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Abstrak :
Latar belakang. Berdasarkan WHO, lesi-lesi prekursor dapat berkembang menjadi karsinoma kolorektal melalui 2 jalur yaitu adenoma - carcinoma sequence dan serrated pathways. Adenoma carcinoma sequence diawali sel atipik - adenoma displasia ringan - adenoma displasia keras -karsinoma kolorektal, sedangkan serrated pathways dimulai dari aberrant crypt foci (ACF) - polip hiperplastik - serrated adenoma (SA) - karsinoma kolorektal. Salah satu komponen penting pada lesi tersebut adalah musin yang berfungsi untuk melindungi lapisan mukosa saluran pencernaan. Musin dapat mengalami perubahan pada tumor ganas yang berperan dalam proses diferensiasi, proliferasi dan invasi sel tumor. Kepustakaan mengatakan bahwa pulasan IHK Mucin-6 (MUC6) dapat digunakan sebagai penanda bagi serrated adenoma dan adenoma konvensional displasia keras. Tujuan. Untuk mengetahui ekspresi MUC6 aberrant di sitoplasma sel epitel kripta mukosa kolorektal pada serrated adenoma (SA) dan adenoma konvensional displasia keras. Bahan dan cara. Penelitian ini dilakukan secara retrospektif, menggunakan studi analitik deskriptif potong lintang, dengan mengumpulkan kasus serrated adenoma (SA) dan pembanding menggunakan kasus adenoma konvensional displasia keras masing-masing 20 kasus. Dilakukan pulasan immunohistokimia (IHK) Mucin-6 (MUC6) terhadap semua kasus. Hasil. Indeks ekspresi MUC6 aberrant kelompok serrated adenoma menunjukkan hasil sedang-kuat pada sebagian besar kasus, sedangkan kelompok adenoma konvensional displasia keras menunjukkan hasil negatif dan positif lemah pada sebagian besar kasus. Maka dapat disimpulkan terdapat hubungan bermakna antara ekspresi MUC6 aberrant pada kelompok serrated adenoma (SA) dan adenoma konvensional displasia keras, dengan nilai p=0,005. Kesimpulan. Terdapat hubungan bermakna antara ekspresi MUC6 aberrant kelompok kasus serrated adenoma (SA) dan adenoma konvensional displasia keras. ...... Background. Based on WHO, precursor lesions can develop into colorectal carcinoma through two pathways, namely adenoma - carcinoma sequence pathways and serrated pathways. Adenoma carcinoma sequence begins atypical cells - adenoma with mild dysplasia - adenoma with severe dysplasia - colorectal carcinoma, whereas serrated pathways begins aberrant crypt foci (ACF) - hyperplastic polyps - serrated adenoma (SA) - colorectal carcinoma. One of the important components of the lesion is the mucin layer which serves to protect the gastrointestinal mucosa. Mucin may experience changes in malignant tumors which play a role in the differentiation, proliferation and invasion of tumor cells. The literature says that the outward appearance of IHC Mucin-6 (MUC6) can be used as a marker for serrated adenoma and conventional adenoma with severe dysplasia. Objective: To find expression aberrant of MUC6 in the cytoplasm of epithelial cells in the colorectal mucosal crypts serrated adenoma (SA) and conventional adenoma with severe dysplasia. Materials and method. This study was conducted retrospectively, using a crosssectional descriptive analytic study, by collecting case serrated adenoma (SA) and a comparison using conventional adenoma with severe dysplasia case each of the 20 cases. Do outward MUC6 immunohistochemistry staining in all cases. Results. Index aberrant expression of Mucin-6 (MUC6) serrated adenoma group showed moderate to strong results in most cases, while the conventional adenoma with severe dysplasia was negative and weakly positive in most cases. So we can conclude there is a relationship between the aberrant expression of Mucin-6 (MUC6) in the serrated adenoma (SA) group and conventional adenoma with severe dysplasia, with p= 0.005. Conclusion. There is a relationship between the aberrant expression of Mucin-6 (MUC6) serrated adenoma (SA) group and conventional adenoma with severe dysplasia.

