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Abstrak :
Telehealth nursing adalah layanan berbasis teknologi informasi yang diharapkan dapat menjadi sarana untuk mempermudah komunikasi antara pasien dan perawat dalam merawat luka terutama pada saat kondisi pandemi COVID-19. Penelitian ini bertujuan untuk mengetahui efektifitas telehealth nursing terhadap penyembuhan ulkus kaki diabetik. Desain penelitian menggunakan quasi eksperimen dengan pre-post test with control group. Jumlah responden dalam penelitian ini sebanyak 46 orang diperoleh melalui teknik consecutive sampling. Kelompok eksperimen diberikan telehealth nursing yang berisi kombinasi edukasi dan monitoring perawatan luka mandiri dan kelompok kontrol diberikan edukasi dan perawatan luka secara langsung di klinik luka. Penyembuhan luka diukur dengan menggunakan Bates Jensen Wound Assessment Tool (BWAT). Hasil penelitian menunjukkan bahwa telehealth nursing memiliki efektifitas yang signifikan yaitu sebesar p=0,873 (α>0.05) pada proses penyembuhan luka. telehealth nursing adalah pilihan terbaik dalam merawat ulkus kaki diabetik pada pasien yang mengalami kesulitan atau dengan kondisi yang tidak memungkinkan untuk perawatan luka secara langsung ke layanan kesehatan. ......Telehealth nursing as an information technology-based service is expected to be a means to facilitate communication between patients and nurses in caring for wounds, especially during the COVID-19 pandemic. This study aims to identify the effectiveness of telehealth nursing in healing diabetic foot ulcers.This study was a quasi-experimental with a pre-post test with a control group. The study was conducted on 46 people using consecutive sampling. The intervention group was given telehealth nursing which contained a combination of education and self manage wound care monitoring and the control group was given education and wound care at the wound clinic. Wound healing was measured using the Bates Jensen Wound Assessment Tool (BWAT). The results showed that telehealth nursing had significant effectiveness of p=0.873 (α>0.05) in the wound healing process. telehealth nursing is the best choice in treating diabetic foot ulcers in patients who have difficulty or with conditions that do not allow direct wound care to health services.

Abstrak :
[ABSTRAK
Latar Belakang: Pasien DM dengan ulkus kaki lebih banyak yang mengalamidepresi dan memiliki kualitas hidup yang buruk. Dalam tatalaksana ulkus kaki diabetic perlu diperhatikan faktor psikososial karena diperkirakan dapat mempengaruhi penyembuhan luka melalui induksi gangguan keseimbangan neuroendokrin-imun. Beberapa penelitian mengenai pengaruh depresi pada proses penyembuhan ulkus diabetik telah dilakukan dengan hasil yang masih kontroversial.

Tujuan: Mengetahui pengaruh depresi terhadap proses perbaikan infeksi ulkus kaki diabetik, serta tingkat depresi pada pasien ulkus kaki diabetik rawat inap.

Metode: Observasional, kohort prospektif, terhadap 95 pasien ulkus kaki diabetic terinfeksi yang dirawat di RSCM dan RS jejaring dalam kurun waktu penelitian, terbagi 2 kelompok yaitu kelompok depresi dan kelompok tidak depresi. Data klinis, penilaian depresi, dan data laboratorium diambil saat pasien masuk rumah sakit kemudian dinilai perbaikan infeksi ulkus kaki diabetik dalam 21 hari masa perawatan. Dilakukan analisis bivariat dengan uji Chi-square berdasarkan batas kemaknaan (α) sebesar 5% dan analisis multivariat.

