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"Latar belakang : Terpajan pelarut organik merupakan kejadian sehari-hari yang dialami oleh banyak pekerja. Pelarut organik banyak digunakan dalam proses pembuatan alas kaki disektor formal maupun informal. Menurut beberapa penelitian beberapa jenis pelarut organik mempunyai sifat neurotoksik sehingga perlu deteksi gejala-gejala tersebut yang mungkin timbul pada para pekerja. Kuesioner Swedish Q16 adalah kuesioner deteksi dini yang paling sering digunakan untuk penupisan pekerja yang terpajan pelarut organik. Penelitian ini bertujuan untuk mengetahui prevalensi gejala neurotoksik akibat pajanan pelarut organik menggunakan Kuesioner Swedish Q16, serta mengetahui beberapa faktor yang mempengaruhi seperti : umur, pendidikan, masa kerja, status gizi, pemakaian APD, kebiasaan minum alkohol, merokok, cuci tangan, makan minum di tempat kerja dan hasil pemantauan kadar pelarut organik di lingkungan,kerja.Metode : Penelitian ini menggunakan desain penelitian cross-sectional dengan subyek penelitian 138 orang pekerja alas kaki di sektor informal Ciomas Bogor. Pengumpulan data dilakukan dengan menggunakan kuesioner dan pengamatan langsung, sedangkan lingkungan kerja dilakukan dengan pengukuranpersonal sampling dan hasilnya diperiksa menggunakan teknik Gas Chromatography. Gejala neurotoksik dideteksi menggunakan kuesioner Swedish Q16. Pengumpulan data dilakukan pada bulan September-Oktaber 2006. Hasilnya diolah menggunakan program statistik SPSS 11,5.Hasil : Hasil identifikasi lem didapatkan lem kuning mengandung : toluen (45,3%), benzen (5,18%) dan metil etil keton (18,68%), lem putih mengandung : toluen (41,31%), benzen (3,52%) dan aseton (19,24%). Kadar toluen di lingkungan kerja rata-rata 1,12 ppm, tertinggi 2,48 ppm dan terendah 0,33 ppm. Keluhan terbanyak kesemutan (62,3%), sakit kepala (62,3%), mudah Ietih (56,5%). Prevalensi gejala neurotoksik pads subyek penelitian sebesar 55,8%. Pada analisis bivariat faktor umur, masa kerja dan IMT memiliki hubungan bermakna terhadap terjadinya gejala neurotoksik. Setelah dilakukan analisis multivariat didapatkan umur < 28 tahun memiliki risiko 6 kali lipat untuk mengalami gejala neurotoksik. (p = 0,000; OR = 6,235). Penieriksaan finger tapping test dilakukan secara sub sampling pada 53 subyek dan dipemleh basil tidak normal pada tangan kanan 47,2% dan tangan kiri 43,3%.Kesimpulan : Prevalensi gejala neurotoksik pada pekerja industri alas kaki sektor informal , Ciomas , Bogor yang terpajan pelarut organik sebesar 55,8%. Faktor umur berhubungan dengan terjadinya gejala neurotoksik (OR = 6,235 ; p = 0,000).

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Background : Exposured by organic solvent is form of occurrence day by day for many workers. Organic solvent is used in many process on footwear manufacture both formal and informal sector. According to several studies , many organic solvent has neurotoxic char tcterisl it:, so need to early detection for symptoms that influences to workers. The Swedish Q16 is a questionnaire that often use for workers screening from exposured by organic solvent. The goal of this study is to identification of glue, prevalence neurotoxic symptoms cause by organic solvent exposure, with Swedish Q16 Questionnaire, and to know factors of influences as : age, education, working periode, body mass index, using of PPE, drink of alcohol, washing hand, smoking, eat and drink at workplace and organic solvent level in workplace.

Method : The design of this study was cross sectionai,and the total number of sample were 138 footwear workers. Data collecting was conducted to interview, direct monitoring and measuring personal sampling at workplace which checking by Gas Chromatography technique. Neurotoxic symptoms detected by Swedish Q16 Quetionnaire. Data collecting was done on September-October 2006. All data research result processing by Statistic Program SPSS version 11.5.

