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"ABSTRAKPenelitian ini bertujuan untuk mengetahui perbedaan perubahan kadarmalondialdehida plasma pada perawat dan pegawai administrasi yang telahbekerja selama 7 jam berturut-turut dan mendapatkan modifikasi makanan berupamakanan dengan kandungan makronutrien sebesar 65% dari kebutuhan sehari danasupan mikronutrien antioksidan (β-karoten, vitamin C, vitamin E, Cu, Zn, danSe) sebesar 65% dari AKG/DRI. Penelitian ini merupakan suatu penelitianpotong lintang berulang dengan rentang jangka waktu pemeriksaan pertamadengan pemeriksaan kedua adalah satu shift kerja (7 jam). Pengambilan datadilakukan di RSUD Tarakan, Jakarta pada bulan Januari sampai Februari 2013.Sebanyak 39 orang subyek bersedia ikut serta dalam penelitian ini dan sebanyak31 orang subyek (15 perawat dan 16 pegawai administrasi) memenuhi kriteriapenelitian. Data yang dikumpulkan meliputi karakteristik demografi, dataantropometri (berat badan dan tinggi badan), pola asupan makronutrien danmikronutrien antioksidan, serta pemeriksaan kadar malondialdehida plasma.Rerata persentase asupan lemak terhadap energi pada kelompok perawat (37 +5,79 %) dan kelompok pegawai administrasi (36,57 + 6,72 %) melebihi asupanlemak total yang dianjurkan. Sebesar 42,86% subyek pada kelompok perawat danpegawai administrasi memiliki asupan β-karoten yang kurang berdasarkan DRI,14,29% subyek pada kelompok perawat dan 35,71% subyek pada kelompokpegawai administrasi memiliki asupan vitamin C yang kurang berdasarkan AKG.Sebagian besar subyek pada kedua kelompok memiliki asupan vitamin E, Cu, Zndan Se yang kurang dibandingkan AKG/DRI. Terdapat peningkatan bermaknakadar MDA plasma kelompok perawat setelah bekerja dan mendapatkan asupanmakanan (p = 0,001) tetapi tidak pada kelompok pegawai administrasi (p =0,063). Tidak terdapat perbedaan bermakna antara rerata perubahan kadar MDAplasma sebelum dan setelah bekerja serta mendapatkan asupan makanan padakelompok perawat dan pegawai administrasi. Dari penelitian ini dapatdisimpulkan bahwa terdapat peningkatan bermakna kadar MDA plasma setelahbekerja dan mendapatkan asupan makanan pada kelompok perawat yangmenunjukkan peningkatan kerusakan oksidatif setelah bekerja.

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ABSTRACTThe aim of study is to find out the differences of plasma malondialdehydeconcentration in nurses and administrative workers after 7 hours of work and hadmeal modifications which contain 65% of total daily needs macronutrient and65% of AKG/DRI antioxidant (β-carotene, vitamin C, vitamin E, Cu, Zn, and Se).This is a repeated cross-sectional study. The range from first examination tosecond examination is one work shift (7 hours). The data were obtained inTarakan District General Hospital, Jakarta from January to February 2013. Outof 39 people whom signed the consents, 31 people matched the study criteria. Thedata taken in this study include demographic characteristic, anthropometric(weight and height), assessment of macronutrient and antioxidant micronutrientintake, and plasma malondialdehyde. The mean of percentage fat intake perenergy in nurses group were 37 + 5,79 % and in administrative workers groupwere 36,57 + 6,72 %, both of them exceed the recommendation of fat intake. Asmuch as 42,86% subjects in both group had a low β-carotene intake according toDRI, 14,29% subjects in nurses group and 35,71% in administrative workersgroup had a low vitamin C intake according to AKG. Most subjects in both grouphad a low vitamin C, Cu, Zn, and Se intake according to AKG/DRI. There was asignificant increase of plasma MDA concentration after work and mealmodification within nurses group (p = 0,001), but not on administrative workers?(p = 0,063). There were no significant increases of plasma MDA concentrationafter work and meal modification between nurses group and administrativeworkers group. The conclusion of this study is there was a significant increase ofplasma MDA concentration after work and had meal modification within nursesgroup, which implicates an increase of oxidative damage after work."

