Hasil Pencarian  ::  Simpan CSV :: Kembali

Abstrak :
Latar Belakang: TB hingga saat ini masih termasuk dalam sepuluh besar penyebab kematian di dunia. Dalam penatalaksanaannya terdapat beberapa tantangan seperti infeksi HIV/AIDS, diabetes melitus, dan beban resistensi obat. Berdasarkan Global Tuberculosis Report 2019, di Indonesia terdapat 9.118 kasus TB RO dengan 46% di antaranya memulai pengobatan. Dan pada Global Tuberculosis Report 2020, terdapat kenaikan sekitar 2,345 kasus menjadi 11.463 kasus dengan kenaikkan cakupan memulai pengobatan hanya 2%. Selain itu, munculnya pandemi COVID-19 membuat deteksi, konfirmasi, dan pengobatan TB dan TB MDR menurun. Hal ini dapat meningkatkan risiko lebih jauh beban resistensi obat, khususnya TB MDR. Tujuan: Penelitian ini bertujuan untuk mengetahui faktor-faktor yang berhubungan dengan kasus TB MDR di RSUP Persahabatan tahun 2020. Metode: Penelitian ini merupakan studi analitik observatif dengan data kuantitatif. Sumber data berasal dari data sekunder berupa rekam medik RSUP Persahabatan tahun 2020. Dengan desain studi kasus kontrol, 50 sampel dalam kelompok kasus dan 100 sampel dalam kelompok kontrol dianalisis menggunakan SPSS dengan uji chi square, OR untuk mengetahui derajat hubungan antar variabel, dan p<0,05 sebagai batas kemaknaan. Hasil: Usia ≤30 tahun (OR=0,30; p=0,019) dan kepatuhan minum obat (OR=6,64; p=0,000) memiliki hubungan statistik yang signifikan dengan kasus TB MDR di RSUP Persahabatan tahun 2020. Kesimpulan: Faktor risiko yang berhubungan dengan kasus TB MDR di RSUP Persahabatan tahun 2020 adalah usia dan kepatuhan minum obat. Diperlukan pengawasan lebih di masa pandemi COVID-19 ini terhadap kepatuhan minum obat pada kelompok usia >30 tahun. Serta diperlukan penelitian mengenai hubungan COVID-19 dengan TB MDR. ......Background: Tuberculosis is still one of the top ten diseases causing death globally. Several challenges could not be omitted in TB treatment, for instance HIV/AIDS infection, diabetes mellitus, dan drug resistant burden. According to Global Tuberculosis Report 2019, in Indonesia there were 9,118 drug resistant TB cases which around 46% were on treatment. However, in Global Tuberculosis Report 2020, the case increased about 2,345 cases to 11,463 cases, yet the treatment enrollment only raised about 2%. The emerging of COVID-19 pandemic causing TB and MDR-TB’s notification, confirmation, and treatment decrease significantly. Due to this situation, the burden of drug resistant TB would be uncontrollable and causing more serious damage in the future. Aim: The aim of this study is to identify factors associated with MDR-TB in Persahabatan Hospital year 2020. Methods: This is a quantitative analytic-observational study using secondary data from Persahabatan Hospital’s medical records. With case control as the study design, 50 cases and 100 controls were analyzed with SPSS. Chi square analysis, OR to understand the association degree between variables, and P-Value <0,05 as significance level are used in this study. Result: Age ≤30 years (OR=0,30; p=0,019) and treatment adherence (OR=6,64 p=0,000) have significant statistical association with MDR-TB cases in Persahabatan Hospital year 2020. Conclusion: Age and treatment adherence are the risk factors associated with MDR-TB cases in Persahabatan Hospital year 2020. Further treatment supervision needed in COVID-19 pandemic era among patients age of >30 years. And furthermore, studies about association between COVID-19 and MDR-TB are needed.

