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"With a new team of authors, Larone’s Medically Important Fungi, Seventh Edition, continues the longstanding tradition of high-quality content to expand your knowledge and support your work in clinical mycology by: Providing detailed descriptions of the major mycoses as viewed in patients’ specimens by direct microscopic examination of stained slides; Offering a logical step-by-step process for identification of cultured organisms, utilizing detailed descriptions, images, pointers on organisms’ similarities and distinctions, and selected references for further information; Covering more than 150 of the fungi most commonly encountered in the clinical mycology laboratory, including new entries for Emergomyces, Metarhizium anisopliae, Rasamsonia argillacea, Rhinocladiella mackenziei, Schizophyllum commune, and Thermothelomyces thermophilus; Presenting details on each organism’s pathogenicity, growth characteristics, relevant biochemical reactions, and microscopic morphology, illustrated with photomicrographs, unique and elegant drawings, and color photos of colony morphology and various test results; Explaining changes in fungal taxonomy and nomenclature that are due to information acquired through molecular taxonomic studies of evolutionary fungal relationships; Providing basic information on molecular diagnostic methods, e.g., nucleic acid amplification and sequencing, MALDI-TOF mass spectrometry, and other commercial platforms Including an extensive section of easy-to-follow lab protocols, a comprehensive list of media and stain procedures, guidance on collection and preparation of patient specimens, and an illustrated glossary. With Larone’s Medically Important Fungi: A Guide to Identification, both novices and experienced professionals in clinical microbiology laboratories can confidently identify commonly encountered fungi"

"Transmisi infeksi protozoa usus dapat diminimalisir melalui memperhatikan pola hidup bersih dengan baik. Pola hidup bersih terdiri dari status sanitasi dasar, kebersihan pribadi, dan kebersihan konsumsi. Penelitian ini dilakukan untuk mengamati hubungan antara pola hidup bersih dan temuan protozoa usus dengan menggunakan desain penelitian potong lintang. Pengambilan data dilakukan pada Juli 2014 terhadap 94 penduduk dewasa sebagai subyek penelitian di DKI Jakarta dan TPA Bantar Gebang. Subyek penelitian dibagi menjadi dua kelompok, status pola hidup bersih yang baik dan pola hidup bersih yang tidak baik. Hasil penelitian didapatkan pada 53 subyek dengan status sanitasi dasar yang baik ditemukan hanya 41,5% temuan protozoa usus positif. Pada 70 subyek dengan kebersihan pribadi yang baik, hanya 48,6% temuan protozoa usus positif. Pada 56 subyek dengan kebersihan konsumsi yang baik, hanya 39,3% temuan protozoa usus positif. Pada penelitian ini, didapatkan p:0,035; 0,409;0,006, berurutan.Rasio prevalensi pada kebersihan konsumsi yang didapatkan yakni 3 (IK 95% 1,4-7,9).

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Transmission of the intestinal protozoan infection can be minimized by focusing on hygienic lifestyle. Hygienic lifestyle consists of basic hygiene, personal hygiene, and food hygiene. This research was made to observe the correlation between hygiene lifestyle and the finding of intestinal protozoan, using cross sectional design. The data collection was held in July 2014 to the 94 adult people as the research subjects in Jakarta and Bantar Gebang landfill. The research subjects were divided into two groups, good hygienic lifestyle and poor hygienic lifestyle.

Result of this research was known that 53 subjects as good basic hygienic, positive finding of intestinal protozoan was only 41,5%. In 70 subjects as good personal hygiene, positive finding of intestinal protozoan was only 48,6%. In 56 subjects as good food hygiene, positive finding of intestinal protozoan was only 39,3%. In this research, p: 0,035; 0,409; 0,006, respectively. Prevalence ratio of food hygiene was 3 (CI 95% 1,4-7,9)."

