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"Vitamin A deficiency, iron deficiency anemia and growth retardation have long been three of the main health problems in Vietnam. The National vitamin A distribution program for preschool children started since 1988. However, some studies outside Vietnam showed that this method does not maintain the retinal status until the next vitamin A capsule distribution. (Bloem et al 1989). Iron intervention and fortified supplementary feeding have not been done in preschool children. The objective of the study was to investigate the effects of vitamin A and iron fortified soybean milk (SBM) supplementary feeding on nutritional status of Vietnamese preschool children. The study consisted of 5 parts: The relative bioavailability test of iron in SBM fortified with 300 EtgRE and 5 mg of iron pyrophosphate, the acceptability test of fortified SBM by preschool children, the study in the per/-urban area, the study in the rural area and the intervention study in the rural area. The fortified SBM with a relative bioavailability of 45% was very well accepted by the rural preschool children attending day-care centers. The studies in the peri-urban and rural areas were done at day-care centers on boys and girls aged respectively 15-72 and 8-62 months, 438 and 417 children. Inadequate dietary intake, high infectious diseases and high worm infestation were detected in both areas. The rural children had significantly worse nutritional status in terms of serum retinol (SR) and physical growth status. However, the prevalence of anemia was about 20% in both areas. Considering this condition, the 5 months intervention study was carried out in the same rural area with the same subjects and number. Before randomly allocated into three groups, the stool of all subjects was examined and Mebendazole was given to those parasite egg positive subjects. The groups received respectively fortified SBM (FSBM), unfortified SBM (UFSBM), and cassava cookies (CC). The FSBM, UFSBM, CC contained respectively 150, 150, 45 kcal; 300, 50, 0 pgRE and 6.8, 1.8, 0.7mg of iron. These supplementary foods were given daily, 6 days a week, at the DCC and provided an additional in percentage of RDA the following: FSBM 12% of energy, 70% of vitamin A, 30% of iron; UFSBM 12% of energy, 12% of vitamin A, 8% of iron; CC about 3% of energy, o% of vitamin A and iron. The daily food of the subjects provided 88.8% energy, 104% iron, 78.5% vitamin A in percentage of (FAO/WHO/UNU 1985, FAO/WHO 1988) 's RDA. Five months of intervention significantly increased serum retinol (SR), hemoglobin (Hb), and physical growth status of all three groups. The best effect was found in the FSBM group. The difference in effect between groups was marginal for SR (p=0.07) and significantly different for Hb (p-0.02). The serum ferritin (SF) significantly increased in the FSBM group only. The mean values of the FSBM group for weight, height, WAZ-score, HAZ-score were significantly higher than the CC group. The best effect found in the FSBM group could be the effect of vitamin A and iron fortification but also of the protein and fat of SBM. The last also explains the improvement found in the UFSBM group. The increase of SR in all the three groups could be the effect of the "intervention" (Hawthorn) but also of deworming which was also shown by other studies. The increase in Hb and SF of the three groups could be related to age increase considering the length (5 months) of the intervention. The increase in Fib concentration could be related to the improvement of vitamin A status. The supplementary feeding using FSBM, preceded with deworming had an excellent effect on the improvement of SR and Hb concentration of preschoolers. Both fortified and UFSBM led to improved physical growth status of preschool children. As bioavailability of iron was low and the serum ferritin did not increase significantly, further research is needed: to identify iron compound suitable for fortification and higher level of iron (3 mg of elemental iron/30 g soybean milk powder), in combination of vitamin C for better effects of supplementation."

"Iron deficiency anemia is prevalent in Indonesia (38-71%), particularly among the pregnant women, despite of the large scale anemia control program launched by the government since 1970’s. The anemia control program included iron supplementation, nutrition education, food fortification, and parasite control. The results of the iron supplementation program is not yet as expected. Low compliance in taking iron pills was a reason suspected as the cause of the unexpected results. Several methods had been studied to increase the number of iron pills intake. However, the synthesis of hemoglobin is not only dependenton iron from the pills but also requires other blood forming nutrients from the diets. A two phase descriptive study was conducted to study the factors influencing the iron status of pregnant women in the second trimester participating in the National Anemia Control program in three subdistricts of Bogor district. The first phase was conducted for four weeks to obtain informations on hemoglobin and serum ferritin, socioeconomic condition, daily diet and nutrients intake, knowledge on anemia, on iron pills,and on Puskesmas Services, health behaviour, ante natal care attendance, and number of iron pills intake. The number of pregnant women joining the study was 456, they attended the ante natal care clinic of the Puskesmas of three subdistricts of the district of Bogor. The prevalence of anemia (Hb"