Abstrak :
Latar Belakang dan tujuan: Masalah penting dalam pengobatan tuberkulosis multidrug-resistant (TB MDR) yaitu pemberian obat lini kedua jangka panjang yang erat kaitannya dengan nefrotoksisitas. Tujuan penelitian ini untuk mengetahui prevalens acute kidney injury yang terjadi pada pasien yang mendapatkan paduan obat antituberkulosis MDR lini kedua serta faktor-faktor yang mempengaruhinya. Metode: Penelitian ini merupakan penelitian kohort retrospektif dengan berbasis data rekam medis pasien TB MDR di poliklinik MDR dan ruangan rawat inap TB MDR RSUP Persahabatan yang mendapat paduan standar fase awal OAT MDR lini kedua. Pengambilan sampel dilakukan secara total sampling dalam kurun waktu Januari 2015 sampai dengan Desember 2015. Hasil: Pada penelitian ini yang memenuhi kriteria inklusi sebesar 123 pasien TB MDR. Prevalens AKI didapatkan pada 64 subjek (52%) dengan tingkat keparahan AKI terdiri 39 subjek (31,7%) dengan AKI ringan, 17 subjek (13,8%) dengan AKI sedang dan 8 subjek (6,5%) dengan AKI berat. Waktu terjadinya AKI terbanyak pada bulan kedua. Prevalens AKI lebih banyak ditemukan pada usia>40 tahun (66,7%) dibandingkan dengan usia <40 tahun (40,6%), komorbid diabetes melitus (71,9%) dibandingkan dengan tanpa komorbid DM (45,1%) dengan OR 2,45 (IK 95% 0,90-6,70) dan pada penggunaan Kapreomisin (76%) dibandingkan dengan Kanamisin (35,7%) dengan OR 5,45 (IK 95% 2,34-12,67). Hasil ini bermakna secara statistik dengan nilai p<0,05. Faktor jenis kelamin, status merokok, indeks brinkman, indeks massa tubuh (IMT), status human immunodeficiency virus (HIV), penggunaan Etambutol, hipotiroid tidak bermakna secara statistik. Kesimpulan: Usia >40 tahun, komorbid DM dan penggunaan Kapreomisin merupakan faktor risiko terjadinya acute kidney injury pada pasien TB MDR yang medapatkan OAT lini kedua pada fase awal pengobatan MDR.

---

Background: An important problem in multidrug resistant tuberculosis (MDR TB) treatment is the second line tuberculosis drug therapy related to nephrotoxicity given in a long term. The aim of this study was to investigate the prevalence of acute kidney injury that occured in multidrug resistant tuberculosis patients who received second line tuberculosis drug therapy and the contributing factors in Persahabatan Hospital. Method: This is a retrospective cohort study based on medical record data of multidrug resistant tuberculosis patients who received standard regimen of multidrug resistent tuberculosis program at MDR Clinic and inward MDR patients in the intensive phase of second line anti tuberculosis drug. Sampling was conducted from January 2015 until December 2015. Results: Sample of this study was 123 patients multidrug resistant tuberculosis. Prevalence of AKI was obtained from 64 subjects (52%) based on its severity, consisting 39 subjects (31,7%) with mild severity, 17 subjects (13,8%) with moderate severity, and 8 subjects (6,5%) with high severity. The most occurrence of AKI was found in second month. Prevalence AKI was higher in patients with age >40 years (66,7%) than those with age <40 years (40,6%), higher in patients with diabetes melitus comorbid (71,9%) than those without comorbid DM (45,1%) with OR 2,45 (IK 95% 0,90-6,70) and higher in patients receiving Kapreomisin (76%) than those receiving Kanamisin (35,7%) with OR 5,45 (CI 95% 2,34-12,67). These result were statistically significant with p<0,05. Gender, smoking status, index brinkman, body mass index (BMI), human immunodeficiency virus (HIV) status, treatment with Etambutol, and hypothyroidism were not statiscally significant. Conclusion: Age >40 years, DM and using Kapreomycin are risk factors for acute kidney injury in MDR TB patients whose received second line tuberulosis drugs in intensive phase.

Abstrak :

Latar belakang: Resistensi antibiotik merupakan masalah penting dan ancaman bagi kesehatan manusia di hampir seluruh negara. Dampak infeksi bakteri multidrug-resistant (MDR) berupa luaran pasien lebih buruk, biaya perawatan lebih besar, dan penggunaan antibiotik spektrum luas yang berpotensi meningkatkan prevalensi resistensi. Surveilans healthcare-associated infection (HAI) dan identifikasi faktor risiko diharapkan bisa menurunkan laju resistensi.