Hasil: Dari 95 subyek penelitian, 38 orang (40%) masuk dalam kelompok tidak depresi, sedangkan kelompok depresi terdiri atas 57 orang (60%). Subyek perempuan jumlahnya dominan pada kelompok depresi (70%). Komorbid terbanyak adalah hipertensi, dengan angka komorbiditas dan penyakit kardivaskular lebih tinggi pada kelompok depresi. Malnutrisi dan obesitas juga lebih banyak pada kelompok depresi (64,9% dan 31,6%), demikian pula dengan kontrol glikemik yang buruk (73,7%). Sebagian besar pasien (73,7%) yang masuk dalam kelompok depresi memiliki depresi ringan. Pada kelompok depresi 40,4% mengalami perbaikan infeksi dalam 21 hari masa perawatan, sedangkan pada kelompok tidak depresi 68,4%.

Simpulan: Depresi cenderung meningkatkan risiko atau kemungkinan tidak terjadinya perbaikan infeksi ulkus kaki diabetik, walaupun setelah dilakukan penyesuaian terhadap variabel perancu, hasil tersebut tidak bermakna secara statistik (adjusted OR 2,429 dengan IK 95% 0,890-6,632). Lebih banyak subjek dengan depresi sedang yang tidak mengalami perbaikan infeksi ulkus kaki diabetik dibandingkan dengan subjek dengan depresi ringan (93,3% dan 47,6%).

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ABSTRACT
Background: Patients with diabetic foot ulcers are more depressed and have a poor quality of life. In the management of diabetic foot ulcers, psychosocial factors need to be considered because it can influence wound healing through induction of neuroendocrine-immune balance disorders. Several studies on the effect of depression in diabetic ulcer healing process has been carried out with results that are still controversial.

Objective: To investigate the effect of depression on diabetic foot ulcer infection healing process, as well as the level of depression in patients with diabetic foot ulcers.

Methods: Observational, prospective cohort, of the 95 patients with infected diabetic foot ulcers treated at Cipto Mangunkusumo hospital and networking hospitals within the study, divided into 2 groups: group of depressed and non-depressed group. Clinical data, assessment of depression, and laboratory data were taken on admission to hospital then we assessed improvements infection of diabetic foot ulcers in 21 days of treatment. Bivariate analysis performed using Chi-square test based on the limit of significance (α) of 5%, also does multivariate analysis.

Results: Of the 95 subjects, 40%was not depressed, while the depressed group consisted of 60%. Female subjects was dominant in the depressed group (66,7%). Most comorbid was hypertension, with a number of comorbidities and disease cardivascular higher in depressed group. Malnutrition and obesity are also higher in the depression group (64,9% and 31,6%), as well as poor glycemic control (73,7%). Most patients (73,7%) included in the depressed group had mild depression. In the depressed group, 40,4% experienced improvement in 21-day period of treatment, whereas in the non-depressed group 68,4%.