"Latar Belakang: Patogenitas Corynebacterium pada infeksi difteri, sangat terkait dengan toksin yang dihasilkannya. Indonesia merupakan negara ke dua di dunia yang memiliki kasus difteri terbanyak dengan 1.665 kasus dan 29 kasus kematian di tahun 2018. Toksin difteri dapat dihasilkan oleh 3 spesies penyebab, yaitu C. diphtheriae, C. ulcerans, dan C. pseudotuberculosis yang sulit dibedakan secara mikroskopik dan kultur, sehingga diperlukan deteksi molekuler untuk membedakanya. Karakterisasi C. diphtheriae sebagai spesies penyebab utama, diperlukan untuk mengetahui hubungan kekerabatanya dengan spesies negara lain untuk mencari kemungkinan sumber infeksi. Metode: Sebanyak 108 sampel klinis digunakan dalam penenlitian ini. Teknik kultur dilakukan untuk mendeteksi 3 Corynebacterium patogenik, sedangkan realtime PCR hanya dirancang untuk mendeteksi C. ulcerans dan C. pseudotuberculosis. Pengujian inhibitor, sensitifitas, dan spesifisitas dilakukan pada tahap optimasi. Karakterisasi C. diphtheriae dilakukan dengan metode sekuensing menggunakan gen rpoB parsial pada kultur sampel klinis. Hasil: Limit deteksi real-time PCR untuk C. ulcerans dan C. pseudotuberculosis secara berurutan sebanyak 4,49 dan 1,06 DNA copy number. Uji spesifisitas terhadap 18 mikrorganisme menunjukkan tidak terdapat reaksi silang. Pengujian terhadap 108 sampel klinis memberikan hasil yang sama dengan kultur, tidak ditemukan C. ulcerans dan C. pseudotuberculosis. Pada kultur sampel klinis ditemukan C. diphtheriae sebanyak 10 sampel (9,26%), yang dapat dikelompokkan menjadi 4 clade yaitu clade I, III, IV dan V dengan similaritas 99,2 % sampai 99,7%. Kesimpulan: Kasus suspek difteri dalam studi ini tidak berkaitan dengan infeksi C. ulcerans dan C. pseudotuberculosis, dan hanya positif C. diphtheriae . Hasil karakterisasi gen rpoB pada C. diphtheriae, memperlihatkan hubungan kekerabatan dengan beberapa negara.

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Background: Pathogenicity of Corynebacterium in diphtheria infection is closely related to toxin production. Indonesia is the second highest country in the world that has the most diphtheria cases with 1,665 cases and 29 deaths in 2018. Diphtheria toxin can be produced by 3 species, such as C. diphtheriae, C. ulcerans and C. pseudotuberculosis which are difficult to distinguish microscopically and culture, therefor molecular detection is needed to differentiate them. Characterization of C. diphtheriae as the main causative species, is needed to determine its relationship with other countries to find possible source of infection.

Method: A total of 108 clinical samples were used in this study. Culture techniques were performed to detect 3 pathogenic Corynebacterium and real-time PCR was only designed to detect C. ulcerans and C. pseudotuberculosis. Inhibitor, sensitivity and specificity testing were carried out at the optimization stage. Characterization of C. diphtheriae from culture of clinical samples, was carried out by sequencing method using partial rpoB genes.

Result: The real-time PCR detection limits for C. ulcerans and C. pseudotuberculosis were 4.49 and 1.06 DNA copy number, respectively. Specificity test for 18 microorganism showed no cross reaction. Tested on 108 clinical samples gave the same results as culture, there were not found C. ulcerans and C. pseudotuberculosis. In clinical culture samples found 10 (9.26%) C. diphtheriae, which can be grouped into 4 clades namely clades I, III, IV and V with similarities of 99.2% to 99.7%.

Conclusion: Suspected diphtheria cases in this study were not related to C. ulcerans and C. pseudotuberculosis infections, and were only positive for C. diphtheriae. The results of the rpoB gene characterization test on C. diphtheriae showed a close relationship with several countries.

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"The antimicrobial effects of rhizophora apiculata pyroligneous acid on pathogenic microorganisms were evaluated. Pyroligneous acid (PA) and concentrated pyroligneous acid (CPA) showed parious levels of antimocrobial activity against 14 speciest of microorganisms (10 species of bacteria, 2 species of yeasts and 2 species of fungi) with bacteria, as the most suscaptible miicroorganisms. The bio-active component(s) of PA was isolated using dichloromethane as the extraction solvent (resulted in DCM A) and also an acid - base treatment to DCM A (resulted in DCM B) which was believed to contain all the valuable phenolic compounds in PA . Antimicrobial screening on DCM A and DCM B showed significant activity againts all the microorganisms tested. DCM B was further subjected to MIC/MLC (Minimum Inhibitory Concentration and Minimum Lethal Concentration) and SEM studies. The results showed that bacteria were the most susceptible againts DCM B with MIC/MLC value of 1.6-3. 1/3. 1-6.3 mg ml, while yeasts and fungi shared the same MIC/MLC value of 3.1/6.3 mg ml. The SEM study revealed that in addition of inhibiting the growth of the microorganisms, DCM B also caused severe morphological alterations on the cells of the microorganisms in which it was suggested that cell lysis and death had taken place."