Result : Identification of glue has result that content of yellow glue are toluene (45,3%), benzene (5,18%) dan metyl etyl ketone (18,68%), white glue content are : toluene (41,31%), benzene (3,52%) dan acetone (19,24%). Degree of toluene at workplace was average 1,12 ppm, and range 2,48 ppm to 0,33 ppm. Highest complaint from subject are : tingling ((62,3%), headache (62,3%), fatigue (56,5%). Study's subject neurotoxic symptoms prevalence was 55,8%. On bivariate analysis, age factor, work periode, body mass index, have related to neurotoxic symptoms outcome. On multivariate analysis be found that age < 28 years have risk six time to experience with neurotoxie symptoms, (p0,000; OR = 6,235). Examination on finger tapping test to be done as sub sampling on 53 subject and the result is unnormally on right hand 47,2% and left hand 43,3%.

Conclutions : Prevalence of neurotoxicity symptoms in informal sector footwear workers at Ciomas Bogor was 55,8%. Age factor was related to the neurotoxic symptoms (OR = 6,235 ; p = 0,000)."

"Latar belakang: Bahan perekat/lem merupakan bahan utama yang digunakan untuk merekatkan bagian-bagian dari sepatu dalam proses industri alas kaki. Pelarut organik yang terkandung di dalam bahan perekat dapat mempengaruhi kesehatan antara lain iritasi mata yang kemudian menjadi konjungtivitis. Penelitian ini dilakukan untuk mengetahui hubungan antara pajanan uap pelarut organik dengan terjadinya konjungtivitis dan keluhan iritasi mata serta faktor-faktor yang berhubungan pada pekerja laki-laki industri alas kaki sektor informal, Kecamatan Ciomas,Bogor.Metode penelitian : Penelitian ini menggunakan disain cross sectional. Data dikumpulkan dengan melakukan wawancara, pengamatan dan pengukuran lingkungan serta pemeriksaan kesehatan mata pekerja. Wawancara digunakan untuk mengumpulkan data mengenai demografi, riwayat penyakit, keluhan pada mata, kebiasaan merokok, sedangkan pengamatan dilakukan untuk mengumpulkan data tentang pemakaian APD saat bekerja, merokok sambil bekerja dan intensitas pajanan. Indentifikasi jenis pelarut organik dilakukan dengan menganalisis kandungan dan proporsi jenis pelarut organik pada kedua jenis bahan perekat kemudian dilakukan penilaian skoring berdasarkan parameter konsentrasi, daya uap dan daya iritasi. Pelarut dengan skor tertinggi dijadikan pajanan utama untuk dilakukan pemeriksaan kadamya di lingkungan kerja. Pemeriksaan mata dilakukan untuk mendiagnosis konjungtivitis berdasarkan gejala dan tanda Minis sedangkan keluhan iritasi mata berdasarkan gejala klinis. Terhadap semua variabel dilakukan uji bivariat menggunakan tes CM square atau Mann-Whitney dan kemudian variabel yang rnempunyai nilai p<0,25 dilakukan uji multivariat menggunakan Regresi Logistic BinaryHasil : Berdasarkan penilaian skoring terhadap konsentrasi, daya uap, daya iritasi masingmasing pelarut organik didapatkan bahwa toluen merupakan pajanan utama. Didapatkan bahwa prevalensi konjungtivitis 10% dan keluhan iritasi mata 21,6 %. Dari hasil analisis mutivariat didapatkan bahwa variabel yang paling berhubungan dengan keluhan iritasi mata adalah intensitas pajanan. Kelompok responder yang terpajan tinggi mempunyai risiko 4,6 kali lebih besar untuk terjadinya keluhan iritasi mata dibandingkan kelompok dengan pajanan rendah (OR=4,6; p=0,004; CI=1,65-12,84)Kesimpulan dan Saran : Hasil penelitian menunjukkan bahwa intensitas pajanan toluen berhubungan dengan terjadinya iritasi mata. Perbaikan sistem dan pola kerja termasuk pelatihan kepada tenaga kerja perlu dilakukan.

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Glue, the main substance in shoes industry, is widely used to assemble shoe parts. Organic solvent contained in glue influence worker's health such as eye irritation/conjunctivitis. The aim of this study was to know the relation between exposure of organic Solvent Fume with Conjunctivitis and Eye Irritation among men workers in shoes industry (informal sector) at Ciomas District, Bogor.