Conclusion: Depression tends to increse diabetic foot ulcer infection risk to not improved, although after adjusment of confounding variables the result was not statistically significant (adjusted OR 2,429 with CI95% 0,890-6,632). More subjects with moderate depression who did not exeperience improvement when compared to subjects with mild depression did not exeperience improvement (93,3% and 47,6%). ;Background: Patients with diabetic foot ulcers are more depressed and have a poor quality of life. In the management of diabetic foot ulcers, psychosocial factors need to be considered because it can influence wound healing through induction of neuroendocrine-immune balance disorders. Several studies on the effect of depression in diabetic ulcer healing process has been carried out with results that are still controversial. Objective: To investigate the effect of depression on diabetic foot ulcer infection healing process, as well as the level of depression in patients with diabetic foot ulcers. Methods: Observational, prospective cohort, of the 95 patients with infected diabetic foot ulcers treated at Cipto Mangunkusumo hospital and networking hospitals within the study, divided into 2 groups: group of depressed and non-depressed group. Clinical data, assessment of depression, and laboratory data were taken on admission to hospital then we assessed improvements infection of diabetic foot ulcers in 21 days of treatment. Bivariate analysis performed using Chi-square test based on the limit of significance (α) of 5%, also does multivariate analysis. Results: Of the 95 subjects, 40%was not depressed, while the depressed group consisted of 60%. Female subjects was dominant in the depressed group (66,7%). Most comorbid was hypertension, with a number of comorbidities and disease cardivascular higher in depressed group. Malnutrition and obesity are also higher in the depression group (64,9% and 31,6%), as well as poor glycemic control (73,7%). Most patients (73,7%) included in the depressed group had mild depression. In the depressed group, 40,4% experienced improvement in 21-day period of treatment, whereas in the non-depressed group 68,4%. Conclusion: Depression tends to increse diabetic foot ulcer infection risk to not improved, although after adjusment of confounding variables the result was not statistically significant (adjusted OR 2,429 with CI95% 0,890-6,632). More subjects with moderate depression who did not exeperience improvement when compared to subjects with mild depression did not exeperience improvement (93,3% and 47,6%). ;Background: Patients with diabetic foot ulcers are more depressed and have a poor quality of life. In the management of diabetic foot ulcers, psychosocial factors need to be considered because it can influence wound healing through induction of neuroendocrine-immune balance disorders. Several studies on the effect of depression in diabetic ulcer healing process has been carried out with results that are still controversial. Objective: To investigate the effect of depression on diabetic foot ulcer infection healing process, as well as the level of depression in patients with diabetic foot ulcers. Methods: Observational, prospective cohort, of the 95 patients with infected diabetic foot ulcers treated at Cipto Mangunkusumo hospital and networking hospitals within the study, divided into 2 groups: group of depressed and non-depressed group. Clinical data, assessment of depression, and laboratory data were taken on admission to hospital then we assessed improvements infection of diabetic foot ulcers in 21 days of treatment. Bivariate analysis performed using Chi-square test based on the limit of significance (α) of 5%, also does multivariate analysis. Results: Of the 95 subjects, 40%was not depressed, while the depressed group consisted of 60%. Female subjects was dominant in the depressed group (66,7%). Most comorbid was hypertension, with a number of comorbidities and disease cardivascular higher in depressed group. Malnutrition and obesity are also higher in the depression group (64,9% and 31,6%), as well as poor glycemic control (73,7%). Most patients (73,7%) included in the depressed group had mild depression. In the depressed group, 40,4% experienced improvement in 21-day period of treatment, whereas in the non-depressed group 68,4%. Conclusion: Depression tends to increse diabetic foot ulcer infection risk to not improved, although after adjusment of confounding variables the result was not statistically significant (adjusted OR 2,429 with CI95% 0,890-6,632). More subjects with moderate depression who did not exeperience improvement when compared to subjects with mild depression did not exeperience improvement (93,3% and 47,6%). , Background: Patients with diabetic foot ulcers are more depressed and have a poor quality of life. In the management of diabetic foot ulcers, psychosocial factors need to be considered because it can influence wound healing through induction of neuroendocrine-immune balance disorders. Several studies on the effect of depression in diabetic ulcer healing process has been carried out with results that are still controversial. Objective: To investigate the effect of depression on diabetic foot ulcer infection healing process, as well as the level of depression in patients with diabetic foot ulcers. Methods: Observational, prospective cohort, of the 95 patients with infected diabetic foot ulcers treated at Cipto Mangunkusumo hospital and networking hospitals within the study, divided into 2 groups: group of depressed and non-depressed group. Clinical data, assessment of depression, and laboratory data were taken on admission to hospital then we assessed improvements infection of diabetic foot ulcers in 21 days of treatment. Bivariate analysis performed using Chi-square test based on the limit of significance (α) of 5%, also does multivariate analysis. Results: Of the 95 subjects, 40%was not depressed, while the depressed group consisted of 60%. Female subjects was dominant in the depressed group (66,7%). Most comorbid was hypertension, with a number of comorbidities and disease cardivascular higher in depressed group. Malnutrition and obesity are also higher in the depression group (64,9% and 31,6%), as well as poor glycemic control (73,7%). Most patients (73,7%) included in the depressed group had mild depression. In the depressed group, 40,4% experienced improvement in 21-day period of treatment, whereas in the non-depressed group 68,4%. Conclusion: Depression tends to increse diabetic foot ulcer infection risk to not improved, although after adjusment of confounding variables the result was not statistically significant (adjusted OR 2,429 with CI95% 0,890-6,632). More subjects with moderate depression who did not exeperience improvement when compared to subjects with mild depression did not exeperience improvement (93,3% and 47,6%). ]

