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Christina Olly Lada
"Latar Belakang : Stunting pada anak usia di bawah dua tahun (U2) menggambarkan kekurangan nutrisi kronis dengan berbagai faktor predisposisi dan prevalensinya masih tinggi di Indonesia. Kurang nutrisi kronis menyebabkan tubuh berdaptasi pada ukuran dan fungsi organ, yang berdampak meningkatnya risiko kardiometabolik (RKM) kemudian hari. Tujuan penelitian ini membuktikan perbedaan faktor predisposisi intrauterin (FPIntra), ekstrauterin (FPEkstra), stres oksidatif (SO), adaptasi metabolik (AM) dan RKM pada anak stunting (AnS) dan tidak stunting (AnTS) usia 6-24 bulan (U6-24).
Metode : Penelitian nested -kohort, cross-sectional komparatif digunakan untuk menilai peran FPIntra, yaitu antropometri ibu sebelum hamil, asupan dan status gizi ibu hamil, berat lahir (BL) dan panjang lahir (PL) subjek, FPEkstra yaitu ASI eksklusif, berat badan (BB) dan panjang badan (PB) enam bulan pertama (U6I), antropometri anak, asupan gizi AnS dan AnTS U6-24. Indikator SO yaitu kadar MDA serum. Indikator AM yaitu ekspresi microRNA -148a. Indikator RKM yaitu ukuran lingkar pinggang (LP), kadar kolesterol-LDL, kolesterol-HDL, trigliserida, dan glukosa darah. Semua subjek merupakan peserta TKA, Bogor dan pengambilan data dilakukan sejak bulan Juli 2017 hingga Februari 2018, dilaksanakan di Rumah Kohort TKA, Bogor. Analisis statistik univariat, bivariat dan multivariat digunakan untuk membandingkan kelompok AnS dan AnTS dengan batas kemaknaan p <0,05.
Hasil : Sebanyak 38 AnS dan 46 AnTS U6-24 memenuhi kriteria penelitian dan didapatkan FPIntra AnS lebih rendah secara bermakna dibanding AnTS, yaitu kategori kadar seng serum ibu hamil, tinggi badan ibu, BL dan PL subjek (p = 0,047, p < 0,001, p = 0,009, p = 0,025). Asupan mangan (p= 0,007), isoleusin (p =0,015), pertambahan BB U6-I (p =0,002), rerata pertambahan BB/bulan U6-I (p =0,002), pertambahan PB U6-I (p <0,001), rerata pertambahan PB/bulan U6-I (p <0,001) dan kadar Hb anak (p =0,005) lebih rendah secara bermakna pada AnS, sementara RDW-CV lebih tinggi pada AnS (p =0,009). Tidak ditemukan perbedaan SO pada kedua kelompok, tetapi gambaran adanya AM pada usia dini terlihat pada normalized expression ratio microRNA -148a AnS sebesar 2,6 kali lebih cepat dibandingkan dengan AnTS, yang mengakibatkan kolesteol-LDL di sirkulasi lebih tinggi pada AnS. Ditemukan dua indikator RKM berbeda bermakna yaitu ukuran LP AnS lebih kecil bermakna, namun kadar trigliseridanya lebih tinggi pada AnS. Kadar kolesterol-LDL cenderung lebih tinggi pada AnS.
Kesimpulan : FPIntra dan FPEkstra terbukti memberikan dampak terhadap kejadian stunting anak U6-24. Adaptasi metabolik dan RKM pada AnS sudah terdeteksi pada U6-24.
Saran : Penting untuk memantau status gizi ibu sebelum hamil dan memberikan intervensi nutrisi dalam 1000 hari awal kehidupan untuk mengurangi RKM di kemudian hari.

Background : Stunting children under two years of age (U2) illustrates chronic nutritional deficiency with various predisposing factors and the prevalence is still high in Indonesia. Chronic malnutrition causes the body to adapt organ size and function, which results in increased cardio metabolic risk (CMR) in adulthood The aim of this study was to prove differences in intrauterine predisposition (PFIntra), extra uterine (PFExtra), oxidative stress (OxS), metabolic adaptation (MetAdapt) and CMR in stunting children (StC) and non stunting children (NStC) aged 6-24 months (U6-24).
