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Abstrak :
Tesis ini bertujuan mengetahui kadar vitamin D dan zinc serum pasien preeklamsia berat dan hamil normal, mengetahui hubungan antara kadar vitamin D dan zinc dengan kejadian preklamsia berat, dan prevalensi preeklamsia berat di RSCM. Penelitian ini merupakan observasional potong lintang. Subyek penelitian adalah perempuan hamil yang menjalani persalinan di Kamar Bersalin RSCM pada Januari sampai dengan April 2014. Terdapat 22 subyek kelompok preeklamsia berat dan 22 subyek kelompok hamil dengan tekanan darah normal. Hasil penelitian didapatkan rerata kadar vitamin D dan median kadar zinc lebih rendah pada kelompok preeklamsia berat dibandingkan hamil normal, namun tidak berbeda bermakna. Kadar vitamin D dan zinc tidak berhubungan bermakna dengan kejadian preklamsia berat, dengan p=0,689 dan 0=0,517. Prevalensi hipertensi dalam kehamilan di RSCM adalah 31,07%, dengan rincian sebagai berikut: hipertensi kronik, hipertensi gestasional, preeklamsia ringan, preeklamsia berat, preeklamsia berat superimposed, sindrom HELLP, dan eklamsia gravidarum adalah 0,54%, 2,14%, 1,96%, 17,14%, 3,21%, 4,64%, dan 1,44%.

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The purpose of this investigation was to examine the maternal plasma level of vitamin D and zinc in cases of severe preeclampsia compare to normal pregnancy, to know association between level of vitamin D and zinc and severe preeclampsia, and to know prevalence of severe preeclampsia in Cipto Mangunkusumo. This is a cross sectional observational study. Subjects were pregnant women who gave birth in delivery room Cipto Mangunkusumo Hospital in between January and April 2014. There are 22 subjects in severe preeclampsia group and 22 subjects in normotensive pregnancy. Subject with severe preeclampsia were noted to have lower maternal vitamin D and zinc level to normotensive pregnancy with not significant statistically (p 0,689 and p 0,517). Prevalence of hypertension in Cipto Mangunkusumo hospital is 31,07% which is contain of: chronic hypertension 0,54%, gestational hypertension 2,14%, mild preeclampsia 1,96%, severe preeclampsia 17,14%, superimposed severe preeclampsia 3,21%, HELLP syndrome 4,64%, and eclampsia 1,44%.

Abstrak :
Latar Belakang. Sepsis neonatal awitan dini SNAD masih merupakan masalah di Indonesia. Vitamin D memiliki efek pada fungsi imunitas. Neonatus kurang bulan NKB berisiko mengalami defisiensi kadar vitamin D. Hubungan kadar vitamin D dengan kejadian SNAD pada NKB belum jelas. Tujuan. Menganalisis hubungan kadar vitamin D dengan kejadian SNAD pada NKB. Metode. Duapuluh NKB dengan klinis dan pemeriksaan laboratorium menyokong SNAD kelompok kasus dan 20 NKB tanpa hasil laboratorium SNAD kelompok kontrol ikut dalam penelitian ini. Subjek penelitian adalah NKB usia gestasi ge; 28 sampai dengan < 37 minggu dirawat di RSUPN Cipto Mangunkusumo selama bulan Juli - September 2017. Pemeriksaaan kadar vitamin D 25 OH D dengan metode competitive chemiluminescense immunoassay CLIA direk dengan alat Diasorin Liaison. Hasil. Median kadar vitamin D pada NKB dengan SNAD 8,95 4,10 - 16,30 ng/mL dengan rerata usia gestasi 33,25 1,71 minggu dan rerata berat lahir 1863,75 415,06 gram. Median kadar vitamin D tanpa SNAD 11,75 5,80 - 42,80 ng/mL dengan rerata usia gestasi 34,67 1,53 minggu dan rerata berat lahir 2125,0 340,55 gram. Median kadar vitamin D NKB SNAD lebih rendah secara bermakna dibandingkan NKB tanpa SNAD.

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Background. Early onset neonatal sepsis EONS is still a problem in Indonesia. Vitamin D has effect on immune function. Preterm infants have a risk of deficiency of vitamin D levels. The association between vitamin D levels with EONS were unclear. Objective. To determine the association between vitamin D levels with EONS in preterm infants. Methods. Twenty preterm infants with clinical and laboratory finding of EONS study group and 20 preterm infants with no signs of laboratory infection control group were enrolled this study. The subjects were preterm infants of gestational age ge 28 37 weeks in Cipto Mangunkusumo Hospital during July September 2017. Vitamin D 25 OH D levels were measured using Diasorin Liason with competitive chemilunescence immunoassay CLIA technique. Results. Median vitamin D levels with EONS was 8,95 4,10 16,30 ng mL, mean of gestational age and birth weight were 33,25 1,71 weeks and 1863,75 415,06 g, respectively. Median vitamin D levels without EONS was 11,75 5,80 42,80 ng mL, mean of gestational age and birth weight were 34,67 1,53 weeks and 2125,0 340,55 g, respectively. Median vitamin D levels of preterm infants with EONS was significantly lower than without EONS.Conclusion. Vitamin D levels are associated with EONS in preterm infants.

