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Abstrak :
Background: arterial stiffness is a mortality predictor in hemodialysis patients, hemodialysis induces inflammation, marked by an intradialysis increase in the inflammatory marker pentraxin 3 (PTX3). Arterial stiffness in twice-weekly hemodialysis patients in Indonesia is lower than has been found in studies of thrice-weekly patients. This study therefore aims to determine the factors associated with arterial stiffness, focusing on the role of hemodialysis frequency and PTX3. Methods: a cross-sectional study was conducted at Cipto Mangunkusumo Hospital, Fatmawati Hospital, and Medistra Hospital involving patients with twice- and thrice-weekly hemodialysis. Arterial stiffness was measured by carotid-femoral pulse wave velocity after hemodialysis, and blood samples for PTX3 testing were taken before hemodialysis. Bivariate and multivariate analyses were performed using chi-squared tests and logistic regression. Results: out of 122 subjects, 82 underwent twice-weekly hemodialysis. There was no difference in arterial stiffness between patients with twice- and thrice-weekly hemodialysis. In bivariate analysis, PTX3, cardiovascular disease, dialysis vintage had p values of <0.05, while the subsequent multivariate analysis showed that PTX3>2.3 ng/ml was associated with arterial stiffness (adjusted OR 5.18; 95% CI 1.07–24.91), as well as cardiovascular disease (adjusted OR 3.67; 95% CI 1.40–10.55), LDL (adjusted OR 3.10; 95% CI 1.04–9.24), and dialysis vintage (adjusted OR 2.72; 95% CI 1.001–7.38). Conclusion: predialysis PTX3 levels above 2.3 ng/ml were associated with arterial stiffness. There was no difference in arterial stiffness between patients with twice- and thrice-weekly hemodialysis.

Abstrak :
Pendahuluan. Berbagai panduan menganjurkan hemodialisis HD tiga kali seminggu. Di Indonesia pasien dengan hemodialisis dua kali seminggu lebih banyak ditemukan. Perlu dilakukan penelitian untuk mengetahui gambaran klinis dan kualitas hidup pada pasien yang menjalani hemodialisis dua kali seminggu dibandingkan tiga kali seminggu. Metode. Merupakan studi potong lintang pada pasien yang menjalani HD dua dan tiga kali seminggu di RS Cipto Mangunkusumo dan beberapa RS swasta. Dilakukan pemeriksaan laboratorium dan penilaian kualitas hidup dengan menggunakan Kidney Disease Quality of Life KDQOL-SF 36. Hasil. Didapatkan 80 subjek dengan kelompok usia >50 tahun lebih banyak ditemukan. Secara bermakna lebih tinggi pada kelompok HD dua kali yaitu Interdialytic Weight Gain IDWG 4,91 SB 1,52 dan 3,82 SB 1,28 p=0,002. albumin 4,05 SB 0,26 dan 3,86 SB 0,48 p=0,027, saturasi transferin 25,5 12,0-274,0 dan 21,95 5,8-84,2 p=0,004, kadar fosfat 5,82 SB 1,68 dan 5,82 SB 1,68 p=0,026. Kadar TIBC 235,20 SB 55,72 dan 273,73 SB 58,29 p=0,004 pada kelompok tiga kali HD secara bermakna lebih tinggi. Pada kelompok HD dua kali seminggu 68 mencapai Kt/V>1,8, 93,3 yang HD tiga kali seminggu mencapai Kt/V>1,2. Kualitas hidup antara kedua kelompok tidak berbeda bermakna baik pada Physical Componet Score PCS p=0,227, Mental Component Score MCS p=0,247 dan Kidney Disease Component Score KDCS p=0,889. Simpulan. Didapatkan secara bermakna lebih tinggi pada kelompok HD dua kali seminggu pada pemeriksaan IDWG, albumin, saturasi transferin, fosfat, sedangkan TIBC lebih tinggi pada kelompok HD tiga kali seminggu. Kualitas hidup kedua kelompok tidak berbeda bermakna. ...... Introduction. Many guidelines recommend hemodialysis HD three times a week. In Indonesia there are more patients undergoing hemodialysis twice a week. It is necessary to investigate the clinical features and the quality of life in patients undergoing hemodialysis twice a week. Method. A cross sectional study in patients undergoing HD two and three times weekly at Cipto Mangunkusumo Hospital and some private hospitals. Laboratory examination and assessment of quality of life by using Kidney Disease Quality of Life KDQOL SF 36. Results. There were 80 subjects with age group 50 years is more common. Significantly higher in group HD twice a week were Interdialytic Weight Gain IDWG 4.91 SB 1.52 and 3.82 SB 1.28 p 0.002. 4,05 albumin SB 0.26 and 3.86 SB 0.48 p 0.027, transferrin saturation 25.5 12.0 to 274.0 and 21.95 5.8 to 84.2 p 0.004, the phosphate level 5.82 SB 1.68 and 5.82 SB 1.68 p 0.026. The TIBC level 235.20 55.72 SB and 273.73 58.29 SB p 0.004 was significantly higher in group HD thrice a week. In twice a week HD group 68 reached Kt V 1.8, 93.3 of HD thrice a week achieved Kt V 1.2. Quality of life between the two groups was not significant either on Physical Componet Score PCS p 0.227, Mental Component Score MCS p 0.247 and Kidney Disease Component Score KDCS p 0.889. Conclusion. There were significantly higher in group HD twice a week on examination IDWG, albumin, transferrin saturation and phosphate levels, whereas the TIBC was higher in group HD three times a week. Quality of life of the two groups was not significant difference.