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"Untuk menghasilkan produk obat yang aman, berkhasiat, dan bermutu, suatu industri farmasi di Indonesia harus mengikuti persyaratan dan regulasi yang ditegakkan oleh pemerintah Indonesia. Persyaratan ini diatur dalam Cara Pembuatan Obat yang Baik atau disingkat CPOB. Salah satu standar yang perlu perhatian khusus adalah pembuatan produk steril yang dijelaskan pada aneks 1 CPOB. PT Kalbe Farma Tbk merupakan perusahaan industri di bidang farmasi yang beroperasi di Indonesia dan juga memproduksi sediaan steril sehingga pedoman CPOB terutama aneks 1 harus diimplementasikan. Laporan ini dibuat agar calon apoteker mengerti tentang pembuatan produk steril yang baik yang diatur dalam CPOB dan dapat mengimplementasikannya. Metode yang digunakan dalam laporan ini adalah dengan studi literatur melalui pedoman CPOB, materi Kua Lima Plus bab 1 mengenai produk steril dari Kalbe Learning Center, dan Standar Operasional Prosedur milik PT Kalbe Farma Tbk, serta peraturan perundang-undangan. Kesimpulan laporan ini adalah bahwa pedoman CPOB aneks 1 mengenai pembuatan produk steril mencakup persyaratan area pembuatan produk steril, penanganan produk steril, teknologi isolator, teknologi peniupan/pengisian/penyegelan, personil, bangunan dan fasilitas, peralatan, sanitasi, air, pengolahan, sterilisasi, filtrasi obat yang tidak dapat disterilkan dalam wadah akhirnya, indikator biologis dan kimiawi, penyelesaian produk steril, dan pengawasan mutu yang masing-masing memiliki persyaratan khusus dan spesifik dan tidak dapat dikesampingkan.

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To produce safe, efficacious and quality medicinal products, the pharmaceutical industry in Indonesia must follow the requirements and regulations enforced by the Indonesian government. These requirements are regulated in Cara Pembuatan Obat yang Baik or abbreviated as CPOB. A standard that requires special attention is the manufacture of sterile products which is described in annex 1 of the CPOB. PT Kalbe Farma Tbk is an industrial company in the pharmaceutical sector that operates in Indonesia and also produces sterile preparations so that the CPOB guidelines, especially annex 1, must be implemented. This report was created so that prospective pharmacists understand about producing good sterile products as regulated in CPOB and can implement them. The method used in this report is literature study through CPOB guidelines, Kua Lima Plus chapter 1 regarding sterile products from Kalbe Learning Center, and PT Kalbe Farma Tbk's Standard Operating Procedures, as well as statutory regulations. The conclusion of this report is that the CPOB annex 1 guidelines regarding Universitas Indonesia the manufacture of sterile products include requirements for the area for making sterile products, handling of sterile products, isolator technology, blowing/filling/sealing technology, personnel, buildings and facilities, equipment, sanitation, water, processing, sterilization, filtration of non-sterilizable drugs in their final containers, biological and chemical indicators, sterile product finishing, and respective quality control which each has specific requirements and cannot be waived."

"Produk steril memiliki persyaratan minimal risiko kontaminasi mikroba, partikulat, dan endotoksin/pirogen pada fasilitas, peralatan, dan proses harus dirancang, dikualifikasi, dan divalidasi dengan tepat untuk meningkatkan perlindungan produk. Strategi pengendalian kontaminasi / Contamition Control Strategy (CCS) harus diterapkan di seluruh fasilitas industri farmasi untuk menilai efektivitas seluruh rancangan, prosedur, teknis, dan organisasional serta pemantauan yang telah digunakan untuk mengelola risiko terhadap mutu produk. Penyusunan Risk Assessment Terkait Control Contamination Strategy (CCS) di PT Finusolprima Farma International dilakukan dengan melakukan studi literatur pada Prosedur Tetap, membandingkan prosedur yang telah ada dengan ketentuan EU GMP & CPOB 2018 dan menyusun hasil penerapan CCS. Dengan adanya kegiatan Penyusunan Risk Assessment Terkait Control Contamination Strategy (CCS) di PT Finusolprima Farma International diketahui elah dilakukannya analisis efektivitas Contamination Control Strategy (CCS) menggunakan prinsip manajemen risiko mutu pada PT Finusolprima Farma International namun masih terdapat prosedur pengendalian kontaminasi yang belum terdokumentasi dengan baik sehingga perlu ditambahkan untuk memudahkan personil terkait dan pencegahan kontaminasi dapat lebih dikendalikan.

