0.15) or between vitamin E intake and MoCA-Ina scores were found in this study (r = 0.04, p = 0.72). In conclusion, there is no association between vitamin E serum and cognitive function., Oxidative stress increases during ageing, is considered as a major contributor to neuro-degeneration and neuronal loss, and is a primary factor in the pathology of both Alzheimer’s disease and age-related cognitive decline. Vitamin E has been the main focus of investigation in studies of cognitive impairment and alzheimer’s disease during aging as a potent antioxidant. A cross-sectional study of an elderly population in Cikoko Regency in December 2014 was conducted to evaluate the association between serum vitamin E levels and cognitive function in elderly. Correlation between intakes of vitamin C and E as well as Body Mass Index to the MoCA-Ina scores were also investigated. Fifty four elderly were included in the study and interviewed for their vitamins intake using a Food Frequency Questionnaires (FFQ). Cognitive function was examined by Montreal Cognitive Assessment Indonesian version (MoCA-Ina). Levels of vitamin E serum were assessed by high performance liquid chromatography. Data were analyzed by using the Mann-Whitney and Chi-square test. The majority of the subjects were female (75.9%) with median age 65 years old. While, the median levels of vitamin E was 21.55 μmol/L. The result of this study showed that there was no association between vitamin E level and MoCA-Ina scores. Although normal weight to obese I was significantly associated with cognitive scores (r = 0,17 p = 0.026), no significant correlation between vitamin C intake and cognitive function scores (r = 0.19 p = 0.15) or between vitamin E intake and MoCA-Ina scores were found in this study (r = 0.04, p = 0.72). In conclusion, there is no association between vitamin E serum and cognitive function.]"