"ABSTRACTThe social impact of the crisis in Indonesia, both monetary and natural disaster had been investigated by some studies. There is empirical evidence at national level that suggests the crisis impact is very heterogeneous both between urban and rural areas and across regions. It is also found that there is little connection between initial poverty levels and the extent to which an area had been hit by the crisis. The main objective of this study was to investigate the influence of the recent economic crisis and the benefit of the Social Safety Net Program for the nutritional status of under-five children during the economic crisis in selected poor areas of Indonesia. A cross sectional study to get information on the nutritional status of children and its determinants in urban poor area of Jakarta, and rural areas of Banggai in Central Sulawesi, and Alor-Rote in East Nusa Tenggara was followed by another cross sectional study in one selected poor urban area of Cilincing sub-district, Jakarta to see the changes of key determinant(s) of the under-five children's nutritional status after receiving the Social Safety Net intervention program for 1 year period. Two-stage cluster sampling was used to get 1078 households with under-five children in the urban poor area of Jakarta, and 262 and 631 households with under-five children each for the rural areas of Banggai and Alor-Rote, respectively as the subjects of the cross-sectional study-1; and 587 households with under-five children for the cross sectional study-2 in poor urban area of Cilincing sub-district. For both studies, general socio-demographic characteristics, socio-economic, health and nutritional status, and child feeding practices data were collected through interview and observation methods using structured questionnaires. Anthropometrical assessments (of weight, stature, and arm-circumference) were done both for children and their mothers in both studies. Hemoglobin assessment was done for sub-samples of approximately 50% of the total under-five children in both studies. Quality control procedures were performed during the course of the study. Data collection for both studies was performed from January 1999 to January 2001. It revealed that 34% of fathers in the study area of Jakarta had finished junior high school and even less for mothers (22%). More than 70% of the fathers had no regular income and 7% of the sample households had both the fathers and mothers work regularly. About 42 % of the sample households was classified as having sufficient purchasing power and less that 60% of sample households was classified as having appropriate luxury goods (mostly of electronic goods). For the study area in Banggai, 23% of fathers had finished junior high school and even only 10% for mothers. Approximately 14% of the fathers had no regular income and 24% of the sample households was classified as having appropriate employment status. About 45% of the sample households was classified as having sufficient food production/purchasing power in this study and less than 50% of the sample households was classified as having appropriate luxury goods (mostly of cultivated land). For the study area in Alor-Rote, 23% of fathers had finished junior high school and even only 10.9% for mothers. Approximately 21% of the fathers had no regular income and 47% of the sample households had both the fathers and mothers work regularly. About 48% of the sample households was classified as having sufficient food production/ purchasing power in this study and 26% of sample household was classified as having appropriate luxury goods (mostly of cultivated land). Besides having a high severity of anemia (>40%), under-five children in the urban poor area of Jakarta had a very high severity of wasting (>15%) as compared to the medium severity of stunting condition (20-29%). Similar findings were found for the rural area of Banggai. Different findings for the rural area of Alor-Rote were only for its very high severity in stunting condition (>40%). By multivariate and path analyses, it was shown that Jakarta as the study site contributed significantly to the variation of wasting indicator (WHZ value) as the recent-type of malnutrition, and Alor-Rote as the study site contributed significantly to the variation of stunting indicator (HAZ value) as the longterm-type of malnutrition. For hemoglobin value, both Jakarta and Alor-Rote as the study sites contributed to its variation. High prevalence of infectious diseases in all study areas were significantly related to the higher prevalence of wasting in the study areas of Jakarta and Banggai, and also significantly related to the higher prevalence of stunting and anemia in the study area of Alor-Rote. For Jakarta, besides infectious diseases, BMI status of mothers and the possession of motorcycle used for income earning were also significantly related to the prevalence of wasting. On the other hand, for Alor-Rote, besides infectious diseases, possession of luxury goods (access to electricity, possession of transportation facility and electronic goods), environmental sanitation (housing conditions), maternal nutritional knowledge and access to complete immunization were also significantly related to the prevalence of stunting. And, infectious diseases and households' employment status contributed to the variation of stunting (HAZ value). Furthermore, for anemia, access to health services (for complete immunization) was the only key determinant which contributed significantly to the variation of hemoglobin value in Jakarta. For Alor-Rote, besides infectious diseases, formal education of the parents, employment status (especially working mothers), environmental sanitation (especially access to safe drinking water), maternal nutritional knowledge and access to health services were also significantly associated with the prevalence of anemia. And, infectious diseases, environmental sanitation, access to health services and households' employment status contributed significantly to the variation of hemoglobin value in Alor-Rote. The Social Safety Net Intervention Program in the urban poor area of Cilincing sub-district, Jakarta resulted in significant improvement in the prevalence of wasting and anemia