Tujuan: Menilai kekuatan pengaruh dari komorbiditas, riwayat pengobatan dengan antibiotik intravena 15 hari terakhir, tindakan bedah, penggunaan lebih dari 2 indwelling medical device, dan rawat inap lebih dari 7 hari terhadap terjadinya infeksi bakteri MDR pada pasien anak.

Metode: Penelitian retrospektif di Rumah Sakit Cipto Mangunkusumo Jakarta terhadap pasien berusia 1 bulan-18 tahun dengan pertumbuhan bakteri pada hasil kultur. Data diperoleh dari electronic health record yaitu data demografi, komorbid, riwayat terapi antibiotik, tindakan bedah, medical device, lama rawat inap, data mikrobiologi, dan luaran akhir perawatan.

Hasil: Proporsi bakteri MDR pada penelitian ini sebesar 76,3%. Analisis bivariat tidak menunjukkan adanya hubungan antara komorbiditas, riwayat terapi antibiotik, tindakan bedah, dan penggunaan lebih dari 2 indwelling medical device, dengan infeksi bakteri MDR pada pasien anak. Namun rawat inap lebih dari 7 hari akan meningkatkan risiko pasien anak mengalami infeksi bakteri MDR (OR 2,755; 95% IK 1,107-6,857; P = 0,036).

Simpulan: Pasien anak dengan rawat inap lebih dari 7 hari memiliki risiko hampir 2,7 kali lipat untuk mengalami infeksi bakteri MDR dibanding pasien anak dengan rawat inap 7 hari atau kurang.

---

Background: Antibiotic resistance is an important problem and threats to human health worldwide. Multidrug-resistant (MDR) bacteria infection is associated with poor outcome, higher treatment cost, and higher rate of broad spectrum antibiotic use which may lead to subsequent antibiotic resistance. Healthcare-associated infection surveillance and identification of risk factors can provide effort to control the development of antibiotic resistance.

Objective: Measure the strength of association between comorbidity, intravenous antibiotic use within the last 15 days, surgery procedure, use of more than two indwelling medical devices, and hospital stay more than 7 days, with MDR bacteria infection in pediatric patient.

Methods: Restrospective study in 1 month - 18 years old pediatric patient at Cipto Mangunkusumo Hospital Jakarta who had bacteria growth on microbiological culture. Demographic data, comorbid condition, history of antibiotic use, surgery, indwelling medical device use, length of hospital stay, microbiological data, and mortality were collected from the electronic health record.

Results: Rate of MDR bacteria infection in this study was 76,3%. Bivariate analysis showed no relationships between comorbidity, intravenous antibiotic use in prior 15 days, surgery, and use of more than two indwelling medical devices, with MDR bacteria infection. Pediatric patients with hospital stay longer than 7 days were more likely to have MDR bacteria infection (OR 2,755; CI 95% 1,107-6,857; P = 0,036) compared to those with hospital stay 7 days or less.

Conclusion: Hospital stay longer than 7 days increase risk pediatric patient to contract MDR bacteria infection by 2,7 fold.

