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Hafiza Fathan
Pola resistensi bakteri terhadap antibiotik pada akne vulgaris sedang dan berat di Departemen Ilmu Kesehatan Kulit dan Kelamin RS Dr. Cipto Mangunkusumo = Antibiotic resistance of bacteria isolated from moderate and severe acne vulgaris patients visiting dermatology and venereology outpatient clinics Dr. Cipto Mangunkusumo Hospital, Jakarta
"ABSTRAK
Latar belakang dan tujuan. Penggunaan antibiotik pada akne vulgaris (AV) saat ini
dihadapi permasalahan resistensi Propionibacterium acnes (PA) dan bakteri lain
yang berperan pada AV. Data pola resistensi AVS dan AVB di RS Cipto
Mangunkusumo (RSCM) tahun 2006 menunjukkan adanya resistensi PA terhadap
eritromisin (63,2%), klindamisin (57,9%), dan tetrasiklin (47,4%). Tidak ditemukan
PA yang resisten terhadap doksisiklin maupun minosiklin. Penggunaan antibiotik
pada AV dapat menyebabkan perubahan pola resistensi sehingga penelitian ini
bertujuan memberikan data terbaru mengenai pola bakteri dan resistensinya terhadap
antibiotik lini pertama pada AVS dan AVB di Departemen Ilmu Kesehatan Kulit dan
Kelamin RSCM, yaitu tetrasiklin, doksisiklin, minosiklin, klindamisin dan
eritromisin.
Metode. Penelitian ini merupakan penelitian deskriptif dengan desain potong lintang.
Spesimen untuk kultur dan uji resistensi didapatkan dari ekstraksi komedo tertutup
yang selanjutnya dibiakkan secara aerob dan anaerob. Pemeriksaan uji resistensi
dilakukan secara kuantitatif dengan menggunakan MIC strip test.
Hasil. Dari 91 subjek, bakteri yang ditemukan terdiri atas PA 11,0%, Staphylococcus
epidermidis (SE) 50,5%, Staphylococcus aureus (SA) 7,7% dan bakteri lain sebesar
40,7% (aerob) dan 19,8% (anaerob). Sebagian kecil PA (10%) resisten terhadap
tetrasiklin, klindamisin, dan eritromisin. Tidak ditemukan PA yang resisten terhadap
doksisiklin dan minosiklin. Bakteri SE resisten terhadap eritromisin (65,2%),
klindamisin (52,2%), tetrasiklin (32,6%), dan doksisiklin (4,3%). Tidak ditemukan
SE yang resisten terhadap minosiklin. Sebagian kecil SA resisten terhadap
eritromisin (28,6%), doksisiklin (14,3%) dan klindamisin (14,3%). Tidak ditemukan
SA yang resisten terhadap tetrasiklin dan minosiklin.
Kesimpulan. Bakteri yang ditemukan pada pasien AVS dan AVB antara lain,
Staphylococcus epidermidis 50.5%, Propionibacterium acnes 11.0%, dan
Staphylococcus aureus 7.7%. Bakteri paling banyak ditemukan resisten terhadap
eritromisin dan ketiga bakteri tersebut seluruhnya masih sensitif terhadap minosiklin. ABSTRACT
Background and objective: The resistance of Propionibacterium acnes (PA) and
other bacteria that implicated in acne vulgaris (AV), has been a problem in AV
therapy. The latest data in the Department of Dermatology and Venereology, Cipto
Mangunkusumo Hospital, Jakarta (2006) showed resistance to erythromycin
(63.2%), clindamycin (57.9%) and tetracycline (47.4%), and no resistance to
doxycycline and minocycline. The use of antibiotics may cause changes in
susceptibility. This study aimed to provide the latest bacterial profile and resistance
pattern to first-line antibiotics used in moderate and severe AV: tetracycline,
doxycycline, minocycline, clindamycin and erythromycin.
Methods: This is a descriptive, cross-sectional study. Specimens were extracted
from closed comedones and cultured in media for aerobic and anaerobic bacteria.
Antibiotic resistance was measured quantitatively using MIC strip test.
Results: Bacteria were isolated from 91 subjects and consisted of Staphylococcus
epidermidis (SE)(50.5%), PA (11.0%), Staphylococcus aureus (SA)(7.7%) and other
bacteria [aerobic (40.7%) and anaerobic (19.8%)]. A small number of PA (10%) was
resistant to tetracycline, clindamycin, and erythromycin but not to doxycycline and
minocycline. SE was resistant to erythromycin (65.2%), clindamycin (52.2%),
tetracycline (32.6%), and doxycycline (4.3%) but not to minocycline. A small
number of SA was resistant to erythromycin (28.6%), doxycycline (14.3%) and
clindamycin (14.3%) but not to tetracycline and minocycline.
