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ABSTRAKLatar belakang: Konstipasi fungsional kronik adalah masalah yang sering
ditemukan di masyarakat dengan prevalensi sekitar 15-25%. Konstipasi
menimbulkan berbagai gejala, meningkatkan angka kesakitan dan biaya kesehatan.
Saat ini, penggunaan probiotik untuk pengobatan konstipasi kronik pada dewasa
telah diteliti, namun, dari berbagai penelitian yang telah dilakukan hasil yang
diperoleh masih terbatas dan menimbulkan kontroversi.
Tujuan: Untuk menilai manfaat Lactobacillus reuteri dalam memperbaiki skor
konstipasi Agachan, jumlah L. reuteri feses dan pH feses pada pasien konstipasi
fungsional kronik.
Metode: Uji acak tersamar ganda dilakukan pada 40 pasien dewasa (12 laki-laki/
28 perempuan), rerata usia 45,95+/-16 tahun, yang menderita konstipasi fungsional
kronik sesuai kriteria Rome III, selanjutnya dilakukan randomisasi dan diberikan
L.reuteri atau Plasebo selama 4 minggu.
Hasil: Pada minggu ke-4, setelah pemberian L.reuteri terjadi perbaikan gejala
konstipasi, yang dinilai dari penurunan skor konstipasi Agachan dari 17 menjadi 8
dengan p <0.001. Terjadi peningkatan jumlah L.reuteri feses dari 6,80x10
menjadi 2,12x10 8 dengan p <0,001 dan penurunan pH feses dari 5,44 (SB 0,70) menjadi
4,78 (SB 0,56) dengan p <0,001 pada kelompok L.reuteri, sedangkan pada
kelompok Plasebo tidak didapatkan hasil yang bermakna pada perbaikan skor
konstipasi Agachan, jumlah L.reuteri feses dan pH feses.
Kesimpulan: L.reuteri lebih efektif dibandingkan Plasebo dalam memperbaiki
konstipasi, meningkatkan jumlah L.reuteri feses dan menurunkan pH feses pada
pasien konstipasi fungsional kronik dewasa.
ABSTRACTBackground: Chronic functional constipation is a common problem that affects
between 15-25% of the population and cause symptoms and disorders, that creates
discomfort, morbidity and high costs for health care. Recently, the consumption of
probiotics in treating chronic constipation in adults have been investigated.
However, there are still limited and controversial evidences available from
controlled trials.
Aim: To evaluate the effects of L. reuteri in improving the Agachan constipation
score, the number of L. reuteri in the feces and the fecal pH in the patients with
chronic functional constipation.
Methods: A double-blind, placebo RCT was conducted in 40 adult (12 male/ 28
female with mean age 45,95+/-16 years) affected by chronic functional constipation
according to Rome III criteria. Patients were randomly assigned to receive a
supplementation of L.reuteri or Placebo for 4 weeks.
Results: At week 4, the decrease in Agachan constipation score was from 17.00 to
8.00 with p <0.001, the increase number of L.reuteri was from 6,80x10
with p <0,001 and the decrease of pH feces was from 5,44 (SB 0,70) to 4,78 (SB
0,56) with p <0,001 in the L. reuteri group, otherwise in the Placebo group there
were no significant results in Agachan constipation score, the number of L.reuteri
and fecal pH assessed.
Conclusion: L.reuteri is more effective than the Placebo group in improving the
Agachan constipation score, increasing the number of L. reuteri in the feces and
decreasing the fecal pH in adult with chronic functional constipation.;Background: Chronic functional constipation is a common problem that affects
between 15-25% of the population and cause symptoms and disorders, that creates
discomfort, morbidity and high costs for health care. Recently, the consumption of
probiotics in treating chronic constipation in adults have been investigated.
However, there are still limited and controversial evidences available from
controlled trials.
Aim: To evaluate the effects of L. reuteri in improving the Agachan constipation
score, the number of L. reuteri in the feces and the fecal pH in the patients with
chronic functional constipation.
Methods: A double-blind, placebo RCT was conducted in 40 adult (12 male/ 28
female with mean age 45,95+/-16 years) affected by chronic functional constipation
according to Rome III criteria. Patients were randomly assigned to receive a
supplementation of L.reuteri or Placebo for 4 weeks.
Results: At week 4, the decrease in Agachan constipation score was from 17.00 to
8.00 with p <0.001, the increase number of L.reuteri was from 6,80x10
with p <0,001 and the decrease of pH feces was from 5,44 (SB 0,70) to 4,78 (SB
0,56) with p <0,001 in the L. reuteri group, otherwise in the Placebo group there
were no significant results in Agachan constipation score, the number of L.reuteri
and fecal pH assessed.
Conclusion: L.reuteri is more effective than the Placebo group in improving the
Agachan constipation score, increasing the number of L. reuteri in the feces and
decreasing the fecal pH in adult with chronic functional constipation.;Background: Chronic functional constipation is a common problem that affects
between 15-25% of the population and cause symptoms and disorders, that creates
discomfort, morbidity and high costs for health care. Recently, the consumption of
probiotics in treating chronic constipation in adults have been investigated.
However, there are still limited and controversial evidences available from
controlled trials.
Aim: To evaluate the effects of L. reuteri in improving the Agachan constipation
score, the number of L. reuteri in the feces and the fecal pH in the patients with
chronic functional constipation.
Methods: A double-blind, placebo RCT was conducted in 40 adult (12 male/ 28
female with mean age 45,95+/-16 years) affected by chronic functional constipation
according to Rome III criteria. Patients were randomly assigned to receive a
supplementation of L.reuteri or Placebo for 4 weeks.
Results: At week 4, the decrease in Agachan constipation score was from 17.00 to
8.00 with p <0.001, the increase number of L.reuteri was from 6,80x10
with p <0,001 and the decrease of pH feces was from 5,44 (SB 0,70) to 4,78 (SB
0,56) with p <0,001 in the L. reuteri group, otherwise in the Placebo group there
were no significant results in Agachan constipation score, the number of L.reuteri
and fecal pH assessed.
Conclusion: L.reuteri is more effective than the Placebo group in improving the
Agachan constipation score, increasing the number of L. reuteri in the feces and
decreasing the fecal pH in adult with chronic functional constipation."