"Tikus liar dan domestikasi mempunyai potensi faktor risiko bagi kesehatanmasyarakat. Mereka dapat membawa mikroorganisme yang dapat ditrans-misi melalui kontak dengan urine maupun feses atau melalui ektoparasityang ada di tubuh mereka. Pada penelitian ini, diamati prevalensi mikro-organisme zoonotik pada tikus yang tertangkap di Pasar Kota KabupatenBanjarnegara. Bakteri Salmonella paratyphi B dan Salmonella paratyphi Cmenunjukkan prevalensi yang paling tinggi (masing-masing 20%). Spesiesbakteri lain yang ditemukan antara lain Salmonella typhimurium, Citroto-bacter, Citrotobacter frendii, Enterotobacter cloacae, Escherichia coli (E.coli) dan Proteus miriabilis. Hasil penelitian ini mengindikasikan bahwa tikusyang berada di pasar dapat berperan sebagai reservoir untuk berbagaibakteri zoonotik seperti Salmonella dan E.coli.Commensal as well as wild rats and mice may present a potential risk topublic health. They may harbour microorganisms that can be transmittedeither through contact with infected rodent urine or faeces, or throughectoparasites. Prevalence of zoonotic microorganism in house rat (Rattustanezumi) was studied in City Market of Banjarnegara Regency. Salmonellaparatyphi B and Salmonella paratyphi C showed the highest prevalence infaecal material of Rattus tanezumi (20%). The other species of bacteriasuch as Salmonella typhimurium, Citrotobacter, Citrotobacter frendii,Enterotobacter cloacae, Eschericia coli (E. coli) and Proteus miriabilis werealso found in this study. These results indicated that house rat may act asreservoir for zoonotic bacteria such as Salmonella and E.coli."

"Toksoplasmosis adalah penyakit yang disebabkan oleh Toxoplasma gondii, penyakit tersebut menyebabkan kelainan kongenital seperti hidrosefalus, katarak, retinitis, retardasi mental, abortus dan pada penderita imunodefisiensi gejala menjadi lebih berat. Karena itu pelt' dilakukan diagnosis dini, supaya dapat di beri pengobatan secepatnya.Penelitian ini bertujuan untuk mengetahui apakah teknik PCR dapat mendeteksi DNA genom Toxoplasma gondii. Teknik ini dilakukan terhadap DNA genom takizoit T gondii, dengan menggunakan primer 5' GGA ACT GCA TCC GTT CAT GAG 3' dan 5' TCT TTA AAG CGT TCG TGG TC 3', dan dilakukan standarisasi terhadap konsentrasi MgCI2 (1.5 dan 2.0 mM), konsentrasi enzim taq polimerase (0.7 unit dan 1.75 unit), konsentrasi DNA cetakan 50, 5, 1, 0.5, 0.1, 0.05, 0.01, 0.005, dan 0.001 ng, dan jumlah siklus (35 siklus dan 55 siklus).Hasil menunjukkan bahwa konsentrasi MgCI2 (1.5 mM), 1.75 unit taq polimerase, konsentrasi DNA cetakan 50, 5, 1, 0.5, 0.1, 0.05, 0.01, 0.005, dan 0.001 ng, dan jumlah siklus 55 memberikan hasil produk PCR berupa pita berukuran 193 pb.Berdasarkan hasil ini dapat disimpulkan bahwa teknik PCR sangat sensitif, yaltu dapat mendeteksi 1 pg DNA Toxoplasma gondii (1 takizoit)."

"Study microbial in the Aceh coastal waters and its vicinity were carried out in the period of August-September2006. The purpose of the study is to monitor the marine and coastal environments related to the bacterial condition in Aceh waters after the tsunami disaster....."