among under-five children but not for the prevalence of stunting. It was also found that maternal and childcare, access to health services and hemoglobin were still retained as determinants of child malnutrition besides households' employment status and variety of food intake. There is a need to improve the nutritional and health status of under-five children and their mothers through the existing health care system providing basic health services and improving the capacity of health staffs across Indonesia as part of the decentralization process. Besides, the private sector and communities may support the local government in the form of informal Social Safety Net intervention programs. The significant association found between mother's BMI and wasting status of their under-five children found in this study can be used to prioritize the appropriate type of intervention needed by the poor households. Furthermore, since anemia was highly prevalent, besides iron supplementation, chronic diseases such as tuberculosis and malaria, and the prevalence of thalasemic-trait should also be considered. Further operational and academic research in the area of health and nutrition are needed to be able to construct a model that provides indicators used to predict the nutritional condition in each community setting across Indonesia during any crisis. "

"ABSTRAKTujuan: Mengetahui status metabolisme penderita SHD rawat inap di rumah sakit, dan memperoleh rumus untuk menentukan kebutuhan energi yang sesuai dengan status metabolisme penderita.Tempat: Bagian Gizi dan Bagian Penyakit Dalam Rumah Sakit Sumber Waras, Jakarta.Metode Penelitian didisain Cross Sectional, pada 49 subyek SHD laki-laki atau perempuan 30-80 tahun yang diseleksi secara konsekutif, dan 40 kontrol sehat yang diseleksi secara random dari karyawan RSSW. Data REE diperoleh dari hasil pemeriksaan konsumsi O2 dan CO2 yang dikeluarkan tubuh, dengan mempergunakan Kalorimeler Indirek. Asupan makanan dicatat selama 3 hari berturut-turut sebelum pemeriksaan REE. Data antropometri (LLA, TLLBK, KAOLA, TB, dan BB) dan pengumpulan urin dilakukan satu hari sebelum pemeriksaan REE, pengambilan darah untuk pemeriksaan IGF-l dan GH dilakukan setelah pemeriksaan Kalorimetri Indirek. Uji Statistik: Univariat mempergunakan tes Kormogorov Smimov, Bivarial mempergunakan uji t tidak berpasang, uji Mann Whitney dan Korelasi Pearson. Uji multivariat mempergunakan uji regresi linier ganda.Hasil dari 49 subyek SHD yang masuk RS karena komplikasi: hematemesis (34,69%), malaria (46,94%), ikterus (55,1%), dan yang terbanyak asites (87,76%). Dari jumlah tersebut 67,35% tergolong Child C, sisanya Child B. Ditemukan 63,27 % subyek SHD mengeluh mual dan 75,52% anoreksia. Rerata asupan energi subyek SHD secara bermakna lebih rendah dari kontrol sehat (1282,04 ± 229,85 vs 1448,71 ± 325,56; p = 0,006), dan mempunyai korelasi dengan derajat penyakit. Proporsi asupan terhadap kebutuhan energi subyek SHD hanya mencapai 79,49% ± 17,60% REE. Proporsi asupan terhadap kebutuhan energi lebih besar pada subyek SHD yang tanpa keluhan mual dan anoreksia. Penelitian ini menemuken 73,57 % dari subyek SHD daiam keadaan malnutrisi, dan 58,26 % diantaranya (42,86% total subyek SHD) dalam keadaan muscle wasting (AOLA pada persentil < 5) dan menunjukkan korelasi dengan asupan energi (p=0,007). Meningkatnya mobilisasi lemak dan oksidasi substrat lemak ditandai oleh TLLBK pada lebih dari 67% subyek SHD pada persentil < 15 dan RQ = 0,7 ± 0,08, serta menunjukkan korelasi yang bermakna dengan kurangnya asupan energi (p = 0,005). Meningkatnya mobilisasi lemak dan lipolisis diduga mempunyai hubungan dengan rendah IGF-1 dan tingginya GH dalam darah. Walaupun oksidasi lemak diduga untuk mencegah berlanjutnya katabolisme otot, penelitian ini menunjukkan katabolisme otot berlanjut, hal ini ditandai dengan; imbang nitrogen negatif, rasio NUU/K.AOLA subyek SHD bermakna lebih tinggi dari kontrol sehat, dan RQ sekitar 0,43-0,86. Namun, pada penelitian ini tidak didapatkan perbedaan yang bermakna REE subyek SHD dengan kontrol sehat; hal ini disebabkan oleh menurunnya massa otot, dan meningkatnya oksidasi substrat lemak sehingga konsumsi oksigen dan REE rendah. Data menunjukkan rasio REE/K.AOLA bermakna lebih tinggi dari kontrol sehat. Keadaan ini menujukkan subyek SHD dalam kondisi hipermetabolisme disertai penyimpangan metabolisme yang dapat ditandai oleh berlanjutnya mobilisasi lemak; oksidasi substrat lemak (tak sempurna); dan oksidasi substrat protein berlangsung bersama. Asupan nutrisi, komposisi tubuh, dan status metabolisme penderita SHD telab diidentifikasi merupakan acuan penting untuk menentukan REE. Dengan menggunakan variabel; rerata asupan energi, komposisi tubuh (TB, BB, AOLA, dan lainnya) dan derajat penyakit (skor Child-Pugh, albumin, dan NUU) sebagai variabel independen. Melalui uji regresi linier ganda (metode STEPWISE) penelitian ini menemukan 3 variabel merupakan determinan kuat REE yaitu TB, AOLA dan kadar albumin. Dan uji tersebut diperoleh persamaan model yang merupakan model REE estimasi SHD yang reliabel, sehingga dapat direkomendasikan sebagai rumus estimasi REE atau kebutuhan energi penderita SHD yaitu :kebutuhan energi = -270,40+17,26*AOLA - 217,83*Albumin + 11,42*TB. Kesimpulan Pada penderita SHD, keadaan hipermetabolisme tidak dapat ditentukan hanya dengan indikator REE. Hipermetabolisme pada subyek SHD menjadi nyata dengan menentukan REE/K.AOLA dan NUU/K.AOLA. Nasib oksidasi makronutrien pada SHD berbeda dengan pada starvasi. Pada subyek SHD lerjadi rangsangan mobilisasi lemak, oksidasi substrat lemak, katabolisme protein otol, dan oksidasi substrat protein secara bersama. Keadaan yang membuktikan adanya penyimpangan metabolisme. Dengan uji regresi limier ganda (metoda STEPWISE), AOLA, albumin dan tinggi badan ditemukan sebagai determinan kuat dari REE atau kebutuhan energi pada penderita SHD rawat inap di RS.