Abstrak :
Latar Belakang: Penegakkan diagnosis sedini dan setepat mungkin menjadi hal utama dalam penatalaksanaan kanker paru. Beberapa penelitian sebelumnya tentang biopsi transtorakal dengan panduan USG menunjukkan akurasi diagnosis yang cukup baik. USG dinilai sebagai modalitas radiologi yang mudah digunakan secara aman, bedside, real-time, mobile dan bebas pajanan radiasi. Saat ini di RSUP Persahabatan Jakarta belum terdapat penelitian tentang biopsi jarum halus transtorakal dengan panduan USG. Metode Penelitian:  Studi observasional dengan pendekatan potong lintang terhadap subjek dengan tumor paru atau tumor mediastinum yang dilakukan biopsi jarum halus transtorakal dengan panduan ultrasononografi toraks pada bulan April-September 2021. Pengambilan sampel dilakukan secara consecutive sampling. Peneliti melakukan observasi terhadap karakteristik lesi, karakteristik prosedur dan komplikasi. Diagnosis akhir berdasarkan hasil sitologi biopsi jarum halus transtorakal dengan panduan USG. Hasil Penelitian: Dari 46 subjek, rerata usia subjek adalah 52 tahun dan didominasi jenis kelamin laki-laki (69,6%) dan jenis tumor terbanyak adalah tumor paru (80,4%). Proporsi kepositifan sitologi biopsi jarum halus transtorakal dengan panduan USG toraks adalah 78,3%. Karakteristik lesi pada subjek dengan hasil sitologi TTNA positif antara lain memiliki rerata diameter lesi 9,61 ± 2,27 cm, lesi di anterosuperior paru (63,9%), memiliki gambaran ekogenitas hipoekoik heterogen (58,3%) dan memiliki kontak dengan pleura (77,8%). Karakteristik prosedur pada subjek dengan hasil sitologi TTNA positif antara lain dilakukan teknik aspirasi (77,8%), pengambilan TTNA sebanyak < 3 set (58,3%), rerata jumlah gelas objek yang terpakai adalah 15 ± 4 dan median kedalaman insersi adalah 4 (2 – 6) cm. Komplikasi pasca tindakan terjadi pada dua subjek yaitu hemoptisis (4%). Kesimpulan: Biopsi jarum halus transtorakal merupakan metode diagnostik yang invasif minimal dengan proporsi kepositifan yang tinggi (78,3%) dan angka komplikasi yang rendah (4%). ......Background: Treatment of multidrug-resistant tuberculosis (MDR-TB) using second-line drugs is known to have more side effects. Recent studies have shown concern about bedaquiline and delamanid that can cause a prolonged QT interval. This condition is a known risk factor for Torsades de Pointes, a lethal cardiac arrhythmia. This study sought to observe the condition among such patients treated in the study location. Methods: This study was a prospective cohort study  of MDR-TB patients receiving bedaquilin in the outpatient clinic and inpatient ward of National Respiratory Referral Hospital Persahabatan, Jakarta, Indonesia between February 2020 to February 2021. Patients received 400 mg on week 0-2 (intensive phase) and followed by 200 mg 3 times per week (continuation phase) of bedaquiline. Sampling was carried out by consecutive sampling and data on subjects who met the inclusion criteria were taken from medical records. Result: From a total of 71 subjects, all of them met the inclusion criteria. Prolonged QT interval was experienced in 18.3% patients. From eleven patients who experienced prolonged QT interval, two patients required hospitalization: one presented with nausea and gastric upset and one patient presented with dyspnea and palpitation. Prolonged QT interval occurred in initial phase and correlated with drug dosing. A mycobacterial culture conversion at month-6 was observed in those receiving multidrug regimens which include bedaquiline, quinolone, and clofazimine. There was a correlation between prolonged QT interval and hypocalemia. Treatment success rate was 46.5% without prolonged QT. Other outcomes included 4.2% died, 26.8% loss-to-follow up, and 4.1% treatment failed. Conclusion: The use of bedaquiline MDR-TB appeared to be effective and safe across different settings, although the certainty of evidence was assessed as very low. Hypokalemia was correlated with the outcomes of patients receiving bedaquiline, particularly in those experienced prolonged QT interval.

