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Abstrak :
ABSTRACT
Background: resistive index (RI) is highly utilised to assess the graft function using Doppler ultrasonography. The RI has been shown as the best ultrasound parameter to assess kidney allograft dysfunction. Several studies have established the role of the RI as a predictor of transplant failure. However, these studies were using RI measurement in the later stages post transplantation. The present study has conducted to identify the association between early RI measurement and early graft function represented as delayed graft function (DGF) and immediate graft function (IGF), as well as long-term graft survival. Methods: an evidence based clinical review of studies published before May 2018 was conducted from Medline, Science Direct, EMBASE and Cochrane databases. Studies on early measurement of RI whereby the primary or secondary goals of the study related to graft function and/or graft survival were included. Studies using late RI measurement and without RI value groups were excluded. The Mantzel Haenzel method was used to analyse pooled risk ratio and 95% confidence interval, while the heterogeneity of the study was calculated through I2 value. Data analysis was performed using Review Manager 5.3. Results: nine studies with a total of 1802 patients who had undergone a kidney transplant were analysed. DGF was found in 19% (193/1015) of the low RI group and in 42.8% (337/787) of the high RI group (RR 2.04 (95% CI 1.72 - 2.41), p < 0.00001, I2 = 28%). IGF was found in 39.5% (62/157) of the low RI group and in 10.5% (28/268) of the high RI group (RR 0.26 (95% CI 0.17 0.40), p < 0.00001, I2 = 0%). Long term graft survival, with follow up between 60 144 months, was found in 83% (701/845) of the low RI group and in 69.4% (395/569) of the high RI group (RR 0.82 (95% CI 0.72 0.93), p = 0.002, I2 = 63%). Conclusion: the results of this study emphasise the association between early measurement of RI and early graft function, and longterm graft survival. An elevated RI provides the chance of recognizing the patients with poor longterm prognosis, from the first moment after kidney transplant.

Abstrak :
Latar Belakang : Ultrasonografi dua dimensi sampai saat ini masih digunakan untuk mendeteksi penyakit ginjal kronik , namun hasil yang didapat sering tidak memuaskan terutama pada penderita penyakit ginjal diabetik karena hasil yang didapatkan seringkali normal. Pemeriksaan ultrasonografi color doppler dengan renal resistive index(RI) banyak digunakan sebagai alat diagnostik dan prognostik bebagai kondisi vaskuler ginjal baik pada transplantasi maupun pada penyakit ginjal kronik, namun manfaat pemeriksaan RI pada penyakit ginjal diabetik masih belum jelas. Tujuan : Mengetahui korelasi Renal Resistive Index dengan e GFR (CKD-EPI) pada penderita penyakit ginjal diabetik. Metode Penelitian : Studi Potong Lintang dengan subjek penelitia pasien PGD stadium 1-5, dilakukan di RSCM pada Bulan Januari-Februari 2015. Jumlah subjek sebanyak 34 orang. Dilakukan Pemeriksaan USG 2 Dimensi dan USG doppler dan pemeriksaan eGFR (CKDEPI). Analisa statistik dengan Spearman?s correlation. Hasil : Rerata Usia subjek penelitian 55,8 tahun, Rerata RI pada stadium 1 adalah 0,65, stadium 2 ,0,64, stadium 3 rerata RI adalah 0,72, stadium 4 adalah 0,78 dan stadium 5, rerata RI 0,8. Korelasi antara RI dan e GFR (CKD-EPI) pada penderita penyakit ginjal diabetik adalah r=-0,84 dengan p=0.000, R2 =0,714. Simpulan : Terdapat korelasi negatif yang kuat antara Renal resistive index dengan eGFR(CKD-EPI) pada penyakit ginjal diabetik. ...... Background : Two dimension ultrasonografi is still be used to detect chronic kidney disease but the result is not satisfying because the image shows normal on early phase of diabetic kidney disease. Doppler ultrasound with using renal resistive index (RI) Doppler ultrasound with renal resistive index (RI) used as diagnostic and prognostic tool in every vasculer condition of kidney in transplantation or chronic kidney disease, but the advantages of RI in diabetic kidney disease still unclear. Objective : To Determine correlation between renal resistive index (RI) and e GFR (CKDEPI) in diabetic kidney disease. Methods : A cross sectional Study, All patients with diabetic kidney disease stage 1-5 (n=34). Patients were examined using doppler ultrasound to look for renal resistive index and e GFR using CKD-EPI method, from January to February 2015 in Cipto Mangunkusumo Hospital Jakarta. Statistically analyzed by Spearman's Correlation. Results : The mean Age of the patients was 55,8 yr. The mean RI in stage 1 was 0,65, stage 2 was 0,64, stage 3 was 0,72, stage 4 was 0,78 and stage 5 was 0,8. The correlation between RI and e GFR (CKD-EPI) in diabetic kidney disease, r= -0,84 with p=0,000, R2=0,714. Conclusion :There is a strong negative correlation between RI and e GFR (CKD-EPI) in diabetic kidney disease.

