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Hasil Pencarian

Ditemukan 51 dokumen yang sesuai dengan query
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Harrington, Mary
Belmont, CA : Thomson/Wadsworth, 2006
612.807 2 HAR d (1)
Buku Teks  Universitas Indonesia Library
cover
London: MIT Press, 2000
153 NEW
Buku Teks SO  Universitas Indonesia Library
cover
Benarroch, Eduardo E.
Philadelphia: Butterworth Heinemann, Elsevier, 2006
616.8 BEN b
Buku Teks  Universitas Indonesia Library
cover
Abstrak :
Summary: The development of the brain and nervous system is shaped not just by a genetic program, but also by the effects of multiple environmental stimuli. There are currently no book-length treatments of perinatal neurodevelopment. This book fills this gap by presenting a collection of chapters from leading experts in the field. It is comprehensive and covers all aspects of neurodevelopmental programming in lab animals and in human subjects. The third section of the book looks at ways of translating insights we have garnered from animal studies to human and clinical studies. This book is beneficial for basic researchers interested in the effects of perinatal imprinting on the development of the nervous system and associated disease
New York, NY: Springer New York : Imprint : Springer, 2015
612.82 PER
Buku Teks  Universitas Indonesia Library
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Tade Matthias Spranger
Abstrak :
The book contains several country reports from around the world, as well as those of international organizations such as UNESCO, in order to show the different legal approaches to the topic and possible interactions.
Berlin: Springer, 2012
e20400292
eBooks  Universitas Indonesia Library
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Paul A. Lapchak, editor
Abstrak :
This volume sets a basis for effective translational research. Authored by experts in the field of translational stroke research, each chapter specifically addresses one or more components of preclinical stroke research. The emphasis is placed on target identification and drug development using state-of-the-art in vitro and in vivo assays, in combination with in vitro toxicology assays, AMDE and clinical design.
New York: [, Springer], 2012
e20417625
eBooks  Universitas Indonesia Library
cover
McCandless, David W.
Abstrak :
The present volume is intended to be a synopsis of seizure disorders with a goal of describing key studies in animals and humans. The translation of pertinent findings from animal studies to human studies, and to potential human studies will be emphasized. Specific cogent animal studies/results which deserve exploration in human seizure disorders will be detailed. The current rate of translation is estimated to be from 7‐9 years, and the “success” rate of translation was very recently listed as less than one half. The success rate is defined as results in human studies which were predicted in advance by animal studies. Both the time between animal and human attempts plus the success rate need improvement.
New York: [, Springer], 2012
e20417642
eBooks  Universitas Indonesia Library
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Jill Scott, editor
Abstrak :
Examines shared territories in neurobiological anatomy, physiology and media art. This title reveals how scientists investigate perception and behaviour at the molecular, cellular and systems level. It demonstrates how interpretative forms of media art can help to demystify these complexities for diverse audiences.
Berlin: [, Springer], 2012
e20417717
eBooks  Universitas Indonesia Library
cover
Tombran-Tink, Joyce, editor
Abstrak :
This book is designed with two overriding objectives, to help readers understand the impact of vision impairment in people living daily with diabetes rather than considering diabetic retinopathy solely as a medical problem, and to explore what we know and don't know about the ways diabetes affect the eye. With the plethora of new information being generated, there are still a series of fundamental questions that must be addressed if effective treatments for diabetic retinopathy are to be found and applied. Developed by a renowned group of authorities, Visual dysfunction in diabetes, the science of patient impairment and improvement offers responses and context for a range of questions, such as, do metabolic factors beyond glucose contribute to vision-threatening diabetic retinopathy? If so, how do these lead to vision impairment? Is diabetic retinopathy a response to systemic metabolic abnormalities or are there unique ocular problems related to insulin resistance? What is the relationship between the neural, vascular, and inflammatory abnormalities in diabetic retinopathy? Do they represent a pathological cascade induced sequentially or simultaneous responses to one or more metabolic perturbations? The authors note that if we do not address these types of questions, it is possible that the long process of developing new therapeutic
New York: Springer, 2012
e20420723
eBooks  Universitas Indonesia Library
cover
Slominski, Andrzej T., editor
Abstrak :
The skin, the body’s largest organ, is strategically located at the interface with the external environment where it detects, integrates and responds to a diverse range of stressors, including solar radiation. It has already been established that the skin is an important peripheral neuroendocrine-immune organ that is closely networked with central regulatory systems. These capabilities contribute to the maintenance of peripheral homeostasis. Specifically, epidermal and dermal cells produce and respond to classical stress neurotransmitters, neuropeptides and hormones, production which is stimulated by ultraviolet radiation (UVR), biological factors (infectious and non-infectious) and other physical and chemical agents. Examples of local biologically active products are cytokines, biogenic amines (catecholamines, histamine, serotonin and N-acetyl-serotonin), melatonin, acetylocholine, neuropeptides including pituitary (proopiomelanocortin-derived ACTH, b-endorphin or MSH peptides, thyroid stimulating hormone) and hypothalamic (corticotropin-releasing factor and related urocortins, thyroid-releasing hormone) hormones, as well as enkephalins and dynorphins, thyroid hormones, steroids (glucocorticoids, mineralocorticoids, sex hormones, 7-δ steroids), secosteroids, opioids and endocannabinoids. The production of these molecules is hierarchical, organized along the algorithms of classical neuroendocrine axes such as the hypothalamic pituitary adrenal axis (HPA), hypothalamic-thyroid axis (HPT), serotoninergic, melatoninergic, catecholaminergic, cholinergic, steroid/secosteroidogenic, opioid and endocannabinoid systems. Disruptions of these axes or of communication between them may lead to skin and/or systemic diseases. These local neuroendocrine networks also serve to limit the effect of noxious environmental agents to preserve local and consequently global homeostasis. Moreover, the skin-derived factors/systems can also activate cutaneous nerve endings to alert the brain to changes in the epidermal or dermal environments, or alternatively to activate other coordinating centers by direct (spinal cord) neurotransmission without brain involvement. Furthermore, rapid and reciprocal communications between epidermal and dermal and adnexal compartments are also mediated by neurotransmission including antidromic modes of conduction. Lastly, skin cells and the skin as an organ coordinate and/or regulate not only peripheral but also global homeostasis.
Berlin : Springer, 2012
e20426017
eBooks  Universitas Indonesia Library
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