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"Micronutrient supplementation is one approach that could correct the child impairment of development caused by micronutrient deficiencies. However micronutrient deficiencies in developing countries usually associated with marginal deficiency of several micronutrients. Therefore, it was assumed that supplementation with multiple micronutrients would be more effective.

In the previous Indonesia study, a randomized placebo controlled trial study has been done in 17 villages of Magelang district, Central Java for 6 mo among children aged 6-12 mo (n=284) who randomly assigned into four experimental groups: 1 RDA daily multi-micronutrient, 2 RDA weekly multi-micronutrient, iron daily supplementation and a placebo group. Nutritional status, development, and hemoglobin concentration was no difference between treatment groups at the end of supplementation. To answer the possibility of age responsiveness and manifestation of treatment effect on development and nutritional status, this present follow up study has been done at 6-mo after supplementation commenced when children aged 18-24 mo. At 6-mo follow up, there was difference between group in height for age Z-score and psychomotor development index (PDI). The scores differences are may be due to treatment differences."

"TB is still major problem even though number of TB cases had been decline steadily due to discovery and continuing research of TB drugs since 1940 and also increasing of funding and attention to global TB problem. Indonesia is the third country in descending order of TB case numbers. It is considered as the third main cause of death after cardiovascular and respiratory diseases in this country. Several years ago, East Nusa Tenggara province had the highest incidence of sputum smear positive compared with other provinces in Indonesia. TB creates certain burdens in the community, initially in health and nutrition aspect, and then followed by other human aspects including economy and social. It is, therefore, eradicating TB in an effective and efficient way becomes a very emerging issue on TB treatment strategy. Since TB is an immune-related disease, hence, enhancing the immune system might be considered as an important strategy to be considered on TB treatment. Zinc, vitamin A and a new discovered protein, leptin, take a part on that issue. A cross sectional study was conducted with a main objective of investigating the relationship between nutritional and leptin status of new diagnosed pulmonary TB disease with the disease severity in selected districts of East Nusa Tenggara province, Indonesia. This research report is divided into three parts. Part 1 includes comprehensive reviews on the background of the study, literature review, problem statement and rationale, objective, hypotheses, conceptual framework and variable indicator matrix. Part 2 wraps up the manuscript for publication, entitled "Micronutrients and Leptin status Are Associated with the Radiological Features Among New Diagnosed Pulmonary Tuberculosis Patients." It is written and formatted based on author's guideline of the Journal of Nutrition. Part 3 covers the supporting documents including detailed methodology and other result, author's guideline of the journal, questionnaire, ethical approval, informed consent, official permit letter, references and curriculum vitae. It is expected that the results of this study may contribute to the body of knowledge about the severity of TB that reflects the specific profile of nutritional status (body fat, BMI, MUAC and micronutrient status) and plasma leptin. Furthermore, it will serve as reference data for further investigations, better interventions and treatments on active pulmonary TB patients."

"In general, many studies have shown the association between TB and malnutrition. However, the mechanism between nutritional status and host defense in TB remains unclear, particularly the role of antioxidant status. This study was undertaken to investigate the antioxidant level (vitamin C, β-carotene, α-tocopherol), food intake and nutritional status in active pulmonary TB patients and healthy subjects."

"Low birth weight (LBW), iron deficiency anemia (IDA), vitamin A deficiency (VAD), and iodine deficiency disorder (IDD) are still serious public health problems in Asia Pacific region. LBW newborns have some micronutrient deficiencies, such as vitamin A, iron, and iodine. Studies on micronutrient status among female adolescents aged 12-15 y are still limited, particularly those who having birth weight history. For that reason, research on micronutrient status among female adolescents having low birth weight history was performed. The study design was nested cohort retrospective community based.The subjects were chosen by simple randomization, based on their cohort record collected by Frontiers for Health Foundation, Padjajaran University, Bandung. The assessment of micronutrient status (Hb, plasma retinol and urinary iodine excretion), anthropometrics measurement, history of diseases, and food intake were done among female adolescents with low birth weight (LBW) and normal birth weight (NBW) history. The prevalence of IDA, VAD, and iodine deficiency among all female adolescents were 9.9%, 12.9% and 40.7%, respectively. The mean concentrations of blood hemoglobin, plasma retinol and urinary iodine excretion were not significantly different between LBW and NBW group. Nutritional status, diseases during the last three months, current nutritional status, food intake, and onset of menstruation were not significantly different between groups. In conclusion, micronutrients status, nutritional status, food intake and morbidity status in female adolescents with LBW and NBW history were not different."

