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Hasil Pencarian

Ditemukan 2 dokumen yang sesuai dengan query
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Iwan Inrawan Wiratmadja
"Literature studies
indicate that information technology (IT) clusters encourage innovation and
increase firm-level productivity by providing external economies and facilitating
joint action for its members. The purpose of this study is to identify the
external economy and joint action factors that affect firm innovation and
productivity in the IT cluster. A research model was developed based on earlier
models of joint action and external economies. The model consists of three external
economy related factors, i.e., access to skills, finance, and infrastructure, as
well as three joint action related factors, i.e., vertical, horizontal, and
research and development (R&D) cooperation as the independent variables,
firm innovation as the intervening variable, the firm?s absorptive capacity as
the moderating variable, and firm productivity as the dependent variable. Data
collection was conducted through a survey with respondents from 32 IT firms
located in three clusters in Bandung and one cluster in Cimahi (West Java ?
Indonesia). The partial least square (PLS) approach was used for hypotheses
testing. The results indicate that horizontal cooperation, access to
infrastructure, and access to skill have a positive impact on productivity,
while horizontal cooperation and R&D cooperation have a positive impact on
innovation. Finally, firm innovation is proven to positively influence firm
productivity."
2016
J-Pdf
Artikel Jurnal  Universitas Indonesia Library
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I Saleh
"Abstrak
Over the past decade, antimalarial drug resistance has rapidly become a major public health problem in South East Asia region including South Sumatra. This study aimed to determine the extent of gene polymorphisms associated with chloroquine resistance (CQR) in P. falciparum isolates from Lahat, Sekayu, Baturaja and Palembang district.
Methods: A molecular study was conducted to identify the mutant alleles of the genes associated with the resistance to chloroquine among the isolates of Plasmodium falciparum from South Sumatera. Blood from 25 patients was collected, DNA was isolated, and the sequences of two different genes (Plasmodium falciparum chloroquine resistance transporter/pfcrt and Plasmodium falciparum multidrug resistance/pfmdr1) were analyzed using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP).
Results: This study identified polymorphism in the pfcrt 76-Thr in all isolates and pfmdr1 86-Tyr. These findings may reflect the failure of treatment with the standard dose of chloroquine within the last few years in South Sumatera.
Conclusion: PCR-RFLP technique provide a simple and rapid method of detecting polymorphisms in genes that may predict chloroquine resistance (CQR). Although the identification of the polymorphism in the pfcrt and pfmdr1 genes provides a significant indicator of CQR, further studies are needed to determine the role of these polymorphisms in the in vivo and in vitro responses to drug treatment."
Jakarta: Faculty of Medicine Universitas Indonesia, 2014
610 UI- MJI 23:1 (2014) (2)
Artikel Jurnal  Universitas Indonesia Library