Methods : A nested-cohort, comparative cross-sectional study was used to assess the role of PFIntra, namely maternal anthropometry before pregnancy, nutrition intake and nutritional status of pregnant women, birth weight (BW) and birth length (BL) of subjects, PFExtra namely exclusive breastfeeding, weight and body length in the first six months (U6I), pediatric anthropometry and nutritional intake in StC and NStC U6- 24. Indicator of OxS was serum MDA level. MetAdapt indicator was microRNA-148a expression. The CMR indicators were waist circumference (WC), LDL-cholesterol levels, HDL-cholesterol, triglycerides, and blood glucose. All subjects were participants in Bogor Longitudinal Study Child Growth and Development (BLSCGD), in Bogor Tengah sub-district. Univariate, bivariate and multivariate statistical analyzes were used to compare StC and NStC groups with significant p value <0.05.
Results : There were 38 StC and 46 NStC U6- 24 fulfilled the study criteria and obtained significantly lower PFIntra in StC compare to NStC, namely the serum zinc level category of pregnant women, maternal height, BW and BL subjects (p = 0.047, p <0.001, p = 0.009, p = 0.025). Manganese intake (p = 0.007), isoleucine intake (p = 0.015), increase in weight U6-I (p = 0.002), weight gain per month U6-I (p = 0.002), increase in length U6-I (p <0.001), length increase per month U6-I (p <0.001) and Hb levels of children (p = 0.005) were significantly lower in StC, while RDW-CV was higher in StC (p = 0.009). There were no significant differences in OxS between two groups, but MetAdapt at an early age was seen in the StC as show in normalized expression ratio of microRNA-148a was 2.6 times faster than NStC, which resulted in higher circulation of LDL in StC. Two of five CMR indicators were significantly different, namely the size of WC in StC was significantly smaller, but the triglyceride level was higher in StC. LDL-cholesterol levels tend to be higher in StC.
Conclusion : PFIntra and PFExtra proved to have an impact on the incidence of stunting children U6- 24. Metabolic adaptation and CMR in StC have been detected in U6- 24.
Suggestion: It is important to monitor the nutritional status of the mother before pregnant and provide nutritional interventions within the first 1000 days of life to reduce cardio metabolic risk in the future."
Depok: Universitas Indonesia, 2018
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UI - Disertasi Membership  Universitas Indonesia Library
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Hervita Diatri
"Komorditas risiko kardiometabolik pada ODS lebih besar dibandingkan populasi umum dan menyebabkan mortalitas tinggi di usia produktif. Berbagai modalitas tata laksana untuk masalah kesehatan tersebut tersedia di fasilitas primer hingga tersier. Sayangnya, akses layanan yang terpadu dan bermutu belum ada di Indonesia. Penelitian ini bertujuan untuk mengembangkan model layanan terpadu tersebut di fasilitas kesehatan primer di Indonesia. Penelitian ini menggunakan model pengembangan sistem spiral yang mengikuti tiga tahap action research. Tahap pertama menggabungkan metode kuantitatif desain potong lintang studi komparatif dan kualitatif observasi, penelusuran kepustakaan, wawancara mendalam, dan lokakarya untuk mengidentifikasi masalah, gambaran pelayanan, dan potensi penyelesaian masalah sebagai dasar pengembangan model layanan terpadu. Subjek penelitian kuantitatif pada tahap ini adalah ODS usia 18-59 tahun yang menjalani pengobatan di 20 puskesmasprovinsi DKI Jakarta. Data kualitatif berasal dari ODS, keluarga, penyedia layanan, akademisi, dan pemangku kebijakan di daerah maupun pusat. Model awal dikembangkan berdasarkan modifikasi terhadap clinical pathway dari WHO-PEN Package of essential noncommunicable disease interventions . Kemamputerapan dan kebutuhan penyesuaian model dinilai berdasarkan hasil identifikasi solusi. Model layanan terpadu yang dikembangkan, kemudian diujicobakan dan dinilai secara kuantitatif dan kualitatif di tahap kedua untuk melihat kemampulaksanaan melalui ketersediaan layanan, kesesuaian penerapan, dan kesediaan tenaga kesehatan untuk melanjutkan layanan. Evaluasi dampak model layanan melalui desain eksperimental kuasi dinilai melalui efektivitas terhadap parameter klinis dan nonklinis. Proporsi ODS dengan risiko kardiometabolik adalah 88 dari 216 partisipan ODS , dan hanya 6,8 yang mendapatkan akses layanan komorbiditas. Data kuantitatif maupun kualitatif menunjukkan bahwa para pemangku kepentingan berharap akan model layanan terpadu dapat dikembangkan di puskesmas 63,7 , menggunakan berbagai sumber daya yang telah ada, melibatkan tim 61,1 , ditekankan pada upaya skrining dan pemantauan berkala 59,5 . Model layanan terpadu dalam bentuk clinical pathway maupun alur layanan ternyata tidak dapatditerapkan sepenuhnya di puskesmas karena masalah ketersediaan layanan, infrastruktur, keberadaan tenaga kesehatan, sistem komunikasi antar tenaga kesehatan, dan budaya kerja, serta faktor pasien dan keluarga. Namun demikian > 79 tenaga kesehatan yang terlibat bersedia untuk melanjutkan penerapan alur layanan. Model layanan efektif memperbaiki kadar kolesterol-HDL darah, tetapi untuk parameter tekanan darah, lingkar pinggang, kadar