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Abstrak :
Bau mulut adalah masalah yang dapat membuat orang tidak nyaman. Stelechocarpus burahol (kepel) terbukti secara empiris dapat menghilangkan bau mulut, karena mengandung flavonoid yang berfungsi sebagai agen pengadsorbsi. Untuk meningkatkan potensinya dilakukan ekstraksi dari buah kepel. Untuk mendapatkan hasil yang baik, ekstrak distandardisasi. Standardiasi yang dilakukan antara lain parameter spesifik kadar total flavonoid adalah 0,30 %, kadar total fenol adalah 7,85 g GAE/100 g, kadar logam berat adalah 0 ppm, dan kadar sisa pelarut adalah 0 ppm, sedangkan pada parameter non spesifik berupa kadar abu adalah 94,95 %, kadar abu tidak larut asam adalah 0,97 %, kadar air adalah 28,36 %, uji kelarutan ekstrak 1:10. Ekstrak dibuat menjadi sediaan obat kumur agar mudah digunakan sehari-hari. Sediaan obat kumur ini mengandung ekstrak buah kepel, isomaltulosa, mentol, asam malat, natrium benzoat, sorbitol, dan etanol. Pada formulasi I, II, dan III secara berturut-turut memiliki pemanis isomaltulosa 4 %, 8 %, dan 12 %, dari ketiga formulasi tersebut diuji untuk menentukan formulasi yang paling disukai dan stabil. Formula II mendapatkan nilai rata-rata tertinggi pada parameter warna dan aroma, serta mendapat peringkat kedua pada parameter rasa, sedangkan pada pengujian fisik obat kumur, pada formulasi I memiliki bau mentol; jernih; warna incosete 0605 orange; pH 5,35; dan bobot jenis 1,0349; formula II memiliki bau mentol; jernih; warna incosete 0605 orange; pH 5,36; dan bobot jenis 1,1234; formula III memiliki bau mentol; jernih; warna incosete 0605 orange; pH 5,37; dan bobot jenis 0,9953.

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Halitosis is a problem that can make people uncomfortable. Stelechocarpus burahol (Kepel) empirically proven to eliminate bad breath, because it contains flavonoid which serves as an adsorbent agent. To improve the potency, kepel fruit is extracted. To get a good result, standardized extract. Standardization is carried out include specific parameters such as levels of total flavonoids was 0.30%, the total phenol content was 7.85 g GAE/100 g, heavy metal content is 0 ppm, and levels of residual solvent was 0 ppm, whereas the non-specific parameters form of ash content is 94.95%, acid insoluble ash content was 0.97%, the water content was 28.36%, solubility test extract 1:10. Extracts made ​​into a mouthwash preparations for daily use. This mouthwash contains fruit extracts Kepel, isomalt, menthol, malic acid, sodium benzoate, sorbitol and ethanol. In the formulations I, II, and III consecutive had a sweetener isomalt 4%, 8%, and 12%, all three formulations were tested to determine the most preferred formulation and stable. Formulation II get the highest average score on the parameters of color and aroma, and was ranked second in the taste parameters, whereas the physical testing of mouthwash, the formulation I have a menthol smell, transparant, 0605 incosete orange color, pH 5.35, and a specific gravity of 1.0349, formulation II has the smell of menthol, transparant, 0605 incosete orange color, pH 5.36, and a specific gravity of 1.1234, formulation III has a menthol odor, transparent, 0605 incosete orange color, pH 5.37, and a specific gravity of 0.9953.