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Sterile products have minimal risk requirements for microbial, particulate and endotoxin/pyrogen contamination. Facilities, equipment and processes must be appropriately designed, qualified and validated to increase product protection. Contamination control strategies (CCS) must be implemented in all pharmaceutical industry facilities to assess the effectiveness of all designs, procedures, and technical and organizational monitoring used to manage product quality risks. Preparing a Risk Assessment Related to Control Contamination Strategy (CCS) at PT Finusolprima Farma International was carried out by conducting a literature study on Standing Procedures, comparing existing procedures with the provisions of EU GMP & CPOB 2018 and compiling the results of CCS implementation. With the activity of Preparing a Risk Assessment Related to Control Contamination Strategy (CCS) at PT Finusolprima Farma International, it is known that an analysis of the effectiveness of Contamination Control Strategy (CCS) has been carried out using quality risk management principles at PT Finusolprima Farma International. However, contamination control procedures still need to be properly documented. So, it needs to be added to make it easier for related personnel and contamination prevention to be better controlled."

"Penelitian yang telah dilakukan dari Maret –Mei 2015, bertujuan untuk mengetahui pengaruh media tanam serta menentukan inokulum optimum untuk pembibitan tanaman padi varietas Ciherang. Pembibitan padi dilakukan selama 14 hari di rumah kaca menggunakan 4 media tanam berbeda, yaitu tanah kebun steril dan non steril serta pupuk organik steril dan non steril. Strain Nostoc CPG24 dan GIA13a masing- masing sebanyak 0,2; 0,4; dan 0,6 g diinokulasikan pada keempat media tanam pada hari ke-1 pembibitan. Parameter yang diukur adalah tinggi, panjang akar, serta berat basah dan berat kering tanaman. Hasil uji statistik menunjukkan media tanam berpengaruh terhadap pembibitan padi varietas Ciherang. Pengaruh strain CPG4 dan GIA13a terhadap pembibitan hanya terdapat di media pupuk organik steril. Pemberian variasi inokulum (0,2; 0,4; dan 0,6 g) strain CPG24 dan GIA13a mampu meningkatkan tinggi dan panjang akar secara signifikan (P<0,05) dibandingkan kontrol pada media pupuk organik steril.

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The experiment that has been done from Maret– May 2015 was used to know the effect of media and determine optimum inoculum for Ciherang rice germination. The rice germination was done for 14 days in the green house used four different medias, they are sterilized and unsterilized garden soil and also sterilized and unsterilized organic soil. Strains CPG24 and GIA13a was inoculated into four different medias on first day of rice germination as much as 0,2; 0,4; and 0,6 gram fresh weight for each strain. The effect of Nostoc strain to rice germination was evaluated by using vegetative parameters, including plant height, root lenght, fresh and dry weight. The statistic result showed that media gave effect for rice germination. Application of three variations of inoculum from both strains only gave effect on sterilized organic soil. Variations of inoculum of CPG24 and GIA13a strains had significant effect (P<0,05) to increase plant height and root lenght of plants in sterilized organic soil."

"Tugas sarjana ini berisi rancangan sistem tata udara ruang produksi obat sterl P.T. Bristol Myers Squibb Indonesia. Sistam tata udara dirancang dengan menarapkan konsep dasar rqang barsih. Hal ini dimaksudkan agar obat yang sedang da1arn prosas produksi tidak terkontaminasi oleh partikel melayang (airborne particle) yang ada di udara, baik barupa bakteri maupun partikel padat.Kondisi udara dalam ruangan (konsentrasi partikel, temperatur, keIembaban, tekanan ruangan, bentuk aliran udara dan penerangan)d'ir'anc:a.ng untuk memenuhi persyaratan Pedoman Cara Pembuatan Obat yang Baik (CPOB) yang diterbitkan Departemen Kesehatan FLI.Untuk mencapai kelas kebarsihan yang disyaratkan, udara yang telah dikondisikan daiam unit pengolah udara (AHU) disuplai ke dalam ruangan melalui HEPA filter dan untuk ruangan dengan kelas kebarsihan yang paIing tinggi yaitu dalam ruang pendinginan dan ruang pangisian obat steril dialirkan aliran udara satu arah (Unidirectional Air Flow). Hasil rancangan menunjukkan bahwa dengan manggunakan modal ruang bersih dangan sistem konfigurasi seperti ini dapat dicapai kondisi ruangan dengan tingkat kebersihan keIas I."