Abstrak :
Lapangan M merupakan lapangan gas yang terletak di Cekungan Sumatera Selatan dan sudah dikembangkan dengan pemboran 5 sumur pengembangan dari reservoar paparan karbonat Formasi Baturaja, dengan rata-rata produksi sebesar 4 MMCFPD per sumur. Berdasarkan hasil interpretasi seismik dan analog dengan lapangan minyak disebelah utara lapangan M, yaitu lapangan A, masih terdapat potensi reservoar minyak (oil rim) yang terletak downdip dari reservoar gas yaitu daerah yang belum dikembangkan di antara batas kontak gas dan minyak dengan batas kontak minyak dan air. Data produksi minyak sumur-sumur di lapangan A berkisar antara 100 - 800 BOPD per sumur. Hasil studi ini diharapkan dapat mengidentifikasi zona prospek minyak tersebut dan juga untuk pengembangan lebih lanjut zona gas. Menggunakan data seismik 3D dan data sumur, dilakukan evaluasi melalui metode dekomposisi spektral Continuous Wavelet Transform (CWT) data seismogram sintetik sumur dan data tras seismik yang melewati sumur, kemudian hasilnya disebarkan ke seluruh lapangan untuk mengidentifikasi penyebaran lateral keberadaan zona anomali frekuensi rendah. Hasil analisa dekomposisi spektral CWT pada data sumur dan data tras seismik yang ditunjukkan pada crossplot antara Amplitudo CWT dengan Frekuensi memperlihatkan korelasi yang cukup bagus. Sumur gas menunjukkan nilai amplitudo CWT paling tinggi pada frekuensi 10 ? 13 hz dan sumur minyak pada frekuensi 17 - 22 hz. Nilai amplitudo menurun pada frekuensi yang lebih tinggi. Pada sumur air, nilai amplitudo CWT selalu paling rendah pada frekuensi rendah hingga tinggi, sehingga dari crossplot tersebut dapat disimpulkan bahwa cut-off amplitudo zona air adalah pada 1,0+E09. Berdasarkan hasil analisis CWT dari data sumur ini, analisa dekomposisi spektral CWT kemudian disebarkan ke seluruh lapangan untuk bisa mengidentifikasi zona prospek. Selain itu, hasil crossplot antara nilai amplitudo CWT dengan nilai Saturasi air (Sw) pada zona reservoir memperlihatkan adanya hubungan yaitu nilai amplitudo CWT yang tinggi berkorelasi dengan nilai saturasi air yang rendah, begitupun sebaliknya.

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Field M is a gas field located in the South Sumatra Basin and has been developed by the drilling of five development wells from carbonate platform reservoir of Baturaja Formation, with average production of 4 MMCFPD per well. Based on the result of seismic interpretation and its analog to the oil field located to the north of field M, namely field A, there is still potential of oil reservoir (oil rim) located downdip from the gas reservoir The potential area is limited in the area that has not been developed between gas and oil contact and between oil and water contact. The production of oil wells in the field A ranges between 100-800 BOPD per well. The result of this study is expected to identify the oil zone and other prospects for further gas development. Based on 3D seismic data and well data, the evaluation was carried out using one of spectral decomposition methods, the Continuous Wavelet Transform (CWT). The analysis was done using both well synthetic seismogram data and seismic trace that crossing-through the wells. Then CWT was run on both data. Referring to the result of the analysis, CWT was distributed across the field to identify the presence of low-frequency zone. The results of the CWT analysis from well data and seismic trace data are shown on the crossplots between the amplitude and the frequency. They show a fairly good correlation. Gas zone shows the highest value of CWT amplitude at a frequency of 10-13 Hz and oil zone shows the highest value at a frequency of 17- 22 Hz. Amplitude values decreased in the higher frequencies. In the water zone, the value of the CWT amplitude is always lower in low to high frequencies. From the crossplot it can be concluded that the cut-off amplitude value for water zone is at 1.0 + E09. In any frequency, the CWT amplitudes below that value is nonhydrocarbon or water. The result of spectral decomposition that is based the above analysis and distributed throughout the field is able to identify zones of prospects. In addition to that, the crossplot between the CWT value and the water saturation (Sw) in each oil, gas and water zone shows a correlation. High CWT amplitudes correlate to low water saturation, and vice versa.