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Abstrak :
ABSTRAK Latar belakang dan tujuan Pekerja redaksi merupakan aset utama bagi suatu perusahaan media cetak. Mereka bekerja dengan deadline yang sangat ketat, oleh karena itu mereka harus senantiasa sehat secara fisik, mental dan sosial. Penelitian ini bertujuan untuk mengetahui keberadaan stres kerja dan hubungannta dengan kecenderungan gejala gangguan mental emosional. Metode penelitian ini menggunakan desain potong melintang dengan analisis perbandingan internal. Data yang dikumpulkan meliputi karakteristik sosiodemografi responden, karakteristik lingkungan kerja, data pengukuran stres kerja dengan menggunakan kuesioner Survey Symptomp Check List 90 (SCL-90), serta data pengukuran tingkat kebisingan, pencahayaan, dan suhu kelembaban di lingkungan kerja. Hasil Dari 100 responden didapatkan prevalensi kecenderungan gejala gangguan mental sebesar 38% dengan kecenderungan gejala terbanyak adalah psikotism 36%, somatisasi dan paranoid masing-masing 33% serta obsesif-konvulsif 29%. Stres kerja bermakna berhubungan dengan kecenderungan gejala gangguan mental emosional melalui stresor pengembangan karir (p 0.00, OR 13,75, CI 3.69.51.11). Jenis stres kerja yang dominan terhadap stres kerja adalah beban kerja berlebih kuantitatif 83%. Faktor karakteristik yang bermakna berhubungan dengan stres kerja adalah pendidikan pada stresor beban kerja berlebih kuantitatif (p 0.00, OR 0.17, CI 0.05-0.52), asa kerja pada stresor konflik kerja (p 0.04, OR 2.72, CI 1.04-7.09), dan olah raga pada stresor tanggung jawab terhadap orang lain (p 0.00 OR 4.66 CI 1.66-13.08 ). Faktor kebiasaan yang bermakna berhubungan dean stres kerja adalah merokok pada stres tanggung jawab terhadap orang lain (p 0.00 OR 4.77, CI 1.37-11.64). Kesimpulan Stres kerja mempunyai hubungan bermakna dengan kecenderungan gejala gangguan mental emosional melalui stres pengembangan karir. Pendidikan merupakan faktor protektif terhadap stres kerja pada stresor bebas kerja berlebih kuantitatif. Masa kerja pada stresor konflik peran dan olah raga pada stresor tanggung jawab terhadap orang lain berisiko mengkonsumsi rokok empat kali lebih banyak dibanding dengan responden yang tidak stres.

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Background and Objectives The joumalist is a valuable asset for publishing company. They work with a very strict deadline and that requires them to have a good state ol' physical, mental, and social health. This research aims to find out the existance of work-related stress and its relationship with die tendency of acquiring symptom ot' mental emotional disorder. Method This research uses a cross sectional design with internal comparison analysis. The data collected were respondent?s characteristic of sociodemograplty, work envirenmcnfs characteristic, measurement of work-related stress by using Survey Disgnostic Stress questionnaire, data of the tendencies of acquiring symptom of mental emotional disorder by using Sympromp Check Lis! 90 (SCL-90), and data measurement of noise, lighting, and moisture level within work environment. Result From 100 respondents, it was found that the prevalence ofthe tendency of acquiring symptom of mental emotional disorder is 58% with tendency of phsyeotism 36%, somatisation and paranoid symptoms each of 33%, and obsesive-convulsive 29%. There is signilieant relationship between work-related stress and the tendency of acquiring symptom of mental emotional disorder on stressor of carrier development (p 0.00, OR 13. 7.5, CI 3.69-51.11 ). The dominant stressor is role of overload quantitative 83%. The significant characteristic relationship to work-related stress is education on stressor of role of overload quantitative (p 0.00. OR 0.17, CI 0.05-052), work period on stressor of role of conflict (p 0.04, OR 2.72, CI L04-7.09), and time spent on exercise on strcssor of responsibility for people (p 0.00, OR 4.66, C7 1.66-l3.08). Smoking has significant relationship to work-related stress on stressor of responsibility for people (p 0. 00, OR 4. 77, CI 1.37-11.64). Conclusion Work-related stress has a signilieant relationship with the tendency of acquiring symptom of mental emotional disorder on strcssor of carrier development. Education is a work-related stress protective factor on strcssor of role of overload quantitative. Work period on stressor of role of conflict and time spent on exercise on strcssor of responsibility for people have a siginificant relationship to stress at work. Respondent who experiences work-related stress because of stressor of responsibility for people has a greater tendency to smoke tour times more than one who does not experience it.