Abstrak :
Latar belakang: Status gizi dan kadar vitamin D adalah dua masalah yang menjadi sorotan di dunia karena masih banyak negara dengan kejadian status gizi yang buruk dan defisiensi kadar vitamin D pada anak termasuk negara Indonesia. Anak dengan usia dibawah lima tahun dengan berat badan normal dan pendek dapat mengalami berat badan berlebih di kemudian hari. Kadar vitamin D yang menurun pada BMI lebih tinggi menjadi kemungkinan adanya pengaruh antara kadar vitamin D dengan status gizi. Tujuan: Mengetahui korelasi antara kadar vitamin D dengan status gizi anak Metode: Penelitian ini merupakan penelitian potong lintang. Menggunakan data dari SEANUTS II bulan September 2019 – Maret 2020. Digunakan 132 sampel pada anak usia 6-59 bulan di Indonesia yang memenuhi kriteria penelitian dengan random sampling. Hasil kadar vitamin D dari hasil pemeriksaan lab, asupan vitamin D menggunakan food recall 24 jam, dan status gizi diukur dengan Z-skor BB/TB. Kemudian dilakukan uji normalitas Kolmogorov- Smirnov dan uji korelasi Spearman. Hasil: Status gizi anak usia 6-59 bulan di Indonesia 89,4% memiliki status gizi normal.Sebanyak 88,6% anak kurang mendapatkan asupan vitamin D sesuai dengan rekomendasi AKG. Didapatkan 90,2% anak mengalami defisiensi vitamin D. Ditemukan korelasi bermakna antara asupan vitamin D dan kadar. Vitamin D (r= 0,234, nilai p=0,007). Tidak ada korelasi bermakna antara kadar vitamin D dengan Z skor BB/ TB ( r= -0,016, p=0,854). Simpulan: Tidak terdapat korelasi antara kadar vitamin D dengan Z-skor BB/TB pada anak usia 6-59 bulan di Indonesia. ......Background: Nutritional status and vitamin D levels are two highlighted global problem because there are still many countries with incidence of poor nutritional status and deficiency of vitamin D in children, including Indonesia. Children under five years of age with normal weight and short can develop to overweight later in life if not treated. A decreased vitamin D level at a higher BMI is a possible influence between vitamin D levels and nutritional status. Objective: To determine the correlation between vitamin D levels and children's nutritional status Methods: This research is a cross sectional study. Using data from SEANUTS II collected from September 2019 until March 2020. A total of 132 samples children aged 6-59 months in Indonesia who met the research criteria chosen by random sampling. Vitamin D levels data from lab tests, vitamin D intake record with 24- hour food recall, and nutritional status was measured based on Z-score BW / TB. Then, performed normality test with Kolmogorov- Smirnov and correlation test with Spearman. Results: The nutritional status of children aged 6-59 months in Indonesia 89,4% had normal nutritional status. Most of the children ( 88.6% ) did not get enough vitamin D intake according to the RDA recommendation. It was found that 90.2% of children had vitamin D deficiency. There was a significant correlation between vitamin D intake and levels. Vitamin D (r = 0.234, p value = 0.007). There was no significant correlation between vitamin D levels and Z score BW / TB (r = -0.016, p = 0.854). Conclusion: There was no correlation between vitamin D levels and Z-score Weight/Height in children aged 6-59 months in Indonesia.

Abstrak :
ABSTRAK Latar belakang: Rinitis alergi RA merupakan masalah kesehatan global dengan prevalensi tinggi pada anak. Akhir-akhir ini, kekurangan vitamin D pada anak dipercaya berhubungan dengan disregulasi sistem imun, yang berujung pada makin beratnya RA. Analisis hubungan antara kadar vitamin D dan keparahan RA diperlukan untuk mencegah komplikasi lebih lanjut. Tujuan: 1 Mengetahui rerata kadar vitamin D pada anak dengan rinitis alergi; 2 Membandingkan rerata kadar vitamin D pada anak dengan rinitis alergi dan anak pada populasi normal; 3 Mengetahui rerata kadar 25 OH D serum sesuai dengan tingkat keparahan rinitis alergiMetode: Penelitian potong lintang pada 60 anak usia 6-18 tahun yang memenuhi kriteria inklusi dan berkunjung ke RSCM dan RSI Pondok Kopi. Seluruh subyek dibagi menjadi kelompok rinitis alergi n=30 dan kontrol n=30 . Kemudian, dilakukan pemeriksaan kadar 25 OH D serum dengan cara CLIA chemiluminescence immunoassay . Kadar 25 OH D serum normal, insufisiensi, dan defisiensi lalu dihubungkan dengan RA berdasarkan lama gejala yaitu intermiten dan persisten. Hasil: Rerata kadar vitamin D pada anak dengan rinitis alergi didapatkan 17,75 SB 5,60 ng/mL. Tidak terdapat perbedaan bermakna antara rerata kadar vitamin D di kelompok RA 17,75 5,60 ng/mL dengan kelompok kontrol 19,22 6,11 ng/mL , p=0,336. Didapatkan hubungan bermakna antara rerata kadar vitamin D pada rinitis intermiten 22,82 4,59 ng/mL dengan rinitis persisten 15,22 4,19 ng/mL , p