"This randomized double-blind placebo-controlled trial aimed to compare the efficacy of daily iron supplementation and multi-micronutrient supplementation both daily and weekly basis on increasing iron status among 284 apparently healthy Indonesian infants aged 6-12 mo. Infants were randomly assigned to receive either daily 1 RDA multi micronutrient supplement (n = 72), weekly 2 RDA multi micronutrient supplement (n = 70), daily ferrous sulphate 10 mg (n = 72), or placebo (n = 70) for wk. Blood hemoglobin, plasma ferritin, plasma zinc, and plasma C-reactive protein concentrations were measured prior to intervention and after 23 wk of supplementation. At baseline, 58.1% of subjects were anemic, 28.2% were iron deficient, and 11.2% were zinc deficient. After 23 wk of supplementation, both daily 1 RDA multi micronutrient and iron supplemented groups had significantly increased blood hemoglobin and plasma ferritin concentration, furthermore reducing the percentage of anemia and iron deficiency. However, the changes of hemoglobin were not significantly different among the treatment groups. Changes of hemoglobin were significantly higher in daily 1 RDA multi micronutrient group than in placebo group when initial blood hemoglobin was low. The change of plasma ferritin concentration in both daily 1 RDA multi micronutrient and iron groups was significantly higher than in other groups. Hemoglobin and ferritin concentrations of weekly 2 RDA multi micronutrient group were not significantly increase, but there were significantly increased in the subjects with low concentration of blood hemoglobin or plasma ferritin. Proportion of infants with zinc deficiency was increased significantly in iron group Daily I RDA multi micronutrient and daily iron supplementation are efficacious in improving the concentration of blood hemoglobin and plasma ferritin and reducing the percentage of infants with anemia and iron deficiency of Indonesian infants aged 6-12 months in a rural community. However, there was an increasing proportion of infants with zinc deficiency in daily iron supplementation. The efficacy of daily 1 RDA multi micronutrient supplementation was higher among the children with blood hemoglobin < 110 g/L Efficacy of weekly 2 RDA multi micronutrient supplementation on the concentration of blood hemoglobin and plasma ferritin of all subjects was not found, but it affected in children with low concentration of blood hemoglobin or plasma ferritin."

"Berat plasenta umum digunakan untuk mengukur pertumbuhan dan fungsi yang baik dari plasenta. Anemia merupakan salah satu faktor risiko dari berat plasenta yang tinggi. Namun sampai saat ini belum dapat dipastikan apakah anemia karena kekurangan zat besi mempengaruhi berat plasenta. Penelitian ini meneliti hubungan antara anemia defisiensi besi dan berat plasenta pada wanita hamil anemia di Jakarta Timur. Penelitian ini menggunakan desain penelitian potong lintang yang melibatkan 90 ibu hamil anemia di 10 Puskesmas Kecamatan, Jakarta Timur. Prevalensi defisiensi besi pada ibu hamil anemia adalah 36,9%. Berat plasenta rata-rata adalah 549,3 ± 115 gr. Ada hubungan positif antara anemia defisiensi besi dan berat plasenta setelah dikontrol oleh variabel paritas, perokok pasif dan frekuensi kunjungan pemeriksaan kehamilan (B = 0,22; p = 0,038). Berat plasenta yang tinggi pada ibu hamil dengan anemia defisiensi besi menunjukkan adanya mekanisme adaptasi dari plasenta dikarenakan kurangnya oksigen dalam darah.

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Placental weight is a commonly used to measure placental growth and function including nutrient transfer to the fetus. Anemia may link to a risk factor for higher placental weight, however, it is uncertain whether iron deficiency anemia influence a placental weight, and could be used a public health measure for fetal growth and healthy pregnancy. This study investigated the relationship between iron deficiency anemia and placental weight among anemic pregnant women in East Jakarta. We conducted a cross sectional study of 90 anemic pregnant women and their singleton pregnancies in 10 Primary Health Center in East Jakarta. The prevalence of iron deficiency among anemic pregnant women was 36.9%. The mean placental weight was 549.3 ± 115 gr. There was a positive relationship between iron deficiency anemia and placental weight after adjusting for parity, passive smoker and ANC visit frequency (B=0.22; p=0.038). A higher placenta weight was observed among iron deficiency anemic pregnant women, suggesting the adaptive mechanism of placenta to chronic poor oxygenation."