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"Latar belakang: Adenokarsinoma prostat adalah keganasan tersering kedua yang dialami pria di Indonesia. Skor Gleason digunakan untuk mengklasifikasi tingkat diferensiasi dari tumor sedangkan menghitung kadar PSA digunakan sebagai salah satu cara untuk mendiagnosis kanker prostat.Tujuan: Riset ini bertujuan untuk mengetahui korelasi antara skor Gleason dengan kadar PSA pada pasien adenokarsinoma prostat di departemen Patologi Anatomik RSCM. Metode Penelitian: Data dikumpulkan dari 77 sampel yang didapat dari form pemeriksaan hasil diagnosis pasien adenokarsinoma prostat tahun 2011 sampai 2014 di arsip Department Patologi Anatomik RSCM. Data diolah menggunakan analisis uji korelasi Kendall Tau-b di program SPSS 20.Hasil: Sebagian besar pasien datang dengan skor Gleason yang sudah tinggi skor Gleason >7. Nilai PSA terkecil yang didapat dari arsip departemen Patologi Anatomik sebesar 2,73 ng/ml, nilai tertinggi mencapai 7100 ng/ml. Nilai rata-rata PSA meningkat dengan meningkatnya skor Gleason. Rata-rata nilai PSA dari skor Gleason 6, 7, 8, 9, dan 10 adalah 46,641 ng/ml, 63,935 ng/ml, 231,762 ng/ml, 542,146 ng/ml, and 1044,348 ng/ml p = 0,003, r = 0,254. Kesimpulan: Terdapat korelasi yang lemah antara skor Gleason dengan nilai PSA pada pasien adenokarsinoma prostat di Department Patologi Anatomik RSCM. Nilai PSA meningkat seiring meningkatnya skor Gleason.

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Background: Prostatic adenocarcinoma is the second most frequent malignancies occur in men in Indonesia. Gleason score is used to classify the grading of the tumor and PSA is used as one of diagnostic tools for prostate cancer.

Aim: To identify the correlation between Gleason score and PSA level in patients with prostate adenocarcinoma at Department of Anatomical Pathology Cipto Mangunkusumo Hospital. Method The data was obtained from 77 samples taken from request forms from patients with prostatic adenocarcinoma from 2011 to 2014 in the archive of Department of Anatomical Pathology and analyzed using Kendall Tau b rsquo s Rank Correlation in SPSS 20.

Result: Most patient came with high Gleason Score Gleason score 7 . The minimum PSA level obtained from the arcieve in Department of Anatomical Pathology is 2.73 ng ml and the highest value reached up to 7100 ng ml. The average PSA level increased with the Gleason score. Gleason score 6, 7, 8, 9, and 10 has the average PSA level of 46.641 ng ml, 63.935 ng ml, 231.762 ng ml, 542.146 ng ml, and 1044.348 ng ml respectively p 0.003, r 0.254.

Conclusion: There is statistically weak significant correlation between Gleason score and PSA level in patients with prostatic adenocarcinoma in Department of Anatomical Pathology Cipto Mangunkusumo Hospital. PSA increased as the Gleason score increase."

"Latar Belakang: Pasien adenokarsinoma prostat sering kali datang dalam kondisi telah lanjut atau bermetastasis. Terapi yang dapat diberikan pada kasus adenokarsinoma stadium lanjut umumnya pengobatan androgen deprivation therapy (ADT), namun sebagian pasien mengalami castration-resistant prostate cancer (CRPC). Jalur inhibitor immune check point dapat menjadi alternatif pilihan terapi. Tujuan penelitian ini adalah untuk mengetahui korelasi ekspresi PD-L1 dengan gambaran histopatologik dan gejala klinikopatologis adenokarsinoma prostat.Metode: Penelitian ini merupakan penelitian analitik korelasi terhadap kasus-kasus adenokarsinoma prostat retrospektif. Dilakukan pulasan imunohistokimia PD-L1 klon 22C3 terhadap 30 subjek dan dinilai menggunakan combined proportion score (CPS). dilakukan penilaian ulang skor Gleason dan WHO/ISUP grade, serta penilaian tumor infiltrating lymphocytes (TILS). Dilakukan uji korelasi menggunakan SPSS 20.0 untuk melihat korelasi dengan derajat WHO/ISUP, TILS, nilai PSA dan body mass indek (BMI).Hasil: Dari 30 sampel yang dipilih secara acak didapatkan rata-rata usia 63 tahun. Body mass index antara 17,6 hingga 35,2. Nilai PSA antara 4,1 ng/ml hingga 973 ng/ml. Tidak terdapat korelasi antara ekspresi PD-L1 dengan derajat WHO/ISUP, BMI dan nilai PSA. Didapatkan korelasi dengan intratumoral TILS tapi tidak pada Stromal TILS.Diskusi: Pada penelitian ini didapatkan korelasi bermakna dengan intratumoral TILS, namun sebagian besar penelitian lain pada umumnya menggunakan hanya stromal TILS. Dibutuhkan penelitian lebih lanjut untuk diaplikasikan secara klinis.

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Background: Prostate adenocarcinoma patients often present in an advanced or metastatic condition. Treatment that can be given in cases of advanced adenocarcinoma is androgen deprivation therapy (ADT), but some patients experience castration-resistant prostate cancer (CRPC). Immune check point inhibitor pathways can be an alternative treatment option. The aim

of this study was to determine the correlation of PD-L1 expression with histopathologic features and clinicopathological symptoms of prostate adenocarcinoma.

Methods: This study is a retrospective correlation analytic study of cases of prostate adenocarcinoma. 30 subjects were performed with PD-L1 clone 22C3 immunohistochemistry and assessed using a combined proportion score (CPS). a reassessment of the Gleason score and WHO/ISUP grade, as well as an assessment of tumor infiltrating lymphocytes (TILS). Correlation test was performed using SPSS 20.0 to see the correlation with WHO/ISUP degrees, TILS, PSA values and body mass index (BMI).

Results: From 30 randomly selected subjects, the mean age was 63 years. Body mass index between 17.6 and 35.2. PSA values are between 4.1 ng/ml to 973 ng/ml. There was no correlation between PD-L1 expression and WHO / ISUP degree, BMI and PSA value. There was a correlation

with intratumoral TILS but not Stromal TILS,

Discussion: PD-L1 expression with TILS has been shown to be associated with various tumors. In this study, there was a significant correlation with intratumoral TILS, but most other studies generally used only stromal TILS. Further research is needed for its clinical applicatio."