Conclusion: Bacterial profile in moderate and severe acne vulgaris consisted of
Staphylococcus epidermidis 50.5%, Propionibacterium acnes 11.0%, and
Staphylococcus aureus 7.7%. Bacteria were commonly resistant to erythromycin, but
still completely sensitive to minocycline.
;Background and objective: The resistance of Propionibacterium acnes (PA) and
other bacteria that implicated in acne vulgaris (AV), has been a problem in AV
therapy. The latest data in the Department of Dermatology and Venereology, Cipto
Mangunkusumo Hospital, Jakarta (2006) showed resistance to erythromycin
(63.2%), clindamycin (57.9%) and tetracycline (47.4%), and no resistance to
doxycycline and minocycline. The use of antibiotics may cause changes in
susceptibility. This study aimed to provide the latest bacterial profile and resistance
pattern to first-line antibiotics used in moderate and severe AV: tetracycline,
doxycycline, minocycline, clindamycin and erythromycin.
Methods: This is a descriptive, cross-sectional study. Specimens were extracted
from closed comedones and cultured in media for aerobic and anaerobic bacteria.
Antibiotic resistance was measured quantitatively using MIC strip test.
Results: Bacteria were isolated from 91 subjects and consisted of Staphylococcus
epidermidis (SE)(50.5%), PA (11.0%), Staphylococcus aureus (SA)(7.7%) and other
bacteria [aerobic (40.7%) and anaerobic (19.8%)]. A small number of PA (10%) was
resistant to tetracycline, clindamycin, and erythromycin but not to doxycycline and
minocycline. SE was resistant to erythromycin (65.2%), clindamycin (52.2%),
tetracycline (32.6%), and doxycycline (4.3%) but not to minocycline. A small
number of SA was resistant to erythromycin (28.6%), doxycycline (14.3%) and
clindamycin (14.3%) but not to tetracycline and minocycline.
Conclusion: Bacterial profile in moderate and severe acne vulgaris consisted of
Staphylococcus epidermidis 50.5%, Propionibacterium acnes 11.0%, and
Staphylococcus aureus 7.7%. Bacteria were commonly resistant to erythromycin, but
still completely sensitive to minocycline.
;Background and objective: The resistance of Propionibacterium acnes (PA) and
other bacteria that implicated in acne vulgaris (AV), has been a problem in AV
therapy. The latest data in the Department of Dermatology and Venereology, Cipto
Mangunkusumo Hospital, Jakarta (2006) showed resistance to erythromycin
(63.2%), clindamycin (57.9%) and tetracycline (47.4%), and no resistance to
doxycycline and minocycline. The use of antibiotics may cause changes in
susceptibility. This study aimed to provide the latest bacterial profile and resistance
pattern to first-line antibiotics used in moderate and severe AV: tetracycline,
doxycycline, minocycline, clindamycin and erythromycin.
Methods: This is a descriptive, cross-sectional study. Specimens were extracted
from closed comedones and cultured in media for aerobic and anaerobic bacteria.
Antibiotic resistance was measured quantitatively using MIC strip test.
Results: Bacteria were isolated from 91 subjects and consisted of Staphylococcus
epidermidis (SE)(50.5%), PA (11.0%), Staphylococcus aureus (SA)(7.7%) and other
bacteria [aerobic (40.7%) and anaerobic (19.8%)]. A small number of PA (10%) was
resistant to tetracycline, clindamycin, and erythromycin but not to doxycycline and
minocycline. SE was resistant to erythromycin (65.2%), clindamycin (52.2%),
tetracycline (32.6%), and doxycycline (4.3%) but not to minocycline. A small
number of SA was resistant to erythromycin (28.6%), doxycycline (14.3%) and
clindamycin (14.3%) but not to tetracycline and minocycline.
Conclusion: Bacterial profile in moderate and severe acne vulgaris consisted of
Staphylococcus epidermidis 50.5%, Propionibacterium acnes 11.0%, and
Staphylococcus aureus 7.7%. Bacteria were commonly resistant to erythromycin, but
still completely sensitive to minocycline.