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Rumah sakit adalah institusi pelayanan kesehatan yang memiliki peran dalam meningkatkan derajat kesehatan masyarakat. Agar dapat memberikan pelayanan secara optimal untuk masyarakat, rumah sakit harus menjalankan operasional secara efektif dan efisien, salah satunya dengan merencanakan anggaran pendapatan dan belanja rumah sakit, yang dapat dilakukan dengan menentukan besaran tarif setiap layanan dengan cara menghitung biaya satuan (unit cost). Biaya satuan merupakan hasil perhitungan total biaya (total cost) masing- masing kegiatan yang dikeluarkan rumah sakit. Perhitungan biaya satuan bertujuan untuk mendapatkan informasi mengenai perencanaan anggaran, pengendalian biaya, penetapan harga, penetapan subsidi, serta membantu pengambilan keputusan. Dispensing sediaan steril merupakan salah satu bentuk pelayanan di rumah sakit. Pelayanan dispensing sediaan steril memerlukan pesryaratan khusus untuk sumber daya manusia maupun sarana dan prasarananya, dan menghasilkan banyak macam produk campuran obat, serta memerlukan alat tertentu, sehingga anggarannya perlu dikelola secara tepat. Berdasarkan latar belakang tersebut, diperlukan adanya perhitungan biaya satuan pada unit pelayanan produksi steril di Rumah Sakit Universitas Indonesia. Oleh karena itu, penelitian ini dilakukan untuk mengetahui biaya satuan pada unit pelayanan produksi steril Rumah Sakit Universitas Indonesia dengan menggunakan data produksi bulan Januari-Maret 2022. Melalui tugas khusus ini diketahui nilai biaya satuan yang diperoleh untuk unit produksi steril yaitu sebesar Rp 245.377. Berdasarkan hasil analisis biaya satuan pada unit produksi steril diperoleh nilai biaya satuan yang cukup tinggi yang disebabkan karena perhitungan biaya satuan tidak dilakukan berdasarkan per jenis obat dan perbedaan jenis dan jumlah obat yang digunakan setiap bulannya.

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Hospital is a health service institution that has a role in improving public health status. In order to do so, hospitals must carry out operations effectively and efficiently, one of which is by planning the hospital's revenue and budget, which can be done by determining the rate of each service by calculating unit costs. Unit cost is the result of calculating the total cost of each activity issued by the hospital. Calculation of unit costs aims to obtain information regarding budget planning, cost control, pricing, setting subsidies, and also decision making. Dispensing of sterile products is a form of service in a hospital. Dispensing services for sterile products require special requirements for human resources and facilities and infrastructure, and produce many kinds of mixed drug products, and require certain tools, therefore the budget needs to be managed appropriately. Thus, it is necessary to calculate unit costs for sterile production service at the University of Indonesia Hospital. Therefore, this research was conducted to determine the unit cost of the sterile production service at the University of Indonesia Hospital using production data for January-March 2022. Through this research, it is known that the unit cost value for sterile production service is IDR 245,377. Based on the analysis of the unit cost for sterile production service, the unit cost value was quite high because the unit cost calculation was not based out on a per drug type basis and differences in the type and amount of drug used each month."

"Industri farmasi merupakan suatu badan usaha yang memiliki izin sesuai dengan ketentuan peraturan perundang-undangan yang melakukan kegiatan pembuatan obat atau bahan obat. Suatu industri farmasi yang memproduksi produk sediaan steril perlu dibuat dengan persyaratan khusus yang bertujuan untuk memperkecil risiko kontaminasi mikroba, partikulat dan pirogen, Dimana hal ini dapat dipengaruhi dari keterampilan, pelatihan dan sikap personel yang terlibat. Oleh karena itu dibutuhkan sebuah sistem digitalisasi yang bertujuan untuk melakukan pemantauan jumlah sterilisasi baju steril. Metode yang digunakan yaitu menggunakan sebuah aplikasi yang dibuat dalam bentuk web base. Dari hasil penelitian bahwa aplikasi yang digunakan sudah baik akan tetapi perlu adanya perbaikan dalam pengaturan notifikasi.

