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Abstrak :
ABSTRAK
Senyawa turunan pirimidin telah berhasil disintesis dengan mereaksikan benzaldehida, etil asetoasetat, dan urea melalui reaksi kondensasi Biginelli. Produk yang terbentuk dikarakterisasi menggunakan alat FTIR, UV-Vis, dan GC-MS. Pada sintesis senyawa ini digunakan nanokatalis CuFe2O4 yang berhasil disintesis dengan metode kopresipitasi dan dikonfirmasi dengan FTIR, XRD, TEM dan PSA. Berdasarkan optimasi (senyawa 1) dengan nama IUPAC 5-(ethoxy carbonyl)-4-(phenyl)-6-methyl-3,4-dihydropyrimidin2(1-)one diperoleh kondisi optimum dengan waktu 4 jam reaksi, suhu 70°C, dan 7,5% berat katalis dengan yield sebesar 71,57%, untuk (senyawa 2) 5-(ethoxy carbonyl)-4- (phenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)thione diperoleh kondisi optimum selama waktu 4 jam reaksi, suhu 50°C, dan 7,5% berat katalis dihasilkan yield sebesar 76,84% sedangkan untuk (senyawa 3) pada waktu 4 jam reaksi, suhu 70°C, dan 7,5% berat katalis dengan yield sebesar 73,69% belum berhasil membentuk senyawa 5-(ethoxy carbonyl)-4-(phenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)imine dari reaktan benzaldehida, etil asetoasetat dan guanidin.

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ABSTRACT
Pyrimidine derivatives have been synthesized by reacting benzaldehyde, ethyl acetoacetate, urea through Biginelli condensation reaction using CuFe2O4 nanocatalyst . Characterization of the three of product were performed by using FTIR, UV-Vis and GC-MS. In the synthesis of these compounds using CuFe2O4 nanocatalyst were successfully synthesized by coprecipitation method and characterized by FTIR, XRD, PSA, TEM. Optimum conditions for producing (compound 1) 5-(ethoxy carbonyl)-4- (phenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)one were 4 hours reaction, temperature 70° C and 7.5% weight catalyst with yield 71.57% , (compound 2) 5-(ethoxy carbonyl)- 4-(phenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)thione was at 4 hours reaction, 50° C and 7.5% weight catalyst with yield 76.84% and compound 3 were 4 hours reaction, temperature 70° C and 7.5% weight catalyst with yield 73.69% has not succeeded in forming a 5-(ethoxy carbonyl)-4-(phenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)imine.

Abstrak :
Senyawa pirimidin merupakan senyawa heterosiklik bahan alam yang memiliki bioaktivitas seperti penghambat kanal kalsium, antimikroba, antivirus, antioksidan, dan antikanker. Senyawa turunan pirimidin dapat disintesis melalui reaksi Biginelli yang termasuk reaksi multikomponen. Reaksi ini dapat dilakukan pada suhu ruang dalam satu wadah dengan menggunakan prekursor tiourea, etil asetoasetat, dan aldehida aromatik. Pada penelitian ini, dilakukan sintesis senyawa turunan pirimidin dengan bantuan katalis organik L-prolin nitrat. Katalis L-prolin nitrat dapat meningkatkan efisiensi waktu dan meningkatkan yield hasil sintesis. Hasil sintesis senyawa pirimidin optimal dilakukan pada kondisi penggunakan katalis sebesar 10% mol dan menggunakan pelarut metanol. Hasil sintesis didapatkan berupa senyawa 1 dengan %yield sebesar 86,74%, senyawa 2 sebesar 87,93%, dan senyawa 3 sebesar 84,80%. Produk hasil sintesis dan katalis L-prolin nitrat dikonfirmasi dengan menggunakan intrumen KLT, FT-IR, spektrofotometer ......Pyrimidine is a natural heterocyclic compound which has bioactivities such as calcium channel blocker, antibacterial, antivirus, antioxidant, and anticancer. Pyrimidine derivatives can be synthesized using Biginelli reaction which classified as a multicomponent reaction. This reaction can be undergone in room temperature in one pot using thiourea, ethyl acetoacetate, and aromatic aldehyde as the precursors. Synthesis of pyrimidine derivatives using L-proline nitrate as organocatalyst has been conducted, which was elevating time efficiency and elevating yield of the products on the system of the reaction. The optimum results could be achieved at 10 mol % using methanol as a solvent. The % yield of the compound  1, 2, and 3 are 86.74%, 87.93%, and 84.80%, respectively. The results of the Biginelli reaction and the L-proline nitrate have been confirmed using TLC, FT-IR spectrometer, UV-Vis spectrometer, and GC-MS.