;Background and objective: The resistance of Propionibacterium acnes (PA) and
other bacteria that implicated in acne vulgaris (AV), has been a problem in AV
therapy. The latest data in the Department of Dermatology and Venereology, Cipto
Mangunkusumo Hospital, Jakarta (2006) showed resistance to erythromycin
(63.2%), clindamycin (57.9%) and tetracycline (47.4%), and no resistance to
doxycycline and minocycline. The use of antibiotics may cause changes in
susceptibility. This study aimed to provide the latest bacterial profile and resistance
pattern to first-line antibiotics used in moderate and severe AV: tetracycline,
doxycycline, minocycline, clindamycin and erythromycin.
Methods: This is a descriptive, cross-sectional study. Specimens were extracted
from closed comedones and cultured in media for aerobic and anaerobic bacteria.
Antibiotic resistance was measured quantitatively using MIC strip test.
Results: Bacteria were isolated from 91 subjects and consisted of Staphylococcus
epidermidis (SE)(50.5%), PA (11.0%), Staphylococcus aureus (SA)(7.7%) and other
bacteria [aerobic (40.7%) and anaerobic (19.8%)]. A small number of PA (10%) was
resistant to tetracycline, clindamycin, and erythromycin but not to doxycycline and
minocycline. SE was resistant to erythromycin (65.2%), clindamycin (52.2%),
tetracycline (32.6%), and doxycycline (4.3%) but not to minocycline. A small
number of SA was resistant to erythromycin (28.6%), doxycycline (14.3%) and
clindamycin (14.3%) but not to tetracycline and minocycline.
Conclusion: Bacterial profile in moderate and severe acne vulgaris consisted of
Staphylococcus epidermidis 50.5%, Propionibacterium acnes 11.0%, and
Staphylococcus aureus 7.7%. Bacteria were commonly resistant to erythromycin, but
still completely sensitive to minocycline.
"
Fakultas Kedokteran Universitas Indonesia, 2016
SP-PDF
UI - Tugas Akhir  Universitas Indonesia Library
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Dyah Saptarini
Hubungan antara kadar vitamin D serum dengan derajat akne vulgaris pada remaja sekolah menengah atas usia 15-18 Tahun = The relationship between vitamin D serum level and the degree of acne vulgaris in high school adolescents aged 15-18 years
"

Akne vulgaris (AV) adalah penyakit inflamasi yang kronis pada bagian pilosebasea.  Pada umumnya akne terjadi pada masa pubertas, dewasa muda, dan banyak terjadi pada remaja. AV mempengaruhi 85% dewasa muda usia 12-25 tahun dan secara konsisten menduduki “the top three most prevalence skin condition“ dalam populasi umum Salah satu faktor yang mempengaruhi timbulnya akne vulgaris dan yang masih menjadi perebatan adalah faktor nutrisi. Dengan menggunakan cut-off <20 ng/mL, prevalensi defisiensi vitamin D bervariasi antara 6-70% di Asia Tenggara, hasil penelitian di Malaysia lebih dari setengah (58%) jumlah remaja memiliki 25(OH)D <50 nmol/L. Penelitian ini merupakan studi potong lintang yang membandingkan nilai rerata kadar vitamin D serum antara dua kelompok derajat akne pada remaja siswa sekolah menengah atas usia 15-18 tahun di kota Depok. Jumlah subjek total 60 orang terbagi dalam 2 kelompok, 30 orang kelompok akne vulgaris ringan (AVR) dan 30 orang akne vulgaris sedang-berat (AVS). Rerata kadar vitamin D serum subjek adalah 17,29±6,77 ng/ml. Sebanyak 21 subjek (35%) berada pada kondisi sufisiensi vitamin D dan 39 subjek (65%) berada dalam kondisi insufisiensi-defisiensi (terdiri dari 43,3% insufisiensi, 21,7% defisiensi). Kadar rerata vitamin D serum pada kelompok AVR 15,45±6,7 ng/ml dan pada AVS 19,13±6,8 ng/ml dengan p=0,034.

Kesimpulan : hasil penelitian ini menunjukkan ada hubungan yang bermakna antara kadar vitamin D serum dengan akne vulgaris. vitamin D serum.