Abstrak :
ABSTRAK
Pendahuluan: Modifikasi dari kriteria klinis infeksi menurut International Disease Society of America dan International Working Group on Diabetic Foot (IDSA-IWGDF) diperlukan untuk mengevaluasi infeksi pada ulkus kaki diabetik setelah pengobatan. Prokalsitonin (PCT), penanda infeksi yang spesifik untuk infeksi bakteri diketahui bermanfaat dalam menegakkan diagnosis infeksi pada ulkus kaki diabetik. Namun, peranannya dalam menentukan ada tidaknya infeksi pada ulkus kaki diabetik setelah pengobatan belum diketahui, begitu juga nilai tambahnya terhadap penanda klinis infeksi. Penelitian ini dilakukan untuk menentukan kemampuan penanda klinis infeksi menurut IDSA-IWGDF yang dimodifikasi dan PCT dalam mengevaluasi masih ada atau tidaknya infeksi pada ulkus kaki diabetik setelah pengobatan. Metode: Dilakukan studi potong lintang berbasis riset diagnostik pada penyandang diabetes dengan ulkus kaki terinfeksi yang sedang mendapatkan pengobatan dan perawatan di Rumah Sakit dr. Cipto Mangunkusumo (RSCM) Jakarta pada kurun waktu Oktober 2011-April 2012. Pasien yang sudah memenuhi kriteria inklusi dan eksklusi penelitian dilakukan penilaian infeksi pada ulkus menggunakan kriteria klinis infeksi menurut IDSA-IWGDF yang dimodifikasi (eritema, edema, nyeri, dan panas) dan pemeriksaan PCT. Kemudian dinilai kemampuannya dalam mengevaluasi masih ada atau tidaknya infeksi pada ulkus kaki diabetik setelah pengobatan dengan membuat kurva ROC dan menghitung AUC. Lalu ditentukan titik potong dengan sensitivitas dan spesifisitas terbaik pada penelitian ini yang dibandingkan dengan baku emas berupa pemeriksaan bakteri secara kuantitatif dari kultur jaringan ulkus. Hasil: Dari 47 subjek yang diteliti, terdapat 41 subjek dengan ulkus kaki diabetik yang masih terinfeksi berdasarkan pemeriksaan bakteri secara kuantitatif dari kultur jaringan ulkus. Penanda klinis infeksi menurut IDSA-IWGDF yang dimodifikasi memilki kemampuan prediksi yang baik dalam menentukan masih ada atau tidaknya infeksi pada ulkus kaki diabetik setelah pengobatan dengan AUC: 0,744 (IK 95% 0,576-0,912) dengan titik potong bila ditemukan ≥2 tanda klinis infeksi (Sn: 41,46%; Sp: 100%; NPP: 100%, NPN: 20%). Sedangkan, untuk prokalsitonin didapatkan AUC: 0,642 (IK 95% 0,404-0,880). Simpulan: Kriteria klinis infeksi menurut IDSA-IWGDF yang dimodifikasi memiliki kemampuan yang baik untuk menentukan masih ada atau tidaknya infeksi pada ulkus kaki diabetik setelah pengobatan. Belum didapatkan manfaat prokalsitonin dalam mengevaluasi masih ada atau tidaknya infeksi pada ulkus kaki diabetik setelah pengobatan.