Method

The study design was a cross-sectional study which data was collecteu by using questionnaire, field observation, measurement of workplace environment and eye examination. Interview and their questionnaire were used to collect data about demography, health and smoking habits of the workers. Observations were used to know habitually in their being duties. The identification of organic solvent was done by

analyzing the content of two kinds glues and the/: scoring them based on the solvent concentration, volatility and irritably in the eye. The organic solvent which had the highest

score was chosen to be main exposure in this study. Eye examination was done to diagnose conjunctivitis on the basis of clinical symptoms and signs while eye irritation was determined by clinical symptoms. All variable were bivariate tested by using Chi-square test or Mann-Whitney test. The variables which have p value < 0.25 were included into multivariate analysis by using binary logistic regression.

Result

Based on the assessment of substance concentration, volatility and irritably, it was found that toluene was the main exposure organic solvent. It was found that prevalence of conjunctivitis was 10% and eye irritation was 21.6%. Multivariate analysis shows that the most related variable to the eye irritation was exposure intensity. Workers who were high exposed to toluene have 4.6 times more risk to get eye irritation than those who were low exposed (OR =4.6; p=0.006; CI=1.65-12.8)

Conclusion

This study shows that toluene exposure intensity have a relation with the prevalence of eye irritation. Improving system and activity of work are necessary including training for workers."

"ABSTRAKDalam masa perawatan ortodontik, kejadian lepasnya breket sering terjadi sehinggadiperlukan metode pembersihan yang cepat, efektif dan ekonomis. Hal terpenting adalahkarakter breket yang lepas setelah dibersihkan, kualitas tidak berubah sehingga dapatdipasang kembali. Penelitian ini bertujuan untuk mendapatkan sistem pelarut yang dapatmelepas bahan adesif dari basis breket metal berbasis solvolis tanpa mengubahkarakteristik breket metal dan lebih efektif dibandingkan metode yang umum digunakanyaitu sandblasting dan pembakaran. Penelusuran sistem pelarut melibatkan berbagaijenis pelarut dan faktor pendukungnya: termal, katalis dan surfaktan. Kinerja pelepasanbahan adesif dipantau dengan uji Shear Bond Strength SBS pada gigi Reused dan gigibaru, pengamatan topografi permukaan dan komposisi dengan Scanning ElectronMicroscopy SEM dan Electron Dispersive X-ray Spectroscopy EDAX sertagambaran sisa bahan adesif dengan Modifikasi Adhesive Remnant Index ARI .Spesimen penelitian terdiri atas tujuh puluh breket metal Stainless Steel Mini DynaLock dan seratus gigi Premolar satu dengan adesif Transbond XT. Hasil penelusurandiperoleh sistem pelarut dengan susunan pelarut organik N-Methyl-2-Pyrrolidone,katalis Zn Asetat, surfaktan Triton X-100 dan gelombang mikro. Uji Two Way Anovadari nilai SBS sandblasting, pembakaran dan solvolisis menunjukkan perbedaanbermakna p

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ABSTRACTDuring orthodontic treatment, the bracket loose often occurs so that a fast, effective andeconomical cleaning method is needed. The most important thing is the character of thecleaned bracket, the quality does not change so it can be reinserted. The objective of thisresearch is to find a solvent that can remove adhesive material from base metal bracketwithout changing the metal bracket characteristics and more effective than commonlyused method i.e. sandblasting and burning. The search for a solvent system involvesvarious types of solvents and their supporting factors thermal, catalyst and surfaceagent. The adhesive release was monitored by Shear Bond Strength SBS test onreused tooth and new tooth, surface topography observation and composition withScanning Electron Microscopy SEM and Electron Dispersive X Ray Spectroscopy EDAX as well as an overview of residual adhesive with Modified Adhesive RemnantIndex ARI . The study specimens consisted of seventy metal brackets of Stainless SteelMini Dyna Lock and one hundred first Premolar teeth with Transbond XT adhesives.The result of this research is the solvent system with organic solvent N Methyl 2 Pyrrolidone, catalyst Zn Acetate, surfactant Triton X 100 and microwave. Two wayAnova Test of SBS sandblasting, burning and solvolysis values showed significantdifferences p "