 

Acne vulgaris is a chronic inflammatory disease as a part of pilosebaceus. In general acne occurs during puberty, but it can also occur in young adults, and many occur in adolescents. Acne vulgaris affects 85% of young adults aged 12-25 years and consistently occupies "the top three most prevalence skin conditions" in the general population. One of the factors that influence acne vulgaris and which is still a debate pro and contra are nutritional factors. This study aims to find a relationship between vitamin D serum level and the degree of acne in adolescents. Previous researches that linked vitamin D levels with acne was not conclusive, especially in adolescents. This is a cross-sectional study that compares the mean values of serum vitamin D levels between two groups of acne levels in adolescents of high school students aged 15-18 years in the city of Depok. The total number of subjects was 60 people divided into 2 groups, 30 people in the group of mild acne vulgaris and 30 people with moderate-severe acne vulgaris. The mean of vitamin D level of the subject serum was 17.29 ± 6.77 ng / ml. The mean of vitamin D serum level in the mild group was 15.45 ± 6.7 ng / ml and moderate group was 19.13 ± 6.8 ng / ml with p = 0.034. A significant association was found between serum vitamin D levels and the degrees of acne vulgaris.

Conclusion: there is a significant relationship between serum vitamin D levels and degree of acne vulgaris. The mean of vitamin D level are lower in mild acne group than in moderate group

"
Depok: Fakultas Kedokteran Universitas Indonesia, 2019
T-Pdf
UI - Tesis Membership  Universitas Indonesia Library
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Dina Kusumawardhani
Efektivitas dan Keamanan Krim Campuran Ekstrak Spent Grain Wax, Argan Oil, dan Shea Butter Pasca-Bedah Kimia Tricholoroacetic Acid 15%: Uji Klinis, Acak, Terkontrol, Tersamar Ganda, Split-Face = Effectiveness and Safety of Cream Containing Spent Grain Wax Extract, Argan Oil, and Shea Butter Post-Tricholoroacetic Acid 15% Peel: Randomized, Controlled, Double-Blind, Split-Face Clinical Trial
"Bedah kimia trichloroacetic acid (TCA) memiliki efek samping yang lebih banyak dibandingkan larutan bedah kimia lainnya. Penelitian ini bertujuan untuk menilai efektivitas pelembap dalam mengurangi efek samping pasca-bedah kimia TCA. Penelitian ini merupakan uji klinis acak terkontrol tersamar ganda dengan metode split face yang dilakukan di Poliklinik Dermatologi dan Venereologi Rumah Sakit dr. Cipto Mangunkusumo. Penilaian global peneliti (PGP), penilaian subjektif pasien (PSP), pemeriksaan indeks eritema (IE), transepidermal water loss (TEWL), dan skin capacitance (SCap) dilakukan pada hari ke-0, 3, dan 7. Subjek penelitian (SP) merupakan wanita dengan diagnosis penuaan kulit (rata-rata usia 46,7 tahun). Sebanyak 27 SP dirandomisasi untuk mendapatkan krim intervensi (krim campuran ekstrak spent grain wax, argan oil, dan shea butter) atau krim vehikulum pada salah satu sisi wajah pasca-tindakan bedah kimia TCA 15%. Terdapat penurunan nilai PGP, PSP, kadar TEWL, dan IE pada kelompok intervensi pada hari ke-3 dan 7 dibandingkan dengan kelompok vehikulum, namun tidak signifikan secara statistik. Kadar SCap meningkat signifikan pada hari ke-7 pada pasien yang mendapat krim intervensi dibandingkan dengan krim vehikulum. Tidak ada efek samping obat yang dilaporkan pada penelitian ini. Krim campuran ekstrak spent grain wax, argan oil, dan sheabutter  aman digunakan dan dapat mengurangi efek samping pasca-bedah kimia TCA.
TCA chemical peel has more side effects than other chemical peel solutions. This study aims to assess the effectiveness safety of a post-peel cream containing spent grain wax, argan oil, and shea butter in reducing TCA peel side effects. A randomized, placebo-controlled, double-blinded, split face trial on women undergoing TCA 15% chemical peels. Assessment for global investigator assessment (GIA), subject self-assessment (SSA), erythema index, transepidermal water loss (TEWL), and skin capacitance (SCap) was conducted on days 0, 3, and 7. Twenty-seven patients (mean age 46.7 years) were recruited. There were significant improvements in GIA and SSA scores on both groups, but it is not different between the treatment groups. There were erythema index and TEWL improvement on days 3 and 7 compared to baseline, however, there were no differences between groups. The SCap measurement showed significant improvement in skin capacitance on both groups on day 7, but it was better improvement within intervention group. No adverse effects were reported. Cream containing spent grain wax, argan oil, and shea butter showed higher skin capacitance levels but did not significantly affect erythema index, TEWL, clinical and subjective assessments after TCA chemical peeling. "
Jakarta: Fakultas Kedokteran Universitas Indonesia, 2023
SP-pdf
UI - Tugas Akhir  Universitas Indonesia Library