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ABSTRACT

Objective: To study the metabolic status of the Decompensated Liver Cirrhotic (DLC) patients who were hospitalized, and to formulate the equation of energy requirements equal to their metabolic status.

Places: The Department of Nutrition and the Department of Internal Medicine at Sumber Waras Hospital (SWH), Jakarta.

The cross sectional study was carried out on 49 DLC subjects, aged 30-80 years, selected consecutively, and on 40 healthy control subjects, selected at random, from SWH staff. The REE data was determined by assessing the Oz consumption (V02) and CO2 production (VCO2] using an Indirect Calorimeter. Food intake was recorded for 3 consecutive days before determining REE. The anthropometrics data (AC, TSF, C.AMA, Height and Weight) and urine samples were assessed one day prior to determining REE. The blood samples for determining IGF-1 and GH were taken after the Indirect Calorimetric assessment (REE data). The statistical tests: Univarian (using Kormogorof-Smimov), Bivarian (using unpaired T-tests, Mann-Whitney and Pearson Correlation), Multivariate (using multiple linear regression).

Results The 49 DLC subjects were hospitalized mainly due to complications of ascites (87.76%); many also suffered with hematemesis (34.69%), melena (46.94%), or icterus (55.1%). Of the 49 subjects, 67.35% were classified as Child C, the rest were Child B. The subjective findings were nausea (63.27%) and/or anorexia (75.52%). The mean energy intake of DLC subjects was significantly lower than the control (healthy volunteers) (1282.74 229.85 vs. 1448.71 * 325.56; p = 0.006), and had a correlation to the degree of disease, Their intake had only been 79.49 17.60% of REE. The proportion of food intake to energy requirements was larger in the DLC subject who had no symptoms of nausea and anorexia. This study has proved that 73.57% of DLC subjects had malnutrition, and 58.26 % of them (42.86 % of all DLC subjects) were in a muscle wasting condition (the percentile of AMA < 5). Il showed a correlation to a decrease in the energy intake (p = 0.007). The increase of fat mobilization and lipid substrate oxidation were shown by the DLC subjects' TSF of more than 67% with a percentile of less than 15 and the mean RQ = 0.7 ± 0.08. This also had a significant correlation to a decrease in the energy intake (p = 0.005). The increase of fat mobilization and lipolysis was assumed to have a correlation with the low level of blood IGF-1 and the high levels of blood GH. The increase of lipid substrate oxidation was assumed to prevent the subsequent of muscle catabolism, however this study showed that the process of muscle catabolism does not end, which was marked by a negative nitrogen balance, a significantly higher the UNUIC.AMA than the control and a RQ of 0.43 - 0.86. In this study, there was no significant difference between the REE of the DLC subjects and the control; this was due to the decrease of muscle mass and the increase of lipid substrate oxidation. This caused a low V02 consumption and a low REE. This study showed REEIC.AMA of the DLC subjects was significantly higher than the control. This condition indicated that the subjects were hyper metabolic with several abnormalities in metabolism such as: continued stimulation causing lipid mobilization from adipose tissue; incomplete oxidation of fatty acid and protein substrate oxidation running together. Energy intake, body composition, the metabolic status of DLC patients was an important reference for the identification of the REE. By using variables which influenced REE, i.e. the mean energy intake, body composition (height, weight, C.AMA, etc.) and the degree of disease severity (Child-Pugh score, albumin, and UNU), which were tested by the multiple linear regression of STEPWISE method, the equation model has been formulated and tested The final equation for estimating energy requirement is:

Energy requirements = -270.40 + 17.26*AOLA - 217.83*Albumin + 11.42?Height.

Conclusion RITE is not the only indicator of hyper metabolism in DLC patients. Hyper metabolism can be identified in DLC patients using REFIC.AMA and UNUIC.AMA. This study has proved abnormalities in metabolism of DLC patients as follows: continued stimulation causing lipid mobilization from adipose tissue; oxidation of fatty acid; muscle protein catabolism; and protein substrate oxidation running together. Through multiple linear regression analysis (the STEPWISE method), AMA, albumin level and height have been found as strong determiners of REE or determiners of energy requirements for DLC subjects."