"Latar Belakang. Lebih dari 750 bahan kimia dan beberapa kelompok senyawa kimia termasuk pelarut organik diduga bersifat neurotoksik. Namun pada umumnya bahan kimia tersebut belum pernah dilakukan tes untuk menilai efek neurotoksik yang ditimbulkan. Pelarut organik seperti MEK digunakan secara luas pada industri alas kaki yang pada umumnya bersifat padat karya, sehingga jumlah pekerja yang terpajan juga sangat besar. Pelarut organik dapat mengakibatkan ensefaloti toksik kronik pada pekerja yang terpajan berlebihan. Oleh karena keluhan subyektif mungkin mengindikasikan suatu ensefalopati maka deteksi dini sangatlah penting. Kuesioner Swedish Q16 adalah kuesioner deteksi dini yang paling sering digunakan untuk skrining pekerja yang terpajan pelarut organik. Penelitian ini bertujuan untuk mengetahui prevalensi gejala dini neurotoksik akibat terpajan pelarut organik metil etil keton, serta pengaruh faktor umur, jenis kelamin, pendidikan , masa kerja, status gizi, pemakaian APD, kebiasaan minum alkohol, minum kopi, merokok, kadar pajanan tempat kerja, serta hasil pemantauan biologis terhadap timbutnya gejala dini neurotoksik.Metode. Penelitian ini menggunakan disain penelitian cross-sectional dengan jumlah subyek penelitian 123 orang pekerja pada sebuah kelompok perusahaan sepatu. Pengukuran pajanan dilakukan dengan personal sampling dan pemantauan biologis. Pengumpulan data dilakukan pada bulan Desember 2003 sampai Januari 2004. Hasilnya diolah menggunakan program statistik SPSS 11,5.Hasil dan Kesimpulan. Prevalensi gejala dini neurotoksik pada pekerja yang terpapar pelarut organik metil etil keton sebesar 52%, jika prevalensi didasarkan alas kadar pajanan MEK lingkungan kerja, maka pekerja yang terpajan tinggi prevalensinya sebesar 72,1%, sedangkan yang terpajan rendah 41,3%. Secara statistik yang menunjukkan hubungan bermakna dengan timbulnya gejala dini neurotoksik adalah kadar MEK lingkungan kerja (OR 3,68; p 0,001; 95% CI 1,65 - 8,20), basil pemantauan biologik pads urine (OR 4,17; p 0,000; 95% CI 1,87 - 9,29) dan faktor umur (OR 4,07; p 0,001; 95% CI 1,78 - 9,30).

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The Correlation Between Metil Etil Keton Exposure And Early Symptoms Of Neurotoxicity Among Footwear Factory Workers (Based On Swedish Q16 Questionnaire)Back Ground. More than 750 chemicals and several classes of chemical compound including organic solvent are suspected to be neurotoxic, but majority of chemicals are never been tested for neurotoxic properties. Organic solvent such as MEK are widely use in footwear industry. Footwear manufacturing is a labour intensive industry, as a result large group of workers are exposed. Organic solvent can cause a chronic toxic encephalopathy in overexposed workers. Because subjective complaint may indicate an encephalopathy, early recognition is important. Swedish Q16 questionnaire is the most commonly used for screening workers who are exposed to organic solvent . The aim of the study was to examine the effect of exposure to MEK on the prevalence of complaints. Further objective were to analyse the influences of sex, education, alcohol consumption, smoking habits, caffeinated beverage, nutriotional status, PPE, length of service, MEK concentration, and Bio-monitoring result.

Method. In a cross sectional study, 123 workers with occupational exposure to MEK were interviewed by means of Swedish Q16 questionnaire. Exposure estimation was made by personal sampling and biological monitoring. Data collecting was conducted from December 2003 to January 2004. The statistical analysis was performed with SPSS 11,5 statistical software.

Result and conclusions. Prevalence of workers with early symptoms of neurotoxicity was 52%. Age (OR 4,07; p 0,001; 95% CI 1,78 - 9,30), Exposure level of MEK (OR 3,68; p 0,001; 95% CI 1,65 - 8,20), and result of biomonitoring (OR 4,17; p 0,000; 95% CI 1,87 - 9,29) showed statistical significant influence on the early symptoms of neurotoxicity."