"Uji klinis paralel alokasi acak tersamar ganda ini bertujuan untuk mengetahui pengaruh pemberian kreatin monohidrat sebesar 20 gram/hari selama 7 hari berturut-turut terhadap kadar malondialdehida (MDA) plasma pasca latihan lari sprint pada atlet laki-laki lari jarak pendek (100 dan 200 meter), usia 18-25 tahun. Sejumlah 20 subyek dipilih dan dibagi menjadi dua kelompok dengan randomisasi blok, 10 subyek kelompok perlakuan (KP) dan 10 subyek kelompok kontrol (KK). Subyek KP mendapat kreatin monohidrat 20 gram/hari + maltodekstrin 50 gram/hari, sedangkan subyek KK mendapat maltodekstrin 50 gram/hari. Data yang diambil meliputi usia, indeks massa tubuh (IMT), massa lemak (ML), massa bebas lemak (MBL), cairan tubuh total (CTT), asupan energi, karbohidrat, protein, kreatin, karotenoid, vitamin C, vitamin E, dan kadar MDA plasma. Pemeriksaan kadar MDA plasma dilakukan sebelum dan setelah periode perlakuan. Analisis data menggunakan uji t tidak berpasangan dan uji Mann-Whitney dengan batas kemaknaan 5%. Analisis lengkap dilakukan pada 20 subyek yaitu 10 subyek KP [usia 18,50 (18,00-19,00 tahun)] dan 10 subyek KK [usia 18,00 (18,00-24,00 tahun)]. Kadar MDA plasma sebelum perlakuan pada KP dan KK adalah 0,32 ± 0,11 μM dan 0,33 ± 0,10 μM (p = 0,95). Kadar MDA plasma setelah perlakuan lebih rendah pada KP dibandingkan KK, yaitu KP 0,32 ± 0,11 μM dan KK 0,34 ± 0,13 μM (p = 0,66). Perbedaan perubahan kadar MDA plasma pada KP 0,00 ± 0,16 μM dan KK 0,01 ± 0,17 μM (p = 0,83). Tidak terdapat perbedaan signifikan perubahan kadar MDA plasma setelah pemberian kreatin monohidrat 20 gram/hari pada KP dibandingkan KK. Penelitian ini belum dapat membuktikan pengaruh pemberian kreatin monohidrat 20 gram/hari selama 7 hari berturut-turut dalam menurunkan kadar MDA plasma pasca latihan lari sprint pada atlet laki-laki lari jarak pendek.

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This parallel double-blind randomized clinical trial aims to investigate the effect of 20 gram/day creatine monohydrate supplementation for 7 days on plasma malondialdehyde (MDA) level after sprint running in male short-distance runner (100 and 200 meter) aged 18-25 years. A total of 20 subjects were selected and randomly allocated to one of two groups using block randomization, 10 subjects for treatment group (TG) and 10 subjects for control group (CG). The TG received 20 gram/day creatine monohydrate + maltodextrin 50 gram/day, and the CG received 50 gram/day maltodextrin. Data were collected in this study included age, body mass index (BMI), fat mass (FM), fat free mass (FFM), total body water (TBW), intake of energy, carbohydrate, protein, creatine, carotenoid, vitamin C, vitamin E, and plasma MDA level. Assessment of plasma MDA level was carried out before and after supplementation.

Statistical analyses included independent t-test and Mann-Whitney test with significance level was 5%. Twenty subjects completed this study, 10 subjects in TG [aged 18.50 (18.00-19.00) years] and 10 subjects in CG [aged 18.00 (18.00-24.00) years]. Plasma MDA levels before treatment were 0.32 ± 0.11 μM for TG and 0.33 ± 0.10 μM for CG (p = 0.95), respectively plasma MDA levels after treatment for TG was lower than CG; 0.32 ± 0.11 μM and 0.34 ± 0.13 μM (p = 0.66). The difference of plasma MDA level for TG was 0.00 ± 0.16 μM and CG was 0.01 ± 0.17 μM (p = 0.83). No statistically significant difference was found after 20 gram/day creatine monohydrate supplementation between 2 groups. This study has not proven yet the effect of 20 gram/day creatine monohydrate for 7 days in decreasing plasma MDA level after sprint running in male short-distance runner."