Abstrak :
Ulkus kaki diabetik adalah komplikasi kronik diabetes melitus yang mengakibatkan kerusakan kulit yang dapat meluas ke tendon, otot, tulang atau persendian. Ulkus kaki, infeksi, neuroarthropati dan penyakit arteri perifer mengakibatkan gangren dan amputasi ekstremitas bagian bawah. Tujuan penelitian ini untuk mengetahui pengaruh latihan ROM ankle terhadap proses penyembuhan ulkus kaki diabetik di rumah sakit di propinsi Lampung. Penelitian ini menggunakan desain kuasi eksperimen pre post test dengan kelompok kontrol, melibatkan 7 responden kelompok intervensi dan 7 responden kelompok kontrol. Teknik pengambilan sampel dengan non probability consecutive sampling. Penelitian ini menggunakan t test, diperoleh hasil adanya perbedaan yang signifikan rata-rata skor penyembuhan ulkus kaki diabetik antara kelompok intervensi dan kelompok kontrol setelah dilakukan latihan ROM ankle (p= 0,001; α = 0,05 ). Demikian juga terbukti tidak ada hubungan antara lama sakit DM (p = 0,656 ; α = 0,05), GDN (p = 0,648 ; α = 0,05), GDPP (p = 0,883 ; α = 0,05) dan infeksi ulkus (p = 1,000; α = 0,05) dengan skor penyembuhan ulkus kaki diabetik. Peneliti memberikan saran agar latihan ROM ankle dapat diterapkan pada perawatan ulkus kaki diabetik sesuai dengan formula yang ada. Penelitian lebih lanjut perlu dilakukan dengan jenis gerakan yang lain, melibatkan tidak hanya sendi ankle. Selain itu dilakukan penelitian dengan jumlah sampel yang lebih besar.

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Diabetic foot ulcer is a chronic complication of diabetes melitus disease resulting in destructruction of skin that can spread to tendons, muscles, bones or joints. Foot ulcers, infections, neuroarthropati and peripheral arterial disease lead to gangrene and amputation of the lower extremities. The purpose of this study was to determine the effect of ankle ROM exercises on the healing of diabetic foot ulcers in the hospital province of Lampung. This study used quasi-experimental design pre-post test with control group. This study recruited 7 respondents intervention group and 7 respondents control group by non probability consecutive sampling. The t test result showed that there was a significant difference in the mean score of the healing of diabetic foot ulcers between the intervention and control group after ankle ROM exercise (p = 0.001; α = 0.05). There are no relationship among the illness period of DM (p = 0.656; α = 0.05), GDN (p = 0,648 ; α = 0,05), GDPP (p = 0,883 ; α = 0,05) and ulcers infection (p = 1.000; α = 0,05) with a score of healing diabetic foot ulcers. The researcher suggested that ankle ROM exercises could be applied to the diabetic foot ulcers care in accordance with the existing formula. Further research needs to be done with other types of movement, involving not only the ankle joint, but also other parts of joints. In addition the study should be recruite a larger number of samples.