"Latar Belakang : Pekerja di manufaktur sepatu setiap harinya terpajan beragam hazard. Salah satu pajanan adalah pelarut organik. berbagai penelitian melaporkan hubungan yang kuat antara pajanan pelarut organik dengan gangguan fungsi paru obstruksi dan restriksi. Namun belum banyak studi dilakukan untuk mempelajari antara hubungan antara pajanan pelarut organik di manufaktur sepatu dengan faktor-faktor risiko dan gejala klinis gangguan fungsi paru. Metode : Desain potong lintang melibatkan 134 subyek, Cementing n=67 dan stockfit n=67. Pada bagian cementing terpajan pelarut Aseton, bagian stockfit oleh campuran pelarut Aseton dan klorin. Seluruh subyek dilakukan pemeriksaan fungsi paru dengan menggunakan spirometer menilai KVP dan VEP1/KVP. Subyek dilakukan interview untuk mengetahui gejala klinis, riwayat penyakit dahulu dan riwayat pekerjaan. Kadar pelarut organik di kedua tempat diukur. Analisis statistik menggunakan Chi square dengan p0,05. Multivariat menggunakan regresi logistik metode enter. Hasil : Didapatkan 23 orang (17%) mengalami gangguan fungsi paru testriksi. Tidak ada hubungan bermakna antara pejalan pelarut organik, faktor-faktor risiko demografi dan okupasi dengan gejala klinis gangguan fungsi paru restriksi (p>-.05) /disebabkan masa kerja < 10 tahun. Proporsi subyek dengan gejala bronkitis kronik, di cementing 40.3%, stockfit 62.7%. analisis chi-square menegaskan adanya hubungan bermakna. Di bagian cementing, diperoleh hasil berikut, faktor risiko umur (p < 0.015), masa kerja (p < 0.05), dan total kumulatif pajanan p < 0.05). Dan hasil uji regresi logistik didapat bahwa di bagian cementing, masa kerja faktor risiko dominan terhadap gejala bronkitis kronik p. Kesimpulan : Dari studi dapat disimpulkan bahwa pajanan pelarut organik mengakibatkan gejala klinis bronkitis kronik yang berhubungan dengan faktor risiko usia, masa kerja, dan total kumulatif pajanan. Tidak ada hubungan bermakna antara panajan pelarut organik terhadap gangguan fungsi paru. Perlu langkah preventif guna mencegah berkembangnya gejala bronkitis kronik menjadi gangguan fungsi paru. Dilakukan dengan pemakaian alat pelindung diri sesuai dengan pajanan kimia dan pemasangan local exhaust.

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Background : Depending on the kinds of production sites, Shoe factory workers are exposed to many kinds of occupational hazards with one of them being exposure to organic solvent. Organic solvent exposure has been reported to have adverse pulmonary effects including obstructive and restrictive pulmonary diseases. The study aimed to investigate association between organic solvent exposure, risk factor, and clinical symptoms of pulmonary functions impairment among shoe factory workers.

Methods : Cross sectional study group consist of 134 workers in two different production parts i.e cementing n 67 and stockfit n 67. Subjects works in cementing part were exposed to aceton, while in stockfit to a combination of aceton and chlorine. To all subjecs, pulmonary functions testing including measurement of FVC and FEV1 FVC Value were perfomed asking about clinical symptoms and the histories of both their health and work records. Statistic analysis using Chi square p,0,05 and logistic regretion for multivariate.

Result : All of subject, 23 17 suffered from restrictive diseases. However bivariate analysis using chi square did not show significant correlation between organic solvent exposure, demografic risk factors, clinical symptoms and restrictive lung diseases p 0.05. This probably due to the short work duration of the subject 10 years. Despite this observation, it is important to note that the study strongly identified chronic bronchitis symptoms among workers in both cementing 40.3 and in stockfit 62.7. Furthermore chi square analysis showed significant correlation between risk factors and chronic bronchitis symptoms in both places. in cementing, it was observed that age (p < 0.05), work duration (p < 0.05) and total cumulative exposure (p < 0.015) were significantly contributed to the symtoms. Whereas in stockfit, the risk factors were as follows, work duration (p < 0.05) and total cumulative exposure (p < 0.05). Logistic regression analysis showed that in cementing, work duration was observed to be the greatest risk factor to the bronchitis related-symtoms, p < 0.008, OR 12.100 and CI95% (1.92-76.23, whereas in stockfit, total cumulative exposure was associated the most with the symtoms p0.039 OR 6.667 CI95% )1.099-40.434).

Conclusions : The result from the present studi indicate that occupational exposure to organic solvent has significant association with clinical symtoms related to chronic bronchitis. Risk factors sucs as age, work duration, and total cumulative exposure are observed to contribute to the symtoms. However, exposure to organic solben did not significantly caused lung function disorger. Preventions are required to avoid the clinical symtoms develope into pulmonary impairment, such as the use personal protection equipment and local exhaust apparatus."