Abstrak :
ABSTRAK
Nama : Enggar PurnaningsihProgram Studi : Magister KeperawatanJudul : Hubungan Efikasi Diri Dan Stigma Dengan Kepatuhan Pasien Multidrug Resistant Tuberculosis Dalam Menjalani Pengobatan Fase Lanjutan Salah satu faktor yang mempengaruhi keberhasilan pengobatan Multidrug Resistant Tuberculosis TB MDR adalah kepatuhan menjalani pengobatan, termasuk pada fase lanjutan. Efikasi diri dan stigma berperan dalam kepatuhan menjalani pengobatan TB MDR fase lanjutan. Tujuan penelitian ini adalah untuk mengetahui hubungan efikasi diri dan stigma dengan kepatuhan pasien TB MDR dalam menjalani pengobatan fase lanjutan. Penelitian ini menggunakan metode kuantitatif analitik dengan pendekatan cross sectional yang melibatkan 80 responden. Hasil penelitian menunjukkan terdapat hubungan positif bermakna antara efikasi diri r = 0.470; p < 0.001 dan stigma r = 0.602; p < 0.001 dengan kepatuhan menjalani pengobatan TB MDR fase lanjutan. Hasil analisis multivariat didapatkan efikasi diri dan stigma menjadi prediktor kepatuhan menjalani pengobatan TB MDR fase lanjutan. setelah dikontrol akses ke fasilitas layanan kesehatan. Perawat dapat meningkatkan kepatuhan pasien TB MDR dalam menjalani pengobatan fase lanjutan dengan meningkatkan efikasi diri, menurunkan stigma dan meningkatkan keterjangkauan akses ke fasilitas layanan kesehatan.Kata kunci : efikasi diri, fase lanjutan, kepatuhan pengobatan, Multidrug Resistant Tuberculosis, stigma

---

ABSTRACT
Name Enggar PurnaningsihStudy Program Master of NursingTitle Correlation between self efficacy, stigma and patient adherence to continuation Multidrug Resistant Tuberculosis treatment phase In the continuation phase of treatment, patient adherence is one contributing factor to achieve a successful treatment in patients with Multidrug Resistant Tuberculosis MDR TB . Self efficacy and stigma have an important role in adherence to continuation MDR TB treatment phase. This study aimed to investigate the correlation between self efficacy, stigma and patient adherence to continuation MDR TB treatment phase. A cross sectional study was conducted with 80 participated patients with MDR TB. The results revealed that there was a positive significant relationship between self efficacy r 0.470 p 0.001 , stigma r 0.602 p 0.001 and patient adherence to continuation MDR TB treatment phase. Additionally, multivariate analysis showed that self efficacy and stigma were the predictor of patient adherence, in which patients were controlled to access healthcare facilities. This study results indicate that nurses can improve patient adherence to continuation MDR TB treatment phase by increasing self efficacy reducing stigma and improving access to healthcare facilities.Keywords adherence, continuation treatment phase, Multidrug Resistant Tuberculosis, self efficacy, stigma

Abstrak :
ABSTRAK
Tuberculosis TB masih menjadi salah satu masalah utama kesehatan di dunia. Masalah penyakit TB menjadi lebih rumit karena munculnya penyakit Multidrug Resistant Tuberculosis MDR-TB . Masalah kontrol optimal pada pengontrolan penyebaran penyakit TB dan MDR-TB dilakukan dengan memberikan intervensi berupa pemberian vaksin BCG u1 , pengobatan OAT lini pertama u2 , dan pengobatan OAT lini kedua u3 . Tujuan dari masalah kontrol optimal pada skripsi ini adalah untuk meminimalkan jumlah individu terinfeksi sekaligus meminimalkan biaya dari setiap intervensi kesehatan yang diberikan. Kontrol optimal diperoleh dengan menerapkan prinsip minimum Pontryagin, kemudian diselesaikan secara numerik dengan metode gradient descent. Dilakukan simulasi numerik untuk beberapa skenario. Hasil simulasi numerik menunjukkan bahwa kombinasi dari ketiga intervensi yang diberikan dapat mengurangi jumlah individu terinfeksi serta meminimumkan biaya intervensi yang diberikan pada semua skenario.

---

ABSTRACT
Tuberculosis TB remains one of top world rsquo s health problem. Problem of TB becomes more complicated because of the presence of Multidrug Resistant Tuberculosis MDR TB . Optimal control problem on controlling TB and MDR TB transmission with giving intervention, namely BCG vaccination u1 , treatment with first line anti TB drug u2 , and treatment with second line anti TB drug u3 . Optimal control problem aims to minimize the number of infected individuals also minimize cost of the interventions that given. Optimal control derived using Pontryagin minimum principle and then solved numerically using the gradient descent method. Numerical simulations are performed for some scenarios. The results from numerical simulation show that the combination of the three interventions given can reduce the number of infected individuals and minimize the cost of the interventions given in all of scenarios.