Abstrak :
Studi eksperimental hewan memperlihatkan bahwa kadar vasopresin serum yang tinggi berhubungan dengan hiperfiltrasi, albuminuria dan hipertrofi glomerulus, dan dikhawatirkan berlanjut menjadi penurunan laju filtrasi glomerulus (LFG) dalam jangka panjang. Namun, belum terdapat laporan yang membuktikan hubungan sebab-akibat antara peningkatan vasopresin serum dengan gangguan ginjal. Studi ini bertujuan untuk mengetahui hubungan peningkatan vasopresin serum dengan gangguan ginjal, beserta lokasi gangguan ginjal tersebut. Studi ini juga ditujukan untuk melihat kemampuan berat jenis (BJ) urin untuk mendeteksi gangguan ginjal. Penelitian ini adalah studi potong lintang dengan consecutive sampling di sebuah pabrik sepatu pada bulan Januari–Maret 2020. Subjek adalah pekerja terpajan panas yang dinyatakan sehat berdasarkan medical checkup tahun 2019. Sampel darah dan urin diambil lima jam setelah subjek bekerja. Subjek diperiksakan kreatinin plasma, estimasi LFG berdasarkan CKD-EPI, BJ urin, albuminuria carik-celup, albumincreatinine ratio (ACR) urin, vasopresin serum, kidney injury molecule-1 (KIM-1) urin, dan nefrin urin. Data masa kerja, dan jenis kelamin diperoleh melalui wawancara. Pada studi ini, diperoleh 119 subjek wanita dengan median usia 38 (31–51) tahun dan median masa kerja 10 (3–14) tahun. Hiperfiltrasi didapatkan pada 18 subjek, LFG tidak menurun pada 104 subjek (87,4%), dan peningkatan nefrin urin pada 104 pekerja (87,4%). Tidak terdapat hubungan antara vasopresin meningkat dengan hiperfiltrasi, penurunan LFG, albuminuria, nefrin urin, dan KIM-1 urin. Terdapat hubungan bermakna antara peningkatan nefrin urin dengan masa kerja ≥ 10 tahun (p = 0,03). Terdapat hubungan peningkatan KIM-1 urin dengan albuminuria (p = 0,008). Terdapat area under the curve (AUC) antara BJ urin dan nefrin urin sebesar 81,7% (95% CI 68,8–94,6%), dengan titik potong BJ urin ≥ 1,018 yang memiliki sensitivitas 71,2% dan spesifisitas 80% untuk kenaikan nefrin. Sebagai simpulan, peningkatan vasopresin serum tidak berhubungan dengan hiperfiltrasi, penurunan LFG, albuminuria, dan peningkatan KIM-urin. Masa kerja > 10 tahun dihubungkan dengan peningkatan nefrin urin. BJ urin ≥ 1,018 dapat dijadikan acuan untuk mendeteksi kenaikan nefrin urin pada pekerja terpajan panas.

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Animal experimental studies have shown that high serum vasopressin levels are associated with hyperfiltration, albuminuria, and glomerular hypertrophy, which may lead to decreased glomerular filtration rate (GFR) in long-term. However, there was no earlier report that has established the causal relationship between elevated serum vasopressin and renal impairment. This study aims to determine the association between increased serum vasopressin and kidney impairments, along with the location of these impairments. This study is also aimed to look at the ability of urine specific gravity to detect elevated serum vasopressin and kidney impairments. This study was a cross-sectional study with consecutive sampling in a shoe factory from January–March 2020. Subjects were heat-exposed workers who were declared healthy based on the medical checkup in 2019. Blood and urine samples were taken five hours after the subject worked. Subjects were examined for plasma creatinine, estimated GFR (eGFR) based on CKD-EPI, urine specific gravity, dipstick albuminuria, urine albumin-creatinine ratio (ACR), serum vasopressin, urine kidney injury molecule-1 (KIM-1), and urinary nephrin. Data on age, length of service, and gender were obtained through interviews. There were 119 female subjects with a median age of 38 (31–51) years and a median length of service 10 (3–14) years. eGFR was not decreased in 104 subjects (87.4%) and urinary nephrin increased in 104 workers (87.4%). There were no increase in urinary albumin excretion and urinary KIM-1. There were significant association between increased urinary nephrin with length of service ≥ 10 years (p = 0.03), normal-increased eGFR with age 30–39 years (p = 0.001), and increased urinary KIM-1 with albuminuria (p = 0.008). There was an area under the curve (AUC) of 81.7% (95% CI 68.8–94.6%) between urine specific gravity and urinary nephrin, with a cut-off point of urine specific gravity > 1.018 having a sensitivity of 71.2% and a specificity of 80% for the increase in urinary nephrin. In conclusion, increased serum vasopressin does not cause a decrease in GFR, albuminuria, and increase in urinary KIM, but does cause an increase in urinary nephrin. urine specific gravity ≥ 1.018 can be used as a cut-off for detecting increased urinary nephrin in heat-exposed workers.