"[ABSTRAKKegiatan PKP Praktek Kerja Profesi yang dilaksanakan di industri farmasi yaitu PT Guardian Pharmatama memiliki tujuan agar mahasiswa dapat memahami penerapan CPOB Cara Pembuatan Obat yang Baik di industri farmasi mengetahui secara garis besar gambaran pekerjaan kefarmasian di industri farmasi dan mendapatkan pengetahuan wawasan serta pengalaman praktis secara langsung dalam penerapan pekerjaan kefarmasian di industri farmasi Penerapan CPOB diperlukan sebagai syarat utama industri farmasi untuk melakukan kegiatan pembuatan obat dan PT Guardian Pharmatama telah menerapkan serta melakukan pelatihan CPOB dengan baik Tugas khusus yang diberikan saat Praktek Kerja Profesi di industri farmasi adalah pembutan prosedur tetap identifikasi bakteri patogen pada bahan baku dan sediaan sirup Tugas khusus ini memiliki tujuan untuk memberikan pengetahuan dan pemahaman mengenai pembuatan prosedur tetap sebelum pemeriksaan dan memahami proses pemeriksaan bakteri patogen yang memiliki dampak terhadap mutu produk

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ABSTRACTThe aim of Apothecary Internship Program in the pharmaceutical industry namely PT Guardian Pharmatama that students can understand the application of GMP Good Manufacturing Practice in the pharmaceutical industry find out the general outline of the job in the pharmaceutical industry and gain knowledge insight and practical experience directly in the application of pharmaceutical jobs in the pharmaceutical industry Implementation of GMP is the main requirement for the pharmaceutical industry and drug manufacturing activities PT Guardian Pharmatama has implemented GMP and training their personel well The Special Assignment that is given during the apothecary intership program in the PT Guardian Pharmatama was to make standard operating procedure or protocol about identification of pathogenic bacteria on raw materials and syrup This special assingnment has the aim to provide knowledge and understanding of the examination procedure and understand the process of examination of pathogenic bacteria that have impact on product quality ;ABSTRACT Name Carmelta Dissa WardhaniNPM 1406525016Study Program ApothecaryTitle Apothecary Internship Program at PT Guardian Pharmatama January ndash February 2015 The aim of Apothecary Internship Program in the pharmaceutical industry namely PT Guardian Pharmatama that students can understand the application of GMP Good Manufacturing Practice in the pharmaceutical industry find out the general outline of the job in the pharmaceutical industry and gain knowledge insight and practical experience directly in the application of pharmaceutical jobs in the pharmaceutical industry Implementation of GMP is the main requirement for the pharmaceutical industry and drug manufacturing activities PT Guardian Pharmatama has implemented GMP and training their personel well The Special Assignment that is given during the apothecary intership program in the PT Guardian Pharmatama was to make standard operating procedure or protocol about identification of pathogenic bacteria on raw materials and syrup This special assingnment has the aim to provide knowledge and understanding of the examination procedure and understand the process of examination of pathogenic bacteria that have impact on product quality , ABSTRACT Name Carmelta Dissa WardhaniNPM 1406525016Study Program ApothecaryTitle Apothecary Internship Program at PT Guardian Pharmatama January ndash February 2015 The aim of Apothecary Internship Program in the pharmaceutical industry namely PT Guardian Pharmatama that students can understand the application of GMP Good Manufacturing Practice in the pharmaceutical industry find out the general outline of the job in the pharmaceutical industry and gain knowledge insight and practical experience directly in the application of pharmaceutical jobs in the pharmaceutical industry Implementation of GMP is the main requirement for the pharmaceutical industry and drug manufacturing activities PT Guardian Pharmatama has implemented GMP and training their personel well The Special Assignment that is given during the apothecary intership program in the PT Guardian Pharmatama was to make standard operating procedure or protocol about identification of pathogenic bacteria on raw materials and syrup This special assingnment has the aim to provide knowledge and understanding of the examination procedure and understand the process of examination of pathogenic bacteria that have impact on product quality ]"