Abstrak :
Diabetes sering menyebabkan komplikasi ulkus kaki diabetik (UKD) yang penyembuhannya terhambat pada fase inflamasi dan terjadi gangguan pada pembentukan jaringan granulasi. LL-37 memiliki aktivitas antimikrobial, memicu angiogenesis, serta migrasi dan proliferasi keratinosit. Penelitian ini menganalisis pengaruh krim LL-37 terhadap kecepatan penyembuhan UKD derajat ringan dengan mengkaji IL-1a, TNF-a, serta pola dan jumlah kolonisasi bakteri aerob. Penelitian ini adalah uji klinis buta ganda acak yang dilaksanakan Januari 2020–Juni 2021 di RSUPN dr. Cipto Mangunkusumo dan RSUP Persahabatan, Jakarta. Subjek adalah penyandang UKD tanpa infeksi atau infeksi derajat ringan, berusia 18–60 tahun, ABI 0,9–1,3, luas luka ≥ 2 cm2, kedalaman luka sampai dengan subkutis, dan tanpa infeksi sistemik. Subjek dibagi menjadi kelompok krim LL-37 dan plasebo yang dioles dua kali seminggu selama 4 minggu. Dilakukan pengamatan luka pada akhir minggu dengan metode planimetri dan fotografi digital lalu diolah dengan ImageJ. Subjek diperiksa kadar IL-1a dan TNF-a cairan luka dengan metode ELISA dan kultur bakteri aerob dari apusan luka pada setiap akhir minggu. Kadar LL-37 cairan luka pada kelompok LL-37 adalah 1,07 (0,37–4,96) ng/mg protein dan plasebo sebesar 1,11 (0,24–2,09) ng/mg protein (p = 0,44). Penurunan luas luka pada hari ke-14, ke-21, dan ke-28 dibandingkan hari ke-1 pada kelompok LL-37 lebih besar daripada plasebo, walaupun tidak bermakna. Pada kelompok LL-37 terjadi peningkatan luas jaringan granulasi yang lebih besar daripada plasebo pada semua hari, walaupun hanya bermakna pada hari ke-14 yaitu 0,95 (±1,34) cm2 pada kelompok LL-37 dibandingkan -0,24 (±1,01) cm2 pada kelompok plasebo (p = 0,020). Terjadi peningkatan indeks granulasi yang secara konsisten lebih besar dan bermakna (p < 0,05) pada kelompok LL-37 dibandingkan plasebo pada semua hari. Tidak terjadi penurunan kadar IL-1a dan TNF-a yang lebih besar pada kelompok LL-37. Pada hari ke-1, frekuensi bakteri aerob terbanyak adalah S. aureus yaitu 37,1% pada kelompok LL-37 dan 45% pada kelompok plasebo. Penurunan jumlah koloni bakteri pada kelompok plasebo lebih besar dibandingkan dengan kelompok LL-37 pada hari ke-28 dibandingkan dengan hari ke-1, walaupun tidak bermakna (p = 0,98). Simpulan: Kadar LL-37 pada UKD kedua kelompok rendah. Pemberian LL-37 mempercepat penyembuhan UKD tanpa infeksi maupun derajat ringan dengan meningkatkan indeks granulasi. Pemberian LL-37 tidak menurunkan kadar IL-1a dan TNF-a pada UKD. Pemberian LL-37 tidak memengaruhi pola dan jumlah kolonisasi bakteri aerob pada UKD. ......Diabetes often causes DFU (diabetic foot ulcer). Wound healing in DFU has prolonged inflammation phase and defective granulation tissue formation. LL-37 has antimicrobial property, induces angiogenesis, and keratinocyte migration and proliferation. This study analyzes the efficacy of LL-37 cream on wound healing rate in DFU with mild infection by examining IL-1a, TNF-a, and aerobic bacteria colonization. This study was a randomized double-blind controlled trial conducted from January 2020–June 2021 at RSUPN dr. Cipto Mangunkusumo and RSUP Persahabatan, Jakarta. Subjects were patients with uninfected DFU or DFU with mild infection according to IDSA, aged 18–60 years old, ABI 0.9–1.3, wound area ≥ 2 cm2, wound no deeper than subcutaneous layer, and without systemic infection. Subjects were divided into the LL-37 cream and placebo cream group which were applied twice a week for 4 weeks. Wounds were measured at the end of every week using planimetric method and digital photography and subsequently processed with ImageJ. The levels of IL-1a and TNF-a from wound fluid were measured using the ELISA method and aerobic bacteria culture was performed using wound swabs. The level of LL-37 from wound fluid in the LL-37 group was 1.07 (0.37–4.96) ng/mg protein and in the placebo group was 1.11 (0.24–2.09) ng/mg protein (p = 0.44). The decrease in wound area on day 14, 21, and 28 compared to day 1 in the LL-37 group was greater than in the placebo group, although the difference was not significant. In the LL-37 group, there was a greater increase in granulation tissue area than in the placebo group on each day, although the difference was only significant on day 14 which was 0.95 (±1.34) cm2 in the LL-37 group compared to -0.24 (± 1.01) cm2 in the placebo group (p = 0.020). There was a consistently and significantly greater increase in granulation index (p < 0.05) in the LL-37 group compared to placebo group on each day. There was no greater decrease in IL-1a and TNF-a levels in the LL-37 group. On day 1, the highest frequency of aerobic bacteria was S. aureus which was 37.1% in the LL-37 group and 45% in the placebo group. The decrease in the number of bacterial colonies in the placebo group was greater than in the LL-37 group on day 28 compared to day 1, although the difference was not significant (p = 0.98). Conclusion: The level of LL-37 in DFU was low in both groups. Administration of LL-37 accelerated the healing of uninfected DFU or DFU with mild infection by increasing the granulation index. Administration of LL-37 did not reduce the levels of IL-1a and TNF-a in DFU. Administration of LL-37 did not affect the pattern and number of colonization of aerobic bacteria in DFU.