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ABSTRACT Background. Allergic rhinitis AR was a global health problem with high prevalence in children. Recently, vitamin D deficiency in children was found to have a correlation with immune system dysregulation, which leads to more severe symptoms of AR. Association between vitamin D serum level and AR incidence is needed to prevent further complications.Aim. 1 to recognize mean vitamin D serum level in children with AR 2 to compare mean vitamin D serum level in children with AR and normal children population 3 to find out mean vitamin D serum level according to severity level of AR.Methods. A cross sectional study was performed in 60 children aged 6 18 years old, who meet the inclusion criteria and visit CM hospital and Islamic Pondok Kopi hospital. All subjects were divided into 2 groups AR group n 30 and control group n 30 . Blood were taken for 25 OH D serum level examination with CLIA method. Association between 25 OH D serum level normal, insufficiency, deficiency and severity level of AR intermittent and persistent was then being analyzed.Results. Mean vitamin D serum level in children with AR was 17,75 SD 5,60 ng mL. There was no significant difference between mean vitamin D serum level in AR group 17,75 5,60 ng mL and control group 19,22 6,11 ng mL , p 0,336. Association was found between mean vitamin D serum level in intermittent rhinitis 22,82 4,59 ng mL and persistent rhinitis 15,22 4,19 ng mL , p

Abstrak :
ABSTRAK
Preeklampsia ditandai dengan peningkatan tekanan darah dan proteinuri. Vitamin D diduga berperan pada pengaturan tekanan darah dengan menghambat pembentukan renin dan angiotensin II. Penelitian ini merupakan penelitian dengan disain potong lintang komparatif yang bertujuan untuk melihat perbandingan status vitamin D pada ibu hamil normal dan preeklampsia. Perempuan hamil berusia 18-40 tahun, terdiri dari 33 hamil normal dan 33 preeklampsia yang datang di poliklinik dan ruang bersalin Rumah Sakit Tarakan, Jakarta diikutsertakan dalam penelitian ini. Data umur, usia kehamilan, paritas, pendidikan, paparan sinar matahari, asupan vitamin D dengan cara FFQ semikuantitatif didapatkan dengan wawancara, dan dilakukan pengukuran lingkar lengan atas dan kadar vitamin D serum. Tidak ada perbedaan yang bermakna dalam hal umur, usia kehamilan, paritas, paparan sinar matahari, asupan vitamin D, lingkar lengan atas dan kadar vitamin D serum antara hamil normal dengan preeklampsia.Asupan vitamin D lebih rendah dibandingkan dengan angka kecukupan gizi yang dianjurkan pada hamil normal maupun preeklampsia. Defisiensi vitamin D terlihat pada 50% preeklampsia dan 33% hamil normal. Kesimpulan: kadar vitamin D serum tidak berbeda bermakna pada hamil normal maupun preeklampsia.

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ABSTRACT
Preeclampsia is a condition with high blood pressure and proteinuria during pregnancy. Vitamin D plays a role in the regulation of blood pressure by inhibiting renin and angiotensin II formation. This study was a comparative crosssectional study aiming to compare serum vitamin D concentration among normal pregnancy and preeclampsia. Pregnant women aged 18-40 years,were recruitedconsisting of 33 subjects with normal pregnancy and 33 subjects with preeclampsia. Data on age, gestational age, parity, education , MUAC, vitamin D intake using semi-quantitative FFQ, sun exposure and serum vitamin D concentration were assessed. There were no significant differences of age, gestational age, parity, education, vitamin D intake, sun exposure, MUAC and serum vitamin D concentration between normal and preeclamptic pregnancy. In both groups, vitamin D intake was lower than recommended dietary allowance. Half of preeclampsia suffered from vitamin D deficiency, while it was only 33% among normal pregnancy. Conclusion: serum vitamin D was not different among normal pregnancy and preeclampsia.