"ABSTRACTUnder nutrition among Vietnamese children is still a serious health problem. Growth retardation starts as early as 4 to 6 months of life and the prevalence of stunting has remained high (46.9% in 1994). It is documented that growth retardation during early childhood works through in adolescence and is rarely made up; it could also affect cognitive development of children, which eventually influence economic and human development. A longitudinal study on growth and development of Vietnamese children in Hanoi from birth to 17 years old was carried out from 1981 up to 1999.Objectives: To investigate the physical growth, maturation age and academic performance of Vietnamese children on a longitudinal basis from birth to 17 years old and observe their secular trends.Study design: A longitudinal observational study with 2 main cohorts: cohort A and cohort B.Subjects of the study:- Cohort A: 300 newborns, who fulfilled the selection criteria (gestational age from 38 to 42 weeks, birth weight 2500g, normal singleton birth without physical abnormalities, "Kish" ethnic group. mother's age: 20 to 35 years, and apparently healthy parents were randomly recruited and followed-up from birth to 17 years old (1981-1999).- Cohort B. 200 children, who fulfilled above-mentioned criteria, were randomly selected and followed-up, from birth to 12 months; and 200 children were followed-up, from 12 to 24 months (1997-1999).Monitoring of physical growth: Weight, height, feeding practices and diseases were recorded monthly from birth w 12 months, three monthly from 12 to 36 months, six monthly from 36 to 72 months, and annually thereafter until 17 years of age.Results: Mean body weight and height of children from both cohorts at birth were lower than the NCHS reference. Then their weight and height during the first 3-4 months (cohort A) and 5-6 months (cohort B) were comparable to NCHS reference data. However, these trends were going down on subjects' aged above 6 months onwards. Physical growth of the children in cohort B, who have been in better living conditions, health care and more appropriate feeding practices, was better than the other counterparts (cohort A) comparable to French Vietnamese in Paris (1986).The most intense period of growth retardation was observed in children aged 12 10 24 months. Children who were stunted during early childhood were still shorter than those non-stunted ones over observed period from birth to 17 years of age; the children who were stunted during childhood matured later and had lower academic performance than the well-nourished ones.Birth weight, diarrhea and ARI were found to be the main determinants /or nutritional status of the children. Nutritional status of the parents in cohort B was also better compared to that of cohort A, - and the nutritional status of the children, whose mothers were undernourished, was worse than that those of well nourished mothers. Long term effect of exclusive breast feeding on nutritional status of children leas observed in cohort A, however, it was correlated with WAZ of the children in cohort B only during the first 3 months of age.Conclusions: There was a positive secular trend in growth of Vietnamese children over the last 2 decades. There was a partial catch-up growth among the snorted children during adolescence. Birth weight, diarrhea and ARI were the main determinants for nutritional status of the young children. Exclusive breast-feeding determined nutritional status of children in cohort A over the period from birth to 24 months old, however, it was correlated with WAZ of the children in cohort B only during the first 3 months (Ore. Nutritional status of both children and mothers can he used as an indicator for quality of life. The stunted children at preschool age matured later and had lower academic performance than the non-stunted ones."

"Insiden dan prevelansi penyakit ginjal kronik (PGK) meningkat dari tahun ke tahun baik di negara maju ataupun sedang berkembang. Malnutrisi energi protein (MEP) sering dijumpai pada penderita PGK dengan dialisis (PGK-D) ataupun sebelum mendapat terapi dialisis (PGK-ND). Malnutrisi energi protein pada PGK-ND dapat menurunkan kualitas hidup, meningkatkan morbiditas dan mortalitas serta merupakan prediktor yang kuat terhadap survival penderita PGK-D di kemudian hari. Tujuan penelitian untuk memperoleh parameter komposisi tubuh dan fungsi otot yang dapat mendeteksi kecenderungan terjadinya MEP pada penderita PGK-ND. Metode. Penelitian dilakukan di Bagian Penyakit Dalam RS Sumber Waras, RS PGI. Cikini, RS Islam Jakarta dan Universitas Tarumanegara dengan rancangan cross sectional. Subyek penelitian: 45 penderita PGK-ND (30 laki=laki, 15 perempuan) dan 45 subyek kontrol yang disepadankan jenis kelamin, usia (PGK-ND 48,2 ≠7,3 tahun, kontrol 47,7 + 6,2 tahun) tinggi badan (PGK-ND 159,4 ≠ 7,5 cm, kontrol 160,6 ≠ 7,6 