"ABSTRAKNosokomial berasal dari kata Nosos yang berarti penyakit dan kooeo yang berarti merawat. Nosokomion berarti tempat untuk merawat penyakit atau rumah sakit, sehingga nosokomial berarti yang berhubungan dengan rumah sakit dan infeksi nosokomial berarti infeksi yang berasal dari atau terjadi di rumah sakit. Ada 4 macam infeksi nosokomial yang menonjol yaitu infeksi luka operasi (ILO), infeksi saluran kencing (ISK), infeksi saluran napas (ISN) dan bakteremia.Dalam sejarah kedokteran, tercatat kejadian infeksi nosokomial berupa epidemi gangren gas di rumah sakit di Leipzig sekitar tahun 1800, yang menyebabkan ditutupnya rumah sakit.Dalam sejarah penelitian kedokteran tercatat nama Semmelweis (LaForce.F.M 1987) yang mempublikasikan penelitiannya pada tahun 1860 setelah pengamatannya terhadap febris puerperalis sejak tahun 1847. Semmelweis menemukan bahwa angka kematian pada wanita yang melahirkan dengan pertolongan bidan hanya 3% sedangkan angka kematian dari wanita yang melahirkan dengan pertolongan dokter atau mahasiswa kedokteran adalah 10% . Berdasarkan hal itu, dia membuat hipotesis bahwa penyebab tingginya angka kematian itu adalah karena dokter dan mahasiswa yang menolong proses kelahiran, sebelumnya telah melakukan autopsi, dan ini menyebabkan terjadinya kontaminasi yang berasal dari kadaver pada tangan dokter atau mahasiswa dan kontaminasi inilah yang kemudian menjadi penyebab terjadinya febris puerperalis yang menyebabkan kematian itu. Semmelweis kemudian berhasil menurunkan angka kematian dari ibu melahirkan itu dengan menekankan dan mengharuskan para dokter dan mahasiswa kedokteran yang akan menolong melahirkan untuk mencuci tangan mereka dalam larutan kapur chlor sebelum menolong kelahiran bayi. Kemudian Lister (Wilson & Miles 1964, Altemeier 1976, LaForce.F.M. 1987) pada tahun 1874, dengan di pengaruhi penelitian Pasteur mengenai adanya kontaminasi oleh mikroba pada proses fermentasi, menyimpulkan bahwa mikroba itulah yang menyebabkan terjadinya pernanahan (infeksi) pada luka. Infeksi ini dapat dicegah dengan membunuh mikroba pada luka. Berdasarkan hal itu Lister memperkenalkan penggunaan larutan asam karbol untuk mencuci luka fraktur terbuka dan usaha ini ternyata memberikan hasil yang sangat menggembirakan. Sejak Lister mempublikasikan hasil penelitiannya, konsep antisepsis menjadi sangat dikenal dalam bidang ilmu bedah. Sesudah Lister, beberapa ahli bedah Jerman antara lain V.Bergmann dan Schimmelbusch mengajukan konsep cara mematikan kuman dengan mempergunakan panas, sehingga konsep asepsis menjadi terkenal juga dalam bidang ilmu bedah dan kemudian-penggunaan peralatan, pakaian, masker dan sarung tangan yang disterilkan."

"Tujuan: Mengetahui pengaruh mutasi patogenik BRCA1/2 tumor terhadap kesintasan pasien advanced stage-high grade serous epithelial ovarian cancer di RSUPN Dr. Cipto Mangunkusumo, RSUP Persahabatan, dan RS MRCCC Siloam Jakarta.Metode: Sejumlah 68 sampel dari 144 pasien diagnosis high-grade serous epithelial ovarian cancer (HGSOC) stadium FIGO IIB-IV, periode 1 Januari 2015 sampai 31 Maret 2021, di RSUPN Dr. Cipto Mangunkusumo, RSUP Persahabatan, dan RS MRCCC Siloam Jakarta, menjalani pemeriksaan NGS mutasi patogenik BRCA1/2 tumor, dilibatkan dalam penelitian kohort historikal ini. Kami membandingkan karakteristik klinikopatologis pasien, dan hasil luaran kesintasan, setelah pasien menjalani tatalaksana primer, berdasarkan status mutasi patogenik BRCA1/2 tumor. Faktor terkait tatalaksana, yang diperkirakan berpengaruh terhadap hasil luaran kesintasan pasien, juga turut dianalisis dalam penelitian ini.Hasil: Angka kejadian mutasi patogenik BRCA1/2 tumor diketahui sebesar 27,94% (19/68). Antara kelompok mutasi patogenik BRCA1/2 tumor, dengan kelompok tanpa mutasi patogenik, tidak terdapat perbedaan statistik signifikan berdasarkan usia, paritas, indeks massa tubuh (kg/m2), riwayat kanker payudara, stadium FIGO 2014, kadar CA125 serum pre operatif (U/mL), volume cairan ascites intra operatif (mL), lesi residual pasca laparotomi debulking, pemberian neoadjuvant chemotherapy (NACT), pemberian kemoterapi adjuvant. Riwayat kanker keluarga terkait HBOC, merupakan variabel paling berpengaruh terhadap mutasi patogenik BRCA1/2 tumor. Kelompok dengan riwayat kanker keluarga terkait HBOC, berisiko 5,212 kali lebih besar mengalami mutasi patogenik BRCA1/2 tumor, dibandingkan dengan kelompok tanpa riwayat kanker tersebut (RR adjusted 5,212; 95%CI 1,495-18,167; nilai p=0,010).Pada kelompok mutasi patogenik BRCA1/2 tumor, kemungkinan meninggal 86% lebih rendah (RR adjusted 0,149; 95%CI 0,046-0,475; nilai p=0,001), dan median survival yang lebih baik (median 46 bulan; 95%CI 34,009-57,991; nilai p=0,001), apabila dibandingkan dengan kelompok tanpa mutasi patogenik (median 23 bulan; 95%CI 15,657-30,343; nilai p=0,001). Analisis multivariat menunjukkan mutasi patogenik BRCA1/2 tumor merupakan faktor prognostik independen yang baik terhadap hasil luaran kesintasan (RR adjusted 0,149; 95%CI 0,046-0,475; nilai p=0,001).Kesimpulan: Pasien advanced stage-high grade serous epithelial ovarian cancer, dengan mutasi patogenik BRCA1/2 tumor, memiliki kesintasan lebih baik, dibandingkan pasien tanpa mutasi patogenik BRCA1/2 tumor.