Abstrak :
[Bau mulut (Halitosis) merupakan masalah kesehatan gigi dan mulut yang dikeluhkan sebagian besar masyarakat. Komponen utama pada bau mulut adalah volatile sulfur compounds (VSCs), yaitu hidrogen sulfida (H2S), metil merkaptan (CH3SH), dan dimetilsulfida ((CH3)2S). Salah satu bahan alami yang secara tradisional digunakan untuk mengurangi bau mulut adalah buah burahol (Stelechocarpus burahol). Tujuan penelitian ini adalah mengevaluasi efek sediaan tablet hisap yang mengandung buah kepel dalam mengontrol bau mulut. Tiga puluh orang subyek sehat dibagi secara acak menjadi 2 kelompok, yaitu kelompok tablet hisap eksrak buah kepel dan kelompok permen karet xilitol. Subyek menggunakan tablet hisap pada pagi setelah makan pagi dan siang setelah makan siang. Pemeriksaan bau mulut dilakukan sebanyak tiga kali, yaitu segera setelah bangun tidur, setelah makan pagi, dan siang hari sesudah makan siang. Variabel pemeriksaan bau mulut yang diukur adalah skor organoleptik, kadar H2S, kadar CH3SH, dan kadar (CH3)2S. Efek tablet hisap ekstrak buah burahol sebanding dengan permen karet xilitol dalam menurunkan kadar H2S, CH3SH, (CH3)2S dan skor organoleptik bau mulut pada subyek. Tablet hisap yang mengandung ekstrak buah burahol (Stelechocarpus burahol) efektif dalam mengontrol bau mulut sehingga dapat digunakan untuk pengobatan bau mulut (halitosis).; ......Oral malodour (Haitosis) as an oral problem that most people complain. In all cases, bad breath is caused by the presence of volatile organic compounds originating from the mouth or the expired air. The aim of this study is know of the effect of lozenges containing kepel fruit (Stelechocarpus burahol) in controlling oral malodour in normal subjects. Thirty normal subjects were divided into two groups randomly, one groups received lozenges containing kepel fruits and the other groups received lozenges containing xilitol. Subjects receiving as much two tablets lozenges each day during one day, ie morning after breakfast and after lunch. Oral malodour examination performed three times, ie immediately after waking, after breakfast, and afternoon after lunch. Variable oral malodour is measured levels of H2S, CH3SH, (CH3)2S. The result were shown that lozenges containing kepel fruits (Stelechocarpus burahol) did not differ with lozenges containing xilitol in reducing the levels of H2S, CH3SH, (CH3)2S and organoleptics oral malodour in normal subjects. Lozenges containing kepel fruits (Stelechocarpus burahol) is effective in controlling oral malodour so it can be used for the treatment of oral malodour (Halitosis).;Oral malodour (Haitosis) as an oral problem that most people complain. In all cases, bad breath is caused by the presence of volatile organic compounds originating from the mouth or the expired air. The aim of this study is know of the effect of lozenges containing kepel fruit (Stelechocarpus burahol) in controlling oral malodour in normal subjects. Thirty normal subjects were divided into two groups randomly, one groups received lozenges containing kepel fruits and the other groups received lozenges containing xilitol. Subjects receiving as much two tablets lozenges each day during one day, ie morning after breakfast and after lunch. Oral malodour examination performed three times, ie immediately after waking, after breakfast, and afternoon after lunch. Variable oral malodour is measured levels of H2S, CH3SH, (CH3)2S. The result were shown that lozenges containing kepel fruits (Stelechocarpus burahol) did not differ with lozenges containing xilitol in reducing the levels of H2S, CH3SH, (CH3)2S and organoleptics oral malodour in normal subjects. Lozenges containing kepel fruits (Stelechocarpus burahol) is effective in controlling oral malodour so it can be used for the treatment of oral malodour (Halitosis).;Oral malodour (Haitosis) as an oral problem that most people complain. In all cases, bad breath is caused by the presence of volatile organic compounds originating from the mouth or the expired air. The aim of this study is know of the effect of lozenges containing kepel fruit (Stelechocarpus burahol) in controlling oral malodour in normal subjects. Thirty normal subjects were divided into two groups randomly, one groups received lozenges containing kepel fruits and the other groups received lozenges containing xilitol. Subjects receiving as much two tablets lozenges each day during one day, ie morning after breakfast and after lunch. Oral malodour examination performed three times, ie immediately after waking, after breakfast, and afternoon after lunch. Variable oral malodour is measured levels of H2S, CH3SH, (CH3)2S. The result were shown that lozenges containing kepel fruits (Stelechocarpus burahol) did not differ with lozenges containing xilitol in reducing the levels of H2S, CH3SH, (CH3)2S and organoleptics oral malodour in normal subjects. Lozenges containing kepel fruits (Stelechocarpus burahol) is effective in controlling oral malodour so it can be used for the treatment of oral malodour (Halitosis)., Oral malodour (Haitosis) as an oral problem that most people complain. In all cases, bad breath is caused by the presence of volatile organic compounds originating from the mouth or the expired air. The aim of this study is know of the effect of lozenges containing kepel fruit (Stelechocarpus burahol) in controlling oral malodour in normal subjects. Thirty normal subjects were divided into two groups randomly, one groups received lozenges containing kepel fruits and the other groups received lozenges containing xilitol. Subjects receiving as much two tablets lozenges each day during one day, ie morning after breakfast and after lunch. Oral malodour examination performed three times, ie immediately after waking, after breakfast, and afternoon after lunch. Variable oral malodour is measured levels of H2S, CH3SH, (CH3)2S. The result were shown that lozenges containing kepel fruits (Stelechocarpus burahol) did not differ with lozenges containing xilitol in reducing the levels of H2S, CH3SH, (CH3)2S and organoleptics oral malodour in normal subjects. Lozenges containing kepel fruits (Stelechocarpus burahol) is effective in controlling oral malodour so it can be used for the treatment of oral malodour (Halitosis).]

