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"ABSTRAKHiperkolesterolemia adalah peningkatan kadar kolesterol dalam darah diatas nilainormal. Angka kejadian hiperkolesterolemia akan terus bertambah seiring denganmeningkatnya pola hidup tidak sehat seperti kebiasaan merokok, obesitas, kurangberolahraga, dan asupan makanan tinggi lemak. Tanaman mengkudu (Morindacitrifolia L.) adalah salah satu tanaman yang buahnya dapat menurunkan kadarkolesterol total dan kolesterol LDL melalui penghambatan aktivitas HMG Co-Areductase yang sudah diteliti pada tikus.Penelitian bertujuan untuk membuktikan efek menurunkan kadar kolesterol total dankolesterol LDL pada pasien hiperkolesterolemia. Metode penelitian menggunakandesain double blind randomized controlled trial pada 60 pasien. Pasien dibagi duakelompok sama banyak menjadi kelompok perlakuan (kapsul ekstrak buah M. citrifolia)dan kelompok kontrol (plasebo) serta mendapat 3x2 kapsul sehari selama 21 hari. Hasilpenelitian menunjukkan kapsul ekstrak buah M. citrifolia pada kelompok perlakuansecara bermakna menurunkan kadar kolesterol total dan kolesterol LDL (p<0,05) dalamwaktu dua minggu dibandingkan kelompok kontrol. Faktor umur, indeks massa tubuh,olahraga, pola makan, dan kebiasaan merokok pada pasien kelompok perlakuan secarabermakna (p<0,05) bermanfaat dalam penurunan kadar kolesterol total. Kapsul ekstrakbuah M. citrifolia memiliki efek menurunkan kadar kolesterol total dan kolesterol LDLpada pasien hiperkolesterolemia.

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ABSTRACTHypercholestrolemia is characterized by elevated blood cholesterol level above normalvalues. The incidence of hypercholesterolemia will continue to grow unanymous as theunhealthy lifestyle such as smoking, obesity, lack of exercise, and high fat diet increased.Morinda citrifolia L. is one of many kind of plant which its fruit could decrease totalcholesterol and LDL-cholesterol by detaining cholesterol biosynthesis through theactivity of HMG Co-A reductase which has been studied in mouse.This study has a purpose to prove the reducing effect in total cholesterol andLDL-cholesterol in hypercholesterolemia patients. This study design used double blindrandomized controlled trial of 60 patients. Patients were divided into same number,including the intervention group (M. Citrifolia fruit extract capsule) and the controlgroup (placebo) that received 2 capsules 3 times daily for 21 days. The result showed theM. citrifolia fruit extract capsule in the intervention group significantly could decreasetotal cholesterol and LDL-cholesterol (p<0,05) in two weeks compared to the controlgroup. The age, body mass index, exercise, diet, and smoking habits of patients inintervention group has significant effect in decreasing total cholesterol. M. citrifolia fruitextract capsules has the reducing effect in total cholesterol and LDL-cholesterol inhypercholesterolemia patients."

"ABSTRAK Tren kembali ke alam mempengaruhi pertumbuhan industri jamu dan herbal diIndonesia. Namun produk jamu dan herbal di pasaran belum diproses secara higienissehingga terkontaminasi oleh bakteri, jamur dan kapang yang melampaui batasmaksimal cemaran mikroba. Pasteurisasi radiasi sampai dengan dosis 10 kGymampu menurunkan angka lempeng total bakteri simplisia rimpang temu mangga(Curcuma mangga Val and Zijp) 3 – 4 logaritma. Dari segi mikrobiologi,pasteurisasi radiasi sangat menguntungkan, namun informasi mengenai aktivitastemu mangga iradiasi masih terbatas. Oleh karena itu penelitian ini dilakukan untukmengetahui pengaruh dosis pasteurisasi radiasi 0, 5 dan 10 kGy terhadap kandungansenyawa kurkuminoid dan aktivitas antidiabetes C. mangga secara in vitro(penghambatan enzim α-glukosidase) dan in vivo (pada mencit yang diinduksialoksan). Ekstraksi dilakukan dengan cara maserasi dengan etanol. Hasil uji secarain vitro menunjukkan adanya peningkatkan kadar kurkuminoid pada simplisia temumangga yang diiradiasi 5 kGy. Sedangkan simplisia temu mangga 0, 5 dan 10 kGytidak memiliki aktivitas penghambatan enzim α-glukosidase dengan nilai persentasepenghambatan berturut-turut yaitu 9,89 ± 0,68; 8,44 ± 1,21 dan 16,95 ± 2,05 padakonsentrasi 50 ppm. Hasil uji secara in vivo, pada hari ke-15 ekstrak etanol temumangga 0, 5 dan 10 kGy mampu menurunkan kadar glukosa darah relatif sebesar46,53% ± 18,41; 54,66 % ± 19,94 dan 48,13 % ± 36,02.

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ABSTRACT The trend back to nature has influenced the growth of herbal medicine and herbalindustry in Indonesia. But those products in the market have not been processedhygienically so contaminated by bacteria, fungi and mold that have the maximummicrobial contamination. Pasteurization radiation dose up to 10 kGy can reduce thetotal plate count bacteria of Curcuma mangga Val and Zijp until 3 – 4 logarithms. Interms of microbiology, pasteurization radiation very advantageous, but the retrievalof information about the activities of irradiated C. mangga are still limited. Thisstudy was conducted to determine the effect of pasteurization radiation doses of 0, 5and 10 kGy for curcuminoid compound and antidiabetic activity of C.mangga in invitro (inhibition enzyme α-glucosidase) and in vivo (in mice induced alloxan). C.mangga was extracted by maceration eith ethanol. In vitro test result showed thatiradiation 5 kGy could increased the curcuminoid compound while C. mangga 0, 5and 10 kGy did not have inhibitory activity of the enzyme α-glucosidase, with valueof percentage of α-glucosidase inhibition consecutive 9.89 ± 0.68; 8.44 ± 1.21 and16.95 ± 2.05 at a concentration of 50 ppm. In vivo result test, on the 15th day of C.mangga 0, 5 and 10 kGy reduced blood glucose levels relative of 46.53% ± 18.41;54.66 % ± 19.94 and 48.13 % ± 36.02."