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Objective: To evaluate the impact of pathogenic BRCA1/2 tumor mutational status on advanced stage- high grade serous epithelial ovarian cancer survival outcome at RSUPN Dr. Cipto Mangunkusumo, RSUP Persahabatan, and RS MRCCC Siloam Jakarta.

Methods: A total 68 of 144 patients diagnosed with FIGO 2014 stage IIB-IV high grade serous epithelial ovarian cancer (HGSOC) between January 1st, 2015 until March 31st, 2021, at RSUPN Dr. Cipto Mangunkusumo, RSUP Persahabatan, and RS MRCCC Siloam Jakarta, underwent NGS tumor BRCA1/2 gene testing, and were included in this cohort hystorical study. We compared patients clinicopathological characteristics, and survival outcomes after primary treatment, according to pathogenic BRCA1/2 tumor mutational status. Treatment-related factors that might affect patients’ survival outcome were also investigated.

Results: The BRCA1/2 pathogenic tumor mutations prevalence was observed in this study 27.94% (19/68). There were no significant statistical differences in age, parity, body mass index (kg/m2), previous breast cancer history, FIGO 2014 staging, pre-operative serum CA 125 level (U/mL), intra operative ascites volume (mL), post cytoreductive surgery residual lesion, neoadjuvant chemotherapy (NACT), and adjuvant chemotherapy administration, between the pathogenic tumor BRCA1/2 mutation, and no pathogenic tumor BRCA1/2 mutation groups. The hereditary breast ovarian cancer family history (HBOC) variable has the strongest correlation with pathogenic tumor BRCA1/2 mutation. The group with a family history of HBOC-related cancer had a 5.212 times greater risk of developing pathogenic BRCA1/2 tumor mutations, compared with the group without a history of those cancer (RR adjusted 5.212; 95%CI 1.495-18.167; p value=0.010).

The pathogenic BRCA1/2 tumor mutation group displayed better survival outcome. In the pathogenic BRCA1/2 tumor mutation group, the likelihood of dying was 86% lower (RR adjusted 0.149; 95%CI 0.046-0.475; p-value=0.001), and the median survival was better (median 46 months; 95%CI 34.009- 57.991; p value=0.001), than without pathogenic BRCA1/2 tumor mutations group (median 23 months; 95%CI 15.657-30.343; p value=0.001). The multivariate analyses identified pathogenic BRCA1/2 tumor mutation as an independent favorable prognostic factor for survival outcome (RR adjusted 0.149; 95%CI 0.046-0.475; p-value=0.001).

Conclusions: In advanced stage-HGSOC, patients with pathogenic BRCA1/2 tumor mutations have a better prognosis with longer survival outcome than those without pathogenic BRCA1/2 tumor mutations."