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"[ABSTRAKLatar Belakang: Pada kasus borderline periodontitis agresif dan periodontitis kronis diperlukan suatu biomarker imunologis yang dapat membantu menegakkan diagnosis dengan tepat. Human Beta Defensin-3 merupakan suatu protein yang berasal dari host yang dapat menggambarkan derajat keparahan penyakit periodontal. Tujuan: Menganalisis kadar hBD-3 pada cairan krevikular gingiva penderita periodontitis kronis dan periodontitis agresif. Metode: Penelitian ini melibatkan 16 orang penderita periodontitis agresif, 16 orang penderita periodontitis kronis dan 8 subyek sehat. Kadar hBD-3 diukur dengan teknik ELISA. Hasil: Kadar hBD-3 pada periodontitis kronis tidak berbeda bermakna dengan kadar hBD-3 periodontitis agresif (p>0,05). Kesimpulan: Kadar HBD-3 dalam cairan krevikular gingiva tidak berbeda bermakna pada penderita periodontitis kronis dan periodontitis agresif sehingga belum bisa digunakan sebagai alternatif diagnosis.

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ABSTRACTBackground: For borderline cases between chronic and aggressive periodontitis, an immunologic biomarker is needed to fix the diagnosis. Human Beta Defensin-3 is a host protein that can describe the severity of periodontitis. Aim: Analyzing Human Beta Defensin-3 (HBD-3) levels in gingival crevicular fluid of chronic and aggressive periodontitis patient. Method: Samples were collected from 8 healthy subjects, 16 aggressive periodontitis subjects and 16 chronic periodontitis subjects. HBD-3 level was measured by using ELISA technique. Result: HBD-3 levels in chronic periodontitis didn?t show any difference to the hBD-3 levels in aggressive periodontitis (p>0,05). Conclusion: HBD-3 levels in chronic periodontitis didn?t show any difference to the aggressive one so it can not be used as a diagnostic parameter in chronic periodontitis and aggressive as well.;Background: For borderline cases between chronic and aggressive periodontitis, an immunologic biomarker is needed to fix the diagnosis. Human Beta Defensin-3 is a host protein that can describe the severity of periodontitis. Aim: Analyzing Human Beta Defensin-3 (HBD-3) levels in gingival crevicular fluid of chronic and aggressive periodontitis patient. Method: Samples were collected from 8 healthy subjects, 16 aggressive periodontitis subjects and 16 chronic periodontitis subjects. HBD-3 level was measured by using ELISA technique. Result: HBD-3 levels in chronic periodontitis didn’t show any difference to the hBD-3 levels in aggressive periodontitis (p>0,05). Conclusion: HBD-3 levels in chronic periodontitis didn’t show any difference to the aggressive one so it can not be used as a diagnostic parameter in chronic periodontitis and aggressive as well., Background: For borderline cases between chronic and aggressive periodontitis, an immunologic biomarker is needed to fix the diagnosis. Human Beta Defensin-3 is a host protein that can describe the severity of periodontitis. Aim: Analyzing Human Beta Defensin-3 (HBD-3) levels in gingival crevicular fluid of chronic and aggressive periodontitis patient. Method: Samples were collected from 8 healthy subjects, 16 aggressive periodontitis subjects and 16 chronic periodontitis subjects. HBD-3 level was measured by using ELISA technique. Result: HBD-3 levels in chronic periodontitis didn’t show any difference to the hBD-3 levels in aggressive periodontitis (p>0,05). Conclusion: HBD-3 levels in chronic periodontitis didn’t show any difference to the aggressive one so it can not be used as a diagnostic parameter in chronic periodontitis and aggressive as well.]"

"[Latar Belakang: Regenerasi periodontal diawali dengan perlekatan bekuan fibrin yang stabil. Tujuan: Mengamati perbedaan tingkat perlekatan bekuan fibrin pada permukaan akar yang dilakukan root surface conditioning dengan menggunakan minosiklin dan EDTA. Metode: Tiga puluh buah permukaan akar gigi dibagi dalam tiga kelompok yaitu kelompok minosiklin, kelompok EDTA dan kelompok kontrol salin. Pada permukaan akar gigi dilakukan aplikasi darah segar dan dibiarkan berkoagulasi, bekuan fibrin di evaluasi dengan Scaning Electron Microscope. Hasil Penelitian: Tidak terdapat perbedaan bermakna antara bekuan fibrin kelompok minosiklin dengan EDTA (p=0,759). Kesimpulan: Bahan EDTA dan minosiklin menghasilkan kepadatan bekuan fibrin yang sama pada permukaan akar gigi.......Background: Periodontal regeneration starts with a stable fibrin clots on the root surface. Objective: To observe the differences of fibrin clots on root surface with root surface conditioning using Minocycline and EDTA. Method: Thirty root surfaces divided into three groups. Minocycline group, EDTA group and saline group as control. Fresh human blood dropped on the surface and allow to coagulate. Fibrin clots were evaluated using Scanning Electron Microscope. Result: The result showed no significant difference between minocycline and EDTA application (p=0,759) Conclusion: EDTA and minocycline showed equal capability in producing fibrin clots on the root surface;Background: Periodontal regeneration starts with a stable fibrin clots on the root surface. Objective: To observe the differences of fibrin clots on root surface with root surface conditioning using Minocycline and EDTA. Method: Thirty root surfaces divided into three groups. Minocycline group, EDTA group and saline group as control. Fresh human blood dropped on the surface and allow to coagulate. Fibrin clots were evaluated using Scanning Electron Microscope. Result: The result showed no significant difference between minocycline and EDTA application (p=0,759) Conclusion: EDTA and minocycline showed equal capability in producing fibrin clots on the root surface;Background: Periodontal regeneration starts with a stable fibrin clots on the root surface. Objective: To observe the differences of fibrin clots on root surface with root surface conditioning using Minocycline and EDTA. Method: Thirty root surfaces divided into three groups. Minocycline group, EDTA group and saline group as control. Fresh human blood dropped on the surface and allow to coagulate. Fibrin clots were evaluated using Scanning Electron Microscope. Result: The result showed no significant difference between minocycline and EDTA application (p=0,759) Conclusion: EDTA and minocycline showed equal capability in producing fibrin clots on the root surface, Background: Periodontal regeneration starts with a stable fibrin clots on the root surface. Objective: To observe the differences of fibrin clots on root surface with root surface conditioning using Minocycline and EDTA. Method: Thirty root surfaces divided into three groups. Minocycline group, EDTA group and saline group as control. Fresh human blood dropped on the surface and allow to coagulate. Fibrin clots were evaluated using Scanning Electron Microscope. Result: The result showed no significant difference between minocycline and EDTA application (p=0,759) Conclusion: EDTA and minocycline showed equal capability in producing fibrin clots on the root surface]"