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Abstrak :
Penelitian survival secara historical cohort pada enam puluh dua penderita tumor ovarium borderline. Terdapat 9 penderita stadium FIGO IA, 9 stadium IC, 3 stadium IIIA, 2 stadium IIIB, 4 stadium IIIC, 1 stadium IV dan 34 stadium inadekuat. Dua puluh satu penderita dilakukan pembedahan radikal, 10 penderita hanya dilakukan histerektomi total dan salfingo-ooforektomi bilateral, 6 penderita dilakukan pembedahan konservatif, 24 penderita hanya dilakukan unilateral salfingo-ooforektomi atau kistektomi dan 1 penderita hanya biopsi saja. Enam belas penderita mendapat kemoterapi adjuvan kombinasi dengan platinum base, yaitu 8 penderita stadium inadekuat, 7 stadium III dan 1 stadium IV. Lama pengamatan lanjut antara 0,002 sampai 10,48 tahun dengan median 3,5 tahun. Lima puluh sembilan penderita tetap hidup. Tiga penderita meninggal karena penyakitnya. Residif terjadi pada 4 penderita. Ketahanan hidup penderita 2 tahun 96% dan 10 tahun 94%. Pada test ?log rank? didapatkan residu dan tipe histologi merupakan faktor prognostik yang bermakna mempengaruhi survival. (Med J Indones 2002; 11: 222-9)

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Sixty-two patients with borderline tumors of ovary were historical cohort analyzed for survival characteristics. There were 9 patients with FIGO stage IA, 9 with stage IC, 3 with stage IIIA, 2 with stage IIIB, 4 with stage IIIC, 1 with stage IV and 34 with inadequate stage tumors. Twenty one patients had surgical staging with radical surgery, 10 patient had at least a total abdominal hysterectomy and bilateral salpingo-oophorectomy, 6 patient had surgical staging with conservative surgery, 24 patient had at least a unilateral salphingo-oophorectomy or ovarian cystectomy and 1 patient had biopsy. Sixteen patients received cisplatin-based combination chemotherapy, that were 8 with inadequate stage tumors, 7 with stage III tumors and 1 with stage IV tumor. Follow-up range from 0.02 to 10.48 years, with a median of 3.5 years. Fifty nine patient were alive. Three patients died, all of disease. Recurrence were found in 4 patients. The overall 2-years survival rate was 96% and 10-years survival rate was 94%. In log rank test, residual disease and histology type were significant predictor of survival. (Med J Indones 2002; 11:222-9)

Abstrak :
Tujuan penelitian ini adalah untuk mengidentifikasi faktor prediktor metastasis kelenjar getah bening (KGB) pada pasien dengan kanker serviks stadium IB dan IIA. Penelitian dilakukan dari bulan Mei 1996 sampai bulan Desember 2001. Ada 183 pasien kanker serviks dengan stadium menurut FIGO IB dan IIA menjalani operasi histerektomi radikal dan limfadenektomi. Dari pasien tersebut 158 pasien yang dapat dinilai, terdiri dari 43 pasien dengan metastasis KGB dan 115 tanpa metastasis KGB. Rancangan penelitian adalah kasus-kontrol. Kasus adalah pasien dengan metastasis KGB dan kontrol pasien tanpa metastasis KGB. Analisis multivariat dilakukan setelah analisis bivariat. Pada analisis bivariat umur < 39 tahun, diameter lesi >4 cm, stadium IIA > 4 cm, histopatologi dengan diferensiasi sedang dan buruk, invasi ke pembuluh darah dan limfa merupakan variabel yang independen terjadinya metastasis KGB dengan nilai p ≤ 0,05. Tetapi pada analisis multivariat yang muncul sebagai variabel independen adalah umur muda, paritas > 4, diameter lesi, histopatologi adenoskuamosa, dan invasi limfo-vaskular dengan nilai p ≤ 0,05. Kesimpulan: Usia muda, paritas > 4, stadium IIA > 4 cm, diameter lesi, histopatologi adenoskuamosa, invasi limfa-vaskular merupakan faktor risiko terjadinya metastasis dan dapat dipergunakan sebagai faktor prediktor metastasis KGB. (Med J Indones 2004; 13: 113-8)

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The aim of this study was to identify possible predictor factors of lymph node metastases in patients with cervical cancer stage IB and IIA. Study was conducted between May 1996 and December 2001. There were 183 patients of cervical cancer with FIGO Stage IB and IIA who were underwent radical hysterectomy and lymphadenectomy. From those 158 patients could be evaluated, consisting 43 patients with node metastases 115 patients without metastases. Research design was case control study. Case was patients with node metastases and control was those without node metastases. Multivariate analysis was made after bivariate analysis. On bivariate analysis age < 39 years, diameter of lesion > 4 cm, stage IIA > 4 cm, histopathology moderate and poor differentiation, blood and lymphatic vessel invasion were independent variables for node metastases with p value ≤ 0.05. However, on multivariate analysis younger age, parity ≥ 4, diameter of lesion, histopathology adenosquamous, and lymph vascular invasion (+) as independent factors for node metastases with p value ≤ 0.05. Conclusion: Younger age, parity ≥ 4, stage IIA > 4 cm, diameter of lesion, histopathology adenosquamous, and lymph vascular invasion (+) were risk factors for node metastases and can be used as predictors. (Med J Indones 2004; 13: 113-8)

Abstrak :
Tujuan penelitian ini adalah untuk memperoleh informasi tentang survival kanker servik stadium lanjut dengan gangguan fungsi ginjal (KSSLGFG) serta faktor-faktor yang mempengaruhinya. disamping itu diharapkan dapat ditemukan sistem scoring untuk prediksi kematian pasien KSSLGFG. Rancangan studi yang digunakan adalah retrospektif kohort. Data yang dikumpulkan berasal dari rekam medik penderita KSSLGFG dari 1 januari 1998 sampai 31 Desember 2003 di Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Jakarta, dengan jumlah sampel 70 kasus. Hasil penelitian menunjukkan rerata Survival secara keseluruhan pasien KSSLGFG 8,2 bulan, survival bulan ke-6 sebesar 39%, survival 1 tahun sebesar 3,2%. Median survival 5,3 bulan. Faktor-faktor yang berpengaruh terhadap survival pasien KSSLGFG adalah gambaran histopatologik (sel adenoskuamosa dan diferensiasi sel), ketebalan korteks ginjal < 1 cm dan nefrostomi. (Med J Indones 2005; 14: 173-8)

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The objective of this study was to obtain information on the survival rate of advanced cervical cancer patients with renal impairment (ACCRI) and its prognostic factors. In addition, it is hoped that by this method the scoring system for predicting the death of ACCRI patients hopetully could be obtained. Design of the study used was retrospective cohort study. Data collected were retrieved from medical records of ACCRI patients from 1 January 1998 to 31 December 2003 at Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, with a total sample of 70 cases. The results of the study showed that mean survival of all ACCRI patients was 8.2 months, mean survival at sixth month was 39%, and mean survival at one year was 3.2%. Median survival was 5.3 months. Prognostic factors affecting the survival of ACCRI patients included histopathological type (adenosquamous cell and cell differentiation), cortical thickness of the kidney less than 1 cm, and nephrostomy. (Med J Indones 2005; 14: 173-8)