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The pharmaceutical industry is a business entity that has a permit in accordance with the provisions of laws and regulations which carries out activities in the manufacture of medicines or medical substances. A pharmaceutical industri that produces sterile dosage products needs to be made with special requirements aimed at minimizing the risk of microbial, particulate and pyrogen contamination, where this can be influenced by the skills, training and attitudes of the personnel involved. Therefore, a digitalization system is needed which aims to monitor the number of sterilizations of sterile clothing. The method used is using an applicatipn created in the form of a web base. From the research results, the application used is good, but there needs to be improvements in the notification settings.

 

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"Kanker menjadi salah satu penyebab kematian utama pada 10 juta kasus di seluruh dunia pada tahun 2020. Salah satu terapi yang dapat diberikan kepada pasien kanker yaitu menggunakan obat sitostatika. Proses produksi obat sitostatika menurut CPOB memerlukan penanganan khusus seperti produksi di gedung terpisah dari produk non sitostatika, area produksi yang dedikatif, pengaturan sistem tata udara, dan pengaturan kelas kebersihan untuk proses produksi sediaan steril, serta perlindungan terhadap personel dan produk. Penelitian ini bertujuan untuk menelaah proses produksi sediaan sitostatika di PT CKD OTTO Pharmaceuticals, menganalisis kesesuaian proses produksi sediaan sitostatika dengan CPOB dan menganalisis perbedaan proses produksi sediaan sitostatika dibandingkan proses produksi sediaan steril lainnya. Pengambilan data dilakukan dengan observasi, wawancara, dan studi literatur. Hasil penelitian menunjukkan proses produksi sediaan sitostatika di PT CKD OTTO Pharmaceuticals meliputi tahapan  penerimaan bahan awal dan bahan kemas, sampling bahan awal dan bahan kemas, penyiapan sebelum produksi, sterilisasi, pencucian vial dan depyrogenation, penimbangan material, mixing, transfer produk, filling, freeze drying, crimping, external washer, inspeksi visual, pelabelan, pengemasan sekunder, hingga proses agregasi. Seluruh proses produksi sediaan sitostatika di PT CKD OTTO Pharmaceuticals telah sesuai dengan CPOB meliputi aspek bangunan-fasilitas, personalia, kelas kebersihan yang digunakan, pengaturan tekanan udara, sistem terkait produksi, hingga monitoring lingkungan. Terakhir, perbedaan proses produksi sediaan sitostatika dibandingkan proses produksi sediaan steril lainnya terletak pada bangunan, tekanan udara yang digunakan, tahapan penerimaan bahan awal, penimbangan material, mixing, filing, dan external washer.

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Cancer is one of the leading causes of death in 10 million cases worldwide in 2020. One of the therapies that can be given to cancer patients is using cytostatic drugs. The production process of cytostatics according to CPOB requires special handling such as production in a separate building from non-cytostatics products, dedicative production areas, air system settings, and hygiene class settings for the production process of sterile preparations, as well as protection of personnel and products. This study aims to examine the production process of cytostatics preparations at PT CKD OTTO Pharmaceuticals, analyze the suitability of the production process of cytostatics preparations with CPOB and analyze the differences in the production process of cytostatics preparations compared to the production process of other sterile preparations. Data collection was carried out by observation, interview, and literature study. The results showed that the production process of cytostatics preparations at PT CKD OTTO Pharmaceuticals included the stages of receiving initial materials and packaging materials, sampling initial materials and packaging materials, pre-production preparation, sterilization, vial washing and depyrogenation, material weighing, mixing, product transfer, filling, freeze drying, crimping, external washer, visual inspection, labeling, secondary packaging, to the aggregation process. The entire production process of cytostatics preparations at PT CKD OTTO Pharmaceuticals is in accordance with CPOB, including aspects of building-facilities, personnel, hygiene classes used, air pressure settings, production-related systems, and environmental monitoring. Finally, the difference in the production process of cytostatics preparations compared to the production process of other sterile preparations lies in the building, the air pressure used, the stages of receiving initial materials, weighing materials, mixing, filing, and external washers."

