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"Obat LS adalah obat golongan inhibitor HMG CoA reduktase (statin) yang dapat digunakan sebagai antihiperlipidemia. Penggunaan obat LS dimungkinkan dalam jangka panjang, maka perlu dilihat keamanan penggunaannya, salah satunya terhadap organ ginjal. Tujuan penelitian ini adalah untuk mengetahui pengaruh pemberian obat LS per oral dengan dosis 0,9 mg/200 g BB, 1,8 mg/200 g BB, 3,6 mg/200 g BB selama 60 hari terhadap fungsi ginjal ditinjau dari kadar urea dan kreatinin plasma. Berdasarkan hasil penelitian diperoleh kadar rata-rata urea plasma tikus jantan dosis I, dosis II, dosis III dan kelompok kontrol adalah 27.95 ± 1.80, 29.70 ± 3.35, 32.44 ± 4.40, 30.54 ± 4.73 mg/dl. Kadar rata-rata urea plasma tikus betina dosis I, dosis II, dosis III dan kelompok kontrol adalah 35.44 ± 4.24, 36.99 ± 4.19, 40.87 ± 3.58, dan 39.08 ± 5.17 mg/dl. Kadar kreatinin plasma tikus jantan dosis I, dosis II, dosis III dan kelompok kontrol adalah 0.55 ± 0.12, 0.60 ± 0.15, 0.73 ± 0.14, 0.63 ± 0.16 mg/dl. Kadar kreatinin plasma tikus betina dosis I, dosis II, dosis III dan kelompok kontrol adalah 0.45 ± 0.11 mg/dl, 0.56 ± 0.12, 0.63 ± 0.14 mg/dl dan 0.61 ± 0.14 mg/dl. Hasil uji dengan ANAVA (=0,05), menunjukkan tidak ada perbedaan bermakna antara kelompok dosis dengan kontrol, sehingga dapat disimpulkan penggunaan obat LS selama 60 hari tidak mempengaruhi fungsi ginjal.

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LS drug is one of HMG CoA reductase inhibitor (statin) that can be used as lowering cholesterol drug. As like as others statin, there is possibility of using LS drug for long period, so it is important to examinate it's use safety level. One of organ that has to be evaluate is kidney, This experiment were designed to identify the impact of consuming LS drug on rat's kidney function for 60 days in dosage 0,9 mg/200 g body weight, 1,8 mg/200 g body weight, 3,6 mg/200 g body weight in two parameter, urea and creatinin. The average result of male urea plasma level, dosage I, dosage II, dosage III and control group are 27.95 ± 1.80, 29.70 ± 3.35, 32.44 ± 4.40, and 30.54 ± 4.73 mg/dl. The average of female urea plasma level, dosage I, dosage II, dosage III and control group are 35.44 ± 4.24, 36.99 ± 4.19, 40.87 ± 3.58, and 39.08 ± 5.17 mg/dl. The average of male creatinin plasma, dosage I, dosage II, dosage III and control group are 0.55 ± 0.12, 0.60 ± 0.15, 0.73 ± 0.14, and 0.63 ± 0.16 mg/dl. The average of female creatinin plasma, dosage I, dosage II, dosage III and control group are 0.45 ± 0.11 mg/dl, 0.56 ± 0.12, 0.63 ± 0.14 mg/dl and 0.61 ± 0.14 mg/dl. ANAVA statistical analysis evaluated that there was no significant differences at the level urea and creatinin between normal and doses group. It is concluded that, the usage of LS drug for 60 days, does not have significant effect to rat's kidney function."

"LS drug is a synthetic of statin group that has been used as an antihyperlipidemia. The LS drug has been used long-term repeated administration must be assessing especially for liver function of rat through alanine aminotransferase (ALT) activity plasma and histological structure. This study used Sprague Dawley rats that is divided into 4 groups, each one consist of 10 male and female rats. Group I, II, III were given statin with 1,8; 3,6; 7,2mg/ 200g bw dosage as a study groups, while group IV was given CMC 0,5% orally as a control group. The studies have been finished for 90 days and 91st day, the blood samples were taken from orbital sinus of eye, and the liver was taken to observe its histology. The ALT plasma activities were measured with colorimetric method (Reitman-Frankel) and histological structure were colored by paraffin method and Haematoxylin-Eosin stain by further central vein diameters was measured. One way varian analysis of ALT plasma activities and central vein diameter (α = 0,05) showed that there was no significant differences between studies groups and control group. The result was indicated that given LS drug for 90 days did not have sigificant effect on the liver function.

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Obat LS merupakan obat sintesis golongan statin yang digunakan sebagai antihiperlipidemia. Obat LS digunakan berulang dan dalam jangka panjang sehingga perlu diketahui pengaruhnya terhadap fungsi hati, dengan menilai aktivitas Alanin aminotransferase (ALT) plasma dan gambaran histologi hati. Penelitian menggunakan tikus putih jantan dan betina galur Sprague Dawley yang dibagi ke dalam empat kelompok masing-masing 10 ekor. Kelompok I, II, III adalah kelompok perlakuan yang diberi larutan uji dengan dosis berturut-turut 1,8; 3,6; dan 7,2mg/ 200g bb perhari. Kelompok IV adalah kelompok kontrol yang diberikan larutan CMC 0,5%. Penelitian dilakukan selama 90 hari dan pada hari ke-91 sampel darah tikus diambil melalui sinus orbital mata kemudian dibedah untuk diambil hatinya. Pengukuran aktivitas ALT plasma menggunakan metode kolorimetri (Reitman-Frankel) serta histologi hati dengan metode parafin dan pewarnaan hematoksilin-eosin kemudian dilakukan pengukuran terhadap diameter vena sentralis. Hasil ANAVA (α=0,05) terhadap ALT plasma dan pengukuran diameter vena sentralis tidak menunjukkan perbedaan bermakna antar kelompok perlakuan maupun kelompok kontrol. Hasil menunjukkan bahwa pemberian obat LS selama 90 hari tidak mempengaruhi fungsi hati."