glukosa, trigliserida darah menunjukkan hasil tidak berbeda bermakna antara kelompok intervensi dan kelompok kontrol. Evaluasi parameter nonklinis yang menunjukkan hasil bermakna terbatas pada tingkat aktivitas fisik ODS, tetapi tidak untuk variabel pola diet, pengetahuan, dan kepuasan pasien. Model layanan luar gedung yang pengaturannya terpisah dari tata laksana kegiatan puskesmas dan model layanan dalam gedung yang terpisah antara layanan penyakit tidak menular PTM dan layanan jiwa, adalah sebab utama kurang mampu laksananya model yang diujikan. Proses skrining dan pemantauan berkala perlu dilakukan pada semua ODS sebagai awal akses layanan. Peningkatan pengetahuan dan keterampilan ODS dan keluarga penting untuk meningkatkan kapasitas partisipatif, sedangkan bagi tenaga kesehatan diperlukan untuk manajemen risiko melalui skrining dan pemantauan berkala. Pengembangan tim terpadu PTM dan jiwa baik untuk kegiatan di dalam maupun luar gedung diharapkan dapat memudahkan kerja tim untuk mengatasi hambatan kesinambungan penyediaan layanan, infrastruktur, dan kesulitan akses ODS sehingga efektivitas layanan semakin baik.

Cardiometabolic comorbidity is higher in people with schizophrenia than in general population and this caused high mortality in productive age. A variety of management modalities for this specific health problem are available in primary to tertiary health facilities. Unfortunately, high quality and accessible comprehensive service did not exist in Indonesia. This research aimed to develop an integrated service in primary health facilities for PwS and cardiometabolic risks in public health centers in Indonesia.Using the spiral model of system development, this research followed the three phase of action research. The first phase combined quantitative comparative cross-sectional study and qualitative observation, literature review, in-depth interview, and workshop methods to identify problems, health service condition, and potential solutions as a basis for developing an integrated service model. Subjects for the quantitative research in this phase were PwS who were at the age of 18-59 years old who underwent treatment in 20 public health centers in Jakarta Special Capital Region. Qualitative data came from PwS, their families, academia, and policy makers at national and sub-national levels. Early model was developed based on modification to the WHO-PEN Package of essential noncommunicable disease interventions clinical pathway. Implementability and needs for model adjustments were evaluated from the result of solutions identification. The developed comprehensive service model was tested and evaluated quantitative and qualitatively in the second phase to see if it is feasible by means of availability of services, suitability of implementation, and availability of health workers to continue the service. Evaluation on the impact of the service model was done through quasi-experimental design to evaluate its efficacy using clinical and non-clinical parameters. Proportion of PwS with cardiometabolic risks was 88 from 216 PwS participants , from which only 6.8 had access to service for comorbidities. Quantitative and qualitative data showed that stake-holders would like to see that this integrated service model can be implemented in primary health care service PHCs 63.7 , using various existing resources, involving team approach 61.1 , and stressing on screening and periodic monitoring 59.5 . An integrated service model in the form of clinical pathway or service algorithm could not be fully implemented because of problems with service availability, infrastructures, availability of health workers, communication system among health workers, working culture, patient and family factors. In spite of that, more than 79 of health workers who were involved in the research are willing to continue implementing the service pathway. This service model was proven to be effective in controlling blood HDL-cholesterol level, but failed to show significant differences in blood pressure, waist circumference, blood glucose, and triglyceride between intervention and control groups. Evaluation on non-clinical parameters showed limited meaningful results on level of physical activities, but not on diet pattern, knowledge, and satisfaction. Extramural model, which separated arrangement from management activities in the PHC and disintegration intramural services between Non-communicable diseases NCDs and mental health services, was the main reason for the lack of efficacy in the tested model. Screening and periodic monitoring should be done for all PwS as initial access to service. Improvement of knowledge and skills of PwS and their families is important in increasing their participatory capacity and for health workers to be able to manage risks through screening and periodic monitoring. It is expected that the development of an integrated non-communicable disease and psychiatric team, intra and extra-mural of PHCs, could overcome the barriers of continuous provision of service, infrastructure, and access of PwS."
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2018
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UI - Disertasi Membership  Universitas Indonesia Library