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"Budaya keselamatan pasien merupakan pondasi utama dalam pelaksanaan keselamatan pasien. Penelitian ini bertujuan untuk mengetahui pengaruh pemberdayaan champion keselamatan pasien terhadap penerapan budaya keselamatan pasien di Rumah Sakit Haji Jakarta. Metode penelitian ini menggunakan pre-experiment design: pretest-posttest without control group design, sampel yang digunakan 81 perawat. Data analisis dengan menggunakan Mc Nemar. Hasil menunjukkan terdapat peningkatan persentasi penerapan budaya keselamatan pasien setelah program pemberdayaan champion keselamatan pasien dengan pengaruh yang tidak bermakna secara statistik (p= 0,451; CI= 0.084-0.928). Penelitian ini merekomendasikan perlunya pengembangan champion keselamatan pasien dengan memperhatikan kriteria kelayakan sebagai champion keselamatan pasien serta membangun program pemberdayaan champion keselamatan pasien berkelanjutan sesuai kebutuhan rumah sakit. ......The culture of patient safety is the main foundation in the implementation of patient safety. This study aimed to determine the influence of the patient safety champion empowerment on the application of patient safety culture in Jakarta Hajj Hospital. This research method used pre-experimental design: pretest-posttest without control group design, the sample was 81 nurses. Data were analyzed using Mc Nemar test. The results showed there was an increase in the percentage of the implementation of a patient safety culture after the program of patient safety champions empowerment had been implemented, which was not statistically significant (p = 0.451; CI = 0084-0928). It is recommended to develop the patient safety champions by taking into account the eligibility criteria as a patient safety champion and to build a sustainable program of patient safety champion empowerment that suitable to the needs of the hospital."