cm) dan indeks massa tubuh (IMT) (PGK-ND 22,4 ≠ 3,4 kg/m2, kontrol 22,5 ≠ 3,1 kg/m2). Status nutrisi dikelompokkan dalam status nutrisi kurang, normal dan lebih berdasarkan IMT, WHO, 1995. Pada penderita dan subyek kontrol dilakukan penilaian asupan nutrisi (tanya ulang 2 X 24 jam dan pncatatan asupan makanan), pemeriksaan biokimiawi (darah dan urin), pengukuran komposisi tubuh (antropimetri dan bioelectric impedance analysis, BIA). dan fungsi otot (kekuatan genggam tangan). Hasil. Penderita dan subyek kontrol didapatkan 7 (15,6%) status nutrisi kurang, 28 (62,2%) normal dan 10 (22,2%) lebih. Rerata laju filtrasi glomerulus penderita PGK-ND sebesar 19,3 + 1,7 mL/men/1,73m2, 13 (28,9%) penderita stadium 3, 17 (37,8%) stadium 4 dan 15 (33,3%) stadium 5. Konsentrasi albumin, prealbumin dan insulin like growth factor-1 (IGF-1) penderita PGK-ND tidak berbeda bermakna berdasarkan status nutrisi dan stadium PGK. Konsentrasi transferin didapatkan lebih tinggi bermakna pada penderita PGK-ND status nutrisi lebih dibandingkan dengan status nutrisi kurang dan normal. Konsentrasi C reactive protein (CRP) lebih tinggi bermakna pada penderita PGK-ND status nutrisi kurang dibandingkan dengan status nutrisi baik. Derajat asidosis metabolik (konsentrasi HCO3) penderita PGK-ND tidak berbeda berdasarkan status nutrisi dan stadium PGK. Secara antropometri massa bebas lemak (MBL), indeks-MBL (I-MBL), massa lemak (ML) dan persen (ML penderita PGK-ND tidak berbada bermakna dengan subyek kontrol. Berdasarkan BIA didapatkan MBL, dan I-MBL, persen ML penderita PGK-ND lebih tinggi bermakna dibandingkan subyek kontrol (p < 0,05). Massa bebas lemak (MBL), I-MBL dan ML mempunyai linearitas dengan klasifikasi status nutrisi berdasarkan uji trend analysis. Massa bebas lemak dan I-MBL berkolerasi dengan IMT. Massa bebas lemak, I-MBL, ML dan PGK-ND tidak berbeda dengan subyek kontrol dan berdasarkan status nutrisi serta stadium PGK. Status (KGT) penderita lebih rendah bermakna dibandingkan dengan kontrol, dan KGT penderita dengan status nutrisi kurang lebih rendah bermakna dibandingkan dengan status nutrisi baik. Kekuatan genggam tangan mempunyai korelasi dengan I-MBL dan IMT. Terdapat kesesuaian yang baik antara I-MBL dan KGT dengan IMT untuk penilaian status nutrisi penderita PGK-ND. Dengan uji Receiver Operating Curve didapatkan titik potong I-MBL sebesar 14,23 kg/m2 dan titik potong KGT sebesar 9,7 kg untuk membedakan status nutrisi kurang dan baik. Kesimpulan. Penelitian ini menunjukkan protein viseral (albumin, prealbumin, transferin dan insulin like growth factor-1) merupakan parameter status nutrisi yang lemah untuk penderita PGK-ND. Indeks massa tubuh mempunyai kolerasi positif dengan I-MBL dan KGT. Indeks-MBL dan KGT dapat membedakan derajat status nutrisi penderita (PGK-ND stadium 3,4 dan 5, dan dapat digunakan sebagai prediktor untuk skrining status nutrisi pada penderita PGK-ND."

"Anemia is the main micronutrient deficiency problem among adolescent school girls in Indonesia. Anemia due to iron deficiency often coexists with zine deficiency. Iron and zinc have anlagonistic interaction. Therefore, it was appropriate ratio of iron-zinc supplementation.ObjectiveThe study was aimed to investigate the different ratios of iron-zinc supplementation Fe: Zn = 2: 1 and Fe: Zn = 4: 1 on improving the iron and zinc status and eventually reduction of the morbidity of anemic adolescent school girls compared to iron supplementation alone.MethodologyA randomized, double blind community trial was conducted among anemic adolescent school girls (10-12 years old). Selection of subjects was conduted in two steps. Firstly, 238 girls (out of 1358 girls), with hemoglobin concentration level < 115 g/L using Hemocue were recruited and given antihelminthic drug (500 mg mebendazole as a single dose). Secondly, those who had hemoglobin concentration < 120 g/L using Cell Dyn from venous blood one week after deworming (n+133) were enrolled into the study.The 133 subjects were assigned randomly to one of the three groups for daily iron-zinc supplementation for 12 weeks with: Group 1 (n=45): iron (60 mg/day), Group 2 (n=45): iron and zinc (30 mg and 15 mg/day) or group 3 (n=43): iron and zinc (60 mg and 15 mg/day).Supplement intake was supervised at base line, weight and height were measured and the available iron and zinc intake from diet was estimated using a model modified from WHO/FAO and Murphy, based on the data 24-hour Food Recall and Food Frequency Questionnare. Iron (hemoglobin/Hb, serum ferritin/SF, serum transferrin receptor/TfR, zinc protoporphyrin/ZPP, Mean Corpuscular Volume/MCV, Red-cell Distribution Width/RDW, body iron/BI) and zinc (serum zinc/SZ) status and supplementation. Morbidity status of diarrhea and Acule Respiratory Infection (ARI) were recorded weekly. The phagocytes cell and Cell-Mediated Immunity were measured only for 50% of the subjects.Results