"Mengelahui efek pemberian suplementasi vitamin C dan E terhadap kadarmalondialdehida plasma pada perokok kretek filter selama empat minggu di Jakarta.Penelitian ini merupakan uji klinis paralel, acalg tersamar tunggal antara kelompokyang inendapat suplementasi vitamin C dan E (P) dengan kelompok yang mendapatplasebo (K). Sebanyak 40 orang perokok kretek filterr di rumah makan, Jakarta Utaramemenuhi ln-iteria dan diikutkan dalam penelitian Dilakukan randomisasi blolc untukmenentukan kclompok perlakuan dan kontrol. Kelompok perlakuan mendapatkansuplementasi vitamin C 500 mg dan E 400 IU/hari selama empat minggu, dankclompok kontrol mendapat plasebo. Data yang dikumpulkan meliputi data demograti(usia, konsumsi rokok, indeks Brinkman, tekanan dan lg kadar glukosa darah puasa,kadar kolesterol tétal), IMT, analisis asupan zat gizi, kadar malondialdehida plasma.Analisis data menggunakan uji t tidak berpasangan atau uji Mann Whimsy denganbatas kemaknaan p <0,05.Karakteristik demografi subyek pada awal penelitian meliputi usia, konsumsi rokok,indeks Brinkman, tel-canan damh, Radar glukosa darah puasa, kadar kolesterol total,IMT , analisis asupan zat gizi, kadar malondialdchida plasma antara kelompokperlakuan dan kontrol homogen. Rerata kadar MDA plasma awal pada kelompokperlakuan dan pada kelompok kontrol 1,39i0,19 vs 1,34=b=0,09 nmol/mL. Pada akhirperlakuan, rerata kadar MDA plasma sabesar 1,18=l=0,22 pada kelompok perlakuan dan1,3 1=k0,13 nmol/mL kelompok kontrol, berbeda bermakna (p <0,03‘7).Setelah suplementasi vitamin C 500 mg dan E 400 IU/hari selama empat minggutcrdapat perbedaan bermakna renta kadar MDA plasma antara kedua kelompok.

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AbstractTo investigate the effects of vitamin C and E supplementation on plasmamalondialdehycle in clove cigarettes smokers during four weeks in JakartaThis is a parallel randomized single-blind clinical study between interventionalgroup with vitamin C and E supplementation (P) and control group with hasplacebo (K). Forty clove cigarettes smokers in Rmtaurant, Jakarta had fulfilledthe criteria and recruited in the research. Subjects were allocated by blockrandomization into intervention and control group. Intervention group treatedwith vitamin C 500 mg and vitamin E 400 IU daily for 4 weeks, while controlgroup treated with placebo. Data collection includes demographic characteristic(age, smoking habits, Brinkman index, blood pressure, blood glucose, totalcholesterol), body mass index (BMI), daily nutrient analysis, plasma MDA.Statistical analysis using unpairod t-test or Mann Whitney test with significantlevel at p < 0,05.Demographic characteristic (age, smoking habits, Brinlcman index, bloodpressure, blood glucose, total cholesterol), body mass index (BMI), dailynutrient analysis, plasma MDA between both groups were homogen. Initialplasma MDA in the intervention group. and control were l,39=|=0,l9 vsl,34=l=0,09 nmol/tnL. After intervention plasma MDA were l,l8=k0,22 in theintervention group and 1,3l£),13 nmol/mL in control group (p <0,03'7).After supplementation of vitamin C 500 mg/day and vitamin E 400 IU/dayduring 4 weeks, showed significantly differences average of plasma MDAbetween two groups."