Abstrak :
Latar Belakang: Peningkatan tekanan intraabdomen dapat menurunkan perfusi berbagai sistem organ, terutama organ intraabdomen dengan vaskularisasi tinggi seperti ginjal. Indeks resistensi RI dan indeks pulsatilitas PI ginjal adalah parameter kuantitatif ultrasonografi USG Doppler yang mengukur derajat resistensi atau impedansi aliran darah dan dapat berperan sebagai indikator perfusi ginjal. Dalam kepustakaan masih belum terdapat data nilai korelasi antara RI dan PI ginjal terhadap tekanan intraabdomen melalui insuflasi CO2 pada subjek manusia. Tujuan: Mengetahui korelasi antara nilai RI dan PI ginjal dengan tekanan intraabdomen. Metode: Desain penelitian merupakan potong lintang dan menggunakan data sekunder. Sampel berjumlah 36 data pasien yang telah menjalani laparoskopi nefrektomi donor ginjal hidup di RSUPN Cipto Mangunkusumo RSCM dan RSCM Kencana periode Agustus 2017 hingga Januari 2018. Data pengukuran tekanan intraabdomen (mmHg), RI dan PI ginjal intraoperatif baik sebelum insuflasi baseline maupun saat insuflasi CO2 didapatkan dari rekam medik dan laporan operasi. Hasil: Setiap subjek mendapatkan tekanan insuflasi CO2 yang berbeda, dengan nilai tekanan antara 8, 9, 10, 12, 13 atau 14 mmHg saat laparoskopi. Terdapat perbedaan bermakna (p<0,001) antara rerata nilai RI dan PI ginjal baseline (0,574 dan 0,951) dibandingkan rerata RI dan PI ginjal saat insuflasi CO2 (0,660 dan 1,188). Namun tidak didapatkan adanya korelasi maupun kemaknaan secara statistik antara tekanan intraabdomen terhadap RI ginjal (r=0,16 dan p=0,349) ataupun PI ginjal (r=0,14 dan p=0,429) saat dilakukan insuflasi CO2. Kesimpulan: Tidak terdapat korelasi antara RI maupun PI ginjal dengan tekanan intraabdomen saat dilakukan insuflasi CO2 intralaparoskopi.

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Background: Increased intraabdominal pressure may decrease perfusion of various organ systems, especially intraabdominal organs with high vascularization such as kidney. The renal resistance index RI and pulsatility index PI are Doppler ultrasound US quantitative parameters which measure degree of blood flow resistance or impedance and may act as indicators of renal perfusion. Amongst literature yet there is still no data of correlation between renal RI and PI with intraabdominal pressure during CO2 insufflation on human subject. Purpose: To evaluate correlation between renal RI-PI value and intraabdominal pressure. Method: The study design is cross sectional and utilize secondary data. Thirty six samples of renal donor patients data who had undergone laparoscopic nephrectomy procedure in Cipto Mangunkusumo National General Hospital RSCM and RSCM Kencana hospital were acquired from August 2017 to January 2018. Intraoperative measurements data of intraabdominal pressure (mmHg), renal RI and PI, both before baseline and during CO2 insufflation were obtained from medical records and surgery reports. Results: Each subject received a different CO2 insufflation pressure, with a pressure value either 8, 9, 10, 12, 13 or 14 mmHg during laparoscopy. There was a significant difference (p <0.001) between mean of baseline renal RI and PI (0.574 and 0.951) compared to mean renal RI and PI during CO2 insufflation (0.660 and 1.188). There was no correlation between intraabdominal pressure with renal RI (r = 0.16 and p = 0.349) or renal PI (r = 0.14 and p = 0.429) during CO2 insufflation. Conclusion: There was no correlation between renal RI or PI with intraabdominal pressure during CO2 insufflation intralaparoscopy.

Abstrak :
Background: living kidney donation is a safe medical procedure. Kidney function after donation is crucial for donors’ health and quality of life. Kidney hyperfiltration is a compensatory mechanism, which will preserve kidney function after unilateral nephrectomy. The number of studies regarding hyperfiltration in living kidney donors is limited. Our study aimed to explain kidney hyperfiltration mechanism and evaluate its effect on the kidney function within 30 days after surgery. Methods: our study was a prospective cohort study with 46 living-kidney donors participating in the study between April and December 2019. We evaluated main outcomes, the 30-day post-surgery kidney function, which was evaluated by calculating estimated glomerular filtration rate (eGFR) and Urinary Albumin to Creatinine Ratio (ACR). The subjects were categorized into two groups based on their 30-day outcomes, which were the adaptive (eGFR > 60 mL/min/1.73 m2 and/or ACR > 30 mg/g) and maladaptive (eGFR < 60 mL/min/1.73 m2 and/or ACR > 30 mg/g) groups. A series of evaluation including calculating the renal arterial resistive index (RI) and measuring urinary vascular endothelial growth factor (VEGF), neutrophil gelatinase-associated lipocalin (NGAL), and heparan sulfate (HS) levels were performed before surgery and serially until 30 days after surgery. Multivariate analysis with adjustments for confounding factors was done. Results: forty donors were included and mostly were female (67.5%). The average age and body mass index (BMI) were 45.85 (SD 9.74) years old and 24.36 (SD 3.73) kg/m2 , respectively. Nineteen donors (47.5%) had maladaptive hyperfiltration outcomes. The hyperfiltration process was demonstrated by significant changes in renal arterial RI, urinary VEGF, NGAL, and HS levels (p<0.005). There was no significant difference regarding RI, urinary VEGF, NGAL, and HS levels between both groups. Several confounding factors (BMI over 25 kg/m2 , familial relationship, age over 40 years old, and arterial stiffness) were significantly influenced by kidney hyperfiltration and outcomes (p<0.05). Conclusion: the hyperfiltration process does not affect the 30-day post-nephrectomy kidney function of the donors. Several other factors may influence the hyperfiltration process and kidney function. Further study is necessary to evaluate kidney function and its other related variables with a longer period of time study duration.