and DiscussionBy the end of the supplementation, most indicators of iron status were increased significantly in all subjects both they took iron supplementation with or without zinc, and the proportion of iron deficiency anemia reduced. Iron supplementation alone or iron-zinc improved zinc status. The proportion of zinc deficiency was sinificantly reduced only among subjects who took iron-zinc supplementation with the ratio of Fe: Zn =2: 1. which was significantly lower compared to the other two groups at the end of supplementation. In iron/zinc 2 : 1 group, no subject had iron deficiency anemia and zinc deficiency after 12 weeks of supplementation, which suggested that iron-zinc supplementation with the ration of Fe: Zn = 2 : 1 had reduced both iron deficiency anemia and zinc deficiency.In this study, iron deficiency among anemic school girls was due to insufficiency of iron in red blood cell, and iron or iron-zinc supplementation for 12 weeks had less benefit to increase iron status. The possibility; of hemoglobinopathies such as thalassemia trait affecting adolescent girls in this study should be considered as several studies indicated that the prevalence of tlinlassemia trait among the same population in Indonesia is high.Iron deficiency also occurred at the storage level, which increased and reached the normal value with iron or iron-zinc supplementation. At the end of supplementation, the mean value of most indicators of iron status in all groups did not reach the normal value (such as Hb < 120 g/L, ZPP > 40 umol/mol heme, MCV <2 80 fL, RDW > l4%), perhaps the 12-weeks of iron supplementation was not long enough to fulfill iron for the 120 erythrocyte life cycle.lt seems, that the competition between iron and zinc occurred both at the storage level and the erythrocyte formation, and iron-zinc supplementation with the ratio of Fe: Zn = 2: 1 had minimal interaction as the improvement of both iron and zinc status was higher compared to the other groups. Most anemic adolescent school girls in this study had low available iron and zinc intake from the diet, with low intake of enhancers and high intake of inhibitors, which is not enough to promote either iron or zinc absorption from the supplements.The reduction of the proportion ol' subjects suffering from ARI was the highest among subjects who took either iron alone (3l.1% to 6.7%) compared to those who took iron- zinc supplement with ratio 2: 1 (1 7.3% to l1.l%) or iron-zinc supplement with ratio 4: 1(16.3 % to l4%), indicating that iron alone reduced morbidity status in tenn of Acute Respiratory Infection (ARI). However, adding zinc to iron supplements with ratio 2: 1 scents to improve the specific immune response of anemic adolescent school girls, as shown that the ratio of CD-4/CD-S was slightly increased among subjects who took iron-zinc supplement with the ratio of Fe: Zn= 2: 1.Conclusions and Recommendationslt was concluded, that both iron deficiency anemia (22%) and zinc deficiency (15.8%) were problems in the study area. Iron deficiency and hemoglobinopathies such as that assemia trait might be the causes of anemia among adolescent school girls. A daily 30 mg iron and 15 mg zinc supplementation among anemic adolescent schools girls for 12 weeks improved iron and zinc status and reduced iron deficiency anemia and zinc deficiency. Iron supplementation alone increased iron status, while adding zinc to iron supplementation protected the adverse effect of iron on decreasing zinc status.The competition between iron and zinc might occur in the role of both nutrients for erythrocytes formation as well-as at storage level, and supplementation with the ratio of Fe: Zn = 2: 1 had minimal interaction on improving bot.h iron and zinc status. As most of the anemic adolescent school girls had inadequate iron and zinc intake from the diet, the deficiencies of other micronutrients such as; vitamin A, folic acid and vitamin B12 should also be considered as the causes of anemia.Combined iron-zinc supplementation with the ratio of Fe: Zn = 2: 1 was appropriate on reducing the risk of anemic adolescent school girls suffering from Acute Respiratory Infection, however the mechanism of both iron and zinc on enhancing immune system could not clearly be shown from the results of this study.It is recommended to establish an iron-zinc supplementation program with ratio of 2: 1 through the existing channel of school health program to alleviate iron de iciency anemia and zinc deficiency 'among adolescent girls. Research cum action prioritized is to explain the contribution of bioavailability iron and zinc intake from the diet including increase the enhancers and minimize the inhibitors to the absorption of iron-zinc supplementation with ratio of Fe: Zn = 2: 1. The possibility of hemoglobinopathies such as thalassemia trait, as the cause of anemia needs further investigations."