Abstrak :
ABSTRAK
Upaya pengendalian TB-MDR telah dilakukan, namun hasil akhir pengobatan pasien TB-MDR masih menjadi permasalahan terkini yang perlu diselesaikan. Di Indonesia, terjadi penurunan success rate pasien TB RO sejak lima tahun terakhir, yaitu kisaran 68-46, sedangkan hasil pengobatan buruk lebih fluktuatif dan masih tinggi yaitu kisaran 28-47. Penelitian ini menggunakan desain kohort retrospektif yang bertujuan untuk mengetahui gambaran dan faktor yang berhubungan dengan hasil pengobatan pasien TB-MDR di Indonesia. Data yang digunakan adalah data pasien TB-MDR yang berusia 15 tahun yangmemulai pengobatan antara Januari 2013-Desember 2015 dan teregister dalam e-TB Manager. Didapatkan 1.683 kasus dengan 49,7 pasien sembuh, 2,7 lengkap, 14,1 meninggal, 4,4 gagal, dan 29,1 loss to follow up.Analisis bivariat dilakukan untuk mengidentifikasi faktor yang berhubungandenganhasil pengobatan buruk kematian, gagal, atau loss to follow up. Faktor risiko terhadap hasil pengobatan buruk adalah usia 45 tahun RR 1.32; 95 CI 1.20-1.46, resistansi OAT lini 1 RR 34.1; 95 CI 8.24-141.0, resistansi OAT lini 1 lini 2 dan/atau florokuinolon RR 32; 95 CI 7.9-134.0, kavitas paru RR 1.21; 95 CI 1.00-1.44, interval inisiasi pengobatan >30 hari RR 1.11; 95 CI 1.00-1.24, dan tempat tinggal di desa RR 1.15; 95 CI 1.02-1.30. Sedangkan faktor protektor terhadap hasil pengobatan buruk adalah paduan standar RR 0.73; 95 CI 0.59-0.91.

---

ABSTRACT
Efforts to control MDR TB have been done, but treatment outcome of MDR TB patients remains a current issue that needs to be resolved. In Indonesia, success rate was declining in the last five years, from 68 46 , whereas poor treatment results are more fluctuate and still high at 28 47. This cohort retrospective study was conducted to analyze the characteristics and factors influencing treatment outcomes of MDR TB patients in Indonesia. This research was use data from e TB Manager and included all MDR TB patients who were ge 15 years and starting treatment between January 2013 and December 2015. Overall, 1.683 MDR TB patientswere included,49.7 recovered, 2.7 complete treatment, 14.1 died, 4.4 treatment failure, and 29.1 loss to follow up. A bivariate analysis was used to identify risk factors for poor treatment outcomes, which were defined as death, treatment failure, or loss to follow up. The risk factors for poor treatment outcome were age above 45 years RR 1.32, 95 CI 1.20 1.46, patients who are resistant first lines TB drugs RR 34.1 95 CI 8.24 141.0 and first lines TB drugs 2nd lines injection and or fluoroquinolone RR 32 95 CI 7.9 134.0, lung cavity RR 1.21, 95 CI 1.00 1.44, treatment initiation interval 30 days RR 1.11 95 CI 1.00 1.24, and residence in rural areas RR 1.15 95 CI 1.02 1.30. While the protector factor for poor treatment outcome is standardized regimen RR 0.73 95 CI 0.59 0.91.

Abstrak :
Background: multidrug-resistant organisms (MDRO) caused pneumonia has become a crucial case. MDRO infection has been a problem concern to community-acquired pneumonia (CAP). A lot of factors play roles in CAP with MDRO infection. This study aimed to analyze MDRO as the etiology of hospitalized patients with CAP along with its risk factors in Dr. Soetomo Hospital as one of the top referral hospitals in east Indonesia. Methods: this retrospective cohort study was conducted from January 2016 to December 2018. Data were collected from patients' medical records. Automatic Rapid Diagnosis (Phoenix TM) was used as a standard method for culture and susceptibility test. Various risk factors were analyzed for MDRO infection. Results: five most common pathogens in hospitalized patients with CAP were Acinetobacter baumannii 244/1364 (17.9%), Klebsiella pneumoniae 134/1364 (9.8%), Pseudomonas aeruginosa 91/1364 (6.7%), Escherichia coli 58/1364 (4.3%), and Enterobacter cloacae 45/1364 (3.3%). There were 294/1364 (21.5%) MDROs isolated from patients with CAP. MDRO infection was linked to previous hospitalization, malignancy, cardiovascular disease, and structural lung disease with p values of 0.002, <0.001, 0.024, and <0.001, respectively. Conclusion: the incidence of MDRO in CAP is high (21.5%). The risk factors related were previous hospitalization, malignancy, cardiovascular disease, and structural lung disease.