Abstrak :
Stelechocarpus Burahol buah asli nusantara penghilang bau mulut dan bau badan diketahui turun temurun di gunakan masyarakat ,sumber bahan alami pembuatan larutan kumur penghilang bau mulut. Tujuan : Mengetahui daya hambat bakteri ekstrak buah kepel, serta efikasi larutan kumur ekstrak buah kepel dibanding larutan komersial dalam mengontrol halitosis fisiologis. Metode : Cross-over 30 subyek penelitian, single blind,dua kelompok. Pengujian organoleptik test serta pengukuran VSCs dengan Oralchroma?. Hasil: uji daya anti bakteri Phyromonas ginggivalis ATCC 33277, Metode dilusi, kepel KBM 75%, KHM (-), larutan komersial KBM 25%, KHM 25%. Metode difusi,kepel;daya hambat konsentrasi 50%:8mm, 75%:8mm, 100%:10mm, larutan komersial;25%:10mm, 50%:11mm, 75%:14mm, 100%:14mm,signifikan larutan komersial ,P-value 0.034,alpha 5%. Analisa crossover;H2S kepel 0.05, komersial 0.25,P-value 0.0349 ,alpha 1%,nilai R-square sebesar 69.1%. Nilai CH3SH kepel 0,24,komersial 0.17 P-value 0.324,alpha 1%. Nilai (CH3)2S kepel 0.246, komersial 0.238, P-value 0.338 alpha 1%. P-value nilai tengah H2S , CH3SH, dan (CH3)2S, diatas alpha 1%. Kesimpulan : Kemampuan daya hambat bakteri larutan kumur komersial lebih baik secara bermakna, namun kemampuan larutan kepel dan komersial dalam menghambat H2S , CH3SH dan (CH3)2S tidak beda bermakna.

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Kepel (Stelechocarpus Burahol) an nusantara's fruit of origin, well known as oral and body anti mallodour for a long time ago specialy in javanish heritage, its become natural promising source for develope natural mouthwash in controling fisiologic halitosis. This research aimed in testing efficacy betwen kepel and commercial mouthwash containing green tea extract as oral anti mallodour in fisiologic halitosis. Method: A randomized, single blind, two-group ,Cross-over design with 30 subject. Using organoleptic test and Oralchroma ?. Result : anti bacterial test against Phyromonas ginggivalis ATCC 33277, diluted methode ; kepel KBM 75%, KHM (-), comercial mouthwash KBM 25%, KHM 25%. Difused methode kepel mouthwash positive in concentration 50%:8mm, 75%:8mm, 100%:10mm, comercial moutwash 25%:10mm, 50%:11mm, 75%:14mm, 100%:14mm, better result in commercial mouthwash ,P-value 0.034 alpha 5%. Crossover analytic H2S kepel 0.05, commercial 0.25,P-value 0.0349 alpha 1%, R-square 69.1%. Result for CH3SH kepel 0,24,commercial 0.17 Pvalue 0.324 alpha 1%. Result (CH3)2 kepel 0.246, commercial 0.238, P-value 0.338 alpha 1%. P-value for H2S , CH3SH and (CH3)2S above alpha 1% . Conclusion : Anti bacterial ability of commercial mouthwash better than kepel's, thougt both kepel and commercial mouthwash had almost same resulted in reducting levels H2S , CH3SH and (CH3)2S.