"Anemia is the main micronutrient deficiency problem among adolescent school girls in Indonesia. Anemia due to iron deficiency often coexists with zine deficiency. Iron and zinc have anlagonistic interaction. Therefore, it was appropriate ratio of iron-zinc supplementation. Objective The study was aimed to investigate the different ratios of iron-zinc supplementation Fe: Zn = 2: 1 and Fe: Zn = 4: 1 on improving the iron and zinc status and eventually reduction of the morbidity of anemic adolescent school girls compared to iron supplementation alone. Methodology randomized, double blind community trial was conducted among anemic adolescent school girls (10-12 years old). Selection of subjects was conduted in two steps. Firstly, 238 girls (out of 1358 girls), with hemoglobin concentration level < 115 g/L using Hemocue were recruited and given antihelminthic drug (500 mg mebendazole as a single dose). Secondly, those who had hemoglobin concentration < 120 g/L using Cell Dyn from venous blood one week after deworming (n+133) were enrolled into the study. The 133 subjects were assigned randomly to one of the three groups for daily iron-zinc supplementation for 12 weeks with: Group 1 (n=45): iron (60 mg/day), Group 2 (n=45): iron and zinc (30 mg and 15 mg/day) or group 3 (n=43): iron and zinc (60 mg and 15 mg/day).Supplement intake was supervised at base line, weight and height were measured and the available iron and zinc intake from diet was estimated using a model modified from WHO/FAO and Murphy, based on the data 24-hour Food Recall and Food Frequency Questionnare. Iron (hemoglobin/Hb, serum ferritin/SF, serum transferrin receptor/TfR, zinc protoporphyrin/ZPP, Mean Corpuscular Volume/MCV, Red-cell Distribution Width/RDW, body iron/BI) and zinc (serum zinc/SZ) status and supplementation. Morbidity status of diarrhea and Acule Respiratory Infection (ARI) were recorded weekly. The phagocytes cell and Cell-Mediated Immunity were measured only for 50% of the subjects. Results and Discussion By the end of the supplementation, most indicators of iron status were increased significantly in all subjects both they took iron supplementation with or without zinc, and the proportion of iron deficiency anemia reduced. Iron supplementation alone or iron-zinc improved zinc status. The proportion of zinc deficiency was sinificantly reduced only among subjects who took iron-zinc supplementation with the ratio of Fe: Zn =2: 1. which was significantly lower compared to the other two groups at the end of supplementation. In iron/zinc 2 : 1 group, no subject had iron deficiency anemia and zinc deficiency after 12 weeks of supplementation, which suggested that iron-zinc supplementation with the ration of Fe: Zn = 2 : 1 had reduced both iron deficiency anemia and zinc deficiency. In this study, iron deficiency among anemic school girls was due to insufficiency of iron in red blood cell, and iron or iron-zinc supplementation for 12 weeks had less benefit to increase iron status. The possibility; of hemoglobinopathies such as thalassemia trait affecting adolescent girls in this study should be considered as several studies indicated that the prevalence of tlinlassemia trait among the same population in Indonesia is high. Iron deficiency also occurred at the storage level, which increased and reached the normal value with iron or iron-zinc supplementation. At the end of supplementation, the mean value of most indicators of iron status in all groups did not reach the normal value (such as Hb < 120 g/L, ZPP > 40 umol/mol heme, MCV <2 80 fL, RDW > l4%), perhaps the 12-weeks of iron supplementation was not long enough to fulfill iron for the 120 erythrocyte life cycle. lt seems, that the competition between iron and zinc occurred both at the storage level and the erythrocyte formation, and iron-zinc supplementation with the ratio of Fe: Zn = 2: 1 had minimal interaction as the improvement of both iron and zinc status was higher compared to the other groups. Most anemic adolescent school girls in this study had low available iron and zinc intake from the diet, with low intake of enhancers and high intake of inhibitors, which is not enough to promote either iron or zinc absorption from the supplements. The reduction of the proportion ol' subjects suffering from ARI was the highest among subjects who took either iron alone (3l.1% to 6.7%) compared to those who took iron- zinc supplement with ratio 2: 1 (1 7.3% to l1.l%) or iron-zinc supplement with ratio 4: 1(16.3 % to l4%), indicating that iron alone reduced morbidity status in tenn of Acute Respiratory Infection (ARI). However, adding zinc to iron supplements with ratio 2: 1 scents to improve the specific immune response of anemic adolescent school girls, as shown that the ratio of CD-4/CD-S was slightly increased among subjects who took iron- zinc supplement with the ratio of Fe: Zn= 2: 1 Conclusions and Recommendations lt was concluded, that both iron deficiency anemia (22%) and zinc deficiency (15.8%) were problems in the study area. Iron deficiency and hemoglobinopathies such as that assemia trait might be the causes of anemia among adolescent school girls. A daily 30 mg iron and 15 mg zinc supplementation among anemic adolescent schools girls for 12 weeks improved iron and zinc status and reduced iron deficiency anemia and zinc deficiency. Iron supplementation alone increased iron status, while adding zinc to iron supplementation protected the adverse effect of iron on decreasing zinc status. The competition between iron and zinc might occur in the role of both nutrients for erythrocytes formation as well-as at storage level, and supplementation with the ratio of Fe: Zn = 2: 1 had minimal interaction on improving bot.h iron and zinc status. As most of the anemic adolescent school girls had inadequate iron and zinc intake from the diet, the deficiencies of other micronutrients such as; vitamin A, folic acid and vitamin B12 should also be considered as the causes of anemia. Combined iron-zinc supplementation with the ratio of Fe: Zn = 2: 1 was appropriate on reducing the risk of anemic adolescent school girls suffering from Acute Respiratory Infection, however the mechanism of both iron and zinc on enhancing immune system could not clearly be shown from the results of this study. It is recommended to establish an iron-zinc supplementation program with ratio of 2: 1 through the existing channel of school health program to alleviate iron de iciency anemia and zinc deficiency 'among adolescent girls. Research cum action prioritized is to explain the contribution of bioavailability iron and zinc intake from the diet including increase the enhancers and minimize the inhibitors to the absorption of iron-zinc supplementation with ratio of Fe: Zn = 2: 1. The possibility of hemoglobinopathies such as thalassemia trait, as the cause of anemia needs further investigations."