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Hasil Pencarian

Ditemukan 2 dokumen yang sesuai dengan query
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Lenny Elita
"Latar belakang : Neuropati perifer merupakan salah satu efek samping kemoterapi yang sering ditemui. Beberapa gejala neuropati perifer berupa rasa nyeri yang hebat, perubahan sensoris dan kelemahan. Gejala tersebut menyebabkan keterbatasan dalam beraktivitas sehari-hari, menyebabkan pengurangan dosis, perubahan protokol kemoterapi atau bahkan penghentian obat kemoterapi tersebut. Sehingga meningkatkan angka morbiditas dan mortalitas pasien dengan keganasan.
Tujuan: Mengetahui insidensi neuropati perifer pada anak yang mendapat kemoterapi dengan obat alkaloid vinka dan/atau platinum serta faktor risikonya.
Metode: Penelitian kohort prospektif pada anak di bagian hematologi onkologi kiara RSCM yang mendapat obat vinkristin dan platinum (sisplatin dan atau karboplatin) dalam pengamatan 12 minggu. Pemeriksaan neuropati perifer dilakukan dengan metode pemeriksaan kecepatan hantar saraf (KHS).
Hasil: Sebanyak 55 subjek diikutkan dalam penelitian ini, Insiden neuropati perifer adalah 50,9%. Faktor risiko yang bermakna pada penelitian ini adalah obat vinkristin (p=0.001), dengan risiko 3 kali lebih tinggi untuk kejadian neuropati perifer. Hasil lain yang bermakna adalah kombinasi kemoterapi (p=0,01) dan dosis kumulatif vinkristin 9 mg/m2 (p=0,027). Usia dan status gizi tidak didapatkan bermakna.
Kesimpulan: Pada penelitian ini faktor risiko yang bermakna dengan neuropati perifer adalah jenis obat kemoterapi (vinkristin), kombinasi obat, dan dosis kumulatif vinkristin 9 mg/m2.

Background: Peripheral neuropathy is one of the frequently encountered side effects of chemotherapy. Symptoms of peripheral neuropathy include severe pain, sensory changes, and weakness that cause limitations in daily activities, leading to dose reduction, changes in chemotherapy protocols, or even discontinuation of the chemotherapy drug. This can increase the morbidity and mortality of patients with malignancy.
Objective: To determine the incidence of peripheral neuropathy in children receiving chemotherapy with vinca alkaloids and/or platinum and the risk factors.
Methods: Prospective cohort study of children in the hematology-oncology department at Kiara RSCM who received vincristine and platinum drugs (cisplatin and/or carboplatin) for 12 weeks of observation. Peripheral neuropathy was assessed using the nerve conduction velocity examination.
Results: A total of 55 subjects were included. The incidence of peripheral neuropathy was 50.9%. A significant risk factor in this study was the type of chemotherapy drug, which is vincristine (p=0.001). Patients who received vincristine had a 3 times higher risk of developing peripheral neuropathy. The combination of chemotherapy (p=0.01) and the cumulative dose of vincristine of 9 mg/m2 (p=0.027) also appears to become significant risk factors. Age and nutritional status were not significant risk factor.
Conclusion: The significant risk factors for peripheral neuropathy were the type of chemotherapy drug (vincristine), drug combination, and the cumulative dose of vincristine of 9 mg/m2.
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Jakarta: Fakultas Kedokteran Universitas Indonesia, 2024
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UI - Tesis Membership  Universitas Indonesia Library
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Reiner Reza Rahardja
"Latar belakang: Pengukuran luas penampang lintang nervus ulnaris menggunakan USG siku pada populasi dewasa normal pada posisi ekstensi dan fleksi telah banyak dilakukan, tetapi belum banyak penelitian yang menyatakan apakah ada perbedaan bermakna antara kedua posisi tersebut. Bila ditemukan perbedaan yang bermakna, maka pengukuran harus memperhatikan posisi siku karena memiliki rerata normal yang berbeda. Selain itu, hingga saat ini belum ada publikasi maupun data mengenai luas penampang lintang nervus ulnaris pada populasi dewasa normal menggunakan USG siku di Indonesia, khususnya pada posisi ekstensi dan fleksi.
Metode: Penelitian ini menggunakan desain deskriptif dan desain potong lintang komparatif dengan data primer. Total sampel 61 nervus ulnaris normal yang dibuktikan dengan pemeriksaan kecepatan hantaran saraf (KHS) dan dilanjutkan dengan pemeriksaan USG pada level terowongan kubital serta 2 cm proksimal dan distalnya, kemudian dilakukan pengukuran luas penampang lintang nervus ulnaris di ketiga level tersebut. Analisis statistik dilakukan dengan uji T 2 kelompok berpasangan, dan perbedaan dianggap bermakna apabila p kurang dari 0,05.
Hasil: Rerata luas penampang lintang nervus ulnaris di level 2 cm proksimal dari terowongan kubital, terowongan kubital, dan 2 cm distalnya secara berurutan pada posisi ekstensi adalah 6,0 ± 0,7 mm2, 6,3 ± 0,9 mm2, dan 5,9 ± 0,7 mm2; pada posisi fleksi juga secara berurutan adalah 5,7 ± 0,8 mm2, 5,2 ± 0,9 mm2, dan 5,7 ± 0,7 mm2. Rerata luas penampang lintang nervus ulnaris pada posisi ekstensi lebih besar secara bermakna (p < 0,001) dibandingkan posisi fleksi di ketiga level tersebut pada populasi dewasa normal.
Kesimpulan: Rerata luas penampang lintang nervus ulnaris di siku pada posisi ekstensi lebih besar secara bermakna dibandingkan posisi fleksi, sehingga posisi siku subjek perlu diperhatikan pada saat pengukuran karena masing-masing posisi memiliki nilai normal yang berbeda signifikan.

Background: There are many cross sectional area measurement of ulnar nerve ultrasound of the elbow in extended and flexed position the normal adult population that have been done, but but not many studies have stated whether there are significant differences between the two positions. If significant differences are found, then the measurement must pay attention to the elbow position because it has a different normal mean value. In addition, until now there has been no publication or data on the cross-sectional area of the ulnar nerve in the normal adult population using elbow ultrasound in Indonesia, especially in the position of extension and flexion.
Methods: This study used descriptive design and comparative cross-sectional study design with primary data. A total of 61 normal ulnar nerve samples were proven by nerve conduction velocities examination (NCV) and continued with ultrasound examination at the level of the cubital tunnel and 2 cm proximal and distal, then the cross sectional area of the ulnar nerve at all three levels were measured. Statistical analyses were performed using paired sample t test, and the difference was considered significant if p was less than 0.05.
Results: The mean cross sectional area of the ulnar nerve at the level of 2 cm proximal to the cubital tunnel, cubital tunnel, and distal distal 2 cm in the extension position were 6.0 ± 0.7 mm2, 6.3 ± 0.9 mm2, and 5.9 ± 0.7 mm2, respectively; in the flexion position, they were 5.7 ± 0.8 mm2, 5.2 ± 0.9 mm2, and 5.7 ± 0.7 mm2, respectively as well. The mean cross sectional area of the ulnar nerve in the extension position was significantly greater (p <0.001) than the flexion position at all three levels in the normal adult population.
Conclusion: The mean cross sectional area of the ulnar nerve at the elbow at the extension position was significantly greater than the flexion position, so the elbow position of the subject needs to be considered at the time of measurement because each position has a significantly different normal value.
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Jakarta: Fakultas Kedokteran Universitas Indonesia, 2020
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UI - Tugas Akhir  Universitas Indonesia Library