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"Tujuan: Mengetahui karakteristis kualitas hidup serta faktor risiko yang berpengaruh pada pasien kanker serviks stadium lanjut lokal pasca radiasi Metode: Penelitian adalah penelitian potong lintang pada 82 subjek penelitian. Uji normalitas menggunakan uji Kolmogorov-Smirnov dan perbandingan rerata menggunakan uji Mann Whitney Hasil: Rerata kualitas hidup skala kesehatan global 74,49%, skala fungsional 87,39%, skala gejala umum 39,02%, skala fungsional seksual 45,94%, dan skala gejala seksual 42,68%. Kesimpulan: Kualitas hidup pasien kanker servis pasca radiasi tergolong baik, kecuali pada skala fungsi seksual. Faktor terkait penyakit yang secara statistik signifikan dalam mempengaruhi peningkatan kualitas hidup adalah stadium lebih dini dan tidak ada komorbid; diferensiasi baik mempengaruhi peningkatan kualitas hidup walau tidak signifikan. Faktor terkait pengobatan yang secara statistik signifikan dalam mempengaruhi peningkatan kualitas hidup adalah interval waktu diagnosis dan tatalaksana ≤ 90 hari, overall treatment time ≤ 56 hari, teknik brakiterapi, dan pemberian kemoradiasi; sedangkan respon terapi komplit dan tidak ada efek samping mempengaruhi peningkatan kualitas hidup walau tidak signifikan. Faktor terkait sosioekonomi yang secara statistik mempengaruhi peningkatan kualitas hidup adalah usia ≤ 45 tahun, status menikah, pendidikan lanjutan, dan penghasilan diatas UMR.

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Aims: Knowing the characteristics of quality of life and risk factors that affect advanced local cervical cancer patients after radiation Materials and methods: The study was a cross-sectional study on 82 research subjects. Normality test using the Kolmogorov-Smirnov test and comparison of the mean using the Mann Whitney test. Results: The mean of quality of life on the global health scale is 74.49%, the functional scale is 87.39%, the general symptom scale is 39.02%, the sexual functional scale is 45.94%, and the sexual symptom scale is 42.68%. Conclusion: The quality of life of post-radiation cervical cancer patients is good, except on the sexual function scale. Disease-related factors that were statistically significant in influencing the improvement of the quality of life were earlier stage and no comorbidities; Good differentiation affects the quality of life, although not significantly. Treatment-related factors that were statistically significant in influencing the improvement of the quality of life were the interval between diagnosis and treatment ≤ 90 days, overall treatment time ≤ 56 days, brachytherapy technique, and chemoradiation; while the complete therapy response and no side effects affected the improvement of the quality of life, although not significantly. Socio-economic related factors that statistically affect the improvement of the quality of life are age ≤ 45 years, marital status, further education, and income above the minimum wage."

"Tujuan: Mengetahui hubungan nilai DSC (Dice Similarity Coefficient) GTVMRI dan GTVCT dengan jarak waktu MRI sebelum radiasi dan CT Simulator dalam radiasi eksterna kanker serviks. Metode: Dilakukan studi potong lintang pada 25 pasien kanker serviks yang belum mendapatkan terapi definitif sebelumnya, dan sudah dilakukan MRI pelvis diagnostik dan CT Simulator pelvis pada periode Januari 2018 – Februari 2021. Dilakukan registrasi/fusi antara MRI dan CT, dilakukan delineasi GTV primer pada T2WI MRI dan CT Simulator. Dihitung nilai DSC dan dilakukan analisis korelasi antara nilai DSC dan jarak waktu. Batasan waktu dihitung menggunakan kurva ROC (Receiving Operator Characteristic). Hasil: Median jarak waktu MRI dan CT Simulator 24 (1-71) hari. Volume GTVMRI 104.35±66.23, GTVCT 167.79±97.15. Nilai DSC sebesar 0.53±0.16. Korelasi antara DSC dan jarak waktu r = -0.421, p = 0.036. Kurva ROC dengan sensitivitas 85.7%, spesifitas 54.5%, dengan indeks Youden yang paling optimal dan Area Under Curve (AUC) 0.682, 95% CI 0.461-0.902 didapatkan pada 10 hari. Kesimpulan: Semakin lama jarak waktu antara pemeriksaan MRI dan CT akan menurunkan nilai DSC. Diperlukan pertimbangan lebih jika akan dilakukan fusi antara MRI dan CT pada delineasi GTV primer kanker serviks dengan jarak waktu antara pemeriksaan lebih dari 10 hari.

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Objective: The aim of this study is to assess the correlation between DSC (Dice Similarity Coefficient) values of GTVMRI and GTVCT ​​with the MRI time interval before radiation and CT Simulator.

Method: A cross-sectional study was conducted on 25 cervical cancer patients who had not previously received definitive therapy, and already had a diagnostic pelvic MRI and pelvic CT simulator in periode January 2018 – February 2021. Rigid Body Registration/fusion between MRI and CT was carried out, primary GTV delineate on T2WI MRI and CT Simulator. The DSC value was calculated and a correlation analysis was performed between the DSC value and the interval time. The time limit was calculated using the ROC (Receiving Operator Characteristic) curve.

Result: Median time interval between MRI and CT Simulator was 24 (1-71) days. GTVMRI volume 104.35±66.23, GTVCT 167.79±97.15. Mean DSC value was 0.53±0.16. Correlation between DSC and time interval r = -0.421, p = 0.036. ROC curve with sensitivity 85.7%, specificity 54.5%, with the most optimal Youden index and Area Under Curve (AUC) 0.682, 95% CI 0.461-0.902 obtained at 10 days.

Conclusion: The longer the time interval between the MRI and CT planning, the lower the DSC value. Need to be more caution in doing the fusion if the time interval between MRI and CT is more than 10 days."