Abstrak :
Kasus multidrug-resistant tuberkulosis (MDR-TB) paru di Indonesia semakin meningkat dan berdasarkan WHO Global Tuberculosis Report 2018, Indonesia merupakan satu dari 20 negara yang memiliki kasus MDR-TB terbanyak di dunia dengan tingkat keberhasilan terapi 47%. Beberapa penelitian didapatkan bahwa pada pasien TB paru terjadi peningkatan kadar malondialdehida (MDA) dan radikal bebas lainnya, selain itu juga terdapat penurunan kadar antioksidan di dalam tubuh, salah satunya adalah vitamin E. Tujuan dari penelitian ini adalah untuk mengetahui hubungan vitamin E serum dengan kualitas hidup yang dimediasi oleh MDA pada penyandang MDR-TB paru. Pada penelitian ini didapatkan 91 penyandang MDR-TB yang masih dalam terapi fase intensive dengan usia di antara18-59 tahun. Dalam penelitian ini akan dinilai kadar vitamin E dan MDA dalam serum, serta kualitas hidup dengan menggunakan kuesioner short form-36 (SF-36). Data didapatkan dari wawancara, rekam medis, pengukuran antropometri, penilaian asupan makanan (food recall 1x24jam dan FFQ semikuantitatif), dan pemeriksaan laboratorium. Analisis variabel mediasi menggunakan metode kausal step menurut Baron dan Kenny. Hasil dari penelitian ini tidak didapatkan korelasi antara kadar vitamin E dengan total skor kualitas hidup, physicall component summary (PCS), dan mental component summary (MCS). Selain itu juga MDA bukan merupakan variabel mediasi antara kadar vitamin E dengan kualitas hidup pada penyandang MDR-TB paru. Hasil lain yang didapat dalam penelitian ini adalah terdapat korelasi positif rendah signifikan antara asupan vitamin E dengan total skor kualitas hidup. Serta terdapat korelasi negatif rendah signifikan antara kadar MDA dengan total skor kualitas hidup, PCS, dan MCS. ......Pulmonary multidrug-resistant tuberculosis (MDR-TB) in Indonesia has increased and WHO Global Tuberculosis Report data in 2018 showed that Indonesia is one of 20 countries with the most common cases of MDR-TB in the world with 47% therapeutic success rate. Several studies conducted in pulmonary TB patients showed an increase in the level of malondialdehyde (MDA) and other free radicals and a decrease in the level of antioxidants in the body, including vitamin E. The purpose of this study is to find out the correlation of serum Vitamin E with quality of life mediated by MDA in pulmonary MDR-TB. This study involved ninety-one MDR-TB patients that were still in the intensive phase treatment process with age ranged from 18 to 59 years old. In this study, we examined the levels of serum vitamin E and MDA, and also quality of life using short form-36 (SF-36) questionnaire. Data were collected from interviews, medical records, anthropometric measurements, dietary assessments (24-hours food recall and semi-quantitative FFQ), and laboratory tests. The mediation variable analysis was tested using the causal step method according to Baron and Kenny. The results of this study didn't find a correlation between vitamin E levels with total quality of life scores, physicall component summary (PCS), and mental component summary (MCS). It was also found that MDA wasn't a mediation variable between vitamin E levels and quality of life in pulmonary MDR-TB patients. Another result obtained from this study was that there were a significant low positive correlation between vitamin E intake and total quality of life scores. There were also a significant low negative correlation between MDA levels and total quality of life scores, PCS and MCS.