Abstrak :
Ulkus kaki diabetik (UKD) merupakan luka kronik pada pasien diabetes melitus (DM). Vitamin D dipercaya memiliki peran penting pada diferensiasi, proliferasi, pertumbuhan sel, dan modulasi sistem imunitas sehingga kadar yang optimal dibutuhkan untuk penyembuhan luka. Defisiensi vitamin D juga diduga mengganggu produksi dan sekresi insulin sehingga berkontribusi pada kronisitas UKD. Penelitian bertujuan membandingkan kadar vitamin D pada pasien DM dengan dan tanpa UKD; serta untuk mengetahui korelasi antara durasi UKD dan keparahan UKD berdasarkan skor PEDIS (perfusion, extension, depth, infection, sensation) dengan kadar vitamin D. Serum 25-hidroksivitamin D (25(OH)D) dianalisis menggunakan in-vitro chemiluminescent immunoassay (CLIA). Analisis statistik yang sesuai dilakukan untuk membuktikan tujuan penelitian. Perbandingan nilai median (Q1-Q3) kadar vitamin D pada pasien DM dengan dan tanpa UKD secara berurutan adalah 8,90 ng/mL (6,52-10,90) dan 16,25 ng/mL (13-19,59), serta bermakna secara statistik (p<0,001). Tidak ada korelasi antara durasi UKD dan keparahan UKD berdasarkan skor PEDIS terhadap kadar vitamin D, serta tidak bermakna secara statistik. Hasil pada penelitian ini menunjukkan bahwa kadar vitamin D pada pasien DM dengan UKD lebih rendah dibandingkan pasien tanpa UKD. Namun belum ada bukti yang cukup untuk menyimpulkan bahwa tidak ada korelasi antara durasi UKD dan keparahan UKD berdasarkan skor PEDIS terhadap kadar vitamin D. ......Diabetic foot ulcers (DFU) are chronic wounds in patients with diabetes mellitus (DM). Vitamin D believed have important role in differentiation, proliferation, cell growth, and immune system modulation hence optimal levels are needed for wound healing. Vitamin D deficiency also thought to interfere insulin production and secretion, thereby contributing to DFU chronicity. This study aims to compare vitamin D levels in DM patients with and without DFU; and determine the correlation between DFU duration and severity by PEDIS (perfusion, extension, depth, infection, sensation) score to vitamin D levels. 25-hydroxyvitamin D serum analyzed using in-vitro chemiluminescent immunoassay. Appropriate statistical analysis was done following the study. Comparison of median values ​​(Q1-Q3) vitamin D levels in DM patients with and without DFU were 8.90 ng/mL (6.52-10.90) and 16.25 ng/mL (13-19.59) respectively, and statistically significant (p<0.001). There was no correlation between DFU duration and severity PEDIS score to vitamin D levels, and it was not statistically significant. The results of this study indicate that vitamin D levels in DM patients with DFU are lower than patients without DFU. However, there is not enough evidence to conclude that there is no correlation between DFU duration and severity by PEDIS score to vitamin D levels.