"ABSTRAKTuntutan pengguna bahan seperti pakaian, kermaik, kaca, dan lain-lain dengan semakin buruknya lingkungan menginginkan bahan terbuat dari material swa-bersih dan swa-steril. Hal tersebut dapat dilakukan dengan modifikasi bahan dengan fotokatalis TiO2, untuk meningkatkan kinerja TiO2 maka diberikan komposit dopan CuO sebagai electron trapper dan SiO2 yang mempertahankan hidrofilitas, namun perlu diketahui seberapa efektif nanokomposit TiO2-SiO2-CuO dari aspek komposisi dan morfologi yang bertujuan mendapatkan komposisi dan morfologi yang terbaik pada sifat swa-bersih dan swa-steril. Pengembangan Nanokomposit TiO2-SiO2-CuO untuk aplikasi swa-bersih dan swa-steril telah dilakukan, nanokomposit dibuat dengan PAD (Photo Assisted Deposition) untuk menempelkan logam Cu pada nanokomposit dan metode Stober untuk menambahkan SiO2 pada nanokomposit kemudian dikalsinasi. Urutan metode pembuatan nanokomposit TiO2-SiO2-CuO dapat dibedakan untuk mendapatkan morfologi nanokomposit yang berbeda dan nanokomposit yang terbentuk dikarakterisasi. Hasil FTIR (Fourier Transform Infra-Red) menunjukkan adanya ikatan Ti-O-Si pada nanokomposit yang dapat meningkatkan sifat hidrofilitas TiO2, sedangkan karakterisasi XRD (X-Ray Diffraction) menunjukkan bahwa adanya silika amorf dan ukuran struktur kristal TiO2 pada nanokomposit rata-rata sebesar 30 nm. Respon sinar tampak nanokomposit meningkat karena adanya dopan logam Cu berdasarkan hasil UV-Vis DRS (Diffuse Reflectance Spectroscopy) dengan bandgap sekitar 2,93 eV. Hasil morfologi pada permukaan nanokomposit TiO2-SiO2-CuO menunjukkan adanya silika yang membentuk granular pada nanokomposit dan persentase massa Cu menurun dengan penambahan komposisi SiO2 dari hasil EDX (Energy Dispersive X-Ray). Hasil CAM (Contact Angle Meter) menunjukkan bahwa nanokomposit memiliki sifat yng hidrofilik dengan sudut kontak 60. Nanokomposit TiO2-SiO2-CuO dengan 3% berat Cu terhadap TiO2 dan komposisi SiO2 sebesar 33% mol memiliki kemampuan disinfeksi E. Coli terbaik hingga 91% disinfeksi dan dekolorisasi metilen biru terbaik sebesar 97% dengan sifat yang superhidrofilik. Nanokomposit TiO2-SiO2-CuO M1 (morfologi 1) yang dibuat dengan memberikan dopan CuO pada TiO2 lalu diselimuti SiO2 memiliki sifat swa-bersih yang lebih unggul dibandingkan nanokomposit TiO2-SiO2-CuO M2 (morfologi 2) yang dibuat dengan menyelimuti TiO2 dengan SiO2 lalu diberikan dopan CuO dengan memiliki konstanta laju dekolorisasi metilen biru hingga 2x lebih besar dan sifat yang lebih hidrofilik, tetapi untuk sifat swa-steril nanokomposit M2 lebih unggul dengan rata-rata disinfeksi bakteri E. Coli sebesar 74,25%.

