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Ditemukan 2 dokumen yang sesuai dengan query
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Joko Untung
Sintesis, uji solubilitas, dan koefisien partisi senyawa analog baru kurkumin, kurkumin pirazol di-mannich dimetilmorfolin = Synthesis, solubility test, and partition coeffiecient of new curcumin analogue compound, curcumin pyrazole dimannich dimethylmorpholine
"[ABSTRAK
Kurkumin merupakan senyawa yang dikenal memiliki aktivitas farmakologis luas dan relatif aman Tetapi kurkumin memiliki bioavailibilitas rendah yang disebabkan karena rendahnya kelarutan kurkumin dalam cairan biologis tubuh Dalam penelitian ini dilakukan modifikasi struktur kurkumin menjadi kurkumin pirazol di Mannich dimetilmorfolin KPMDMM dengan penambahan 2 gugus basa Mannich dimetilmorfolin dan siklisasi diketon menjadi cincin pirazol Hasil sintesis kemudian diuji solubilitas dan koefisien partisinya Hasil sintesis mendapatkan yield sebesar 72 50 yang dikonfirmasi oleh spektra IR dan NMR Dari hasil uji solubilitas dan koefisien partisi KPMDMM memiliki nilai kelarutan 1 61 ppm dan logP 1 71 dalam air dan 9 16 ppm dan logP 1 94 larutan dapar fosfat pH 7 4
ABSTRACT
Curcumin is a compound that has a broad pharmacological activity and relatively safe But curcumin shows a poor bioavailability caused by poor solubility in biological fluid In this study I have carried out a modification of curcumin structure into curcumin pyrazole di Mannich dimethylmorpholine KPMDMM by added 2 base Mannich dimethylmorpholine groups and cyclization of di ketone into pyrazole ring The product is then performed solubility test and it rsquo s partition coefficient The yield of product is 72 50 confirmed by IR and NMR spectra Based on solubility test and partition coefficient KPMDMM showed solubility value 1 61 ppm and logP 1 71 in water and 9 16 ppm and logP 1 94 buffer phosphate solution pH 7 4 , Curcumin is a compound that has a broad pharmacological activity and relatively safe But curcumin shows a poor bioavailability caused by poor solubility in biological fluid In this study I have carried out a modification of curcumin structure into curcumin pyrazole di Mannich dimethylmorpholine KPMDMM by added 2 base Mannich dimethylmorpholine groups and cyclization of di ketone into pyrazole ring The product is then performed solubility test and it rsquo s partition coefficient The yield of product is 72 50 confirmed by IR and NMR spectra Based on solubility test and partition coefficient KPMDMM showed solubility value 1 61 ppm and logP 1 71 in water and 9 16 ppm and logP 1 94 buffer phosphate solution pH 7 4 ]"
2016
T45539
UI - Tesis Membership  Universitas Indonesia Library
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Wida Adelia Putri
Pengaruh Konsentrasi Asam Klorida (HCl) terhadap Dispersibilitas, Solubilitas, dan Toksisitas Carbon nanotube Terfungsionalisasi sebagai Penghantar Obat Kanker = The Effect of Hydrochloric acid (HCl) Addition on Dispersibility, Solubility, and Toxicity of Functionalized Carbon nanotube as Drug Delivery Material for Cancer
"Aplikasi Carbon nanotube (CNT) dalam metode pengobatan kanker dapat dilakukan
karena menghasilkan selektivitas dan efektivitas targeting obat yang tinggi.
Fungsionalisasi CNT diperlukan untuk memperbaiki dispersibilitas, solubilitas, dan
toksisitas CNT. Fungsionalisasi dilakukan secara kovalen dengan oksidasi asam yang
terdiri dari campuran HNO3 dan H2SO4 dengan penambahan asam klorida (HCl).
Variasi yang dilakukan adalah konsentrasi HCl 6M, 8M, 10M, dan 12M pada suhu sonikasi
C. CP-­f dikarakterisasi dengan uji dispersi, Fourier Infrared Transformation
Spectroscopy (FTIR), Thermal Gravimetry Analysis (TGA), UV-­Vis Spectroscopy,
Electron Miscroscopy-­Energy Dispersive Spectroscopy (SEM-­EDS), dan Brine Shrimp
Lethality Test (BSLT). Hasil penelitian menunjukkan bahwa CP-­f dengan penambahan
HCl 10M (CPf-­3) menghasilkan persen solubilitas tertinggi 11,46% dan suspensi dispersi
yang paling stabil pada hari ke-­51. Disamping dari peningkatan dispersibilitas dan
solubilitas, morfologi sampel CPf-­3 membentuk beberapa aglomerat yang mengarahkan
pada kemunculan sifat dengan nilai LC50 355,62 ppm
......Carbon nanotube application in cancer treatment methods is selected due to its high
selectivity and effectivity in drugs targeting delivery. Functionalization is needed to
improve dispersibility, solubility, and toxicity of CNT. CNT is treated covalently by
oxidation which consist of HNO3 and H2SO4 with the addition of HCl. Variation is
performed in HCl concentration of 6M, 8M, 10M, and 12M at sonication temperature of The addition of HCl in certain molarity increase the purity and dispersion time
on functionalized CNT (CP-­f). CP-­f were characterized through dispersion test, Fourier
Infrared Transformation Spectroscopy (FTIR), UV-­Vis Spectroscopy, Thermal
Gravimetry Analysis (TGA), Electron Miscroscopy-­Energy Dispersive Spectroscopy
(SEM-­EDS), and Brine Shrimp Lethality Test (BSLT)The study resulted that CP-­f with
HCl 10M addition (CPf-­3) produce the highest solubility for 11.46% and the most stable
dispersion suspension in 51 days. Besides, CPf-­3 morphology shows some agglomerates
which indicate to toxicity with LC50 of 355,62 ppm"
Depok: Fakultas Teknik Universitas Indonesia , 2019
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UI - Skripsi Membership  Universitas Indonesia Library