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ABSTRACTUser demands of various material such as clothe, ceramic, glass, and others with the worse environment wanted a material to have self-cleaning and self-sterile properties. It can be done by modifying the material with TiO2 photocatalyst, to increase the TiO2 performance, it was given CuO doped as an electron trapper and SiO2 composite to maintain the hydrophilicity, however it was needed to be known how effective the TiO2-SiO2-CuO nanocomposite from its composition and morphological aspect so the purpose is to obtained the best composition and morphology of the nanocomposite in self-cleaning and self-sterile properties. TiO2-SiO2-CuO nanocomposite development for the self-clean and self-sterile application were done and were made by PAD (Photo Assisted Deposition) to attach the Cu metal in the nanocomposite and Stober method to added the SiO2 in the nanocomposite and then were calcinated. The order of the method could be arranged to obtain a different TiO2-SiO2-CuO nanocomposite morphology and were characterized. FTIR (Fourier Transform Infra-Red) analysis showed that Ti-O-Si bond were developed in the nanocomposite which could increase the hydrophilicity of TiO2, while XRD (X-Ray Diffraction) analysis showed that amorphous silica in the nanocomposite and the average size of TiO2 crystaline in the nanocomposite was 30nm. The visible light response of the nanocomposite was increase because of the Cu-doped based on the result from UV-Vis DRS (Diffuse Reflectance Spectroscopy) with the value of the bandgap was 2.93 eV. Morphological result on the surface of TiO2-SiO2-CuO nanocomposite consist silica forming a granular and percentage weight of Cu decrease by the increase of SiO2 composition based on EDX (Energy Dispersive X-Ray) analysis. CAM (Contact Angle Meter) result showed that the nanocomposite has hydrophilic properties with contact angle value 60. TiO2-SiO2-CuO nanocomposite with 3% weight Cu to TiO2 and 33% mole composition of SiO2 posses the best antibacterial and self-cleaning activity which has 91% disinfection of E. Coli and 97.9% efficiency of the decolorization of methylen blue with superhydrophilic properties. TiO2-SiO2-CuO M1 (morphology 1) Nanocomposite which was made by adding the CuO dopant to TiO2 first then covered it by SiO2 consist superior self-cleaning activities than M2 (morphology 2) nanocomposite which was made by covering the TiO2 with SiO2 first then added the CuO dopant, that has 2 times larger kinetic rates of decolorization of methylen blue and more hydrophilic properties, while for the antibacterial activity M2 nanocomposite was superior than M1 nanocomposite which has the average of E. Coli disinfection around 74.25%."

"Pemasangan akses kateter intravena perifer (KIP) merupakan prosedur invasif yang paling sering dilakukan pada neonatus di ruang perawatan. Teknik steril merupakan fondasi pencegahan infeksi aliran darah pada neonatus berisiko. Penelitian ini bertujuan untuk mengidentifikasi faktor-faktor yang memengaruhi kepatuhan perawat dalam mempertahankan teknik steril pada pemasangan akses KIP. Desain penelitian yang digunakan adalah cross sectional dengan jumlah sampel 134 perawat. Adapun variabel terkait yang di ukur sehubungan dengan kepatuhan perawat dalam mempertahankan teknik steril diantaranya: penusukan berulang, tempat perawatan bayi (inkubator atau radiant warmer), usia perawat, lama bekerja, tingkat pendidikan perawat, tingkat pengetahuan, jadwal dinas, dan jumlah tim saat berdinas. Pengetahuan perawat diukur dengan menggunakan kuesioner dan tingkat kepatuhan diobservasi dengan lembar obsevasi sesuai Standar Prosedur Operasional (SPO). Data hasil penelitian dianalisis dengan multivariate regresi linier dengan hasil faktor yang memengaruhi kepatuhan perawat dalam mempertahankan teknik steril adalah penusukkan berulang, tempat perawatan bayi (radiant warmer dan inkubator), usia, tingkat pendidikan, jadwal dinas, jumlah tim saat berdinas (p=0,01; alpha 0,05%)

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The insertion of peripheral intravenous catheter access (KIP) is an invasive procedure that is most often performed on neonates in the treatment room. Sterile technique is the foundation for preventing bloodstream infection in at-risk neonates. This study aims to identify the factors that influence nurses' compliance in maintaining sterile techniques for KIP access installation. The research design used was cross sectional with a sample size of 134 nurses. The related variables measured in relation to nurses' compliance in maintaining sterile techniques include: repeated stabbing, place of baby care (incubator or radiant warmer), age of the nurse, length of work, level of nurse education, level of knowledge, schedule of service, and number of teams while serving. Nurses' knowledge was measured using a questionnaire and the level of compliance was observed with an observation sheet according to Standard Operating Procedures (SPO). The data from the research results were analyzed by multivariate linear regression with the results that the factors that influenced nurses' compliance in maintaining sterile techniques were repeated stabbing, place of baby care (radiant warmer and incubator), age, education level, service schedule, number of teams while serving (p = 0, 01; alpha 0.05%)"

"[ABSTRAKLatar belakang penelitian ini adalah fenomena penularan HIV melalui penggunaan alat suntik yang tidak steril dari Pengguna Narkoba Suntik (Penasun). Perilaku menyuntik penasun secara bergantian membuat tingginya angka penularan HIV di kalangan penasun untuk itu dibutuhkan peranan petugas outreach dalam menjalankan pemasaran sosialLayanan Alat Suntik Steril (LASS). Tujuan penelitian ini mendapatkan gambaran mengenai self-disclosure pada komunikasi interpersonal dalam menerapkan pemasaran sosialyang dilakukan oleh petugas outreach untuk merubah perilaku penasun agar menggunakan alat suntik steril. Metode penelitian kualitatif deskriptif. Disimpulkan penelitian ini menunjukkan ketidakberhasilan pemasaran sosial karena petugas outreach yang tidak mampu membuat penasun melakukan self-disclosure, banyak penasun yang belum membuka dirinya.

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ABSTRACTBackground of this research was the phenomenon of HIV transmission through the use of unsterile needle syringe behaviour among Injecting Drug Users IDUs IDUs habbit to used unsterille needle syringe increased HIV transmission among them it make the role of outreach officer in running sosial marketing sterile needle syringe programme became important The purpose of this research was to get the description about self disclosure for social marketing which done by the outreach officer to change their behaviour use sterile needle syringe The methode was using descriptive qualitative The conclusion showed that the social marketing had not been success yet because outreach officer had not been able yet to make IDUs doing self disclosure so most IDUs had not been willing to open themselves to their outreach officer ;Background of this research was the phenomenon of HIV transmission through the use of unsterile needle syringe behaviour among Injecting Drug Users IDUs IDUs habbit to used unsterille needle syringe increased HIV transmission among them it make the role of outreach officer in running sosial marketing sterile needle syringe programme became important The purpose of this research was to get the description about self disclosure for social marketing which done by the outreach officer to change their behaviour use sterile needle syringe The methode was using descriptive qualitative The conclusion showed that the social marketing had not been success yet because outreach officer had not been able yet to make IDUs doing self disclosure so most IDUs had not been willing to open themselves to their outreach officer ;Background of this research was the phenomenon of HIV transmission through the use of unsterile needle syringe behaviour among Injecting Drug Users IDUs IDUs habbit to used unsterille needle syringe increased HIV transmission among them it make the role of outreach officer in running sosial marketing sterile needle syringe programme became important The purpose of this research was to get the description about self disclosure for social marketing which done by the outreach officer to change their behaviour use sterile needle syringe The methode was using descriptive qualitative The conclusion showed that the social marketing had not been success yet because outreach officer had not been able yet to make IDUs doing self disclosure so most IDUs had not been willing to open themselves to their outreach officer ;Background of this research was the phenomenon of HIV transmission through the use of unsterile needle syringe behaviour among Injecting Drug Users IDUs IDUs habbit to used unsterille needle syringe increased HIV transmission among them it make the role of outreach officer in running sosial marketing sterile needle syringe programme became important The purpose of this research was to get the description about self disclosure for social marketing which done by the outreach officer to change their behaviour use sterile needle syringe The methode was using descriptive qualitative The conclusion showed that the social marketing had not been success yet because outreach officer had not been able yet to make IDUs doing self disclosure so most IDUs had not been willing to open themselves to their outreach officer , Background of this research was the phenomenon of HIV transmission through the use of unsterile needle syringe behaviour among Injecting Drug Users IDUs IDUs habbit to used unsterille needle syringe increased HIV transmission among them it make the role of outreach officer in running sosial marketing sterile needle syringe programme became important The purpose of this research was to get the description about self disclosure for social marketing which done by the outreach officer to change their behaviour use sterile needle syringe The methode was using descriptive qualitative The conclusion showed that the social marketing had not been success yet because outreach officer had not been able yet to make IDUs doing self disclosure so most IDUs had not been willing to open themselves to their outreach officer ]"